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Nick Leslie

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
24
Downes, Peter
6
Gray, Alex
6
Davidson, Lindsay
5
Perera, Nevin
5
Lindsay, Yvonne
5
Batty, Ian
4
Bennett, Deborah
4
Safrany, Steve
3
Pass, Ian
2
Lucocq, John
2
McConnachie, George
2
Walker, Steven
2
Prescott, Alan
2
Alessi, Dario
2
Weijer, Cornelis

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Publications

TOP 3
Leslie Nick R
P-REX2a driving tumorigenesis by PTEN inhibition.
Leslie Nick R; Maccario Helene; Spinelli Laura; Davidson Lindsay
The significance of PTEN's protein phosphatase activity.
Leslie N R; Batty I H; Maccario H; Davidson L; Downes C P
Understanding PTEN regulation: PIP2, polarity and protein stability.

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All Publications

2009: Leslie Nick R
P-REX2a driving tumorigenesis by PTEN inhibition.
Science signaling 2009;2(94):pe68.
2009: Leslie Nick R; Maccario Helene; Spinelli Laura; Davidson Lindsay
The significance of PTEN's protein phosphatase activity.
Advances in enzyme regulation 2009;49(1):190-6.
2008: Leslie N R; Batty I H; Maccario H; Davidson L; Downes C P
Understanding PTEN regulation: PIP2, polarity and protein stability.
Oncogene 2008;27(41):5464-76.
2007: Lackey J; Barnett J; Davidson L; Batty I H; Leslie N R; Downes C P
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
Oncogene 2007;26(50):7132-42.
2007: Maccario Helene; Perera Nevin M; Davidson Lindsay; Downes C Peter; Leslie Nick R
PTEN is destabilized by phosphorylation on Thr366.
The Biochemical journal 2007;405(3):439-44.
2007: Ross Sarah H; Lindsay Yvonne; Safrany Stephen T; Lorenzo Oscar; Villa Fabrizio; Toth Rachel; Clague Michael J; Downes C Peter; Leslie Nick R
Differential redox regulation within the PTP superfamily.
Cellular signalling 2007;19(7):1521-30.
2007: Downes C P; Leslie N R; Batty I H; van der Kaay J
Metabolic switching of PI3K-dependent lipid signals.
Biochemical Society transactions 2007;35(Pt 2):188-92.
2007: Leslie Nick R; Yang Xuesong; Downes C Peter; Weijer Cornelis J
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.
Current biology : CB 2007;17(2):115-25.
2007: Downes C Peter; Ross Sarah; Maccario Helene; Perera Nevin; Davidson Lindsay; Leslie Nick R
Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.
Advances in enzyme regulation 2007;47():184-94.
2007: Downes C Peter; Perera Nevin; Ross Sarah; Leslie Nick R
Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.
Biochemical Society symposium 2007;(74):69-80.
2006: Lindsay Yvonne; McCoull David; Davidson Lindsay; Leslie Nick R; Fairservice Alison; Gray Alex; Lucocq John; Downes C Peter
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.
Journal of cell science 2006;119(Pt 24):5160-8.
2006: Leslie Nick R
The redox regulation of PI 3-kinase-dependent signaling.
Antioxidants & redox signaling 2006;8(9-10):1765-74.
2006: Ning Ke; Miller Lisa C; Laidlaw Hilary A; Burgess Laura A; Perera Nevin M; Downes C Peter; Leslie Nick R; Ashford Michael L J
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.
The EMBO journal 2006;25(11):2377-87.
2005: Leslie N R; Yang X; Downes C P; Weijer C J
The regulation of cell migration by PTEN.
Biochemical Society transactions 2005;33(Pt 6):1507-8.
2005: Bayascas Jose R; Leslie Nick R; Parsons Ramon; Fleming Stewart; Alessi Dario R
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Current biology : CB 2005;15(20):1839-46.
2004: Leslie N R; Lindsay Y; Ross S H; Downes C P
Redox regulation of phosphatase function.
Biochemical Society transactions 2004;32(Pt 6):1018-20.
2004: Leslie Nick R; Downes C Peter
PTEN function: how normal cells control it and tumour cells lose it.
The Biochemical journal 2004;382(Pt 1):1-11.
2004: Spruce Barbara A; Campbell Lorna A; McTavish Niall; Cooper Michelle A; Appleyard M Virginia L; O'Neill Mary; Howie Jacqueline; Samson Jayne; Watt Stephen; Murray Karen; McLean Doris; Leslie Nick R; Safrany Stephen T; Ferguson Michelle J; Peters John A; Prescott Alan R; Box Gary; Hayes Angela; Nutley Bernard; Raynaud Florence; Downes C Peter; Lambert Jeremy J; Thompson Alastair M; Eccles Suzanne
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.
Cancer research 2004;64(14):4875-86.
2004: Downes C P; Walker S; McConnachie G; Lindsay Y; Batty I H; Leslie N R
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.
Biochemical Society transactions 2004;32(Pt 2):338-42.
2004: Walker Steven M; Leslie Nick R; Perera Nevin M; Batty Ian H; Downes C Peter
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
The Biochemical journal 2004;379(Pt 2):301-7.
2004: Watt Stephen A; Kimber Wendy A; Fleming Ian N; Leslie Nick R; Downes C Peter; Lucocq John M
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.
The Biochemical journal 2004;377(Pt 3):653-63.
2004: Orchiston Elaine A; Bennett Deborah; Leslie Nick R; Clarke Rosemary G; Winward Lucinda; Downes C Peter; Safrany Stephen T
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.
The Journal of biological chemistry 2004;279(2):1116-22.
2003: Leslie Nick R; Bennett Deborah; Lindsay Yvonne E; Stewart Hazel; Gray Alex; Downes C Peter
Redox regulation of PI 3-kinase signalling via inactivation of PTEN.
The EMBO journal 2003;22(20):5501-10.
2002: Leslie Nick R; McLennan Alexander G; Safrany Stephen T
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.
BMC biochemistry 2002;3():20.
2002: Leslie Nick R; Downes C Peter
PTEN: The down side of PI 3-kinase signalling.
Cellular signalling 2002;14(4):285-95.
2001: Walker S M; Downes C P; Leslie N R
TPIP: a novel phosphoinositide 3-phosphatase.
The Biochemical journal 2001;360(Pt 2):277-83.
2001: Downes C P; Bennett D; McConnachie G; Leslie N R; Pass I; MacPhee C; Patel L; Gray A
Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.
Biochemical Society transactions 2001;29(Pt 6):846-51.
2001: Leslie N R; Biondi R M; Alessi D R
Phosphoinositide-regulated kinases and phosphoinositide phosphatases.
Chemical reviews 2001;101(8):2365-80.
2001: Leslie N R; Bennett D; Gray A; Pass I; Hoang-Xuan K; Downes C P
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
The Biochemical journal 2001;357(Pt 2):427-35.
2000: Peyrollier K; Hajduch E; Gray A; Litherland G J; Prescott A R; Leslie N R; Hundal H S
A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.
The Biochemical journal 2000;352 Pt 3():617-22.
2000: Leslie N R; Gray A; Pass I; Orchiston E A; Downes C P
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.
The Biochemical journal 2000;346 Pt 3():827-33.

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