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Rick Lesniewski

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Fang Jiang; Rick Lesniewski; Yanping Luo; Daniel H Albert; Steven K Davidsen; Gerard B Fox; Paul Tapang; Ke Zhang; Evelyn M McKeegan
ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models.
Peter J Ansell; Haiying Zhang; Don J Davidson; John E Harlan; John Xue; Sevan Brodjian; Rick Lesniewski; Evelyn McKeegan
Recombinant kringle 5 from plasminogen antagonises hepatocyte growth factor-mediated signalling.
Susan E Lacy; Peter J Devries; Nancy Xie; Emma Fung; Rick Lesniewski; Edward B Reilly
The potency of erythropoietin-mimic antibodies correlates inversely with affinity.

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All Publications

2011: Fang Jiang; Rick Lesniewski; Yanping Luo; Daniel H Albert; Steven K Davidsen; Gerard B Fox; Paul Tapang; Ke Zhang; Evelyn M McKeegan
ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models.
The Journal of pharmacology and experimental therapeutics 2011;338(1):134-42.
2010: Peter J Ansell; Haiying Zhang; Don J Davidson; John E Harlan; John Xue; Sevan Brodjian; Rick Lesniewski; Evelyn McKeegan
Recombinant kringle 5 from plasminogen antagonises hepatocyte growth factor-mediated signalling.
European journal of cancer (Oxford, England : 1990) 2010;46(5):966-73.
2008: Susan E Lacy; Peter J Devries; Nancy Xie; Emma Fung; Rick Lesniewski; Edward B Reilly
The potency of erythropoietin-mimic antibodies correlates inversely with affinity.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1282-7.
2008: L A Tucker; Qian Zhang; George S Sheppard; Pingping Lou; F Jiang; E McKeegan; Rick Lesniewski; Steven K Davidsen; Randy L Bell; Jieyi Wang
Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
Oncogene 2008;27(28):3967-76.
2007: Zhihong Liu; Vincent S Stoll; Peter J Devries; Clarissa Jakob; Nancy Xie; Robert L Simmer; Susan E Lacy; David A Egan; John Harlan; Rick Lesniewski; Edward B Reilly
A potent erythropoietin-mimicking human antibody interacts through a novel binding site.
Blood 2007;110(7):2408-13.
2007: Gary T Wang; Robert A Mantei; Megumi Kawai; Jason S Tedrow; David M Barnes; Jieyi Wang; Qian Zhang; Pingping Lou; Lora A Garcia; Jennifer J Bouska; Melinda Yates; Chang Park; Russell A Judge; Rick Lesniewski; George S Sheppard; Randy L Bell
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids.
Bioorganic & medicinal chemistry letters 2007;17(10):2817-22.
2007: Edward T Olejniczak; Charles Van Sant; Mark G Anderson; Gang Wang; Stephen K Tahir; Guido Sauter; Rick Lesniewski; Dimitri Semizarov
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Molecular cancer research : MCR 2007;5(4):331-9.
2007: Charles Van Sant; Gang Wang; Mark G Anderson; Oscar J Trask; Rick Lesniewski; Dimitri Semizarov
Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway.
Molecular cancer therapeutics 2007;6(1):253-61.
2006: Megumi Kawai; Nwe Y BaMaung; Steve D Fidanze; Scott A Erickson; Jason S Tedrow; William J Sanders; Anil Vasudevan; Chang Park; Charles W Hutchins; Kenneth M Comess; Douglas Kalvin; Jieyi Wang; Qian Zhang; Pingping Lou; Lora Tucker-Garcia; Jennifer J Bouska; Randy L Bell; Rick Lesniewski; Jack Henkin; George S Sheppard
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Bioorganic & medicinal chemistry letters 2006;16(13):3574-7.
2006: George S Sheppard; Jieyi Wang; Megumi Kawai; Steve D Fidanze; Nwe Y BaMaung; Scott A Erickson; David M Barnes; Jason S Tedrow; Lawrence Kolaczkowski; Anil Vasudevan; David C Park; Gary T Wang; William J Sanders; Robert A Mantei; Fabio Palazzo; Lora Tucker-Garcia; Pingping Lou; Qian Zhang; Chang H Park; Ki H Kim; Andrew M Petros; Edward T Olejniczak; David G Nettesheim; Philip J Hajduk; Jack Henkin; Rick Lesniewski; Steven K Davidsen; Randy L Bell
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Journal of medicinal chemistry 2006;49(13):3832-49.
2005: Donald J Davidson; Catherine Haskell; Sandra Majest; Abdullah Kherzai; David A Egan; Karl A Walter; Andrew Schneider; Earl F Gubbins; Larry Solomon; Zhebo Chen; Rick Lesniewski; Jack Henkin
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.
Cancer research 2005;65(11):4663-72.
2005: Fortuna Haviv; Michael F Bradley; Douglas Kalvin; Andrew J Schneider; Donald J Davidson; Sandra Majest; Laura M McKay; Catherine J Haskell; Randy L Bell; Bach Nguyen; Kennan Marsh; Bruce W Surber; John T Uchic; James Ferrero; Yi-Chun Wang; Juan Leal; Rae Record; Jason P Hodde; Stephen F Badylak; Rick Lesniewski; Jack Henkin
Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities.
Journal of medicinal chemistry 2005;48(8):2838-46.
2004: George S Sheppard; Jieyi Wang; Megumi Kawai; Nwe Y BaMaung; Richard A Craig; Scott A Erickson; Linda Lynch; Jyoti Patel; Fan Yang; Xenia B Searle; Pingping Lou; Chang Park; Ki H Kim; Jack Henkin; Rick Lesniewski
3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorganic & medicinal chemistry letters 2004;14(4):865-8.
2003: Jieyi Wang; George S Sheppard; Pingping Lou; Megumi Kawai; Nwe Y BaMaung; Scott A Erickson; Lora Tucker-Garcia; Chang Park; Jennifer J Bouska; Yi-Chun Wang; David Frost; Paul Tapang; Daniel H Albert; Sherry J Morgan; Michael J Morowitz; Susanne Shusterman; John M Maris; Rick Lesniewski; Jack Henkin
Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
Cancer research 2003;63(22):7861-9.
2003: Jieyi Wang; George S Sheppard; Pingping Lou; Megumi Kawai; Chang Park; David A Egan; Andrew Schneider; Jennifer J Bouska; Rick Lesniewski; Jack Henkin
Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese.
Biochemistry 2003;42(17):5035-42.
2003: Jieyi Wang; Pingping Lou; Rick Lesniewski; Jack Henkin
Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly.
Anti-cancer drugs 2003;14(1):13-9.