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David Leslie

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TOP 3
Huriya Beyan; L Wen; R David G Leslie
Guts, germs, and meals: the origin of type 1 diabetes.
R David G Leslie; Robert M Cohen
Biologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications.
Jennifer S Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; tim tree; R David G Leslie; Jennifer M Tremble; Colin M Dayan; Mark Peakman
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.

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All Publications

2012: Huriya Beyan; L Wen; R David G Leslie
Guts, germs, and meals: the origin of type 1 diabetes.
Current diabetes reports 2012;12(5):456-62.
2009: R David G Leslie; Robert M Cohen
Biologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications.
Journal of diabetes science and technology 2009;3(4):635-43.
2009: Jennifer S Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; tim tree; R David G Leslie; Jennifer M Tremble; Colin M Dayan; Mark Peakman
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.
Diabetes 2009;58(1):138-45.
2008: J M Lawson; Jennifer M Tremble; Colin M Dayan; H Beyan; R David G Leslie; Mark Peakman; tim tree
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes.
Clinical and experimental immunology 2008;154(3):353-9.
2008: R David G Leslie; H Kolb; N C Schloot; R Buzzetti; D Mauricio; A De Leiva; K Yderstraede; C Sarti; C Thivolet; D Hadden; S Hunter; Guntram Schernthaner; Werner A Scherbaum; R Williams; Paolo Pozzilli
Diabetes classification: grey zones, sound and smoke: Action LADA 1.
Diabetes/metabolism research and reviews 2008;24(7):511-9.
2008: Roos C Padmos; Nanette C Schloot; Huriya Beyan; Cindy Ruwhof; Frank Staal; Dick de Ridder; Henk-Jan Aanstoot; Wai-Kwan Lam-Tse; Harm de Wit; Christian de Herder; Roos C Drexhage; Barbara Menart; R David G Leslie; Hemmo Drexhage
Distinct monocyte gene-expression profiles in autoimmune diabetes.
Diabetes 2008;57(10):2768-73.
2006: Huriya Beyan; Martin R Goodier; Niga Nawroly; Mohammed I Hawa; Stephen Andrew Bustin; William Ogunkolade; Marco Londei; Nasim Yousaf; R David G Leslie
Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes.
Diabetes 2006;55(12):3439-45.
2006: Martin R Goodier; Niga Nawroly; Huriya Beyan; Mohammed I Hawa; R David G Leslie; Marco Londei
Identical twins discordant for type 1 diabetes show a different pattern of in vitro CD56+ cell activation.
Diabetes/metabolism research and reviews 2006;22(5):367-75.
2006: Robert M Cohen; Harold Snieder; Christopher J Lindsell; Huriya Beyan; Mohammed I Hawa; Stuart Blinko; Raymond Edwards; Timothy D Spector; R David G Leslie
Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins.
Diabetes care 2006;29(8):1739-43.
2006: R David G Leslie; Rhys Williams; Paolo Pozzilli
Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow.
The Journal of clinical endocrinology and metabolism 2006;91(5):1654-9.
2006: Mohammed I Hawa; Antonio Picardi; Flavia Costanza; D D'Avola; G Beretta Anguissola; chiara guglielmi; G Mottini; Leopold Fezeu; Jean-Claude Mbanya; R David G Leslie; Paolo Pozzilli
Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon.
Clinical immunology (Orlando, Fla.) 2006;118(2-3):229-32.
2005: Mohammed I Hawa; Riccardo Bonfanti; Christina Valeri; Michela Delli Castelli; Huriya Beyan; R David G Leslie
No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins.
Diabetes care 2005;28(6):1415-8.
2005: K D Schmidt; C Valeri; R David G Leslie
Autoantibodies in Type 1 diabetes.
Clinica chimica acta; international journal of clinical chemistry 2005;354(1-2):35-40.
2004: R David G Leslie; Michela Delli Castelli
Age-dependent influences on the origins of autoimmune diabetes: evidence and implications.
Diabetes 2004;53(12):3033-40.
2004: Mohammed I Hawa; MG Valorani; Lisa Rebecca Buckley; PE Beales; Antonella Afeltra; Fabio Cacciapaglia; R David G Leslie; Paolo Pozzilli
Lack of effect of vitamin D administration during pregnancy and early life on diabetes incidence in the non-obese diabetic mouse.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2004;36(9):620-4.
2004: Mohammed I Hawa; Huriya Beyan; R David G Leslie
Principles of autoantibodies as disease-specific markers.
Autoimmunity 2004;37(4):253-6.
2003: Tobias Lohmann; Marco Londei; Mohammed I Hawa; R David G Leslie
Humoral and cellular autoimmune responses in stiff person syndrome.
Annals of the New York Academy of Sciences 2003;998():215-22.
2003: R David G Leslie; Huriya Beyan; Pam Sawtell; Bernard O Boehm; Tim D Spector; Harold Snieder
Level of an advanced glycated end product is genetically determined: a study of normal twins.
Diabetes 2003;52(9):2441-4.
2003: Michela Delli Castelli; R David G Leslie
Diabetic retinopathy: medical management and assessment.
Hospital medicine (London, England : 1998) 2003;64(7):400-3.
2003: Huriya Beyan; Lisa Rebecca Buckley; N Yousaf; Marco Londei; R David G Leslie
A role for innate immunity in type 1 diabetes?
Diabetes/metabolism research and reviews 2003;19(2):89-100.
2002: Mohammed I Hawa; R David G Leslie
GAD antigen and its significance in type I diabetes.
Journal of endocrinological investigation 2002;25(7):576.
2002: Mohammed I Hawa; Huriya Beyan; Lisa Rebecca Buckley; R David G Leslie
Impact of genetic and non-genetic factors in type 1 diabetes.
American journal of medical genetics 2002;115(1):8-17.
2002: R David G Leslie; Paolo Pozzilli
An introduction to new advances in diabetes.
Diabetes/metabolism research and reviews 2002;18 Suppl 1():S1-6.
2001: Mohammed I Hawa; R David G Leslie
Early induction of type 1 diabetes.
Clinical and experimental immunology 2001;126(2):181-3.
2001: K A Metcalfe; Graham A Hitman; R E Rowe; Mohammed I Hawa; X Huang; T Stewart; R David G Leslie
Concordance for type 1 diabetes in identical twins is affected by insulin genotype.
Diabetes care 2001;24(5):838-42.
2001: Maria J Redondo; Liping Yu; Mohammed I Hawa; T Mackenzie; DA Pyke; George S Eisenbarth; R David G Leslie
Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States.
Diabetologia 2001;44(3):354-62.
2000: S S Lo; F Medici; R Rowe; Mohammed I Hawa; M St John Sutton; R David G Leslie
Effects of acute hyperglycaemia on cardiac function: an echocardiographic study of monozygotic twins.
International journal of cardiology 2000;74(2-3):139-44.
2000: Tobias Lohmann; Mohammed I Hawa; R David G Leslie; R Lane; J Picard; Marco Londei
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.
Lancet 2000;356(9223):31-5.
2000: R M Schulz; Mohammed I Hawa; R David G Leslie; F Sinigaglia; Nadia Passini; Lars Rogge; J K Picard; Marco Londei
Proliferative responses to selected peptides of IA-2 in identical twins discordant for Type 1 diabetes.
Diabetes/metabolism research and reviews 2000;16(3):150-6.
2000: Mohammed I Hawa; D Fava; F Medici; YJ Deng; Abner Louis Notkins; Giancarlo De Mattia; R David G Leslie
Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.
Diabetes care 2000;23(2):228-33.
1999: F Medici; Mohammed I Hawa; AE Giorgini; Araceli Panelo; Cecilia M Solfelix; R David G Leslie; Paolo Pozzilli
Antibodies to GAD65 and a tyrosine phosphatase-like molecule IA-2ic in Filipino type 1 diabetic patients.
Diabetes care 1999;22(9):1458-61.
1999: BA Kallmann; EF Lampeter; Pejman Hanifi-Moghaddam; Mohammed I Hawa; R David G Leslie; Hubert Kolb
Cytokine secretion patterns in twins discordant for Type I diabetes.
Diabetologia 1999;42(9):1080-5.
1999: F Medici; Mohammed I Hawa; A Ianari; DA Pyke; R David G Leslie
Concordance rate for type II diabetes mellitus in monozygotic twins: actuarial analysis.
Diabetologia 1999;42(2):146-50.
1999: R David G Leslie
United Kingdom prospective diabetes study (UKPDS): what now or so what?
Diabetes/metabolism research and reviews 1999;15(1):65-71.
1999: R David G Leslie; M A Atkinson; Abner Louis Notkins
Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.
Diabetologia 1999;42(1):3-14.
1998: Paolo Pozzilli; Natalia Visalli; Raffaella Buzzetti; Maria Gisella Cavallo; G Marietti; Mohammed I Hawa; R David G Leslie
Metabolic and immune parameters at clinical onset of insulin-dependent diabetes: a population-based study. IMDIAB Study Group. Immunotherapy Diabetes.
Metabolism: clinical and experimental 1998;47(10):1205-10.
1998: D Fava; S Gardner; DA Pyke; R David G Leslie
Evidence that the age at diagnosis of IDDM is genetically determined.
Diabetes care 1998;21(6):925-9.
1998: Abner Louis Notkins; Michael S Lan; R David G Leslie
IA-2 and IA-2beta: the immune response in IDDM.
Diabetes/metabolism reviews 1998;14(1):85-93.
1997: R David G Leslie; DA Pyke
Insulin dependent diabetes is probably due to environmental effect during childhood.
BMJ (Clinical research ed.) 1997;315(7114):1017.
1997: Mohammed I Hawa; R Rowe; Michael S Lan; Abner Louis Notkins; Paolo Pozzilli; M R Christie; R David G Leslie
Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes.
Diabetes 1997;46(8):1270-5.
1997: R David G Leslie; R Taylor; Paolo Pozzilli
The role of insulin resistance in the natural history of type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(4):327-31.
1997: D Fava; Mohammed I Hawa; R Rowe; DA Pyke; R David G Leslie
Clinical hypoglycemia before diabetes is rare. A study of identical twins.
Diabetes care 1997;20(4):678-9.
1997: Paolo Pozzilli; R David G Leslie
Hyperexpression of GAD in the islets may be relevant but is it sufficient to induce autoimmune insulitis?
Diabetologia 1997;40(3):357-61.
1997: S W Dubrey; R Beetham; J Miles; M I Noble; R Rowe; R David G Leslie
Increased urinary albumin and retinol-binding protein in type I diabetes. A study of identical twins.
Diabetes care 1997;20(1):84-9.
1996: Mark Peakman; R David G Leslie; L Alviggi; Mohammed I Hawa; Diego Vergani
Persistent activation of CD8+ T-cells characterizes prediabetic twins.
Diabetes care 1996;19(11):1177-84.
1996: Timothy Hardman; S W Dubrey; R David G Leslie; Ariel F Lant
Kinetic behavior of the erythrocyte sodium-lithium countertransporter in nonnephropathic diabetic twins.
Metabolism: clinical and experimental 1996;45(10):1203-7.
1996: Tobias Lohmann; R David G Leslie; Marco Londei
T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes.
Journal of autoimmunity 1996;9(3):385-9.
1996: Munther J Hussain; Mark Peakman; H Gallati; S S Lo; Mohammed I Hawa; G C Viberti; Peter J Watkins; R David G Leslie; Diego Vergani
Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM.
Diabetologia 1996;39(1):60-9.
1996: Timothy Hardman; S W Dubrey; R David G Leslie; Ariel F Lant
Erythrocyte sodium-lithium countertransport activity in non-nephropathic diabetic twins.
Diabetes care 1996;19(1):32-8.
1995: R E Rowe; R David G Leslie
Twin studies in insulin dependent diabetes and other autoimmune diseases.
Diabetes/metabolism reviews 1995;11(2):121-35.
1995: S S Lo; R David G Leslie; M S Sutton
Effects of type 1 diabetes mellitus on cardiac function: a study of monozygotic twins.
British heart journal 1995;73(5):450-5.
1994: Paolo Pozzilli; R David G Leslie
Infections and diabetes: mechanisms and prospects for prevention.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(10):935-41.
1994: D Fava; R David G Leslie; Paolo Pozzilli
Relationship between dairy product consumption and incidence of IDDM in childhood in Italy.
Diabetes care 1994;17(12):1488-90.
1994: R David G Leslie; Paolo Pozzilli
Type I diabetes masquerading as type II diabetes. Possible implications for prevention and treatment.
Diabetes care 1994;17(10):1214-9.
1994: R David G Leslie; R B Elliott
Early environmental events as a cause of IDDM. Evidence and implications.
Diabetes 1994;43(7):843-50.
1994: R A Smerdon; Mark Peakman; Munther J Hussain; F S Wong; Peter J Watkins; R David G Leslie; Diego Vergani
CD5+ B-cells at the onset of type I diabetes and in the prediabetic period.
Diabetes care 1994;17(7):657-64.
1994: Tobias Lohmann; R David G Leslie; Mohammed I Hawa; M Geysen; S Rodda; Marco Londei
Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus.
Lancet 1994;343(8913):1607-8.
1994: S W Dubrey; D R Reaveley; Mary Seed; D A Lane; H Ireland; M O'Donnell; B O'Connor; Mark I M Noble; R David G Leslie
Risk factors for cardiovascular disease in IDDM. A study of identical twins.
Diabetes 1994;43(6):831-5.
1994: Mark Peakman; L Alviggi; Munther J Hussain; S S Lo; Mohammed I Hawa; R David G Leslie; Diego Vergani
Increased expression of T-cell markers of immunological memory associated with protection from type I diabetes. A study of identical twins.
Diabetes 1994;43(5):712-7.
1994: R Y Tun; Mark Peakman; L Alviggi; Munther J Hussain; S S Lo; M Shattock; DA Pyke; G F Bottazzo; Diego Vergani; R David G Leslie
Importance of persistent cellular and humoral immune changes before diabetes develops: prospective study of identical twins.
BMJ (Clinical research ed.) 1994;308(6936):1063-8.
1994: S Dubrey; F Akhras; G J Song; Timothy Hardman; C Travill; J Hynd; Mark I M Noble; S S Lo; R David G Leslie
Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type 1 (insulin dependent) diabetes.
British heart journal 1994;71(4):341-8.
1994: R Y Tun; M D Smith; S S Lo; Graham Rook; P Lydyard; R David G Leslie
Antibodies to heat shock protein 65 kD in type 1 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(1):66-70.
1994: R David G Leslie; Mohammed I Hawa
Twin studies in auto-immune disease.
Acta geneticae medicae et gemellologiae 1994;43(1-2):71-81.
1993: R David G Leslie; P Carotenuto; Paolo Pozzilli
New developments in non-specific and semi-specific immunosuppression in type I diabetes.
Diabetes/metabolism reviews 1993;9(4):257-67.
1993: S S Lo; M S Sutton; R David G Leslie
Information on type 1 diabetes mellitus and QT interval from identical twins.
The American journal of cardiology 1993;72(3):305-9.
1993: Mark Peakman; R David G Leslie; Diego Vergani
Immunological studies on type 1 diabetes in identical twins.
Archives of disease in childhood 1993;69(1):97-9.
1993: R A Smerdon; Mark Peakman; Munther J Hussain; L Alviggi; Peter J Watkins; R David G Leslie; Diego Vergani
Increase in simultaneous coexpression of naive and memory lymphocyte markers at diagnosis of IDDM.
Diabetes 1993;42(1):127-33.
1992: Michael R Christie; R Y Tun; S S Lo; D Cassidy; T J Brown; J Hollands; M Shattock; G F Bottazzo; R David G Leslie
Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins.
Diabetes 1992;41(7):782-7.
1992: S S Lo; Mohammed I Hawa; S F Beer; DA Pyke; R David G Leslie
Altered islet beta-cell function before the onset of type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1992;35(3):277-82.
1991: S S Lo; R Y Tun; Mohammed I Hawa; R David G Leslie
Studies of diabetic twins.
Diabetes/metabolism reviews 1991;7(4):223-38.
1991: S S Lo; R Y Tun; R David G Leslie
Non-genetic factors causing type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1991;8(7):609-18.
1991: R David G Leslie; S Lo; Beverley A Millward; J Honour; DA Pyke
Decreased growth velocity before IDDM onset.
Diabetes 1991;40(2):211-6.
1990: S F Beer; D A Heaton; K G Alberti; DA Pyke; R David G Leslie
Impaired glucose tolerance precedes but does not predict insulin-dependent diabetes mellitus: a study of identical twins.
Diabetologia 1990;33(8):497-502.
1990: Mark Peakman; Munther J Hussain; Beverley A Millward; R David G Leslie; Diego Vergani
Effect of initiation of insulin therapy on T-lymphocyte activation in type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1990;7(4):327-30.
1990: C Johnston; Beverley A Millward; R David G Leslie; DA Pyke; G F Bottazzo
Are thyrogastric autoantibodies associated with an increased susceptibility to developing type 1 (insulin-dependent) diabetes? A study in identical twins.
Autoimmunity 1990;6(3):195-201.
1989: D A Heaton; N R Lazarus; DA Pyke; R David G Leslie
B-cell responses to intravenous glucose and glucagon in non-diabetic twins of patients with type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1989;32(11):814-7.
1989: C Johnston; Beverley A Millward; P Hoskins; R David G Leslie; G F Bottazzo; DA Pyke
Islet-cell antibodies as predictors of the later development of type 1 (insulin-dependent) diabetes. A study in identical twins.
Diabetologia 1989;32(6):382-6.
1989: R David G Leslie; N R Lazarus; D Vergani
Events leading to insulin-dependent diabetes.
Clinical science (London, England : 1979) 1989;76(2):119-24.
1989: R David G Leslie; N R Lazarus; D Vergani
Aetiology of insulin-dependent diabetes.
British medical bulletin 1989;45(1):58-72.
1988: C Johnston; L Alviggi; Beverley A Millward; R David G Leslie; DA Pyke; Diego Vergani
Alterations in T-lymphocyte subpopulations in type I diabetes. Exploration of genetic influence in identical twins.
Diabetes 1988;37(11):1484-8.
1988: P Olmos; R A'Hern; D A Heaton; Beverley A Millward; D Risley; DA Pyke; R David G Leslie
The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins.
Diabetologia 1988;31(10):747-50.
1988: G Senaldi; Beverley A Millward; Munther J Hussain; DA Pyke; R David G Leslie; Diego Vergani
Low serum haemolytic function of the fourth complement component (C4) in insulin dependent diabetes.
Journal of clinical pathology 1988;41(10):1114-6.
1988: D A Heaton; Beverley A Millward; I P Gray; Y Tun; C N Hales; DA Pyke; R David G Leslie
Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients.
Diabetologia 1988;31(3):182-4.
1988: A Millward; Munther J Hussain; Mark Peakman; DA Pyke; R David G Leslie; Diego Vergani
Characterization of islet cell antibody in insulin dependent diabetes: evidence for IgG1 subclass restriction and polyclonality.
Clinical and experimental immunology 1988;71(2):353-6.
1987: Munther J Hussain; L Alviggi; Beverley A Millward; R David G Leslie; DA Pyke; Diego Vergani
Evidence that the reduced number of natural killer cells in type 1 (insulin-dependent) diabetes may be genetically determined.
Diabetologia 1987;30(12):907-11.
1987: G Senaldi; Beverley A Millward; M J Hussein; DA Pyke; R David G Leslie; Diego Vergani
Complement in type 1 (insulin-dependent) diabetes.
Diabetologia 1987;30(10):823.
1987: Beverley A Millward; K I Welsh; R David G Leslie; DA Pyke; Andrew G Demaine
T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes.
Clinical and experimental immunology 1987;70(1):152-7.
1987: D A Heaton; Beverley A Millward; P Gray; Y Tun; C N Hales; DA Pyke; R David G Leslie
Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics.
British medical journal (Clinical research ed.) 1987;294(6565):145-6.
1986: Beverley A Millward; L Alviggi; P J Hoskins; C Johnston; D Heaton; G F Bottazzo; Diego Vergani; R David G Leslie; DA Pyke
Immune changes associated with insulin dependent diabetes may remit without causing the disease: a study in identical twins.
British medical journal (Clinical research ed.) 1986;292(6523):793-6.
1985: T Wilkin; P J Hoskins; M Armitage; M Rodier; C Casey; J L Diaz; DA Pyke; R David G Leslie
Value of insulin autoantibodies as serum markers for insulin-dependent diabetes mellitus.
Lancet 1985;1(8427):480-1.
1985: P J Hoskins; R David G Leslie; DA Pyke
Height at diagnosis of diabetes in children: a study in identical twins.
British medical journal (Clinical research ed.) 1985;290(6464):278-80.
1985: DA Pyke; P J Hoskins; R David G Leslie
[Monozygotic twins and genetic aspects of diabetes].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1985;():121-33.
1984: L Alviggi; C Johnston; P J Hoskins; D E Tee; DA Pyke; R David G Leslie; Diego Vergani
Pathogenesis of insulin-dependent diabetes: a role for activated T lymphocytes.
Lancet 1984;2(8393):4-6.
1984: P G Wiles; P Hoskins; R David G Leslie; DA Pyke
Prevalence of chlorpropamide alcohol flushing.
British medical journal (Clinical research ed.) 1984;288(6413):328-9.