FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Thomas Leto

Research Profile

Chemicals & Drugs

Disorders

Chronic Granulomatous Disease

Anatomy

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Living Beings

Mouse

Co-author Network

Publications

TOP 3
Balázs Rada; Thomas L Leto
Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.
Balázs Rada; Dae Goon Yoo; Craig P Hayes; Meghan A Jendrysik; Harry L Malech; Samuel M Moskowitz; Lan Pang; Jonathan J Park; Thomas L Leto
Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.
Howard E Boudreau; Benjamin W Casterline; Agnieszka Korzeniowska; Balazs Rada; Thomas L Leto
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Thomas Leto (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Balázs Rada; Thomas L Leto
Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.
Trends in microbiology 2013;21(2):73-81.
2013: Balázs Rada; Dae Goon Yoo; Craig P Hayes; Meghan A Jendrysik; Harry L Malech; Samuel M Moskowitz; Lan Pang; Jonathan J Park; Thomas L Leto
Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.
PloS one 2013;8(1):e54205.
2012: Howard E Boudreau; Benjamin W Casterline; Agnieszka Korzeniowska; Balazs Rada; Thomas L Leto
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.
Free radical biology & medicine 2012;53(7):1489-99.
2012: Michael Waisberg; Stephanie B Yager; Stephen F Porcella; Balazs Rada; Prakash Srinivasan; Kent D Barbian; Gustavo C Cerqueira; Najib El-Sayed; Ivo M B Francischetti; Nidhi Gera; Thomas L Leto; Jinghua Lu; Jan Lukszo; Louis H Miller; Kazutoyo Miura; David Narum; Susan K Pierce
Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5429-34.
2011: Takehiko Ueyama; Hirofumi Sakaguchi; Megumi Sakuma; Jeonghyun Son; Takeshi Kobayashi; Toshihiro Kobayashi; Thomas L Leto; Junya Nakakita; Takashi Nakamura; Naoaki Saito
Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.
The Journal of biological chemistry 2011;286(47):40693-705.
2011: B Rada; P Gardina; Timothy G Myers; Thomas L Leto
Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin.
Mucosal immunology 2011;4(2):158-71.
2010: Balázs Rada; Thomas L Leto
Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa.
FEBS letters 2010;584(5):917-22.
2009: Howard E Boudreau; Suzanne U Emerson; Agnieszka Korzeniowska; Meghan A Jendrysik; Thomas L Leto
Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress.
Journal of virology 2009;83(24):12934-46.
2009: Thomas L Leto; Stanislas Morand; Darrell Hurt; Takehiko Ueyama
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.
Antioxidants & redox signaling 2009;11(10):2607-19.
2009: Stanislas Morand; Takehiko Ueyama; Satoshi Tsujibe; Naoaki Saito; Agnieszka Korzeniowska; Thomas L Leto
Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(4):1205-18.
2009: Balázs Rada; Thomas L Leto
Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin.
Immunologic research 2009;43(1-3):198-209.
2008: Zeev Shmelzer; Maria Karter; Miriam Eisenstein; Thomas L Leto; Nurit Hadad; David Ben-Menahem; Daniel Gitler; Shirly Banani; Baruch Wolach; Meir Rotem; Rachel Levy
Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain.
The Journal of biological chemistry 2008;283(46):31898-908.
2008: Balázs Rada; Kristen Lekstrom; Sorin Damian; Corinne Dupuy; Thomas L Leto
The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4883-93.
2008: Takehiko Ueyama; Tomoko Kusakabe; Satoshi Karasawa; Takumi Kawasaki; Aya Shimizu; Jeonghyun Son; Thomas L Leto; Atsushi Miyawaki; Naoaki Saito
Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):629-40.
2008: Balázs Rada; Thomas L Leto
Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.
Contributions to microbiology 2008;15():164-87.
2007: Anna Orient; Agnes Donkó; Attila Szabó; Thomas L Leto; Miklós Geiszt
Novel sources of reactive oxygen species in the human body.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(5):1281-8.
2007: Takehiko Ueyama; Toshihiko Tatsuno; Takumi Kawasaki; Satoshi Tsujibe; Yasuhito Shirai; Hideki Sumimoto; Thomas L Leto; Naoaki Saito
A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.
Molecular biology of the cell 2007;18(2):441-54.
2007: Takehiko Ueyama; Kristen Lekstrom; Satoshi Tsujibe; Naoaki Saito; Thomas L Leto
Subcellular localization and function of alternatively spliced Noxo1 isoforms.
Free radical biology & medicine 2007;42(2):180-90.
2007: Thomas L Leto; Mark C Lavigne; Neda Homoyounpour; Kristen Lekstrom; Gilda F Linton; Harry L Malech; I De Mendez
The K-562 cell model for analysis of neutrophil NADPH oxidase function.
Methods in molecular biology (Clifton, N.J.) 2007;412():365-83.
2006: Thomas L Leto; Miklós Geiszt
Role of Nox family NADPH oxidases in host defense.
Antioxidants & redox signaling 2006;8(9-10):1549-61.
2006: Itai Pessach; Zeev Shmelzer; Thomas L Leto; Mary C Dinauer; Rachel Levy
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.
Journal of leukocyte biology 2006;80(3):630-9.
2006: Takehiko Ueyama; Miklós Geiszt; Thomas L Leto
Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.
Molecular and cellular biology 2006;26(6):2160-74.
2005: Agnes Donkó; Zalán Péterfi; Adrienn Sum; Thomas L Leto; Miklós Geiszt
Dual oxidases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2301-8.
2004: Miklós Geiszt; Thomas L Leto
The Nox family of NAD(P)H oxidases: host defense and beyond.
The Journal of biological chemistry 2004;279(50):51715-8.
2004: Miklós Geiszt; Kristen Lekstrom; Thomas L Leto
Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant.
The Journal of biological chemistry 2004;279(49):51661-8.
2004: Sergio D Rosenzweig; Owen M Schwartz; Margaret R Brown; Thomas L Leto; Steven M Holland
Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3991-9.
2003: Zeev Shmelzer; Nurit Haddad; Ester Admon; Itai Pessach; Thomas L Leto; Zahit Eitan-Hazan; Michal Hershfinkel; Rachel Levy
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes.
The Journal of cell biology 2003;162(4):683-92.
2003: Miklós Geiszt; Jassir Witta; Judit Baffi; Kristen Lekstrom; Thomas L Leto
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1502-4.
2003: Miklós Geiszt; Kristen Lekstrom; Sebastian Brenner; Stephen M Hewitt; Raya Dana; Harry L Malech; Thomas L Leto
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):299-306.
2003: Miklós Geiszt; Kristen Lekstrom; Jassir Witta; Thomas L Leto
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells.
The Journal of biological chemistry 2003;278(22):20006-12.
2002: Mark C Lavigne; Philip M Murphy; Thomas L Leto; Ji-Liang Gao
The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils.
Cellular immunology 2002;218(1-2):7-12.
2001: TS Liang; Ji-Liang Gao; O Fatemi; Mark C Lavigne; Thomas L Leto; Philip M Murphy
The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6609-14.
2001: Itai Pessach; Thomas L Leto; Harry L Malech; Rachel Levy
Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells.
The Journal of biological chemistry 2001;276(36):33495-503.
2001: Mark C Lavigne; Harry L Malech; Steven M Holland; Thomas L Leto
Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.
Circulation 2001;104(1):79-84.
2001: HL Tiffany; Mark C Lavigne; Y H Cui; Ji Ming Wang; Thomas L Leto; Ji-Liang Gao; Philip M Murphy
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
The Journal of biological chemistry 2001;276(26):23645-52.
2001: Mark C Lavigne; H L Malech; Steven M Holland; Thomas L Leto
Genetic requirement of p47phox for superoxide production by murine microglia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):285-7.
2000: Miklós Geiszt; Jeffrey B Kopp; Péter Várnai; Thomas L Leto
Identification of renox, an NAD(P)H oxidase in kidney.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8010-4.
2000: Brahm H Segal; Thomas L Leto; John Gallin; Harry L Malech; Steven M Holland
Genetic, biochemical, and clinical features of chronic granulomatous disease.
Medicine 2000;79(3):170-200.
1998: E M Mills; Kazuyo Takeda; Zu-Xi Yu; VJ Ferrans; Y Katagiri; Hao Jiang; Mark C Lavigne; Thomas L Leto; Gordon Guroff
Nerve growth factor treatment prevents the increase in superoxide produced by epidermal growth factor in PC12 cells.
The Journal of biological chemistry 1998;273(35):22165-8.
1998: Joseph B Domachowske; Kimberly D Dyer; A G Adams; Thomas L Leto; Helene F Rosenberg
Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity.
Nucleic acids research 1998;26(14):3358-63.
1998: Raya Dana; Thomas L Leto; Harry L Malech; Rachel Levy
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
The Journal of biological chemistry 1998;273(1):441-5.
1997: M Sathyamoorthy; I De Mendez; A G Adams; Thomas L Leto
p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain.
The Journal of biological chemistry 1997;272(14):9141-6.
1997: I De Mendez; N Homayounpour; Thomas L Leto
Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation.
Molecular and cellular biology 1997;17(4):2177-85.
1996: I De Mendez; A G Adams; R A Sokolic; Harry L Malech; Thomas L Leto
Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.
The EMBO journal 1996;15(6):1211-20.
1995: C H Kwong; A G Adams; Thomas L Leto
Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.
The Journal of biological chemistry 1995;270(34):19868-72.
1995: I De Mendez; Thomas L Leto
Functional reconstitution of the phagocyte NADPH oxidase by transfection of its multiple components in a heterologous system.
Blood 1995;85(4):1104-10.
1994: Thomas L Leto; A G Adams; I De Mendez
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10650-4.
1994: I De Mendez; M C Garrett; A G Adams; Thomas L Leto
Role of p67-phox SH3 domains in assembly of the NADPH oxidase system.
The Journal of biological chemistry 1994;269(23):16326-32.
1994: Michael E Kleinberg; Harry L Malech; D A Mital; Thomas L Leto
p21rac does not participate in the early interaction between p47-phox and cytochrome b558 that leads to phagocyte NADPH oxidase activation in vitro.
Biochemistry 1994;33(9):2490-5.
1994: R Levy; O Nagauker; Emanuel Sikuler; Thomas L Leto; F Schlaeffer
Elevated NADPH-oxidase activity in neutrophils from bile-duct-ligated rats: changes in the kinetic parameters and in the oxidase cytosolic factor p47.
Biochimica et biophysica acta 1994;1220(3):261-5.
1993: Richard Kenney; Harry L Malech; N D Epstein; R L Roberts; Thomas L Leto
Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease.
Blood 1993;82(12):3739-44.
1993: C H Kwong; Harry L Malech; Daniel Rotrosen; Thomas L Leto
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
Biochemistry 1993;32(21):5711-7.
1992: J P Katkin; H L Malech; Thomas L Leto
Baculovirus mediated expression of human phagocytic cell oxidase cytochrome b558 in sf9 insect cells.
Inflammation 1992;16(4):393-410.
1992: Daniel Rotrosen; C L Yeung; Thomas L Leto; Harry L Malech; C H Kwong
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.
Science (New York, N.Y.) 1992;256(5062):1459-62.
1992: RW Erickson; Stephen E Malawista; M C Garrett; G Van Blaricom; Thomas L Leto; John T Curnutte
Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.
The Journal of clinical investigation 1992;89(5):1587-95.
1992: Charles S Cobbs; Harry L Malech; Thomas L Leto; S M Freeman; R. Michael Blaese; John Gallin; K J Lomax
Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease.
Blood 1992;79(7):1829-35.
1992: John Gallin; Thomas L Leto; Daniel Rotrosen; C H Kwong; Harry L Malech
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
Current opinion in immunology 1992;4(1):53-6.
1991: Thomas L Leto; M C Garrett; H Fujii; H Nunoi
Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.
The Journal of biological chemistry 1991;266(29):19812-8.
1990: Richard Kenney; Thomas L Leto
A HindIII polymorphism in the human NCF2 gene.
Nucleic acids research 1990;18(23):7193.
1990: Daniel Rotrosen; Thomas L Leto
Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.
The Journal of biological chemistry 1990;265(32):19910-5.
1990: R Levy; Daniel Rotrosen; O Nagauker; Thomas L Leto; Harry L Malech
Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2595-601.
1990: Uta Francke; C L Hsieh; B E Foellmer; K J Lomax; Harry L Malech; Thomas L Leto
Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).
American journal of human genetics 1990;47(3):483-92.
1990: Daniel Rotrosen; Michael E Kleinberg; H Nunoi; Thomas L Leto; John Gallin; Harry L Malech
Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.
The Journal of biological chemistry 1990;265(15):8745-50.
1990: Thomas L Leto; K J Lomax; B D Volpp; H Nunoi; J M Sechler; William M Nauseef; Robert Clark; John Gallin; Harry L Malech
Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.
Science (New York, N.Y.) 1990;248(4956):727-30.
1989: K J Lomax; Thomas L Leto; H Nunoi; John Gallin; Harry L Malech
Minor errors in two published sequences.
Science (New York, N.Y.) 1989;246(4933):987.
1989: K J Lomax; Thomas L Leto; H Nunoi; John Gallin; Harry L Malech
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
Science (New York, N.Y.) 1989;245(4916):409-12.