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John Leszyk

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

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Molecular Sequence Data

Chemicals & Drugs

Anatomy

Adipocytes

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Kate Koles; Ceren Korkut; John Leszyk; Yihang Li; John Nunnari; Bing Zhang; Romina Barria; Cassandra Brewer; Vivian Budnik
Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.
Annie J Kruger; Chaoxing Yang; Sun W Tam; Douglas Hinerfeld; James E Evans; Karin M Green; John Leszyk; Kejian Yang; Dennis L Guberski; John P Mordes; Dale L Greiner; Aldo A Rossini; Rita Bortell
Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
Roberto Romero; Juan Pedro Kusanovic Pivcevic; Francesca Gotsch; OFFER EREZ; Eduard Vaisbuch; Shali Mazaki-Tovi; Allan Moser; Sunny Tam; John Leszyk; Stephen R Master; Peter Juhasz; P Pacora; Giovanna Ogge; Ricardo Gomez; Bo H Yoon; Lami Yeo; Sonia S Hassan; Wade T Rogers
Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation.

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All Publications

2012: Kate Koles; Ceren Korkut; John Leszyk; Yihang Li; John Nunnari; Bing Zhang; Romina Barria; Cassandra Brewer; Vivian Budnik
Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.
The Journal of biological chemistry 2012;287(20):16820-34.
2010: Annie J Kruger; Chaoxing Yang; Sun W Tam; Douglas Hinerfeld; James E Evans; Karin M Green; John Leszyk; Kejian Yang; Dennis L Guberski; John P Mordes; Dale L Greiner; Aldo A Rossini; Rita Bortell
Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
Experimental biology and medicine (Maywood, N.J.) 2010;235(11):1328-37.
2010: Roberto Romero; Juan Pedro Kusanovic Pivcevic; Francesca Gotsch; OFFER EREZ; Eduard Vaisbuch; Shali Mazaki-Tovi; Allan Moser; Sunny Tam; John Leszyk; Stephen R Master; Peter Juhasz; P Pacora; Giovanna Ogge; Ricardo Gomez; Bo H Yoon; Lami Yeo; Sonia S Hassan; Wade T Rogers
Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2010;23(4):261-80.
2008: Qiong L Zhou; Zhen Y Jiang; John Holik; Anil Chawla; G Nana Hagan; John Leszyk; Michael P Czech
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.
The Biochemical journal 2008;411(3):647-55.
2006: Myrtle A Davis; Douglas Hinerfeld; Sajan Joseph; Yu-Hua Hui; Naijia H Huang; John Leszyk; Jennifer Rutherford-Bethard; Sun W Tam
Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89 (N-(2-[p-bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide).
The Journal of pharmacology and experimental therapeutics 2006;318(2):589-95.
2005: Homer Pantua; Lori W McGinnes; John Leszyk; Trudy G Morrison
Characterization of an alternate form of Newcastle disease virus fusion protein.
Journal of virology 2005;79(18):11660-70.
2005: Gregory Pazour; Nathan S Agrin; John Leszyk; George B Witman
Proteomic analysis of a eukaryotic cilium.
The Journal of cell biology 2005;170(1):103-13.
2005: Zhen Y Jiang; Qiong L Zhou; John Holik; Shraddha Patel; John Leszyk; Kerri Coleman; My Chouinard; Michael P Czech
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
The Journal of biological chemistry 2005;280(22):21622-8.
2004: Leanne Wilson-Fritch; Sarah M C Nicoloro; My Chouinard; Mitchell Lazar; Patricia C Chui; John Leszyk; Juerg Straubhaar; Michael P Czech; Silvia Corvera
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
The Journal of clinical investigation 2004;114(9):1281-9.
2004: Matthias Blüher; Leanne Wilson-Fritch; John Leszyk; Palle G Laustsen; Silvia Corvera; C Ronald Kahn
Role of insulin action and cell size on protein expression patterns in adipocytes.
The Journal of biological chemistry 2004;279(30):31902-9.
2004: Adilson Guilherme; Neil A Soriano; Sahana Bose; John Holik; Avirup Bose; Darcy P Pomerleau; Paul Furcinitti; John Leszyk; Silvia Corvera; Michael P Czech
EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
The Journal of biological chemistry 2004;279(11):10593-605.
2003: Sabina Semiz; Jin Gyoon Park; Sarah M C Nicoloro; Paul Furcinitti; Chuanyou Zhang; Anil Chawla; John Leszyk; Michael P Czech
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.
The EMBO journal 2003;22(10):2387-99.
2003: Leanne Wilson-Fritch; Alison Burkart; Gregory Bell; Karen Mendelson; John Leszyk; Sarah M C Nicoloro; Michael P Czech; Silvia Corvera
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.
Molecular and cellular biology 2003;23(3):1085-94.
2002: Thomas Nebl; Kersi N Pestonjamasp; John Leszyk; Jessica L Crowley; Sang W Oh; Elizabeth J Luna
Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.
The Journal of biological chemistry 2002;277(45):43399-409.
2002: Yin Luo; John Leszyk; Bing Li; Zhixing Li; John Gergely; Terence Tao
Troponin-I interacts with the Met47 region of skeletal muscle actin. Implications for the mechanism of thin filament regulation by calcium.
Journal of molecular biology 2002;316(3):429-34.
2001: Jin Gyoon Park; Avirup Bose; John Leszyk; Michael P Czech
PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters.
The Journal of biological chemistry 2001;276(51):47751-4.
2001: Patricia S Vaughan; John Leszyk; Kevin T Vaughan
Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin.
The Journal of biological chemistry 2001;276(28):26171-9.
2001: James M Holaska; Ben E Black; Dona C Love; John Hanover; John Leszyk; Bryce M Paschal
Calreticulin Is a receptor for nuclear export.
The Journal of cell biology 2001;152(1):127-40.
2000: Yin Luo; John Leszyk; Bing Li; John Gergely; Terence Tao
Proximity relationships between residue 6 of troponin I and residues in troponin C: further evidence for extended conformation of troponin C in the troponin complex.
Biochemistry 2000;39(50):15306-15.
2000: Adilson Guilherme; M Emoto; JM Buxton; S Bose; R Sabini; William E Theurkauf; John Leszyk; Michael P Czech
Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes.
The Journal of biological chemistry 2000;275(49):38151-9.
2000: DT Baran; JM Quail; R Ray; John Leszyk; Thomas Honeyman
Annexin II is the membrane receptor that mediates the rapid actions of 1alpha,25-dihydroxyvitamin D(3).
Journal of cellular biochemistry 2000;78(1):34-46.
1999: Yin Luo; John Leszyk; Y Qian; John Gergely; Terence Tao
Residues 48 and 82 at the N-terminal hydrophobic pocket of rabbit skeletal muscle troponin-C photo-cross-link to Met121 of troponin-I.
Biochemistry 1999;38(20):6678-88.
1998: G Szymanska; John Leszyk; Clare M O'Connor
Carboxyl methylation of deamidated calmodulin increases its stability in Xenopus oocyte cytoplasm. Implications for protein repair.
The Journal of biological chemistry 1998;273(43):28516-23.
1998: Je-Yong Choi; Andre J van Wijnen; F Aslam; John Leszyk; Janet L Stein; Gary S Stein; Jane B Lian; Sheldon Penman
Developmental association of the beta-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts.
Journal of cell science 1998;111 ( Pt 20)():3035-43.
1998: Jovenal T San Agustin; John Leszyk; L M Nuwaysir; George B Witman
The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequence.
The Journal of biological chemistry 1998;273(38):24874-83.
1998: John Leszyk; Terence Tao; L M Nuwaysir; John Gergely
Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21.
Journal of muscle research and cell motility 1998;19(5):479-90.
1997: Douglas Ross; Y Gao; W Yang; John Leszyk; J Shively; L Austin Doyle
The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross-reacting antigen of carcinoembryonic antigen.
Cancer research 1997;57(24):5460-4.
1996: A S Kashina; Jonathan M Scholey; John Leszyk; William M Saxton
An essential bipolar mitotic motor.
Nature 1996;384(6606):225.
1995: K A Deyst; M A Bowe; John Leszyk; Justin R Fallon
The alpha-dystroglycan-beta-dystroglycan complex. Membrane organization and relationship to an agrin receptor.
The Journal of biological chemistry 1995;270(43):25956-9.
1995: C A Vater; L M Bartle; John Leszyk; J M Lambert; Victor S Goldmacher
Ricin A chain can be chemically cross-linked to the mammalian ribosomal proteins L9 and L10e.
The Journal of biological chemistry 1995;270(21):12933-40.
1995: Esther Biswas-Fiss; P H Chen; John Leszyk; Subhasis B Biswas
Biochemical and genetic characterization of a replication protein A dependent DNA helicase from the yeast, Saccharomyces cerevisiae.
Biochemical and biophysical research communications 1995;206(3):850-6.
1994: T J Sewell; E Lam; M M Martin; John Leszyk; J Weidner; JR Calaycay; P Griffin; H Williams; S Hung; JG Cryan
Inhibition of calcineurin by a novel FK-506-binding protein.
The Journal of biological chemistry 1994;269(33):21094-102.
1994: Q P Cao; S Pitt; John Leszyk; E F Baril
DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen.
Biochemistry 1994;33(28):8548-57.
1994: M A Bowe; K A Deyst; John Leszyk; Justin R Fallon
Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans.
Neuron 1994;12(5):1173-80.
1992: P Vissavajjhala; John Leszyk; J Lin-Goerke; Alonzo H Ross
Structural domains of the extracellular domain of human nerve growth factor receptor detected by partial proteolysis.
Archives of biochemistry and biophysics 1992;294(1):244-52.
1991: W W Barouch; K E Breese; S A Davidoff; John Leszyk; A G Szent-Györgyi; J L Theibert; J H Collins
Amino acid sequences of myosin essential and regulatory light chains from two clam species: comparison with other molluscan myosin light chains.
Journal of muscle research and cell motility 1991;12(4):321-32.
1991: J H Collins; John Leszyk; Dominique MORNET; E Audemard
Turkey gizzard caldesmon: complete sequence of a C-terminal thrombic fragment that binds actin, tropomyosin and calmodulin.
Protein sequences & data analysis 1991;4(1):29-32.
1990: John Leszyk; Zenon Grabarek; John Gergely; J H Collins
Characterization of zero-length cross-links between rabbit skeletal muscle troponin C and troponin I: evidence for direct interaction between the inhibitory region of troponin I and the NH2-terminal, regulatory domain of troponin C.
Biochemistry 1990;29(1):299-304.
1989: John Leszyk; Dominique MORNET; E Audemard; J H Collins
Caldesmon structure and function: sequence analysis of a 35 kilodalton actin- and calmodulin-binding fragment from the C-terminus of the turkey gizzard protein.
Biochemical and biophysical research communications 1989;160(3):1371-8.
1989: John Leszyk; Dominique MORNET; E Audemard; J H Collins
Amino acid sequence of a 15 kilodalton actin-binding fragment of turkey gizzard caldesmon: similarity with dystrophin, tropomyosin and the tropomyosin-binding region of troponin T.
Biochemical and biophysical research communications 1989;160(1):210-6.
1988: John Leszyk; J H Collins; P C Leavis; Terence Tao
Cross-linking of rabbit skeletal muscle troponin subunits: labeling of cysteine-98 of troponin C with 4-maleimidobenzophenone and analysis of products formed in the binary complex with troponin T and the ternary complex with troponins I and T.
Biochemistry 1988;27(18):6983-7.
1988: John Leszyk; R Dumaswala; James D Potter; J H Collins
Amino acid sequence of bovine cardiac troponin I.
Biochemistry 1988;27(8):2821-7.
1987: J H Collins; John Leszyk
The "gamma subunit" of Na,K-ATPase: a small, amphiphilic protein with a unique amino acid sequence.
Biochemistry 1987;26(26):8665-8.
1987: John Leszyk; J H Collins; P C Leavis; Terence Tao
Cross-linking of rabbit skeletal muscle troponin with the photoactive reagent 4-maleimidobenzophenone: identification of residues in troponin I that are close to cysteine-98 of troponin C.
Biochemistry 1987;26(22):7042-7.
1987: John Leszyk; R Dumaswala; James D Potter; Nikolai B Gusev; Alexander Dmitriyevich Verin; Larry Tobacman; J H Collins
Bovine cardiac troponin T: amino acid sequences of the two isoforms.
Biochemistry 1987;26(22):7035-42.
1986: J H Collins; R Jakes; J Kendrick-Jones; John Leszyk; W Barouch; J L Theibert; J Spiegel; A G Szent-Györgyi
Amino acid sequence of myosin essential light chain from the scallop Aquipecten irradians.
Biochemistry 1986;25(23):7651-6.