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Darren Letley

Research Profile

Living Beings

Helicobacter pylori

Chemicals & Drugs

Disorders

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Anatomy

Genes & Molecular Sequences

Geographic Areas

Iran

Phenomena

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Publications

TOP 3
Daniela Basso; Carlo-Federico Zambon; Darren P Letley; Alessia Stranges; Alberto Marchet; Joanne L Rhead; Stefania Schiavon; Graziella Guariso; Marco Ceroti; Donato Nitti; Massimo Rugge; Mario Plebani; John C Atherton
Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.
Nawfal R Hussein; Marjan Mohammadi; Yeganeh Talebkhan; Masoumeh Doraghi; Darren P Letley; Merdan K Muhammad; Richard H Argent; John C Atherton
Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease.
Richard H Argent; Rachael Thomas; Francisco Aviles-Jimenez; Darren P Letley; Marie C Limb; Emad M El-Omar; John C Atherton
Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families.

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All Publications

2008: Daniela Basso; Carlo-Federico Zambon; Darren P Letley; Alessia Stranges; Alberto Marchet; Joanne L Rhead; Stefania Schiavon; Graziella Guariso; Marco Ceroti; Donato Nitti; Massimo Rugge; Mario Plebani; John C Atherton
Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.
Gastroenterology 2008;135(1):91-9.
2008: Nawfal R Hussein; Marjan Mohammadi; Yeganeh Talebkhan; Masoumeh Doraghi; Darren P Letley; Merdan K Muhammad; Richard H Argent; John C Atherton
Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease.
Journal of clinical microbiology 2008;46(5):1774-9.
2008: Richard H Argent; Rachael Thomas; Francisco Aviles-Jimenez; Darren P Letley; Marie C Limb; Emad M El-Omar; John C Atherton
Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2227-35.
2008: Richard H Argent; Rachael Thomas; Darren P Letley; Michael G Rittig; Kim Hardie; John C Atherton
Functional association between the Helicobacter pylori virulence factors VacA and CagA.
Journal of medical microbiology 2008;57(Pt 2):145-50.
2007: Joanne L Rhead; Darren P Letley; Marjan Mohammadi; Nawfal Hussein; Mohammad Ali Mohagheghi; Mahmoud Eshagh Hosseini; John C Atherton
A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.
Gastroenterology 2007;133(3):926-36.
2006: James R Bebb; L Leach; Abed M Zaitoun; N Hand; Darren P Letley; R Thomas; John C Atherton
Effects of Helicobacter pylori on the cadherin-catenin complex.
Journal of clinical pathology 2006;59(12):1261-6.
2006: Darren P Letley; Joanne L Rhead; Keith Bishop; John C Atherton
Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacA.
Microbiology (Reading, England) 2006;152(Pt 5):1319-25.
2005: Nicola Fitchen; Darren P Letley; Paul O'Shea; John C Atherton; Paul Williams; Kim Hardie
All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion.
Journal of medical microbiology 2005;54(Pt 7):621-30.
2005: Youli Zhang; Richard H Argent; Darren P Letley; Rachael Thomas; John C Atherton
Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cells.
Journal of clinical microbiology 2005;43(2):786-90.
2004: Francisco Aviles-Jimenez; Darren P Letley; Gerardo Gonzalez-Valencia; Nina R Salama; Javier Torres; John C Atherton
Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.
Journal of bacteriology 2004;186(15):5182-5.
2003: Michael G Rittig; Barry Shaw; Darren P Letley; Rachael Thomas; Richard H Argent; John C Atherton
Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status.
Cellular microbiology 2003;5(12):887-99.
2003: James R Bebb; Darren P Letley; Rachael Thomas; F Aviles; HM Collins; Susan A Watson; N M Hand; Abed M Zaitoun; John C Atherton
Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner.
Gut 2003;52(10):1408-13.
2003: Darren P Letley; Joanne L Rhead; Rachel J Twells; Brian Dove; John C Atherton
Determinants of non-toxicity in the gastric pathogen Helicobacter pylori.
The Journal of biological chemistry 2003;278(29):26734-41.
2003: James R Bebb; Darren P Letley; Joanne L Rhead; John C Atherton
Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent.
Infection and immunity 2003;71(6):3623-7.
2000: Darren P Letley; John C Atherton
Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.
Journal of bacteriology 2000;182(11):3278-80.
1999: Darren P Letley; AJ Lastovica; J A Louw; C J Hawkey; John C Atherton
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.
Journal of clinical microbiology 1999;37(4):1203-5.