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Michael Letavic

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Jean Logan; Lisa Muench; Steven Sands; Colleen Shea; Youwen Xu; Nicholas I Carruthers; Pauline Carter; Xiaohui Jiang; Payton King; Michael A Letavic; Joanna S Fowler
Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.
Ruggero Galici; Amir H Rezvani; Leah Aluisio; Brian Lord; Edward D Levin; Ian Fraser; Jamin Boggs; Natalie Welty; James R Shoblock; S Timothy Motley; Michael A Letavic; Nicholas I Carruthers; Christine Dugovic; Timothy W Lovenberg; Pascal Bonaventure
JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
Alejandro Santillan; Kelly J McClure; Brett D Allison; Brian Lord; Jamin D Boggs; Kirsten L Morton; Anita M Everson; Diane Nepomuceno; Michael A Letavic; Alice Lee-Dutra; Timothy W Lovenberg; Nicholas I Carruthers; Cheryl A Grice
Indole- and benzothiophene-based histamine H3 antagonists.

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All Publications

2012: Jean Logan; Lisa Muench; Steven Sands; Colleen Shea; Youwen Xu; Nicholas I Carruthers; Pauline Carter; Xiaohui Jiang; Payton King; Michael A Letavic; Joanna S Fowler
Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.
Psychopharmacology 2012;223(4):447-55.
2011: Ruggero Galici; Amir H Rezvani; Leah Aluisio; Brian Lord; Edward D Levin; Ian Fraser; Jamin Boggs; Natalie Welty; James R Shoblock; S Timothy Motley; Michael A Letavic; Nicholas I Carruthers; Christine Dugovic; Timothy W Lovenberg; Pascal Bonaventure
JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
Psychopharmacology 2011;214(4):829-41.
2010: Alejandro Santillan; Kelly J McClure; Brett D Allison; Brian Lord; Jamin D Boggs; Kirsten L Morton; Anita M Everson; Diane Nepomuceno; Michael A Letavic; Alice Lee-Dutra; Timothy W Lovenberg; Nicholas I Carruthers; Cheryl A Grice
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorganic & medicinal chemistry letters 2010;20(21):6226-30.
2010: Michael A Letavic; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Mark A Feinstein; Ian C Fraser; Kenway Hoey; Xiaohui Jiang; John M Keith; Tatiana Koudriakova; Perry Leung; Brian Lord; Timothy W Lovenberg; Kiev S Ly; Kirsten L Morton; S Timothy Motley; Diane Nepomuceno; Michele Rizzolio; Raymond Rynberg; Kia Sepassi; Jonathan Shelton
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorganic & medicinal chemistry letters 2010;20(14):4210-4.
2010: Daniel J Pippel; Lana K Young; Michael A Letavic; Kiev S Ly; Bita Naderi; Aki Soyode-Johnson; Emily M Stocking; Nicholas I Carruthers; Neelakandha S Mani
Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
The Journal of organic chemistry 2010;75(13):4463-71.
2010: Emily M Stocking; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Ian Fraser; Xiaohui Jiang; Perry Leung; Brian Lord; Kiev S Ly; Kirsten L Morton; Diane Nepomuceno; Chandravadan R Shah; Jonathan Shelton; Akinola Soyode-Johnson; Michael A Letavic
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2010;20(9):2755-60.
2010: Kevin D Jerome; Paul V Rucker; Li Xing; Huey S Shieh; John E Baldus; Shaun R Selness; Michael A Letavic; John F Braganza; Kim F McClure
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.
Bioorganic & medicinal chemistry letters 2010;20(2):469-73.
2010: Emily M Stocking; Michael A Letavic; Pascal Bonaventure; Nicholas I Carruthers
Exploration of structure-activity relationships for dual serotonin transporter reuptake inhibitors-histamine H3 receptor antagonists.
Current topics in medicinal chemistry 2010;10(5):596-616.
2008: Michael A Letavic; John M Keith; Kiev S Ly; Pascal Bonaventure; Mark A Feinstein; Brian Lord; Kirsten L Miller; S Timothy Motley; Diane Nepomuceno; Steven W Sutton; Nicholas I Carruthers
2-Aryloxymethylmorpholine histamine H(3) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(21):5796-9.
2008: Leah Aluisio; Brian Lord; Ann J Barbier; Ian C Fraser; Sandy J Wilson; Jamin D Boggs; Lisa K Dvorak; Michael A Letavic; Bruce E Maryanoff; Nicholas I Carruthers; Pascal Bonaventure; Timothy W Lovenberg
In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
European journal of pharmacology 2008;587(1-3):141-6.
2008: Scott D Bembenek; John M Keith; Michael A Letavic; Richard Apodaca; Ann J Barbier; Lisa Dvorak; Leah Aluisio; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Bioorganic & medicinal chemistry 2008;16(6):2968-73.
2008: Emily M Stocking; Michael A Letavic
Histamine H3 antagonists as wake-promoting and pro-cognitive agents.
Current topics in medicinal chemistry 2008;8(11):988-1002.
2008: Kiev S Ly; Michael A Letavic; John M Keith; Jennifer M Miller; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Brian Lord; Xiaohui Jiang; Jamin D Boggs; Lisa Dvorak; Kirsten L Miller; Diane Nepomuceno; Sandy J Wilson; Nicholas I Carruthers
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):39-43.
2007: Ann J Barbier; Leah Aluisio; Brian Lord; Ying Qu; Sandy J Wilson; Jamin D Boggs; Pascal Bonaventure; Kirsten Miller; Ian Fraser; Lisa Dvorak; Cindy Pudiak; Christine Dugovic; Jonathan Shelton; Curt Mazur; Michael A Letavic; Nicholas I Carruthers; Timothy W Lovenberg
Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.
European journal of pharmacology 2007;576(1-3):43-54.
2007: Michael A Letavic; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Brian Lord; Kirsten L Miller; Sandy J Wilson; Nicholas I Carruthers
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(17):4799-803.
2007: Michael A Letavic; John M Keith; Kiev S Ly; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Brian Lord; Timothy W Lovenberg; Nicholas I Carruthers
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2566-9.
2007: Pascal Bonaventure; Michael A Letavic; Christine Dugovic; S Wilson; Leah Aluisio; Cindy Pudiak; Brian Lord; Curt Mazur; Fredrik Kamme; S Nishino; Nicholas I Carruthers; Timothy W Lovenberg
Histamine H3 receptor antagonists: from target identification to drug leads.
Biochemical pharmacology 2007;73(8):1084-96.
2007: Michael A Letavic; John M Keith; JIll Jablonowski; Emily M Stocking; Leslie A Gomez; Kiev S Ly; Jennifer M Miller; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Sandy J Wilson; Kirsten L Miller; Brian Lord; Heather M McAllister; D J Tognarelli; Jiejun Wu; Marta C Abad; Carsten Schubert; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(4):1047-51.
2007: John M Keith; Leslie A Gomez; Michael A Letavic; Kiev S Ly; JIll Jablonowski; Mark Seierstad; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Bioorganic & medicinal chemistry letters 2007;17(3):702-6.
2006: Amit S Kalgutkar; Heather L Hatch; Frederick Kosea; Hang T Nguyen; Edna F Choo; Kim F McClure; Timothy J Taylor; Kirk R Henne; Alexander V Kuperman; Mark A Dombroski; Michael A Letavic
Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Biopharmaceutics & drug disposition 2006;27(8):371-86.
2006: Michael A Letavic; Ann J Barbier; Curt A Dvorak; Nicholas I Carruthers
Recent medicinal chemistry of the histamine H3 receptor.
Progress in medicinal chemistry 2006;44():181-206.
2005: Kim F McClure; Yuriy A Abramov; Ellen R Laird; John T Barberia; Weiling Cai; Thomas J Carty; Santo R Cortina; dennis danley; Alan J Dipesa; Kathleen M Donahue; Mark A Dombroski; Nancy C Elliott; Christopher A Gabel; Seungil Han; THOMAS HYNES; Peter K LeMotte; Mahmoud N Mansour; Eric S Marr; Michael A Letavic; Jayvardhan Pandit; David B Ripin; Francis J Sweeney; Douglas Tan; Yong Tao
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.
Journal of medicinal chemistry 2005;48(18):5728-37.
2004: Laura J L Norcia; Annette M Silvia; Sheryl L Santoro; Jim Retsema; Michael A Letavic; Brian S Bronk; Kristin M Lundy; Bingwei Yang; Nigel A Evans; Shigeru F Hayashi
In vitro microbiological characterization of a novel azalide, two triamilides and an azalide ketal against bovine and porcine respiratory pathogens.
The Journal of antibiotics 2004;57(4):280-8.
2004: Mark A Dombroski; Michael A Letavic; Kim F McClure; John T Barberia; Thomas J Carty; Santo R Cortina; Csilla Csiki; Alan J Dipesa; Nancy C Elliott; Christopher A Gabel; Crystal K Jordan; Jeffrey M Labasi; William Martin; Kevin M Peese; Ingrid A Stock; Linne Svensson; Francis J Sweeney; Chul H Yu
Benzimidazolone p38 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(4):919-23.
2003: Michael A Letavic; John T Barberia; Thomas J Carty; Joel R Hardink; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Mark C Noe; Lisa M Reeves; Sheri L Snow; Ethan J Stam; Francis J Sweeney; Marcie Vaughn; Chul H Yu
Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(19):3243-6.
2003: Brian S Bronk; Michael A Letavic; Camilla D Bertsche; David M George; Shigeru F Hayashi; Barbara J Kamicker; Nicole L Kolosko; Laura J L Norcia; Margaret A Rushing; Sheryl L Santoro; Bingwei V Yang
Synthesis, stereochemical assignment and biological activity of a novel series of C-4" modified aza-macrolides.
Bioorganic & medicinal chemistry letters 2003;13(12):1955-8.
2002: Michael A Letavic; Brian S Bronk; Camilla D Bertsche; Jeffrey M Casavant; Hengmiao Cheng; Kirsten L Daniel; David M George; Shigeru F Hayashi; Barbara J Kamicker; Nicole L Kolosko; Laura J L Norcia; Vanessa D Oberton; Margaret A Rushing; Sheryl L Santoro
Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: the triamilides.
Bioorganic & medicinal chemistry letters 2002;12(19):2771-4.
2002: Michael A Letavic; Matt Z Axt; John T Barberia; Thomas J Carty; dennis danley; Kieran F Geoghegan; Nadia S Halim; Lise R Hoth; Ajith V Kamath; Ellen R Laird; Lori L Lopresti-Morrow; Kim F McClure; Peter G Mitchell; Vijayalakshmi Natarajan; Mark C Noe; Jayvardhan Pandit; Lisa M Reeves; Gayle K Schulte; Sheri L Snow; Francis J Sweeney; Douglas H Tan; Chul H Yu
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(10):1387-90.