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Norman Letvin

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Ina Hellmann; Norman L Letvin; Jörn E Schmitz
KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Will Fischer; Rajeev Gautam; Beatrice H Hahn; Norman L Letvin; Yingying Li; Gary Nabel; Ivona Pandrea; Mario L Santiago; George M Shaw; Cristian Apetrei; Bette T Korber
Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.
Ina Hellmann; Jörn E Schmitz; Norman L Letvin
Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.

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2013: Ina Hellmann; Norman L Letvin; Jörn E Schmitz
KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Journal of virology 2013;87(9):5305-10.
2012: Will Fischer; Rajeev Gautam; Beatrice H Hahn; Norman L Letvin; Yingying Li; Gary Nabel; Ivona Pandrea; Mario L Santiago; George M Shaw; Cristian Apetrei; Bette T Korber
Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.
Journal of virology 2012;86(24):13217-31.
2012: Ina Hellmann; Jörn E Schmitz; Norman L Letvin
Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.
Journal of virology 2012;86(23):13103-7.
2012: Evita V Grant; Alexander M Klibanov; Jennifer Fortune; Mini Thomas; Norman L Letvin
Enhancement of plasmid DNA immunogenicity with linear polyethylenimine.
European journal of immunology 2012;42(11):2937-48.
2012: Hsun-Hsien Chang; Damien Chaussabel; Barton F Haynes; Marco Ramoni; Jason A Skinner; Kelly Soderberg; Jacques Banchereau; Norman L Letvin
Transcriptional network predicts viral set point during acute HIV-1 infection.
Journal of the American Medical Informatics Association : JAMIA 2012;19(6):1103-9.
2012: Lukas Flatz; Kathryn E Foulds; Jason G D Gall; Sung-Youl Ko; Wing-Pui Kong; Norman L Letvin; John R Mascola; Daniel D Pinschewer; SRINIVAS RAO; Mario Roederer; Rahul Roychoudhuri; Stephen D Schmidt; Ling Shen; Wei Shi; John-Paul Todd; Lingshu Wang; Mohammed Asmal; Saran Bao; Cheng Cheng; Mitzi Donaldson; Gary Nabel
Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates.
Journal of virology 2012;86(15):7760-70.
2012: Sampa Santra; Sydeaka Watson; Zhi-Yong Yang; Harikrishnan Balachandran; Adam P Buzby; Kevin R Carlson; Wing-Pui Kong; Bette T Korber; Linh Mach; John R Mascola; Krisha McKee; Mark Muldoon; Gary Nabel; SRINIVAS RAO; Norman L Letvin
Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens.
Virology 2012;428(2):121-7.
2012: Wendy W Yeh; Jinrong Zhang; Aravind Basavapathruni; Laura M Brassard; Norman L Letvin; John R Mascola; Caroline A Miller; Gary Nabel; SRINIVAS RAO; Michael S Seaman
Envelope variable region 4 is the first target of neutralizing antibodies in early simian immunodeficiency virus mac251 infection of rhesus monkeys.
Journal of virology 2012;86(13):7052-9.
2012: Takuya Yamamoto; Wendy W Yeh; Jorge R Almeida; Daniel C Douek; Elias K Haddad; Matthew J Johnson; Francois Lefebvre; Norman L Letvin; Adrian B McDermott; Gary Nabel; Martha Nason; Constantinos Petrovas; David A Price; SRINIVAS RAO; Mario Roederer; Ling Shen; David I Wolinsky; Richard A Koup
Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection.
Journal of virology 2012;86(10):5877-84.
2012: Mohammed Asmal; Angela Carville; Norman L Letvin; Corinne Luedemann; Robert Steen; James B Whitney; Ralf Geiben-Lynn
In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes.
PloS one 2012;7(11):e48234.
2012: Mohammed Asmal; Raymond T Chung; Norman L Letvin; Wenyu Lin; Michael Seaman; Ralf Geiben-Lynn
Inhibition of HCV by the serpin antithrombin III.
Virology journal 2012;9():226.
2011: Shawn S Jackson; Jörn E Schmitz; Norman L Letvin
Anti-gamma interferon antibodies enhance the immunogenicity of recombinant adenovirus vectors.
Clinical and vaccine immunology : CVI 2011;18(11):1969-78.
2011: Wendy W Yeh; Jinrong Zhang; Laura M Brassard; Adam P Buzby; Alan Dodson; Peter T Hraber; Bette T Korber; So-Yon Lim; Corinne Luedemann; John R Mascola; Gary Nabel; SRINIVAS RAO; Ling Shen; John Paul Todd; James B Whitney; Norman L Letvin
The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys.
Journal of virology 2011;85(19):10389-98.
2011: Evan M Cale; S Munir Alam; Heidi S Bazick; Tony A Rianprakaisang; Norman L Letvin
Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3300-13.
2011: Ben-Jiang Ma; Sampa Santra; Richard M Scearce; Laura L Sutherland; Georgia D Tomaras; S Munir Alam; Cindy Bowman; Heather Desaire; Eden P Go; Thomas B Kepler; Norman L Letvin; Hua-Xin Liao; Xiaozhi Lu; Barton F Haynes
Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
PLoS pathogens 2011;7(9):e1002200.
2011: Genevieve G Fouda; Beatrice H Hahn; Barton Haynes; Linda Kalilani-Phiri; Helen H Kang; Norman L Letvin; Rachel V Lovingood; Tatenda Mahlokozera; Steve R Meshnick; David C Montefiori; Glenn R Overman; Sallie R Permar; Justin Pollara; Maria G Salazar; Jesus F Salazar-Gonzalez; George M Shaw; Xiaoying Shen; Georgia D Tomaras; Andrew B Wilks; Nicole L Yates; Thomas N Denny; Guido Ferrari
HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.
Journal of virology 2011;85(18):9555-67.
2011: Geoffrey O Gillard; Lauren Grandpre; Barton F Haynes; Avi-Hai Hovav; Michael W Panas; Michael S Seaman; Maytal Bivas-Benita; Norman L Letvin
Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes.
PLoS pathogens 2011;7(8):e1002141.
2011: Yue Sun; Mohammed Asmal; Sophie Lane; John R Mascola; Sallie R Permar; Stephen D Schmidt; Norman L Letvin
Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys.
Journal of virology 2011;85(14):6906-12.
2011: Mohammed Asmal; Yue Sun; Sophie Lane; Wendy Yeh; Stephen D Schmidt; John R Mascola; Norman L Letvin
Antibody-dependent cell-mediated viral inhibition emerges after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys coincident with gp140-binding antibodies and is effective against neutralization-resistant viruses.
Journal of virology 2011;85(11):5465-75.
2011: Sandrine L Hulot; Evan M Cale; Bette T Korber; Norman L Letvin
Vaccine-induced CD8+ T lymphocytes of rhesus monkeys recognize variant forms of an HIV epitope but do not mediate optimal functional activity.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5663-74.
2011: Norman L Letvin; SRINIVAS RAO; David C Montefiori; Michael S Seaman; Yue Sun; So-Yon Lim; Wendy W Yeh; Mohammed Asmal; Rebecca S Gelman; Ling Shen; James B Whitney; Cathal Seoighe; Miguel Lacerda; Sheila Keating; Philip J Norris; Michael G Hudgens; Peter B Gilbert; Adam P Buzby; Linh V Mach; Jinrong Zhang; Harikrishnan Balachandran; George M Shaw; Stephen D Schmidt; John-Paul Todd; Alan Dodson; John R Mascola; Gary Nabel
Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys.
Science translational medicine 2011;3(81):81ra36.
2011: Ralf Geiben-Lynn; Kwesi Frimpong-Boateng; Norman L Letvin
Modulation of plasmid DNA vaccine antigen clearance by caspase 12 RNA interference potentiates vaccination.
Clinical and vaccine immunology : CVI 2011;18(4):533-8.
2011: Evan M Cale; Peter Hraber; Elena E Giorgi; Will Fischer; Tanmoy Bhattacharya; Thomas Leitner; Wendy W Yeh; Cheryl Gleasner; Lance D Green; Cliff S Han; Bette Korber; Norman L Letvin
Epitope-specific CD8+ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection.
Journal of virology 2011;85(8):3746-57.
2011: Jin Qiu; Lin Yan; Jianbo Chen; Crystal Y Chen; Ling Shen; Norman L Letvin; Barton F Haynes; Nancy E Freitag; Li Rong; James T Frencher; Dan Huang; Xunming Wang; Zheng W Chen
Intranasal vaccination with the recombinant Listeria monocytogenes ΔactA prfA* mutant elicits robust systemic and pulmonary cellular responses and secretory mucosal IgA.
Clinical and vaccine immunology : CVI 2011;18(4):640-6.
2011: Jesus F Salazar-Gonzalez; Maria G Salazar; Gerald Learn; Genevieve G Fouda; Helen H Kang; Tatenda Mahlokozera; Andrew B Wilks; Rachel V Lovingood; Andrea Stacey; Linda Kalilani-Phiri; Steve R Meshnick; Persephone Borrow; David C Montefiori; Thomas N Denny; Norman L Letvin; George M Shaw; Beatrice H Hahn; Sallie R Permar
Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing.
Journal of virology 2011;85(6):2751-63.
2011: Slave Petrovski; Jacques Fellay; Kevin V Shianna; Nicole Carpenetti; Johnstone Kumwenda; Gift Kamanga; Deborah D Kamwendo; Norman L Letvin; Andrew J McMichael; Barton F Haynes; Myron S Cohen; David B Goldstein
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
AIDS (London, England) 2011;25(4):513-8.
2011: James B Whitney; Peter T Hraber; Corinne Luedemann; Elena E Giorgi; Marcus G Daniels; Tanmoy Bhattacharya; SRINIVAS RAO; John R Mascola; Gary Nabel; Bette T Korber; Norman L Letvin
Genital tract sequestration of SIV following acute infection.
PLoS pathogens 2011;7(2):e1001293.
2011: S Moses Dennison; S Munir Alam; Kara M Anasti; Cindy Bowman; Bing Chen; Frederick H Jaeger; Peter D Kwong; Norman L Letvin; Hua-Xin Liao; Gilad Ofek; Robert Parks; Sampa Santra; Richard M Scearce; Xiaoying Shen; Shelley Stewart; Laura L Sutherland; Georgia D Tomaras; Shi-Mao Xia; Yongping Yang; Ruijun Zhang; Barton F Haynes
Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.
PloS one 2011;6(11):e27824.
2011: Tatenda Mahlokozera; Steve R Meshnick; Sallie R Permar; Andrea R Stacey; Persephone Borrow; James E G Bunn; Thomas N Denny; Nilu Goonetilleke; Linda Kalilani-Phiri; Helen H Kang; Norman L Letvin; Rachel V Lovingood
The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.
PloS one 2011;6(8):e23735.
2011: Mohammed Asmal; Tanmoy Bhattacharya; Marcus Daniels; S Gnanakaran; Beatrice H Hahn; Barton F Haynes; Ina Hellmann; Brandon F Keele; Bette T Korber; Weimin Liu; Alan S Perelson; George M Shaw; Norman L Letvin
A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity.
PloS one 2011;6(8):e23673.
2011: Jae-Sung Yu; John Whitesides; Sun-Hee Lee; Natalie Taylor; William R. Jacobs Jr.; Norman L Letvin; Barton F Haynes
Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression.
Clinical and vaccine immunology : CVI 2011;18(1):43-9.
2010: Andrew B Wilks; Elizabeth C Christian; Michael S Seaman; Piya Sircar; Angela Carville; Carmen E Gomez; Mariano Esteban; Giuseppe Pantaleo; Dan H Barouch; Norman L Letvin; Sallie R Permar
Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):7097-106.
2010: Edwin R Manuel; Wendy W Yeh; Harikrishnan Balachandran; Ryon H Clarke; Michelle A Lifton; Norman L Letvin
Vaccination reduces simian-human immunodeficiency virus sequence reversion through enhanced viral control.
Journal of virology 2010;84(24):12782-9.
2010: Brianne R Barker; Michael N Gladstone; Geoffrey O Gillard; Michael W Panas; Norman L Letvin
Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses.
European journal of immunology 2010;40(11):3085-96.
2010: Yue Sun; Sampa Santra; Adam P Buzby; John R Mascola; Gary Nabel; Norman L Letvin
Recombinant vector-induced HIV/SIV-specific CD4+ T lymphocyte responses in rhesus monkeys.
Virology 2010;406(1):48-55.
2010: Jinyan Liu; Brandon F Keele; Hui Li; Sheila Keating; Philip J Norris; Angela Carville; Keith G Mansfield; Georgia D Tomaras; Barton F Haynes; Dror Kolodkin-Gal; Norman L Letvin; Beatrice H Hahn; George M Shaw; Dan H Barouch
Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
Journal of virology 2010;84(19):10406-12.
2010: Piya Sircar; Kathryn L Furr; Lauren A Dorosh; Norman L Letvin
Clonal repertoires of virus-specific CD8+ T lymphocytes are shared in mucosal and systemic compartments during chronic simian immunodeficiency virus infection in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2191-9.
2010: Sallie R Permar; Andrew B Wilks; Elizabeth P Ehlinger; Helen H Kang; Tatenda Mahlokozera; Rory T Coffey; Angela Carville; Norman L Letvin; Michael S Seaman
Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys.
Journal of virology 2010;84(16):8209-18.
2010: So-Yon Lim; Tiffany Chan; Rebecca S Gelman; James B Whitney; Kara L O'Brien; Dan H Barouch; David B Goldstein; Barton F Haynes; Norman L Letvin
Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys.
PLoS genetics 2010;6(6):e1000997.
2010: Wendy W Yeh; Ishita Rahman; Peter T Hraber; Rory T Coffey; Daiva Nevidomskyte; Ayush Giri; Mohammed Asmal; Svetlana Miljkovic; Marcus Daniels; James B Whitney; Brandon F Keele; Beatrice H Hahn; Bette T Korber; George M Shaw; Michael S Seaman; Norman L Letvin
Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys.
Journal of virology 2010;84(12):6018-32.
2010: Maytal Bivas-Benita; Liat Bar; Geoffrey O Gillard; David R Kaufman; Nathaniel L Simmons; Avi-Hai Hovav; Norman L Letvin
Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization.
Journal of virology 2010;84(11):5764-74.
2010: Roland C Zahn; Melisa D Rett; Ming Li; Haili Tang; Birgit Korioth-Schmitz; Harikrishnan Balachandran; Robert White; Sarah Pryputniewicz; Norman L Letvin; Amitinder Kaur; David C Montefiori; Angela Carville; Vanessa M Hirsch; Jonathan S Allan; Joern schmitz
Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
Blood 2010;115(15):3070-8.
2010: Sampa Santra; Hua-Xin Liao; Ruijun Zhang; Mark Muldoon; Sydeaka Watson; Will Fischer; James Theiler; James Szinger; Harikrishnan Balachandran; Adam Buzby; David Quinn; Robert J Parks; Chun-Yen Tsao; Angela Carville; Keith G Mansfield; George Pavlakis; Barbara K Felber; Barton F Haynes; Bette T Korber; Norman L Letvin
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.
Nature medicine 2010;16(3):324-8.
2010: Sallie R Permar; Helen H Kang; Angela Carville; Andrew B Wilks; Keith G Mansfield; SRINIVAS RAO; Norman L Letvin
Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection.
The Journal of infectious diseases 2010;201(2):302-10.
2010: Thomas F Rogers; So-Yon Lim; T J Sundsvold; Tiffany Chan; Ariel Hsu; Norman L Letvin
Variability in a dominant block to SIV early reverse transcription in rhesus monkey cells predicts in vivo viral replication and time to death.
Virology journal 2010;7():79.
2010: Sallie R Permar; Helen H Kang; Andrew B Wilks; Linh V Mach; Angela Carville; Keith G Mansfield; Gerald Learn; Beatrice H Hahn; Norman L Letvin
Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys.
Retrovirology 2010;7():7.
2010: So-Yon Lim; Thomas Rogers; Tiffany Chan; James B Whitney; Jonghwa Kim; Joseph Sodroski; Norman L Letvin
TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.
PLoS pathogens 2010;6(1):e1000738.
2010: Aravind Basavapathruni; Wendy W Yeh; Rory T Coffey; James B Whitney; Peter T Hraber; Ayush Giri; Bette T Korber; SRINIVAS RAO; Gary Nabel; John R Mascola; Michael S Seaman; Norman L Letvin
Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys.
Journal of virology 2010;84(2):953-63.
2009: Ralf Geiben-Lynn; John R Greenland; Kwesi Frimpong-Boateng; Norman L Letvin
Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.
The Journal of biological chemistry 2009;284(49):33800-6.
2009: Norman L Letvin
Virology. Moving forward in HIV vaccine development.
Science (New York, N.Y.) 2009;326(5957):1196-8.
2009: Avi-Hai Hovav; Michael Santosuosso; Maytal Bivas-Benita; Andre Plair; Alex Cheng; Mazal Elnekave; Elda Righi; Tao Chen; Satoshi Kashiwagi; Michael W Panas; Shi-Hua Xiang; Karina Furmanov; Norman L Letvin; Mark C Poznansky
X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens.
Journal of virology 2009;83(21):10941-50.
2009: Ariane Rodríguez; Ratna Mintardjo; Dennis Tax; Gert Gillissen; Jerome Custers; Maria Grazia Pau; Jaco Klap; Sampa Santra; Harikrishnan Balachandran; Norman L Letvin; Jaap Goudsmit; Katarina Radosević
Evaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys.
Vaccine 2009;27(44):6226-33.
2009: Thomas J Urban; Amy C Weintrob; Jacques Fellay; Sara Colombo; Kevin V Shianna; Curtis Gumbs; Margalida Rotger; Kimberly Pelak; Kristen K Dang; Roger Detels; Jeremy J Martinson; Stephen J O'Brien; Norman L Letvin; Andrew J McMichael; Barton F Haynes; Mary Carrington; Amalio Telenti; Nelson L Michael; David B Goldstein
CCL3L1 and HIV/AIDS susceptibility.
Nature medicine 2009;15(10):1110-2.
2009: Yue Sun; Robert T Bailer; SRINIVAS RAO; John R Mascola; Gary Nabel; Richard A Koup; Norman L Letvin
Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys.
Journal of virology 2009;83(20):10596-604.
2009: Edwin R Manuel; Wendy W Yeh; Michael S Seaman; Kathryn Furr; Michelle A Lifton; Sandrine L Hulot; Patrick Autissier; Norman L Letvin
Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus.
Journal of virology 2009;83(19):10028-35.
2009: Sandrine L Hulot; Michael S Seaman; Pritha Sen; Patrick Autissier; Edwin R Manuel; Norman L Letvin
Diverse cross-reactive potential and Vbeta gene usage of an epitope-specific cytotoxic T-lymphocyte population in monkeys immunized with diverse human immunodeficiency virus type 1 Env immunogens.
Journal of virology 2009;83(19):9803-12.
2009: James B Whitney; Corinne Luedemann; Peter Hraber; SRINIVAS RAO; John R Mascola; Gary Nabel; Norman L Letvin
T-cell vaccination reduces simian immunodeficiency virus levels in semen.
Journal of virology 2009;83(20):10840-3.
2009: Sampa Santra; Yue Sun; Birgit Korioth-Schmitz; Julie Fitzgerald; Cherie Charbonneau; Giannina Santos; Michael S Seaman; Sarah J Ratcliffe; David C Montefiori; Gary Nabel; Hildegund C J Ertl; Norman L Letvin
Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors.
Vaccine 2009;27(42):5837-45.
2009: Bette T Korber; Norman L Letvin; Barton F Haynes
T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces.
Journal of virology 2009;83(17):8300-14.
2009: James B Whitney; Corinne Luedemann; Saran Bao; Ayako Miura; SRINIVAS RAO; John R Mascola; Norman L Letvin
Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model.
AIDS (London, England) 2009;23(12):1453-60.
2009: Michelle H. Larsen; Karolin Biermann; Bing Chen; Tsungda Hsu; Vasan K Sambandamurthy; Andrew A Lackner; Pyone Aye; Peter Didier; Dan Huang; Linyun Shao; Huiyong Wei; Norman L Letvin; Richard Frothingham; Barton F Haynes; Zheng W Chen; William R. Jacobs Jr.
Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates.
Vaccine 2009;27(34):4709-17.
2009: Mark J Cayabyab; Birgit Korioth-Schmitz; Yue Sun; Angela Carville; Harikrishnan Balachandran; Ayako Miura; Kevin R Carlson; Adam P Buzby; Barton F Haynes; William R. Jacobs Jr.; Norman L Letvin
Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses.
Journal of virology 2009;83(11):5505-13.
2009: Brandon F Keele; Hui Li; Gerald Learn; Peter Hraber; Elena E Giorgi; Truman Grayson; Chuanxi Sun; Yalu Chen; Wendy W Yeh; Norman L Letvin; John R Mascola; Gary Nabel; Barton F Haynes; Tanmoy Bhattacharya; Alan S Perelson; Bette T Korber; Beatrice H Hahn; George M Shaw
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
The Journal of experimental medicine 2009;206(5):1117-34.
2009: Nicole M Walley; Boris Julg; Samuel P Dickson; Jacques Fellay; Dongliang Ge; Bruce D Walker; Mary Carrington; Myron S Cohen; Paul I W de Bakker; David B Goldstein; Kevin V Shianna; Barton F Haynes; Norman L Letvin; Andrew J McMichael; Nelson L Michael; Amy C Weintrob
The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.
Cell host & microbe 2009;5(5):408-10; author reply 418-9.
2009: Crystal Y Chen; Dan Huang; Richard C Wang; Ling Shen; Gucheng Zeng; Shuyun Yao; Yun Shen; Lisa Halliday; Jeff Fortman; Milton M McAllister; Jim Estep; Robert Hunt; Daphne Vasconcelos; George Du; Steven A Porcelli; Michelle H. Larsen; William R. Jacobs Jr.; Barton F Haynes; Norman L Letvin; Zheng W Chen
A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.
PLoS pathogens 2009;5(4):e1000392.
2009: Lauren Grandpre; Jonathan S Duke-Cohan; Bonnie A Ewald; Colleen Devoy; Dan H Barouch; Norman L Letvin; Ellis L Reinherz; Lindsey R Baden; Raphael Dolin; Michael S Seaman
Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys.
Vaccine 2009;27(10):1549-56.
2009: Wendy W Yeh; Pimkwan Jaru-Ampornpan; Daiva Nevidomskyte; Mohammed Asmal; SRINIVAS RAO; Adam P Buzby; David C Montefiori; Bette T Korber; Norman L Letvin
Partial protection of Simian immunodeficiency virus (SIV)-infected rhesus monkeys against superinfection with a heterologous SIV isolate.
Journal of virology 2009;83(6):2686-96.
2009: Wing-Pui Kong; Lan Wu; Timothy C Wallstrom; Will Fischer; Zhi-Yong Yang; Sung-Youl Ko; Norman L Letvin; Barton F Haynes; Beatrice H Hahn; Bette Korber; Gary Nabel
Expanded breadth of the T-cell response to mosaic human immunodeficiency virus type 1 envelope DNA vaccination.
Journal of virology 2009;83(5):2201-15.
2008: Roland Zahn; Melisa D Rett; Birgit Korioth-Schmitz; Yue Sun; Adam P Buzby; Simoy Goldstein; Charles R Brown; Russell A Byrum; Gordon J Freeman; Norman L Letvin; Vanessa M Hirsch; Joern schmitz
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.
Journal of virology 2008;82(23):11577-88.
2008: Ralf Geiben-Lynn; John R Greenland; Kwesi Frimpong-Boateng; Nico van Rooijen; Avi-Hai Hovav; Norman L Letvin
CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses.
Blood 2008;112(12):4585-90.
2008: Sallie R Permar; Helen H Kang; Angela Carville; Keith G Mansfield; Rebecca Gelman; SRINIVAS RAO; James B Whitney; Norman L Letvin
Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3643-50.
2008: Yue Sun; Sampa Santra; Joern schmitz; Mario Roederer; Norman L Letvin
Magnitude and quality of vaccine-elicited T-cell responses in the control of immunodeficiency virus replication in rhesus monkeys.
Journal of virology 2008;82(17):8812-9.
2008: Sampa Santra; Bette T Korber; Mark Muldoon; Dan H Barouch; Gary Nabel; Feng Gao; Beatrice H Hahn; Barton F Haynes; Norman L Letvin
A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10489-94.
2008: Elisa I Choi; Keith A Reimann; Norman L Letvin
In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys.
Journal of virology 2008;82(13):6758-61.
2008: Eun-Young Kim; Ronald S Veazey; Roland Zahn; Kimberly J McEvers; Susanne H C Baumeister; Gabriel J Foster; Melisa D Rett; Michael H Newberg; Marcelo J Kuroda; E Peter Rieber; Michael Piatak; Jeffrey D Lifson; Norman L Letvin; Steven Wolinsky; Joern schmitz
Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
Journal of virology 2008;82(11):5631-5.
2008: Elisa I Choi; Rijian Wang; Lauren Peterson; Norman L Letvin; Keith A Reimann
Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.
Immunology 2008;124(2):215-22.
2008: Ralf Geiben-Lynn; John R Greenland; Kwesi Frimpong-Boateng; Norman L Letvin
Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses.
Clinical and vaccine immunology : CVI 2008;15(4):691-6.
2008: Susan W Barnett; Indresh K Srivastava; Elaine Kan; Fengmin Zhou; Amanda Leigh Goodsell; Anthony D Cristillo; Maria Grazia Ferrai; Deborah E Weiss; Norman L Letvin; David Montefiori; Ranajit Pal; Michael Vajdy
Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope.
AIDS (London, England) 2008;22(3):339-48.
2008: Will Fischer; Hua-Xin Liao; Barton F Haynes; Norman L Letvin; Bette Korber
Coping with viral diversity in HIV vaccine design: a response to Nickle et al.
PLoS computational biology 2008;4(1):e15; author reply e25.
2008: Pritha Sen; William A Charini; Ramu A Subbramanian; Edwin R Manuel; Marcelo J Kuroda; Patrick Autissier; Norman L Letvin
Clonal focusing of epitope-specific CD8+ T lymphocytes in rhesus monkeys following vaccination and simian-human immunodeficiency virus challenge.
Journal of virology 2008;82(2):805-16.
2008: Dan Huang; Yun Shen; Liyou Qiu; Crystal Y Chen; Ling Shen; Jim Estep; Robert Hunt; Daphne Vasconcelos; George Du; Pyone Aye; Andrew Lackner; Michelle H. Larsen; William R. Jacobs Jr.; Barton F Haynes; Norman L Letvin; Zheng W Chen
Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
Infection and immunity 2008;76(1):426-36.
2007: Sallie R Permar; SRINIVAS RAO; Yue Sun; Saran Bao; Adam P Buzby; Helen H Kang; Norman L Letvin
Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys.
The Journal of infectious diseases 2007;196(12):1784-93.
2007: Avi-Hai Hovav; Michael W Panas; Christa E Osuna; Mark J Cayabyab; Patrick Autissier; Norman L Letvin
The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells.
Journal of virology 2007;81(23):12793-802.
2007: Avi-Hai Hovav; Michael W Panas; Shaila Rahman; Piya Sircar; Geoffrey Gillard; Mark J Cayabyab; Norman L Letvin
Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6725-33.
2007: Feng Gao; Hua-Xin Liao; Beatrice H Hahn; Norman L Letvin; Bette T Korber; Barton F Haynes
Centralized HIV-1 envelope immunogens and neutralizing antibodies.
Current HIV research 2007;5(6):572-7.
2007: Norman L Letvin; SRINIVAS RAO; Vi Dang; Adam P Buzby; Birgit Korioth-Schmitz; Dilani Dombagoda; Jenny G Parvani; Ryon H Clarke; Liat Bar; Kevin R Carlson; Pamela A Kozlowski; Vanessa M Hirsch; John R Mascola; Gary Nabel
No evidence for consistent virus-specific immunity in simian immunodeficiency virus-exposed, uninfected rhesus monkeys.
Journal of virology 2007;81(22):12368-74.
2007: Michael S Seaman; Daniel F Leblanc; Lauren Grandpre; Melissa T Bartman; David C Montefiori; Norman L Letvin; John R Mascola
Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens.
Virology 2007;367(1):175-86.
2007: Yongkai Mo; Natalie M Quanquin; William H Vecino; Uma Devi Ranganathan; Lydia Tesfa; William Bourn; Keith M Derbyshire; Norman L Letvin; William R. Jacobs Jr.; Glenn Fennelly
Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization.
Infection and immunity 2007;75(10):4804-16.
2007: Lizeng Qin; John R Greenland; Chikaya Moriya; Mark J Cayabyab; Norman L Letvin
Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
Journal of virology 2007;81(19):10606-13.
2007: Brianne R Barker; Jenny G Parvani; Debra Meyer; Adam S Hey; Kresten Skak; Norman L Letvin
IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3596-603.
2007: Norman L Letvin
Correlates of immune protection and the development of a human immunodeficiency virus vaccine.
Immunity 2007;27(3):366-9.
2007: Jacques Fellay; Kevin V Shianna; Dongliang Ge; Sara Colombo; bruno ledergerber; Mike Weale; Kunlin Zhang; Curtis Gumbs; Antonella Castagna; Andrea Cossarizza; Alessandro Cozzi-Lepri; Andrea De Luca; Philippa Easterbrook; Patrick Francioli; Simon Mallal; Javier Martinez-Picado; Jose M Miro; Niels Obel; Jason P Smith; Josiane Wyniger; Patrick Descombes; Stylianos E Antonarakis; Norman L Letvin; Andrew J McMichael; Barton F Haynes; Amalio Telenti; David B Goldstein
A whole-genome association study of major determinants for host control of HIV-1.
Science (New York, N.Y.) 2007;317(5840):944-7.
2007: Sampa Santra; Yue Sun; Jenny G Parvani; Valerie Philippon; Michael S Wyand; Kelledy Manson; Alicia Gomez-Yafal; Gail P Mazzara; Dennis Panicali; Phillip D Markham; David C Montefiori; Norman L Letvin
Heterologous prime/boost immunization of rhesus monkeys by using diverse poxvirus vectors.
Journal of virology 2007;81(16):8563-70.
2007: Yue Sun; Sallie R Permar; Adam P Buzby; Norman L Letvin
Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.
Journal of virology 2007;81(15):8009-15.
2007: Jae-Sung Yu; James W Peacock; William R. Jacobs Jr.; Richard Frothingham; Norman L Letvin; Hua-Xin Liao; Barton F Haynes
Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites.
Clinical and vaccine immunology : CVI 2007;14(7):886-93.
2007: Kimberly McCoy; Nia Tatsis; Birgit Korioth-Schmitz; Marcio O Lasaro; Scott E Hensley; Shih-Wen Lin; Yan Li; Wynetta Giles-Davis; Ann Cun; Dongming Zhou; Zhiquan Xiang; Norman L Letvin; Hildegund C J Ertl
Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors.
Journal of virology 2007;81(12):6594-604.
2007: John R Greenland; Norman L Letvin
Chemical adjuvants for plasmid DNA vaccines.
Vaccine 2007;25(19):3731-41.
2007: John R Greenland; Ralf Geiben; Sharmistha Ghosh; William A Pastor; Norman L Letvin
Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5652-8.
2007: Philip M McKenna; Martin L Koser; Kevin R Carlson; David C Montefiori; Norman L Letvin; Amy Papaneri; Roger J Pomerantz; Bernhard Dietzschold; Peter Silvera; James P McGettigan; Matthias J Schnell
Highly attenuated rabies virus-based vaccine vectors expressing simian-human immunodeficiency virus89.6P Env and simian immunodeficiency virusmac239 Gag are safe in rhesus macaques and protect from an AIDS-like disease.
The Journal of infectious diseases 2007;195(7):980-8.
2007: Thorsten Demberg; Ruth H Florese; Megan J Heath; Kay Larsen; Irene Kalisz; Vaniambadi S Kalyanaraman; Eun Mi Lee; Ranajit Pal; David Venzon; Richard Grant; L Jean Patterson; Birgit Korioth-Schmitz; Adam P Buzby; Dilani Dombagoda; David C Montefiori; Norman L Letvin; Aurelio Aurelio Cafaro; Barbara Ensoli; Marjorie Robert-Guroff
A replication-competent adenovirus-human immunodeficiency virus (Ad-HIV) tat and Ad-HIV env priming/Tat and envelope protein boosting regimen elicits enhanced protective efficacy against simian/human immunodeficiency virus SHIV89.6P challenge in rhesus macaques.
Journal of virology 2007;81(7):3414-27.
2007: Atsuhiko Hasegawa; Chikaya Moriya; Huining Liu; William A Charini; Heather C Vinet; Ramu A Subbramanian; Pritha Sen; Norman L Letvin; Marcelo J Kuroda
Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3409-17.
2007: Will Fischer; Simon Perkins; James Theiler; Tanmoy Bhattacharya; Karina Yusim; Robert Funkhouser; Carla Kuiken; Barton Haynes; Norman L Letvin; Bruce D Walker; Beatrice H Hahn; Bette T Korber
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.
Nature medicine 2007;13(1):100-6.
2007: Dan Huang; Liyou Qiu; Richard Wang; Xioamin Lai; George Du; Probhat Seghal; Yun Shen; Lingyun Shao; Lisa Halliday; Jeff Fortman; Ling Shen; Norman L Letvin; Zheng W Chen
Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunity.
The Journal of infectious diseases 2007;195(1):55-69.
2007: Avi-Hai Hovav; Mark J Cayabyab; Michael W Panas; Sampa Santra; John R Greenland; Ralf Geiben; Barton F Haynes; William R. Jacobs Jr.; Norman L Letvin
Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.
Journal of virology 2007;81(1):74-83.
2006: Norman L Letvin
Progress and obstacles in the development of an AIDS vaccine.
Nature reviews. Immunology 2006;6(12):930-9.
2006: Edwin R Manuel; William A Charini; Pritha Sen; Fred W Peyerl; Marcelo J Kuroda; Joern schmitz; Patrick Autissier; Dennis A Sheeter; Bruce E Torbett; Norman L Letvin
Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses.
Journal of virology 2006;80(24):12032-40.
2006: Jae-Sung Yu; James W Peacock; Stacie Vanleeuwen; Tsungda Hsu; William R. Jacobs Jr.; Mark J Cayabyab; Norman L Letvin; Richard Frothingham; Herman F Staats; Hua-Xin Liao; Barton F Haynes
Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis.
Clinical and vaccine immunology : CVI 2006;13(11):1204-11.
2006: Yue Sun; Joern schmitz; Adam P Buzby; Brianne R Barker; SRINIVAS RAO; Ling Xu; Zhi-Yong Yang; John R Mascola; Gary Nabel; Norman L Letvin
Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge.
Journal of virology 2006;80(22):10950-6.
2006: Michelle L LaBonte; Paul F McKay; Norman L Letvin
Evidence of NK cell dysfunction in SIV-infected rhesus monkeys: impairment of cytokine secretion and NKG2C/C2 expression.
European journal of immunology 2006;36(9):2424-33.
2006: Wendy W Yeh; Evan M Cale; Pimkwan Jaru-Ampornpan; Carol I Lord; Fred W Peyerl; Norman L Letvin
Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations.
Journal of virology 2006;80(16):8168-77.
2006: David H Margolin; Erika H Saunders; Benjamin Bronfin; Nicole de Rosa; Michael K Axthelm; Olga Goloubeva; Sara Eapen; Rebecca Gelman; Norman L Letvin
Germinal center function in the spleen during simian HIV infection in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1108-19.
2006: Eric A Weaver; Zhongjing Lu; Zenaido T Camacho; Fatiha Moukdar; Hua-Xin Liao; Ben-Jiang Ma; Mark Muldoon; James Theiler; Gary Nabel; Norman L Letvin; Bette T Korber; Beatrice H Hahn; Barton F Haynes; Feng Gao
Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen.
Journal of virology 2006;80(14):6745-56.
2006: Renaud A Du Pasquier; Marion C Stein; Marco A Lima; Xin Dang; Jims Jean-Jacques; Yue Zheng; Norman L Letvin; Igor J Koralnik
JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients.
Journal of neuroimmunology 2006;176(1-2):181-6.
2006: Joseph J Mattapallil; Daniel C Douek; Alicia Buckler-White; David Montefiori; Norman L Letvin; Gary Nabel; Mario Roederer
Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge.
The Journal of experimental medicine 2006;203(6):1533-41.
2006: Norman L Letvin; John R Mascola; Yue Sun; Darci A Gorgone; Adam P Buzby; Ling Xu; Zhi-Yong Yang; Bimal K Chakrabarti; SRINIVAS RAO; Joern schmitz; David C Montefiori; Brianne R Barker; Fred L Bookstein; Gary Nabel
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Science (New York, N.Y.) 2006;312(5779):1530-3.
2006: Rong Xu; Indresh K Srivastava; Larene Kuller; Irina Zarkikh; Zane Kraft; Zahra Fagrouch; Norman L Letvin; Jonathan Luke Heeney; Susan W Barnett; Leonidas Stamatatos
Immunization with HIV-1 SF162-derived Envelope gp140 proteins does not protect macaques from heterologous simian-human immunodeficiency virus SHIV89.6P infection.
Virology 2006;349(2):276-89.
2006: Ramu A Subbramanian; William A Charini; Marcelo J Kuroda; Michael S Seaman; Heng Chhay; Michelle A Lifton; Darci A Gorgone; Joern schmitz; Angela Carville; Norman L Letvin
Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys.
AIDS research and human retroviruses 2006;22(5):445-52.
2006: Paula M Acierno; Joern schmitz; Darci A Gorgone; Yue Sun; Sampa Santra; Michael S Seaman; Michael H Newberg; John R Mascola; Gary Nabel; Dennis Panicali; Norman L Letvin
Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5338-45.
2006: Sallie R Permar; Diane E Griffin; Norman L Letvin
Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals.
Clinical and vaccine immunology : CVI 2006;13(4):437-43.
2006: Ranajit Pal; David Venzon; Sampa Santra; Vaniambadi S Kalyanaraman; David C Montefiori; Lindsey Hocker; Lauren Hudacik; Nicolas Rose; Janos Nacsa; Yvette Edghill Spano; Marcin Moniuszko; Zdenek Hel; Igor M Belyakov; Jay A Berzofsky; Robyn Washington Parks; Phillip D Markham; Norman L Letvin; Jim Tartaglia; Genoveffa Franchini
Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.
Journal of virology 2006;80(8):3732-42.
2006: Mark J Cayabyab; Avi-Hai Hovav; Tsungda Hsu; Georgia R Krivulka; Michelle A Lifton; Darci A Gorgone; Glenn Fennelly; Barton F Haynes; William R. Jacobs Jr.; Norman L Letvin
Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.
Journal of virology 2006;80(4):1645-52.
2006: George Du; Liyou Qiu; Ling Shen; Probhat Sehgal; Yun Shen; Dan Huang; Norman L Letvin; Zheng W Chen
Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infection.
Journal of immunological methods 2006;308(1-2):19-35.
2006: SRINIVAS RAO; Phillip Gomez; John R Mascola; Vi Dang; Georgia R Krivulka; Faye Yu; Carol I Lord; Ling Shen; Robert T Bailer; Gary Nabel; Norman L Letvin
Comparative evaluation of three different intramuscular delivery methods for DNA immunization in a nonhuman primate animal model.
Vaccine 2006;24(3):367-73.
2006: Michael H Newberg; Kimberly J McEvers; Darci A Gorgone; Michelle A Lifton; Susanne H C Baumeister; Ronald S Veazey; Joern schmitz; Norman L Letvin
Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):319-28.
2005: Shawn S Jackson; Joern schmitz; Marcelo J Kuroda; Paul F McKay; Shawn M Sumida; Kristi L Martin; Faye Yu; Michelle A Lifton; Darci A Gorgone; Norman L Letvin
Evaluation of CD62L expression as a marker for vaccine-elicited memory cytotoxic T lymphocytes.
Immunology 2005;116(4):443-53.
2005: Fred W Peyerl; Dan H Barouch; Heidi S Bazick; Edwin R Manuel; Norman L Letvin
Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.
Journal of clinical microbiology 2005;43(9):4773-9.
2005: Keith A Reimann; Robert A Parker; Michael S Seaman; Kristin Beaudry; Margaret H Beddall; Lauren Peterson; Kenneth C Williams; Ronald S Veazey; David C Montefiori; John R Mascola; Gary Nabel; Norman L Letvin
Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses.
Journal of virology 2005;79(14):8878-85.
2005: Dan H Barouch; Zhi-Yong Yang; Wing-Pui Kong; Birgit Korioth-Schmitz; Shawn M Sumida; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Ayako Miura; John R Mascola; Norman L Letvin; Gary Nabel
A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates.
Journal of virology 2005;79(14):8828-34.
2005: John R Greenland; Huining Liu; David Berry; Daniel G Anderson; Woong-Ki Kim; Darrell J Irvine; Robert Langer; Norman L Letvin
Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):164-70.
2005: Joern schmitz; R Paul Johnson; Harold M McClure; Kelledy Manson; Michael S Wyand; Marcelo J Kuroda; Michelle A Lifton; Rajinder Khunkhun; Kimberly J McEvers; Jacqueline Gillis; Michael Piatak; Jeffrey D Lifson; Gudrun Grosschupff; Paul Racz; Klara Tenner-Racz; E Peter Rieber; Kristine Kuus-Reichel; Rebecca Gelman; Norman L Letvin; David C Montefiori; Ruth Ruprecht; Ronald C Desrosiers; Keith A Reimann
Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
Journal of virology 2005;79(13):8131-41.
2005: Shawn S Jackson; Petr O Ilyinskii; Valerie Philippon; Linda Gritz; Alicia Gómez Yafal; Kimberly Zinnack; Kristin Beaudry; Kelledy Manson; Michelle A Lifton; Marcelo J Kuroda; Norman L Letvin; Gail P Mazzara; Dennis Panicali
Role of genes that modulate host immune responses in the immunogenicity and pathogenicity of vaccinia virus.
Journal of virology 2005;79(10):6554-9.
2005: Sampa Santra; Michael S Seaman; Ling Xu; Dan H Barouch; Carol I Lord; Michelle A Lifton; Darci A Gorgone; Kristin Beaudry; Krisha Svehla; Brent Welcher; Bimal K Chakrabarti; Yue Huang; Zhi-Yong Yang; John R Mascola; Gary Nabel; Norman L Letvin
Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.
Journal of virology 2005;79(10):6516-22.
2005: Yue Sun; Joern schmitz; Paula M Acierno; Sampa Santra; Ramu A Subbramanian; Dan H Barouch; Darci A Gorgone; Michelle A Lifton; Kristin Beaudry; Kelledy Manson; Valerie Philippon; Ling Xu; Holden T Maecker; John R Mascola; Dennis Panicali; Gary Nabel; Norman L Letvin
Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4753-60.
2005: Michael S Seaman; Sampa Santra; Michael H Newberg; Valerie Philippon; Kelledy Manson; Ling Xu; Rebecca Gelman; Dennis Panicali; John R Mascola; Gary Nabel; Norman L Letvin
Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys.
Journal of virology 2005;79(8):4580-8.
2005: Karen L Hershberger; Jessica Kurian; Bette T Korber; Norman L Letvin
Killer cell immunoglobulin-like receptors (KIR) of the African-origin sabaeus monkey: evidence for recombination events in the evolution of KIR.
European journal of immunology 2005;35(3):922-35.
2005: Michael S Seaman; Ling Xu; Kristin Beaudry; Kristi L Martin; Margaret H Beddall; Ayako Miura; Anna Sambor; Bimal K Chakrabarti; Yue Huang; Robert T Bailer; Richard A Koup; John R Mascola; Gary Nabel; Norman L Letvin
Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys.
Journal of virology 2005;79(5):2956-63.
2005: Dan H Barouch; Jennifer Powers; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Fred W Peyerl; Marcelo J Kuroda; Darci A Gorgone; Michelle A Lifton; Carol I Lord; Vanessa M Hirsch; David C Montefiori; Angela Carville; Keith G Mansfield; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
Nature immunology 2005;6(3):247-52.
2005: Xin Dang; Michael K Axthelm; Norman L Letvin; Igor J Koralnik
Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys.
Journal of virology 2005;79(3):1361-6.
2005: Norman L Letvin
Progress toward an HIV vaccine.
Annual review of medicine 2005;56():213-23.
2005: Philip R Johnson; Bruce C Schnepp; Mary J Connell; Daniela Rohne; Suzanne Robinson; Georgia R Krivulka; Carol I Lord; Rebekah Zinn; David C Montefiori; Norman L Letvin; K Reed Clark
Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques.
Journal of virology 2005;79(2):955-65.
2005: John R Mascola; Anna Sambor; Kristin Beaudry; Sampa Santra; Brent Welcher; Mark K Louder; Thomas C VanCott; Yue Huang; Bimal K Chakrabarti; Wing-Pui Kong; Zhi-Yong Yang; Ling Xu; David C Montefiori; Gary Nabel; Norman L Letvin
Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins.
Journal of virology 2005;79(2):771-9.
2004: David A Price; Sadie M West; Michael R Betts; Laura E Ruff; Jason M Brenchley; David R Ambrozak; Yvette Edghill Spano; Marcelo J Kuroda; Derek Bogdan; Kevin Kunstman; Norman L Letvin; Genoveffa Franchini; Steven Wolinsky; Richard A Koup; Daniel C Douek
T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
Immunity 2004;21(6):793-803.
2004: Yun Shen; Ling Shen; Prabhat Sehgal; Dan Huang; Liyou Qiu; George Du; Norman L Letvin; Zheng W Chen
Clinical latency and reactivation of AIDS-related mycobacterial infections.
Journal of virology 2004;78(24):14023-32.
2004: Fred W Peyerl; Heidi S Bazick; Michael H Newberg; Dan H Barouch; Joseph Sodroski; Norman L Letvin
Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope.
Journal of virology 2004;78(24):13901-10.
2004: Dan H Barouch; Norman L Letvin; Robert A Seder
The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses.
Immunological reviews 2004;202():266-74.
2004: James W Peacock; Sushila K Nordone; Shawn S Jackson; Hua-Xin Liao; Norman L Letvin; Alicia Gómez Yafal; Linda Gritz; Gail P Mazzara; Barton F Haynes; Herman F Staats
Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting.
Journal of virology 2004;78(23):13163-72.
2004: Shawn M Sumida; Paul F McKay; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Michael S Seaman; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Norman L Letvin; Dan H Barouch
Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.
The Journal of clinical investigation 2004;114(9):1334-42.
2004: Ramu A Subbramanian; Chikaya Moriya; Kristi L Martin; Fred W Peyerl; Atsuhiko Hasegawa; Akira Naoi; Heng Chhay; Patrick Autissier; Darci A Gorgone; Michelle A Lifton; Kristine Kuus-Reichel; Joern schmitz; Norman L Letvin; Marcelo J Kuroda
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity.
Nature biotechnology 2004;22(11):1429-34.
2004: M L Labonte; Norman L Letvin
Variable NKG2 expression in the peripheral blood lymphocytes of rhesus monkeys.
Clinical and experimental immunology 2004;138(2):205-12.
2004: Ling Shen; Yun Shen; Dan Huang; Liyou Qiu; Prabhat Sehgal; George Z Du; M Miller; Norman L Letvin; Zheng W Chen
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.
The Journal of infectious diseases 2004;190(8):1438-47.
2004: Woong-Ki Kim; Sarah Corey; Gillian Chesney; Heather Knight; Sherry Klumpp; Christian Wüthrich; Norman L Letvin; Igor J Koralnik; Andrew Lackner; Ronald Veasey; Kenneth Williams
Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with central nervous system vessels and virus.
Journal of neurovirology 2004;10(5):315-25.
2004: Renaud A Du Pasquier; Joern schmitz; Jims Jean-Jacques; Yue Zheng; J Gordon; Kamel Khalili; Norman L Letvin; Igor J Koralnik
Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals.
Journal of virology 2004;78(18):10206-10.
2004: Sallie R Permar; Sherry A Klumpp; Keith G Mansfield; Angela Carville; Darci A Gorgone; Michelle A Lifton; Joern schmitz; Keith A Reimann; Fernando P Polack; Diane E Griffin; Norman L Letvin
Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys.
The Journal of infectious diseases 2004;190(5):998-1005.
2004: Renaud A Du Pasquier; Marcelo J Kuroda; Yue Zheng; Jims Jean-Jacques; Norman L Letvin; Igor J Koralnik
A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy.
Brain : a journal of neurology 2004;127(Pt 9):1970-8.
2004: Dan H Barouch; Diana M Truitt; Norman L Letvin
Expression kinetics of the interleukin-2/immunoglobulin (IL-2/Ig) plasmid cytokine adjuvant.
Vaccine 2004;22(23-24):3092-7.
2004: Sampa Santra; Dan H Barouch; Birgit Korioth-Schmitz; Carol I Lord; Georgia R Krivulka; Faye Yu; Margaret H Beddall; Darci A Gorgone; Michelle A Lifton; Ayako Miura; Valerie Philippon; Kelledy Manson; Phillip D Markham; John Parrish; Marcelo J Kuroda; Joern schmitz; Rebecca Gelman; John W Shiver; David C Montefiori; Dennis Panicali; Norman L Letvin
Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11088-93.
2004: Dan H Barouch; Norman L Letvin
HIV escape from cytotoxic T lymphocytes: a potential hurdle for vaccines?
Lancet 2004;364(9428):10-1.
2004: Michael K Axthelm; Igor J Koralnik; Xin Dang; Christian Wüthrich; Daniela Rohne; Isaac E Stillman; Norman L Letvin
Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys.
Journal of neuropathology and experimental neurology 2004;63(7):750-8.
2004: Norman L Letvin; Yue Huang; Bimal K Chakrabarti; Ling Xu; Michael S Seaman; Kristin Beaudry; Birgit Korioth-Schmitz; Faye Yu; Daniela Rohne; Kristi L Martin; Ayako Miura; Wing-Pui Kong; Zhi-Yong Yang; Rebecca Gelman; Olga G Golubeva; David C Montefiori; John R Mascola; Gary Nabel
Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys.
Journal of virology 2004;78(14):7490-7.
2004: Michelle L LaBonte; Elisa I Choi; Norman L Letvin
Molecular determinants regulating the pairing of NKG2 molecules with CD94 for cell surface heterodimer expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6902-12.
2004: Nancy Haigwood; David C Montefiori; William F Sutton; Janela McClure; Andrew J Watson; Gerald Voss; Vanessa M Hirsch; Barbra A Richardson; Norman L Letvin; Shiu-Lok Hu; Philip R Johnson
Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies.
Journal of virology 2004;78(11):5983-95.
2004: Dan H Barouch; Maria G Pau; Jerome H H V Custers; Wouter Koudstaal; Stefan Kostense; Menzo J E Havenga; Diana M Truitt; Shawn M Sumida; Michael G Kishko; Janelle C Arthur; Birgit Korioth-Schmitz; Michael H Newberg; Darci A Gorgone; Michelle A Lifton; Dennis Panicali; Gary Nabel; Norman L Letvin; Jaap Goudsmit
Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6290-7.
2004: Byeongwoon Song; Mark Cayabyab; Ngoc Phan; Liping Wang; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
Neutralization sensitivity of a simian-human immunodeficiency virus (SHIV-HXBc2P 3.2N) isolated from an infected rhesus macaque with neurological disease.
Virology 2004;322(1):168-81.
2004: Paul F McKay; Dan H Barouch; Sampa Santra; Shawn M Sumida; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Norman L Letvin
Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses.
European journal of immunology 2004;34(4):1011-20.
2004: Shawn M Sumida; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Wouter Koudstaal; Maria G Pau; Stefan Kostense; Menzo J E Havenga; Jaap Goudsmit; Norman L Letvin; Dan H Barouch
Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors.
Journal of virology 2004;78(6):2666-73.
2004: Nina Malkevitch; Daniela Rohne; Joel Pinczewski; Kristine Aldrich; Vaniambadi S Kalyanaraman; Norman L Letvin; Marjorie Robert-Guroff
Evaluation of combination DNA/replication-competent Ad-SIV recombinant immunization regimens in rhesus macaques.
AIDS research and human retroviruses 2004;20(2):235-44.
2004: Joseph J Mattapallil; Norman L Letvin; Mario Roederer
T-cell dynamics during acute SIV infection.
AIDS (London, England) 2004;18(1):13-23.
2004: Fred W Peyerl; Dan H Barouch; Norman L Letvin
Structural constraints on viral escape from HIV- and SIV-specific cytotoxic T-lymphocytes.
Viral immunology 2004;17(2):144-51.
2004: Mark Cayabyab; Daniela Rohne; Georgios Pollakis; Claudia Mische; Tsehaynesh Messele; Almaz Abebe; Bijan Etemad-Moghadam; Peter Yang; Scott Henson; Michael K Axthelm; Jaap Goudsmit; Norman L Letvin; Joseph Sodroski
Rapid CD4+ T-lymphocyte depletion in rhesus monkeys infected with a simian-human immunodeficiency virus expressing the envelope glycoproteins of a primary dual-tropic Ethiopian Clade C HIV type 1 isolate.
AIDS research and human retroviruses 2004;20(1):27-40.
2004: Vanessa M Hirsch; Sampa Santra; Simoy Goldstein; Ronald Plishka; Alicia Buckler-White; Aruna Seth; Ilnour Ourmanov; Charles R Brown; Ronald Engle; David Montefiori; Jennifer Glowczwskie; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.
Journal of virology 2004;78(1):275-84.
2004: Michael S Seaman; Fred W Peyerl; Shawn S Jackson; Michelle A Lifton; Darci A Gorgone; Joern schmitz; Norman L Letvin
Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo.
Journal of virology 2004;78(1):206-15.
2003: Fred W Peyerl; Dan H Barouch; Wendy W Yeh; Heidi S Bazick; Jennifer Kunstman; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.
Journal of virology 2003;77(23):12572-8.
2003: Renaud A Du Pasquier; Marcelo J Kuroda; Joern schmitz; Yue Zheng; Kristi Martin; Fred W Peyerl; Michelle A Lifton; Darci A Gorgone; Patrick Autissier; Norman L Letvin; Igor J Koralnik
Low frequency of cytotoxic T lymphocytes against the novel HLA-A*0201-restricted JC virus epitope VP1(p36) in patients with proven or possible progressive multifocal leukoencephalopathy.
Journal of virology 2003;77(22):11918-26.
2003: John R Mascola; Mark G Lewis; Thomas C VanCott; Gabriela Stiegler; Hermann Katinger; Michael S Seaman; Kristin Beaudry; Dan H Barouch; Birgit Korioth-Schmitz; Georgia R Krivulka; Anna Sambor; Brent Welcher; Daniel C Douek; David C Montefiori; John W Shiver; Pascal Poignard; Dennis R Burton; Norman L Letvin
Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies.
Journal of virology 2003;77(19):10348-56.
2003: Feng Gao; Yingying Li; Julie M Decker; Fred W Peyerl; Frederic Bibollet-Ruche; Cynthia M Rodenburg; Yalu Chen; Denise R Shaw; Susan Allen; ROSEMARY MUSONDA; George M Shaw; Allan J Zajac; Norman L Letvin; Beatrice H Hahn
Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice.
AIDS research and human retroviruses 2003;19(9):817-23.
2003: Ramu A Subbramanian; Marcelo J Kuroda; William A Charini; Dan H Barouch; Cristina Costantino; Sampa Santra; Joern schmitz; Kristi L Martin; Michelle A Lifton; Darci A Gorgone; John W Shiver; Norman L Letvin
Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys.
Journal of virology 2003;77(18):10113-8.
2003: Dan H Barouch; Paul F McKay; Shawn M Sumida; Sampa Santra; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Bimal K Chakrabarti; Ling Xu; Gary Nabel; Norman L Letvin
Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines.
Journal of virology 2003;77(16):8729-35.
2003: Xioamin Lai; Yun Shen; Dejiang Zhou; Prabhat Sehgal; Ling Shen; Meredith Simon; Liyou Qiu; Norman L Letvin; Zheng W Chen
Immune biology of macaque lymphocyte populations during mycobacterial infection.
Clinical and experimental immunology 2003;133(2):182-92.
2003: Norman L Letvin; Bruce D Walker
Immunopathogenesis and immunotherapy in AIDS virus infections.
Nature medicine 2003;9(7):861-6.
2003: Dan H Barouch; Jennifer Kunstman; Jennifer Glowczwskie; Kevin Kunstman; Michael A Egan; Fred W Peyerl; Sampa Santra; Marcelo J Kuroda; Joern schmitz; Kristin Beaudry; Georgia R Krivulka; Michelle A Lifton; Darci A Gorgone; Steven Wolinsky; Norman L Letvin
Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys.
Journal of virology 2003;77(13):7367-75.
2003: Zheng W Chen; Norman L Letvin
Vgamma2Vdelta2+ T cells and anti-microbial immune responses.
Microbes and infection / Institut Pasteur 2003;5(6):491-8.
2003: Zheng W Chen; Norman L Letvin
Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm.
Trends in immunology 2003;24(4):213-9.
2003: Paul F McKay; Dan H Barouch; Joern schmitz; Ronald S Veazey; Darci A Gorgone; Michelle A Lifton; Kenneth C Williams; Norman L Letvin
Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination.
Journal of virology 2003;77(8):4695-702.
2003: Sallie R Permar; Sherry A Klumpp; Keith G Mansfield; Woong-Ki Kim; Darci A Gorgone; Michelle A Lifton; Kenneth C Williams; Joern schmitz; Keith A Reimann; Michael K Axthelm; Fernando P Polack; Diane E Griffin; Norman L Letvin
Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.
Journal of virology 2003;77(7):4396-400.
2003: Jan C Schmollinger; Robert H Vonderheide; Kara M Hoar; Britta Maecker; Joachim L Schultze; F Stephen Hodi; Robert J Soiffer; Ken Jung; Marcelo J Kuroda; Norman L Letvin; Edward Greenfield; Martin Mihm; Jeffery L Kutok; Glenn Dranoff
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3398-403.
2003: Mary Premenko-Lanier; Paul A Rota; Gary H Rhodes; David verhoeven; Dan H Barouch; Nicholas W Lerche; Norman L Letvin; William Joseph Bellini; Michael B McChesney
DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate.
Virology 2003;307(1):67-75.
2003: Dejiang Zhou; Xioamin Lai; Yun Shen; Prabhat Sehgal; Ling Shen; Meredith Simon; Liyou Qiu; Dan Huang; George Z Du; Qifan Wang; Norman L Letvin; Zheng W Chen
Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys.
Journal of virology 2003;77(5):2998-3006.
2003: Werner Kempf; Marshall E Kadin; Ann M Dvorak; Carol C Lord; Günter Burg; Norman L Letvin; Igor J Koralnik
Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin.
Carcinogenesis 2003;24(2):301-6.
2003: Joern schmitz; Marcelo J Kuroda; Sampa Santra; Meredith A Simon; Michelle A Lifton; Wenyu Lin; Rajinder Khunkhun; Michael Piatak; Jeffrey D Lifson; Gudrun Grosschupff; Rebecca Gelman; Paul Racz; Klara Tenner-Racz; Keith A Mansfield; Norman L Letvin; David C Montefiori; Keith A Reimann
Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.
Journal of virology 2003;77(3):2165-73.
2002: Dan H Barouch; Norman L Letvin
Viral evolution and challenges in the development of HIV vaccines.
Vaccine 2002;20 Suppl 4():A66-8.
2002: Jamal Baig; Daniel B Levy; Paul F McKay; Joern schmitz; Sampa Santra; Ramu A Subbramanian; Marcelo J Kuroda; Michelle A Lifton; Darci A Gorgone; Linda S Wyatt; Bernard Moss; Yue Huang; Bimal K Chakrabarti; Ling Xu; Wing-Pui Kong; Zhi-Yong Yang; John R Mascola; Gary Nabel; Angela Carville; Andrew Lackner; Ronald S Veazey; Norman L Letvin
Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination.
Journal of virology 2002;76(22):11484-90.
2002: Michael H Newberg; Marcelo J Kuroda; William A Charini; Ayako Miura; Carol I Lord; Joern schmitz; Darci A Gorgone; Michelle A Lifton; Kristine Kuus-Reichel; Norman L Letvin
A simian immunodeficiency virus nef peptide is a dominant cytotoxic T lymphocyte epitope in Indian-origin rhesus monkeys expressing the common MHC class I allele mamu-A*02.
Virology 2002;301(2):365-73.
2002: Norman L Letvin
Strategies for an HIV vaccine.
The Journal of clinical investigation 2002;110(1):15-20.
2002: Sampa Santra; Dan H Barouch; Marcelo J Kuroda; Joern schmitz; Georgia R Krivulka; Kristin Beaudry; Carol I Lord; Michelle A Lifton; Linda S Wyatt; Bernard Moss; Vanessa M Hirsch; Norman L Letvin
Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Journal of virology 2002;76(12):6376-81.
2002: Bijan Etemad-Moghadam; Daniela Rhone; Tavis Steenbeke; Ying Sun; Judith Manola; Rebecca Gelman; John W Fanton; Paul Racz; Klara Tenner-Racz; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
Understanding the basis of CD4(+) T-cell depletion in macaques infected by a simian-human immunodeficiency virus.
Vaccine 2002;20(15):1934-7.
2002: Robert A Rasmussen; Regina Hofmann-Lehmann; Pei-Lin Li; Josef Vlasak; Joern schmitz; Keith A Reimann; Marcelo J Kuroda; Norman L Letvin; David C Montefiori; Harold M McClure; Ruth Ruprecht
Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques.
AIDS (London, England) 2002;16(6):829-38.
2002: David H Margolin; Erika F Helmuth Saunders; Benjamin Bronfin; Nicole de Rosa; Michael K Axthelm; Xavier Alvarez; Norman L Letvin
High frequency of virus-specific B lymphocytes in germinal centers of simian-human immunodeficiency virus-infected rhesus monkeys.
Journal of virology 2002;76(8):3965-73.
2002: Yun Shen; Dejiang Zhou; Liyou Qiu; Xioamin Lai; Meredith Simon; Ling Shen; Zhongchen Kou; Qifan Wang; Liming Jiang; Jim Estep; Robert Hunt; Michelle Clagett; Prabhat Sehgal; Yunyaun Li; Xuejun Zeng; Craig Morita; Michael B Brenner; Norman L Letvin; Zheng W Chen
Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
Science (New York, N.Y.) 2002;295(5563):2255-8.
2002: Sampa Santra; Joern schmitz; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Carol I Lord; Ranajit Pal; Genoveffa Franchini; Norman L Letvin
Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1847-53.
2002: Yun Shen; Dejiang Zhou; Laura Chalifoux; Ling Shen; Meredith Simon; Xuejun Zeng; Xioamin Lai; Yunyuan Li; Prabhat Sehgal; Norman L Letvin; Zheng W Chen
Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection.
Infection and immunity 2002;70(2):869-77.
2002: Dan H Barouch; Jennifer Kunstman; Marcelo J Kuroda; Joern schmitz; Sampa Santra; Fred W Peyerl; Georgia R Krivulka; Kristin Beaudry; Michelle A Lifton; Darci A Gorgone; David C Montefiori; Mark G Lewis; Steven Wolinsky; Norman L Letvin
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
Nature 2002;415(6869):335-9.
2002: Dan H Barouch; Sampa Santra; Klara Tenner-Racz; Paul Racz; Marcelo J Kuroda; Joern schmitz; Shawn S Jackson; Michelle A Lifton; Daniel C Freed; Helen C Perry; Mary-Ellen Davies; John W Shiver; Norman L Letvin
Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):562-8.
2002: Norman L Letvin; Dan H Barouch; David C Montefiori
Prospects for vaccine protection against HIV-1 infection and AIDS.
Annual review of immunology 2002;20():73-99.
2002: Igor J Koralnik; Renaud A Du Pasquier; Marcelo J Kuroda; Joern schmitz; Xin Dang; Yue Zheng; Michelle A Lifton; Norman L Letvin
Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):499-504.
2002: Paul F McKay; Joern schmitz; Dan H Barouch; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Darci A Gorgone; Norman L Letvin
Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):332-7.
2002: Ranajit Pal; David Venzon; Norman L Letvin; Sampa Santra; David C Montefiori; Neil R Miller; Elzbieta Tryniszewska; Mark G Lewis; Thomas C VanCott; Vanessa M Hirsch; ruth woodward; A Gibson; M Grace; E Dobratz; Phillip D Markham; Zdenek Hel; Janos Nacsa; M Klein; Jim Tartaglia; Genoveffa Franchini
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency.
Journal of virology 2002;76(1):292-302.
2001: Joern schmitz; Ronald S Veazey; Marcelo J Kuroda; D B Levy; Aruna Seth; Keith G Mansfield; Christine E Nickerson; Michelle A Lifton; Xavier Alvarez; Andrew Lackner; Norman L Letvin
Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys.
Blood 2001;98(13):3757-61.
2001: Robert H Vonderheide; Joachim L Schultze; Karen S Anderson; Britta Maecker; Marcus O Butler; Zhinan Xia; Marcelo J Kuroda; Michael S von Bergwelt-Baildon; M M Bedor; Kara M Hoar; D R Schnipper; Mary W Brooks; Norman L Letvin; Katherine Stephans; Kai W Wucherpfennig; William C Hahn; Lee M Nadler
Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals.
Cancer research 2001;61(23):8366-70.
2001: Zdenek Hel; Janos Nacsa; Brian Kelsall; Wen-Po Tsai; Norman L Letvin; Robyn Washington Parks; Elzbieta Tryniszewska; Louis J Picker; Mark G Lewis; Yvette Edghill Spano; Marcin Moniuszko; Ranajit Pal; Liljana Stevceva; John D Altman; Todd M Allen; D Watkins; José V Torres; Jay A Berzofsky; Igor M Belyakov; Warren Strober; Genoveffa Franchini
Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques.
Journal of virology 2001;75(23):11483-95.
2001: Herman F Staats; Curtis Bradney; William M Gwinn; Shawn S Jackson; Gregory D Sempowski; Hua-Xin Liao; Norman L Letvin; Barton F Haynes
Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5386-94.
2001: William A Charini; Marcelo J Kuroda; Joern schmitz; Kristin Beaudry; W Lin; Michelle A Lifton; Georgia R Krivulka; A Necker; Norman L Letvin
Clonally diverse CTL response to a dominant viral epitope recognizes potential epitope variants.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4996-5003.
2001: Dan H Barouch; Tong-Ming Fu; David C Montefiori; Mark G Lewis; John W Shiver; Norman L Letvin
Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.
Immunology letters 2001;79(1-2):57-61.
2001: Suzanne Robinson; William A Charini; Michael H Newberg; Marcelo J Kuroda; Carol I Lord; Norman L Letvin
A commonly recognized simian immunodeficiency virus Nef epitope presented to cytotoxic T lymphocytes of Indian-origin rhesus monkeys by the prevalent major histocompatibility complex class I allele Mamu-A*02.
Journal of virology 2001;75(21):10179-86.
2001: M L LaBonte; K L Hershberger; B Korber; Norman L Letvin
The KIR and CD94/NKG2 families of molecules in the rhesus monkey.
Immunological reviews 2001;183():25-40.
2001: Yun Shen; Ling Shen; Prabhat Sehgal; Dejiang Zhou; Meredith Simon; M Miller; E A Enimi; B Henckler; L Chalifoux; N Sehgal; M Gastron; Norman L Letvin; Zheng W Chen
Antiretroviral agents restore Mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in Macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCG.
Journal of virology 2001;75(18):8690-6.
2001: Renaud A Du Pasquier; K W Clark; P S Smith; Jeffrey T Joseph; J M Mazullo; Umberto De Girolami; Norman L Letvin; Igor J Koralnik
JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy.
Journal of neurovirology 2001;7(4):318-22.
2001: A Craiu; Dan H Barouch; Xin Xiao Zheng; Marcelo J Kuroda; Joern schmitz; Michelle A Lifton; Tavis Steenbeke; Christine E Nickerson; Kristin Beaudry; J D Frost; Keith A Reimann; Terry B Strom; Norman L Letvin
An IL-2/Ig fusion protein influences CD4+ T lymphocytes in naive and simian immunodeficiency virus-infected Rhesus monkeys.
AIDS research and human retroviruses 2001;17(10):873-86.
2001: Luz-Andrea Pfister; Norman L Letvin; Igor J Koralnik
JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy.
Journal of virology 2001;75(12):5672-6.
2001: Bijan Etemad-Moghadam; D Rhone; Tavis Steenbeke; Ying Sun; Judith Manola; Rebecca Gelman; John W Fanton; Paul Racz; Klara Tenner-Racz; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus.
Journal of virology 2001;75(12):5646-55.
2001: Dan H Barouch; Sampa Santra; Marcelo J Kuroda; Joern schmitz; Ronald Plishka; Alicia Buckler-White; A E Gaitan; R Zin; J H Nam; Linda S Wyatt; Michelle A Lifton; Christine E Nickerson; Bernard Moss; David C Montefiori; Vanessa M Hirsch; Norman L Letvin
Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination.
Journal of virology 2001;75(11):5151-8.
2001: Zheng W Chen; Yun Shen; Dejiang Zhou; Meredith Simon; Zhongchen Kou; D Lee-Parritz; Ling Shen; Prabhat Sehgal; Norman L Letvin
In vivo T-lymphocyte activation and transient reduction of viral replication in macaques infected with simian immunodeficiency virus.
Journal of virology 2001;75(10):4713-20.
2001: Norman L Letvin; Suzanne Robinson; Daniela Rohne; Michael K Axthelm; John W Fanton; M Bilska; TJ Palker; Hua-Xin Liao; Barton F Haynes; David C Montefiori
Vaccine-elicited V3 loop-specific antibodies in rhesus monkeys and control of a simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate envelope.
Journal of virology 2001;75(9):4165-75.
2001: Zheng W Chen; Y Li; X Zeng; Marcelo J Kuroda; Joern schmitz; Yun Shen; X Lai; Ling Shen; Norman L Letvin
The TCR repertoire of an immunodominant CD8+ T lymphocyte population.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4525-33.
2001: K L Hershberger; R Shyam; A Miura; Norman L Letvin
Diversity of the killer cell Ig-like receptors of rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4380-90.
2001: J M Huete; P A Chatis; Joern schmitz; Marcelo J Kuroda; Norman L Letvin; Keith A Reimann
Detection of viral RNA in CD4(-)CD8(-) and CD4(-)CD8(+) lymphocytes in vivo in rhesus monkeys infected with simian immunodeficiency virus of macaques.
AIDS research and human retroviruses 2001;17(4):349-60.
2001: A Seth; J Markee; A Hoering; A Sevin; D E Sabath; Joern schmitz; Marcelo J Kuroda; Michelle A Lifton; M S Hirsch; A C Collier; Norman L Letvin; M Juliana McElrath
Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy.
The Journal of infectious diseases 2001;183(5):722-9.
2001: Dan H Barouch; A Craiu; Sampa Santra; Michael A Egan; Joern schmitz; Marcelo J Kuroda; Tong-Ming Fu; J H Nam; Linda S Wyatt; Michelle A Lifton; Georgia R Krivulka; Christine E Nickerson; Carol I Lord; Bernard Moss; Mark G Lewis; Vanessa M Hirsch; John W Shiver; Norman L Letvin
Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys.
Journal of virology 2001;75(5):2462-7.
2001: Norman L Letvin; B R Bloom; S L Hoffman
Prospects for vaccines to protect against AIDS, tuberculosis, and malaria.
JAMA : the journal of the American Medical Association 2001;285(5):606-11.
2001: Norman L Letvin; B D Walker
HIV versus the immune system: another apparent victory for the virus.
The Journal of clinical investigation 2001;107(3):273-5.
2000: Sampa Santra; Dan H Barouch; Shawn S Jackson; Marcelo J Kuroda; Joern schmitz; Michelle A Lifton; A H Sharpe; Norman L Letvin
Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6791-5.
2000: Werner Kempf; David H Margolin; B J Dezube; Marshall E Kadin; Norman L Letvin; Igor J Koralnik
Clinicopathological characterization of an HIV-2-infected individual with two clonally unrelated primary lymphomas.
American journal of hematology 2000;65(4):302-6.
2000: Dan H Barouch; Sampa Santra; Joern schmitz; Marcelo J Kuroda; Tong-Ming Fu; W Wagner; M Bilska; A Craiu; Xin Xiao Zheng; Georgia R Krivulka; Kristin Beaudry; Michelle A Lifton; Christine E Nickerson; Wendy Trigona; K Punt; Daniel C Freed; Liming Guan; Sheri Dubey; Danilo R Casimiro; A Simon; Mary-Ellen Davies; Michael A Chastain; Terry B Strom; Rebecca Gelman; David C Montefiori; Mark G Lewis; Emilio A Emini; John W Shiver; Norman L Letvin
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
Science (New York, N.Y.) 2000;290(5491):486-92.
2000: Sampa Santra; Dan H Barouch; A H Sharpe; Norman L Letvin
B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination.
European journal of immunology 2000;30(9):2650-9.
2000: Marcelo J Kuroda; Joern schmitz; C Lekutis; Christine E Nickerson; Michelle A Lifton; Genoveffa Franchini; Janet M Harouse; Cecilia Cheng-Mayer; Norman L Letvin
Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramer.
Journal of virology 2000;74(18):8751-6.
2000: Marcelo J Kuroda; Joern schmitz; Aruna Seth; Ronald S Veazey; Christine E Nickerson; Michelle A Lifton; P J Dailey; MA Forman; Paul Racz; Klara Tenner-Racz; Norman L Letvin
Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys.
Blood 2000;96(4):1474-9.
2000: Zheng W Chen; Yun Shen; Ian C Davis; Ling Shen; Norman L Letvin; Patricia N Fultz
Down-regulation of macaque gammadelta + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14.
Journal of medical primatology 2000;29(3-4):143-7.
2000: Michael A Egan; William A Charini; Marcelo J Kuroda; Joern schmitz; Paul Racz; Klara Tenner-Racz; Kelledy Manson; Michael S Wyand; Michelle A Lifton; Christine E Nickerson; T Fu; John W Shiver; Norman L Letvin
Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection.
Journal of virology 2000;74(16):7485-95.
2000: Zheng W Chen; Yun Shen; Zhongchen Kou; Chris C Ibegbu; Dejiang Zhou; Ling Shen; Paul Morrison; C Bogle; Harold M McClure; Andre J Nahmias; Prabhat Sehgal; Norman L Letvin
Prolonged dominance of clonally restricted CD4(+) T cells in macaques infected with simian immunodeficiency viruses.
Journal of virology 2000;74(16):7442-50.
2000: Zheng W Chen; A Craiu; Ling Shen; Marcelo J Kuroda; U C Iroku; David Ian Watkins; G Voss; Norman L Letvin
Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6474-9.
2000: E F Helmuth; Norman L Letvin; David H Margolin
Germline repertoire of the immunoglobulin V(H)3 family in rhesus monkeys.
Immunogenetics 2000;51(7):519-27.
2000: Joern schmitz; Marcelo J Kuroda; Ronald S Veazey; Aruna Seth; Wesley Taylor; Christine E Nickerson; Michelle A Lifton; P J Dailey; MA Forman; Paul Racz; Klara Tenner-Racz; Norman L Letvin
Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):6015-9.
2000: Dan H Barouch; A Craiu; Marcelo J Kuroda; Joern schmitz; Xin Xiao Zheng; Sampa Santra; J D Frost; Georgia R Krivulka; Michelle A Lifton; CL Crabbs; Gwendolyn J Heidecker; Helen C Perry; Mary-Ellen Davies; H Xie; Christine E Nickerson; Tavis Steenbeke; Carol I Lord; David C Montefiori; Terry B Strom; John W Shiver; Mark G Lewis; Norman L Letvin
Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4192-7.
2000: Aruna Seth; Y Yasutomi; H Jacoby; J C Callery; S M Kaminsky; W C Koff; D F Nixon; Norman L Letvin
Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals.
AIDS research and human retroviruses 2000;16(4):337-43.
2000: Aruna Seth; Ilnour Ourmanov; Joern schmitz; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Linda S Wyatt; M Carroll; Bernard Moss; D Venzon; Norman L Letvin; Vanessa M Hirsch
Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge.
Journal of virology 2000;74(6):2502-9.
2000: Hua-Xin Liao; B Etemad-Moghadam; David C Montefiori; Y Sun; Joseph Sodroski; Richard M Scearce; Robert W Doms; James R Thomasch; S Robinson; Norman L Letvin; Barton F Haynes
Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.
Journal of virology 2000;74(1):254-63.
1999: J M Crawford; Patricia L Earl; Bernard Moss; Keith A Reimann; Michael S Wyand; Kelledy Manson; Miroslawa Bilska; J T Zhou; C. David Pauza; P W Parren; D R Burton; Joseph Sodroski; Norman L Letvin; David C Montefiori
Characterization of primary isolate-like variants of simian-human immunodeficiency virus.
Journal of virology 1999;73(12):10199-207.
1999: Z Zhang; T Schuler; Mary Zupancic; Stephen Wietgrefe; KA Staskus; Keith A Reimann; Todd A Reinhart; MJ Rogan; W Cavert; Christopher J Miller; Ronald S Veazey; Daan W Notermans; S Little; Sven A Danner; D D Richman; Diane V Havlir; Joseph Wong; HL Jordan; Timothy W Schacker; Paul Racz; Klara Tenner-Racz; Norman L Letvin; Steven Wolinsky; Ashley T Haase
Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
Science (New York, N.Y.) 1999;286(5443):1353-7.
1999: Norman L Letvin; Joern schmitz; HL Jordan; A Seth; Vanessa M Hirsch; Keith A Reimann; Marcelo J Kuroda
Cytotoxic T lymphocytes specific for the simian immunodeficiency virus.
Immunological reviews 1999;170():127-34.
1999: Igor J Koralnik; Joern schmitz; Michelle A Lifton; MA Forman; Norman L Letvin
Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals.
Journal of neurovirology 1999;5(4):430-5.
1999: Sampa Santra; P N Fultz; Norman L Letvin
Virus-specific cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected chimpanzees.
Journal of virology 1999;73(8):7065-9.
1999: Michael A Egan; Marcelo J Kuroda; G Voss; Joern schmitz; William A Charini; Carol I Lord; MA Forman; Norman L Letvin
Use of major histocompatibility complex class I/peptide/beta2M tetramers to quantitate CD8(+) cytotoxic T lymphocytes specific for dominant and nondominant viral epitopes in simian-human immunodeficiency virus-infected rhesus monkeys.
Journal of virology 1999;73(7):5466-72.
1999: Marcelo J Kuroda; Joern schmitz; William A Charini; Christine E Nickerson; Michelle A Lifton; Carol I Lord; MA Forman; Norman L Letvin
Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5127-33.
1999: HL Jordan; Marcelo J Kuroda; Joern schmitz; Tavis Steenbeke; MA Forman; Norman L Letvin
Detection of simian immunodeficiency virus Gag-specific CD8(+) T lymphocytes in semen of chronically infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.
Journal of virology 1999;73(5):4508-12.
1999: Joern schmitz; Marcelo J Kuroda; Sampa Santra; V G Sasseville; Meredith A Simon; Michelle A Lifton; Paul Racz; Klara Tenner-Racz; M Dalesandro; BJ Scallon; John Ghrayeb; MA Forman; David C Montefiori; E Peter Rieber; Norman L Letvin; Keith A Reimann
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
Science (New York, N.Y.) 1999;283(5403):857-60.
1999: Marcelo J Kuroda; Joern schmitz; William A Charini; Christine E Nickerson; Carol I Lord; MA Forman; Norman L Letvin
Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys.
Journal of virology 1999;73(2):1573-9.
1999: Mark Cayabyab; GB Karlsson; Bijan Etemad-Moghadam; W Hofmann; Tavis Steenbeke; M Halloran; John W Fanton; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2).
Journal of virology 1999;73(2):976-84.
1999: Joern schmitz; Michelle A Lifton; Keith A Reimann; David C Montefiori; L Shen; Paul Racz; Klara Tenner-Racz; Markus Ollert; MA Forman; Rebecca Gelman; Carl-Wilhelm Vogel; Norman L Letvin
Effect of complement consumption by cobra venom factor on the the course of primary infection with simian immunodeficiency virus in rhesus monkeys.
AIDS research and human retroviruses 1999;15(2):195-202.
1999: Igor J Koralnik; D Boden; V X Mai; Catherine Lord; Norman L Letvin
JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy.
Neurology 1999;52(2):253-60.
1998: Bijan Etemad-Moghadam; GB Karlsson; M Halloran; Ying Sun; D Schenten; M Fernandes; Norman L Letvin; Joseph Sodroski
Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys.
Journal of virology 1998;72(10):8437-45.
1998: GB Karlsson; M Halloran; D Schenten; Juliette Lee; Paul Racz; Klara Tenner-Racz; Judith Manola; Rebecca Gelman; Bijan Etemad-Moghadam; E Desjardins; Richard Wyatt; Norma P Gerard; L Marcon; David H Margolin; John W Fanton; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.
The Journal of experimental medicine 1998;188(6):1159-71.
1998: Aruna Seth; Ilnour Ourmanov; Marcelo J Kuroda; Joern schmitz; M W Carroll; Linda S Wyatt; Bernard Moss; MA Forman; Vanessa M Hirsch; Norman L Letvin
Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10112-6.
1998: Dan H Barouch; Sampa Santra; Tavis Steenbeke; Xin Xiao Zheng; Helen C Perry; Mary-Ellen Davies; Daniel C Freed; A Craiu; Terry B Strom; John W Shiver; Norman L Letvin
Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1875-82.
1998: Joern schmitz; MA Forman; Michelle A Lifton; O Concepción; Keith A Reimann; C S Crumpacker; J F Daley; Rebecca Gelman; Norman L Letvin
Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals.
Blood 1998;92(1):198-206.
1998: C Lekutis; Norman L Letvin
Substitutions in a major histocompatibility complex class II-restricted human immunodeficiency virus type 1 gp120 epitope can affect CD4+ T-helper-cell function.
Journal of virology 1998;72(7):5840-4.
1998: Marcelo J Kuroda; Joern schmitz; Dan H Barouch; A Craiu; T M Allen; A Sette; David Ian Watkins; MA Forman; Norman L Letvin
Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.
The Journal of experimental medicine 1998;187(9):1373-81.
1998: David C Montefiori; Keith A Reimann; Michael S Wyand; Kelledy Manson; M G Lewis; R G Collman; Joseph Sodroski; Dani P Bolognesi; Norman L Letvin
Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1.
Journal of virology 1998;72(4):3427-31.
1998: N Watanabe; Joe Sypek; S Mittler; Keith A Reimann; P Flores-Villanueva; G Voss; Carol I Lord; Norman L Letvin
Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys.
AIDS research and human retroviruses 1998;14(5):393-9.
1998: E M Race; J Adelson-Mitty; G R Kriegel; T F Barlam; K A Reimann; Norman L Letvin; A J Japour
Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease.
Lancet 1998;351(9098):252-5.
1998: Norman L Letvin; Y Yasutomi; Ling Shen; Keith A Reimann; Zheng W Chen; Joern schmitz; Marcelo J Kuroda
The CD8+ T lymphocyte response during primary SIVmac infection.
Advances in experimental medicine and biology 1998;452():177-9.
1997: Claude P Genain; Linda Gritz; N Joshi; Dennis Panicali; R L Davis; J N Whitaker; Norman L Letvin; Stephen L Hauser
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein.
Journal of neuroimmunology 1997;79(2):119-28.
1997: David H Margolin; Keith A Reimann; Joseph Sodroski; GB Karlsson; Klara Tenner-Racz; Paul Racz; Norman L Letvin
Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses.
Journal of virology 1997;71(11):8582-91.
1997: Norman L Letvin; David C Montefiori; Y Yasutomi; Helen C Perry; Mary-Ellen Davies; C Lekutis; M Alroy; Daniel C Freed; Carol I Lord; Larry Handt; Margaret A Liu; John W Shiver
Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9378-83.
1997: C Lekutis; Norman L Letvin
HIV-1 envelope-specific CD4+ T helper cells from simian/human immunodeficiency virus-infected rhesus monkeys recognize epitopes restricted by MHC class II DRB1*0406 and DRB*W201 molecules.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):2049-57.
1997: Keith A Reimann; W Lin; Sarah A Bixler; Beth Browning; BN Ehrenfels; J Lucci; Konrad Miatkowski; Dian Olson; T H Parish; M D Rosa; F B Oleson; Yen-Ming Hsu; E A Padlan; Norman L Letvin; Linda C Burkly
A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties.
AIDS research and human retroviruses 1997;13(11):933-43.
1997: John W Shiver; Mary-Ellen Davies; Y Yasutomi; Helen C Perry; Daniel C Freed; Norman L Letvin; Margaret A Liu
Anti-HIV env immunities elicited by nucleic acid vaccines.
Vaccine 1997;15(8):884-7.
1997: GB Karlsson; M Halloran; J Li; I W Park; R Gomila; Keith A Reimann; Michael K Axthelm; S A Iliff; Norman L Letvin; Joseph Sodroski
Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.
Journal of virology 1997;71(6):4218-25.
1997: C Lekutis; John W Shiver; Margaret A Liu; Norman L Letvin
HIV-1 env DNA vaccine administered to rhesus monkeys elicits MHC class II-restricted CD4+ T helper cells that secrete IFN-gamma and TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4471-7.
1997: Zheng W Chen; Dejiang Zhou; Laura V Chalifoux; D Lee-Parritz; K Mansfield; C I Lord; Norman L Letvin
Disseminated granulomatous disease in a simian immunodeficiency virus- and bacille Calmette-Guèrin-infected rhesus monkey.
AIDS (London, England) 1997;11(2):266-7.
1996: T Kanai; E K Thomas; Y Yasutomi; Norman L Letvin
IL-15 stimulates the expansion of AIDS virus-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3681-7.
1996: G Voss; Norman L Letvin
Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys.
Journal of virology 1996;70(10):7335-40.
1996: Keith A Reimann; J T Li; R Veazey; M Halloran; I W Park; GB Karlsson; Joseph Sodroski; Norman L Letvin
A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.
Journal of virology 1996;70(10):6922-8.
1996: Y Lu; Maria Salvato; C. David Pauza; J Li; Joseph Sodroski; Kelledy Manson; Michael S Wyand; Norman L Letvin; S Jenkins; N Touzjian; C Chutkowski; N Kushner; M LeFaile; L G Payne; B Roberts
Utility of SHIV for testing HIV-1 vaccine candidates in macaques.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;12(2):99-106.
1996: Shan Lu; J Arthos; D C Montefiori; Y Yasutomi; Kelledy Manson; Farah Mustafa; E Johnson; JC Santoro; J Wissink; J I Mullins; Joel R Haynes; Norman L Letvin; Michael S Wyand; Harriet L Robinson
Simian immunodeficiency virus DNA vaccine trial in macaques.
Journal of virology 1996;70(6):3978-91.
1996: Keith A Reimann; J T Li; G Voss; C Lekutis; Klara Tenner-Racz; Paul Racz; W Lin; D C Montefiori; D Lee-Parritz; Y Lu; R G Collman; Joseph Sodroski; Norman L Letvin
An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys.
Journal of virology 1996;70(5):3198-206.
1996: Harriet L Robinson; Shan Lu; DM Feltquate; C T Torres; J Richmond; C M Boyle; M J Morin; JC Santoro; Robert G Webster; D Montefiori; Y Yasutomi; Norman L Letvin; Kelledy Manson; Michael S Wyand; Joel R Haynes
DNA vaccines.
AIDS research and human retroviruses 1996;12(5):455-7.
1996: Zheng W Chen; Ling Shen; J D Regan; Z Kou; S H Ghim; Norman L Letvin
The T cell receptor gene usage by simian immunodeficiency virus gag-specific cytotoxic T lymphocytes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1469-75.
1996: Margaret A Liu; Y Yasutomi; Mary-Ellen Davies; Helen C Perry; Daniel C Freed; Norman L Letvin; John W Shiver
Vaccination of mice and nonhuman primates using HIV-gene-containing DNA.
Antibiotics and chemotherapy 1996;48():100-4.
1996: Y Yasutomi; Harriet L Robinson; Shan Lu; Farah Mustafa; C Lekutis; J Arthos; J I Mullins; G Voss; Kelledy Manson; Michael S Wyand; Norman L Letvin
Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys.
Journal of virology 1996;70(1):678-81.
1995: Claude P Genain; M H Nguyen; Norman L Letvin; R Pearl; R L Davis; M Adelman; Marjorie B Lees; C Linington; Stephen L Hauser
Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.
The Journal of clinical investigation 1995;96(6):2966-74.
1995: R E Bachelder; J Bilancieri; W Lin; Norman L Letvin
A human recombinant Fab identifies a human immunodeficiency virus type 1-induced conformational change in cell surface-expressed CD4.
Journal of virology 1995;69(9):5734-42.
1995: D C Montefiori; Keith A Reimann; Norman L Letvin; J Zhou; S L Hu
Studies of complement-activating antibodies in the SIV/macaque model of acute primary infection and vaccine protection.
AIDS research and human retroviruses 1995;11(8):963-70.
1995: Norman L Letvin; J Li; M Halloran; Martin Cranage; Erling Rud; Joseph Sodroski
Prior infection with a nonpathogenic chimeric simian-human immunodeficiency virus does not efficiently protect macaques against challenge with simian immunodeficiency virus.
Journal of virology 1995;69(7):4569-71.
1995: Zheng W Chen; Z C Kou; C Lekutis; Ling Shen; Dejiang Zhou; M Halloran; J Li; Joseph Sodroski; D Lee-Parritz; Norman L Letvin
T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus.
The Journal of experimental medicine 1995;182(1):21-31.
1995: C Lekutis; Norman L Letvin
Biochemical and molecular characterization of rhesus monkey major histocompatibility complex class II DR.
Human immunology 1995;43(1):72-80.
1995: G Voss; J Li; Kelledy Manson; Michael S Wyand; Joseph Sodroski; Norman L Letvin
Human immunodeficiency virus type 1 envelope glycoprotein-specific cytotoxic T lymphocytes in simian-human immunodeficiency virus-infected rhesus monkeys.
Virology 1995;208(2):770-5.
1995: L Massacesi; Claude P Genain; D Lee-Parritz; Norman L Letvin; D Canfield; Stephen L Hauser
Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis.
Annals of neurology 1995;37(4):519-30.
1995: Keith A Reimann; Richard L Cate; Y Wu; L Palmer; D Olson; B C Waite; Norman L Letvin; Linda C Burkly
In vivo administration of CD4-specific monoclonal antibody: effect on provirus load in rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques.
AIDS research and human retroviruses 1995;11(4):517-25.
1995: Y Yasutomi; S McAdam; Jonathan Boyson; Marian Piekarczyk; David Ian Watkins; Norman L Letvin
A MHC class I B locus allele-restricted simian immunodeficiency virus envelope CTL epitope in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2516-22.
1995: C Lekutis; Norman L Letvin
MHC expression of African green monkeys of Barbados is limited in heterogeneity.
Journal of medical primatology 1995;24(2):81-6.
1994: Ling Shen; Zheng W Chen; Norman L Letvin
The repertoire of cytotoxic T lymphocytes in the recognition of mutant simian immunodeficiency virus variants.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5849-54.
1994: Chikao Morimoto; C I Lord; C Zhang; J S Duke-Cohan; Norman L Letvin; Stuart F Schlossman
Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9960-4.
1994: N Watanabe; S McAdam; Jonathan Boyson; Marian Piekarczyk; Y Yasutomi; David Ian Watkins; Norman L Letvin
A simian immunodeficiency virus envelope V3 cytotoxic T-lymphocyte epitope in rhesus monkeys and its restricting major histocompatibility complex class I molecule Mamu-A*02.
Journal of virology 1994;68(10):6690-6.
1994: Keith A Reimann; B C Waite; D Lee-Parritz; W Lin; B Uchanska-Ziegler; M J O'Connell; Norman L Letvin
Use of human leukocyte-specific monoclonal antibodies for clinically immunophenotyping lymphocytes of rhesus monkeys.
Cytometry 1994;17(1):102-8.
1994: Claude P Genain; D Lee-Parritz; M H Nguyen; L Massacesi; N Joshi; R Ferrante; K Hoffman; M Moseley; Norman L Letvin; Stephen L Hauser
In healthy primates, circulating autoreactive T cells mediate autoimmune disease.
The Journal of clinical investigation 1994;94(3):1339-45.
1994: Zheng W Chen; Z C Kou; Ling Shen; J D Regan; Carol I Lord; M Halloran; D Lee-Parritz; P N Fultz; Norman L Letvin
An acutely lethal simian immunodeficiency virus stimulates expansion of V beta 7- and V beta 14-expressing T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7501-5.
1994: Keith A Reimann; Klara Tenner-Racz; Paul Racz; D C Montefiori; Y Yasutomi; W Lin; B J Ransil; Norman L Letvin
Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques.
Journal of virology 1994;68(4):2362-70.
1994: Norman L Letvin; Keith A Reimann; Y Yasutomi; D J Ringler; H Yamamoto
The SIVmac specific cytotoxic T lymphocyte response in the acutely infected rhesus monkey.
Current topics in microbiology and immunology 1994;188():175-84.
1993: Norman L Letvin
Vaccines against human immunodeficiency virus--progress and prospects.
The New England journal of medicine 1993;329(19):1400-5.
1993: Y Yasutomi; T J Palker; Murray B Gardner; B F Haynes; Norman L Letvin
Synthetic peptide in mineral oil adjuvant elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):5096-105.
1993: Zheng W Chen; Z C Kou; Ling Shen; Keith A Reimann; Norman L Letvin
Conserved T-cell receptor repertoire in simian immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):2177-87.
1993: Norman L Letvin; M Miller; Ling Shen; Zheng W Chen; Y Yasutomi
Simian immunodeficiency virus-specific cytotoxic T lymphocytes in rhesus monkeys: characterization and vaccine induction.
Seminars in immunology 1993;5(3):215-23.
1993: Y Yasutomi; Scott Koenig; S S Haun; C Kendall Stover; R K Jackson; P Conard; Anthony J Conley; Emilio A Emini; Thomas R Fuerst; Norman L Letvin
Immunization with recombinant BCG-SIV elicits SIV-specific cytotoxic T lymphocytes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):3101-7.
1993: Keith A Reimann; Linda C Burkly; B Burrus; B C Waite; Carol I Lord; Norman L Letvin
In vivo administration to rhesus monkeys of a CD4-specific monoclonal antibody capable of blocking AIDS virus replication.
AIDS research and human retroviruses 1993;9(3):199-207.
1993: Y Yasutomi; Keith A Reimann; Carol I Lord; M D Miller; Norman L Letvin
Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.
Journal of virology 1993;67(3):1707-11.
1993: Ling Shen; Gail P Mazzara; S O DiSciullo; D L Panicali; Norman L Letvin
Immunization with lentivirus-like particles elicits a potent SIV-specific recall cytotoxic T-lymphocyte response in rhesus monkeys.
AIDS research and human retroviruses 1993;9(2):129-32.
1993: Zheng W Chen; Austin Hughes; S H Ghim; Norman L Letvin; David Ian Watkins
Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/A11 family.
Immunogenetics 1993;38(3):238-40.
1993: T L Garber; Austin Hughes; Norman L Letvin; J W Templeton; David Ian Watkins
Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle.
Immunogenetics 1993;38(1):11-20.
1992: Zheng W Chen; Ling Shen; M Miller; S H Ghim; Austin Hughes; Norman L Letvin
Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4060-6.
1992: M Miller; S Gould-Fogerite; Ling Shen; Robert M Woods; Scott Koenig; Raphael J Mannino; Norman L Letvin
Vaccination of rhesus monkeys with synthetic peptide in a fusogenic proteoliposome elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes.
The Journal of experimental medicine 1992;176(6):1739-44.
1992: Norman L Letvin; Zheng W Chen; H Yamamoto; M Watanabe
Active immune therapy for the treatment of HIV infections.
AIDS research and human retroviruses 1992;8(8):1499.
1992: D L Panicali; Gail P Mazzara; John L Sullivan; R Hesselton; Ling Shen; Norman L Letvin; M Daniel; Ronald C Desrosiers; E J Stott
Use of lentivirus-like particles alone and in combination with live vaccinia-virus-based vaccines.
AIDS research and human retroviruses 1992;8(8):1449.
1992: L Massacesi; N Joshi; D Lee-Parritz; A Rombos; Norman L Letvin; Stephen L Hauser
Experimental allergic encephalomyelitis in cynomolgus monkeys. Quantitation of T cell responses in peripheral blood.
The Journal of clinical investigation 1992;90(2):399-404.
1992: Norman L Letvin
Animal models for the study of human immunodeficiency virus infections.
Current opinion in immunology 1992;4(4):481-5.
1992: H Yamamoto; D J Ringler; M Miller; Y Yasutomi; T Hasunuma; Norman L Letvin
Simian immunodeficiency virus-specific cytotoxic T lymphocytes are present in the AIDS-associated skin rash in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):728-34.
1992: M Watanabe; Jonathan Boyson; Carol I Lord; Norman L Letvin
Chimpanzees immunized with recombinant soluble CD4 develop anti-self CD4 antibody responses with anti-human immunodeficiency virus activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5103-7.
1992: Zheng W Chen; H Yamamoto; David Ian Watkins; G Levinson; Norman L Letvin
Predominant use of a T-cell receptor V beta gene family in simian immunodeficiency virus Gag-specific cytotoxic T lymphocytes in a rhesus monkey.
Journal of virology 1992;66(6):3913-7.
1992: Zheng W Chen; S McAdam; Austin Hughes; A L Dogon; Norman L Letvin; David Ian Watkins
Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2547-54.
1992: T Hasunuma; H Tsubota; M Watanabe; Zheng W Chen; Carol I Lord; Linda C Burkly; J F Daley; Norman L Letvin
Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1841-6.
1992: J Li; Carol I Lord; W Haseltine; Norman L Letvin; Joseph Sodroski
Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins.
Journal of acquired immune deficiency syndromes 1992;5(7):639-46.
1992: G Levinson; Austin Hughes; Norman L Letvin
Sequence and diversity of rhesus monkey T-cell receptor beta chain genes.
Immunogenetics 1992;35(2):75-88.
1992: Norman L Letvin
Nonhuman primate models for HIV vaccine development.
Immunodeficiency reviews 1992;3(3):247-60.
1991: Keith A Reimann; G B Snyder; Laura V Chalifoux; B C Waite; M Miller; H Yamamoto; Olivier Spertini; Norman L Letvin
An activated CD8+ lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus.
The Journal of clinical investigation 1991;88(4):1113-20.
1991: M Miller; H Yamamoto; Austin Hughes; David Ian Watkins; Norman L Letvin
Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):320-9.
1991: M Watanabe; C G Levine; Ling Shen; R A Fisher; Norman L Letvin
Immunization of simian immunodeficiency virus-infected rhesus monkeys with soluble human CD4 elicits an antiviral response.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4616-20.
1991: M Watanabe; D J Ringler; P N Fultz; John MacKey; Jonathan Boyson; C G Levine; Norman L Letvin
A chimpanzee-passaged human immunodeficiency virus isolate is cytopathic for chimpanzee cells but does not induce disease.
Journal of virology 1991;65(6):3344-8.
1991: Ling Shen; Zheng W Chen; M Miller; V Stallard; Gail P Mazzara; D L Panicali; Norman L Letvin
Recombinant virus vaccine-induced SIV-specific CD8+ cytotoxic T lymphocytes.
Science (New York, N.Y.) 1991;252(5004):440-3.
1991: Y Torimoto; K Sugita; D S Weinberg; N H Dang; C Donahue; Norman L Letvin; Stuart F Schlossman; Chikao Morimoto
Development of a monoclonal antibody, anti-6C2, which is involved in the interaction of CD4 T helper cells and activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2176-84.
1991: M Watanabe; Zheng W Chen; H Tsubota; Carol I Lord; C G Levine; Norman L Letvin
Soluble human CD4 elicits an antibody response in rhesus monkeys that inhibits simian immunodeficiency virus replication.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):120-4.
1991: David Ian Watkins; Zheng W Chen; T L Garber; Austin Hughes; Norman L Letvin
Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene.
Immunogenetics 1991;34(3):185-91.
1991: David Ian Watkins; T L Garber; Zheng W Chen; G Toukatly; Austin Hughes; Norman L Letvin
Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus).
Immunogenetics 1991;33(2):79-89.
1991: David Ian Watkins; Norman L Letvin
Limited MHC class I polymorphism is not essential for bone marrow chimerism in New World primates.
Immunogenetics 1991;33(3):194-7.
1991: Norman L Letvin; N W King
Naturally occurring animal models of the acquired immune deficiency syndrome (AIDS).
American journal of physiologic imaging 1991;6(1):1-15.
1990: H Yamamoto; M Miller; David Ian Watkins; G B Snyder; N E Chase; Gail P Mazzara; Linda Gritz; D L Panicali; Norman L Letvin
Two distinct lymphocyte populations mediate simian immunodeficiency virus envelope-specific target cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3740-6.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; A Lagos; A M Lewis; J A Shadduck; Norman L Letvin
Syrian hamsters express diverse MHC class I gene products.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(10):3483-90.
1990: H Tsubota; G Winkler; H M Meade; A Jakubowski; D W Thomas; Norman L Letvin
CD4-Pseudomonas exotoxin conjugates delay but do not fully inhibit human immunodeficiency virus replication in lymphocytes in vitro.
The Journal of clinical investigation 1990;86(5):1684-9.
1990: Norman L Letvin
Animal models for AIDS.
Immunology today 1990;11(9):322-6.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; M G Evans; T F Tedder; Norman L Letvin
Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes.
Nature 1990;346(6279):60-3.
1990: David Ian Watkins; Zheng W Chen; Austin Hughes; F S Hodi; Norman L Letvin
Genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar MHC class I gene products.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3726-35.
1990: H Yamamoto; M Miller; H Tsubota; David Ian Watkins; Gail P Mazzara; V Stallard; D L Panicali; A Aldovini; R A Young; Norman L Letvin
Studies of cloned simian immunodeficiency virus-specific T lymphocytes. gag-specific cytotoxic T lymphocytes exhibit a restricted epitope specificity.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3385-91.
1990: M Watanabe; D J Ringler; M Nakamura; P A DeLong; Norman L Letvin
Simian immunodeficiency virus inhibits bone marrow hematopoietic progenitor cell growth.
Journal of virology 1990;64(2):656-63.
1990: David Ian Watkins; Norman L Letvin; Austin Hughes; T F Tedder
Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):1136-43.
1990: Norman L Letvin; N W King
Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques.
Journal of acquired immune deficiency syndromes 1990;3(11):1023-40.
1990: N W King; Laura V Chalifoux; D J Ringler; Michael S Wyand; P K Sehgal; M D Daniel; Norman L Letvin; Ronald C Desrosiers; B J Blake; R D Hunt
Comparative biology of natural and experimental SIVmac infection in macaque monkeys: a review.
Journal of medical primatology 1990;19(2):109-18.
1990: M Miller; Carol I Lord; V Stallard; Gail P Mazzara; Norman L Letvin
The gag-specific cytotoxic T lymphocytes in rhesus monkeys infected with the simian immunodeficiency virus of macaques.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):122-8.
1989: Keith A Reimann; S Turner; J M Lambert; M H Reed; S F Schlossman; Norman L Letvin
In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. V. Evidence that humoral immune response to monoclonal antibodies and immunotoxin conjugates abrogates their cytotoxic activity.
Transplantation 1989;48(6):906-12.
1989: Chikao Morimoto; Y Torimoto; G Levinson; Christopher E Rudd; M Schrieber; N H Dang; Norman L Letvin; Stuart F Schlossman
1F7, a novel cell surface molecule, involved in helper function of CD4 cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3430-9.
1989: H Tsubota; D J Ringler; M Kannagi; N W King; K R Solomon; John MacKey; D G Walsh; Norman L Letvin
CD8+CD4- lymphocyte lines can harbor the AIDS virus in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):858-63.
1989: Ronald C Desrosiers; Michael S Wyand; T Kodama; D J Ringler; L O Arthur; P K Sehgal; Norman L Letvin; N W King; M D Daniel
Vaccine protection against simian immunodeficiency virus infection.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6353-7.
1989: David Ian Watkins; J A Shadduck; F S Hodi; M E Stone; Norman L Letvin
Use of cDNA probes specific for the human MHC class II beta loci for tissue-typing nonhuman primates at their class II beta loci.
Transplantation 1989;48(1):170-3.
1989: David Ian Watkins; J A Shadduck; M E Stone; Harris Lewin; Norman L Letvin
Isoelectric focusing of bovine major histocompatibility complex class I molecules.
Journal of immunogenetics 1989;16(3):233-45.
1989: H Tsubota; Carol I Lord; David Ian Watkins; C Morimoto; Norman L Letvin
A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.
The Journal of experimental medicine 1989;169(4):1421-34.
1989: David Ian Watkins; J A Shadduck; C E Rudd; M E Stone; Harris Lewin; Norman L Letvin
Isoelectric focusing of bovine major histocompatibility complex class II molecules.
European journal of immunology 1989;19(3):567-70.
1989: M Watanabe; Keith A Reimann; P A DeLong; T Liu; R A Fisher; Norman L Letvin
Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques.
Nature 1989;337(6204):267-70.
1989: M H Reed; M E Shapiro; Terry B Strom; E L Milford; Charles B Carpenter; D S Weinberg; Keith A Reimann; Norman L Letvin; Thomas Waldmann; R L Kirkman
Prolongation of primate renal allograft survival by anti-Tac, an anti-human IL-2 receptor monoclonal antibody.
Transplantation 1989;47(1):55-9.
1988: David Ian Watkins; F S Hodi; Norman L Letvin
A primate species with limited major histocompatibility complex class I polymorphism.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7714-8.
1988: David Ian Watkins; M Kannagi; M E Stone; Norman L Letvin
Major histocompatibility complex class I molecules of nonhuman primates.
European journal of immunology 1988;18(9):1425-32.
1988: Keith A Reimann; Victor S Goldmacher; J M Lambert; Laura V Chalifoux; S B Cook; S F Schlossman; Norman L Letvin
In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. IV. Cytotoxic effect of an anti-T11-gelonin immunotoxin.
The Journal of clinical investigation 1988;82(1):129-38.
1988: Chikao Morimoto; T Matsuyama; Christopher E Rudd; A Forsgren; Norman L Letvin; Stuart F Schlossman
Role of the 2H4 molecule in the activation of suppressor inducer function.
European journal of immunology 1988;18(5):731-7.
1988: M D Daniel; Norman L Letvin; P K Sehgal; D K Schmidt; D P Silva; K R Solomon; F S Hodi; D J Ringler; R D Hunt; N W King
Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys.
International journal of cancer. Journal international du cancer 1988;41(4):601-8.
1988: M Kannagi; Laura V Chalifoux; Carol I Lord; Norman L Letvin
Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(7):2237-42.
1988: Chikao Morimoto; Christopher E Rudd; Norman L Letvin; M Hagan; Stuart F Schlossman
2H1--a novel antigen involved in T lymphocyte triggering.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(7):2165-70.
1988: M Kiyotaki; K R Solomon; Norman L Letvin
Herpesvirus ateles immortalizes in vitro a CD3+CD4+CD8+ marmoset lymphocyte with NK function.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(3):730-6.
1987: Chikao Morimoto; Christopher E Rudd; Norman L Letvin; Stuart F Schlossman
A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells.
Nature 1987;330(6147):479-82.
1987: M D Daniel; Norman L Letvin; P K Sehgal; G Hunsmann; D K Schmidt; N W King; Ronald C Desrosiers
Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus.
The Journal of general virology 1987;68 ( Pt 12)():3183-9.
1987: Norman L Letvin; M D Daniel; P K Sehgal; J M Yetz; K R Solomon; M Kannagi; D K Schmidt; D P Silva; Luc Montagnier; Ronald C Desrosiers
Infection of baboons with human immunodeficiency virus-2 (HIV-2)
The Journal of infectious diseases 1987;156(2):406-7.
1987: Ronald C Desrosiers; M D Daniel; Norman L Letvin; N W King; R D Hunt
Origins of HTLV-4.
Nature 1987;327(6118):107.
1987: M Kannagi; M Kiyotaki; N W King; Carol I Lord; Norman L Letvin
Simian immunodeficiency virus induces expression of class II major histocompatibility complex structures on infected target cells in vitro.
Journal of virology 1987;61(5):1421-6.
1987: M D Daniel; Ronald C Desrosiers; Norman L Letvin; N W King; D K Schmidt; P Sehgal; R D Hunt
Simian models for AIDS.
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc 1987;1():501-7.
1986: M Kannagi; M Kiyotaki; R C Desrosiers; K A Reimann; N W King; L M Waldron; Norman L Letvin
Humoral immune responses to T cell tropic retrovirus simian T lymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome.
The Journal of clinical investigation 1986;78(5):1229-36.
1986: Norman L Letvin; Laura V Chalifoux; Keith A Reimann; Jerome Ritz; S F Schlossman; J M Lambert
In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. Delivery of ribosome-inactivating proteins to spleen and lymph node T cells.
The Journal of clinical investigation 1986;78(3):666-73.
1986: Laura V Chalifoux; N W King; M D Daniel; M Kannagi; Ronald C Desrosiers; P K Sehgal; L M Waldron; R D Hunt; Norman L Letvin
Lymphoproliferative syndrome in an immunodeficient rhesus monkey naturally infected with an HTLV-III-like virus (STLV-III).
Laboratory investigation; a journal of technical methods and pathology 1986;55(1):43-50.
1985: J Picus; K Holley; W R Aldrich; James D Griffin; Norman L Letvin
A naturally occurring bone marrow-chimeric primate. II. Environment dictates restriction on cytolytic T lymphocyte-target cell interactions.
The Journal of experimental medicine 1985;162(6):2035-52.
1985: Norman L Letvin; M A Epstein; J M Yetz; M Kannagi; P K Sehgal; R D Hunt
Development of large granular lymphocytes in owl monkeys following EBV inoculation.
The Journal of infectious diseases 1985;152(6):1352-3.
1985: Norman L Letvin; M D Daniel; P K Sehgal; Ronald C Desrosiers; R D Hunt; L M Waldron; J J MacKey; D K Schmidt; Laura V Chalifoux; N W King
Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III.
Science (New York, N.Y.) 1985;230(4721):71-3.
1985: M Kannagi; J M Yetz; Norman L Letvin
In vitro growth characteristics of simian T-lymphotropic virus type III.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(20):7053-7.
1985: Phyllis J Kanki; Mary Fran McLane; N W King; Norman L Letvin; R D Hunt; P Sehgal; M D Daniel; Ronald C Desrosiers; M Essex
Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
Science (New York, N.Y.) 1985;228(4704):1199-201.
1985: M D Daniel; Norman L Letvin; N W King; M Kannagi; P K Sehgal; R D Hunt; Phyllis J Kanki; M Essex; Ronald C Desrosiers
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
Science (New York, N.Y.) 1985;228(4704):1201-4.
1985: Ronald C Desrosiers; M D Daniel; C V Butler; D K Schmidt; Norman L Letvin; R D Hunt; N W King; C S Barker; Eric Hunter
Retrovirus D/New England and its relation to Mason-Pfizer monkey virus.
Journal of virology 1985;54(2):552-60.
1985: J Picus; W R Aldrich; Norman L Letvin
A naturally occurring bone-marrow-chimeric primate. I. Integrity of its immune system.
Transplantation 1985;39(3):297-303.
1984: Norman L Letvin; M D Daniel; P K Sehgal; Laura V Chalifoux; N W King; R D Hunt; W R Aldrich; K Holley; D K Schmidt; Ronald C Desrosiers
Experimental infection of rhesus monkeys with type D retrovirus.
Journal of virology 1984;52(2):683-6.
1984: T Homma; Phyllis J Kanki; N W King; R D Hunt; M J O'Connell; Norman L Letvin; M D Daniel; Ronald C Desrosiers; C S Yang; M Essex
Lymphoma in macaques: association with virus of human T lymphotrophic family.
Science (New York, N.Y.) 1984;225(4663):716-8.
1984: M D Daniel; N W King; Norman L Letvin; R D Hunt; P K Sehgal; Ronald C Desrosiers
A new type D retrovirus isolated from macaques with an immunodeficiency syndrome.
Science (New York, N.Y.) 1984;223(4636):602-5.
1983: Norman L Letvin; W R Aldrich; N W King; B J Blake; M D Daniel; R D Hunt
Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue.
Lancet 1983;2(8350):599-602.
1983: R D Hunt; B J Blake; Laura V Chalifoux; P K Sehgal; N W King; Norman L Letvin
Transmission of naturally occurring lymphoma in macaque monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):5085-9.
1983: Norman L Letvin; Kathryn A Eaton; W R Aldrich; P K Sehgal; B J Blake; S F Schlossman; N W King; R D Hunt
Acquired immunodeficiency syndrome in a colony of macaque monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2718-22.