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Kit-Yi Leung

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Kit-Yi Leung; Peter Gustavsson; Filipe Cabreiro; Andrew J Copp; Sandra C P De Castro; Nicholas D E Greene
Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.
Filipe Cabreiro; Helena M Cochemé; Catherine Au; Nicholas D E Greene; Kit-Yi Leung; Tahereh Noori; Eugene Schuster; Nuria Vergara-Irigaray; David Weinkove; David Gems
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Ayumi Narisawa; Tetsuya Niihori; Darren Partridge; Caroline L Relton; Alexis Robinson; Philip Stanier; Victoria Stone; Yoichi Suzuki; Mitsuyo Tanemura; Teiji Tominaga; Yoko Aoki; Andrew J Copp; Kazuko Fujiwara; Nicholas D E Greene; James Grinham; Peter Gustavsson; Akira Hata; Atsuo Kikuchi; Shoko Komatsuzaki; Kit-Yi Leung; Yoichi Matsubara; Shigeo Kure
Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans.

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All Publications

2013: Kit-Yi Leung; Peter Gustavsson; Filipe Cabreiro; Andrew J Copp; Sandra C P De Castro; Nicholas D E Greene
Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.
Molecular and cellular biochemistry 2013;378(1-2):229-36.
2013: Filipe Cabreiro; Helena M Cochemé; Catherine Au; Nicholas D E Greene; Kit-Yi Leung; Tahereh Noori; Eugene Schuster; Nuria Vergara-Irigaray; David Weinkove; David Gems
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cell 2013;153(1):228-39.
2012: Ayumi Narisawa; Tetsuya Niihori; Darren Partridge; Caroline L Relton; Alexis Robinson; Philip Stanier; Victoria Stone; Yoichi Suzuki; Mitsuyo Tanemura; Teiji Tominaga; Yoko Aoki; Andrew J Copp; Kazuko Fujiwara; Nicholas D E Greene; James Grinham; Peter Gustavsson; Akira Hata; Atsuo Kikuchi; Shoko Komatsuzaki; Kit-Yi Leung; Yoichi Matsubara; Shigeo Kure
Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans.
Human molecular genetics 2012;21(7):1496-503.
2012: Sandra C P De Castro; Andrew J Copp; Peter Gustavsson; Kit-Yi Leung; Ashraf N Malhas; David J Vaux; Nicholas D E Greene
Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice.
PLoS genetics 2012;8(11):e1003059.
2011: Kit-Yi Leung; Kevin Mills; Katie A Burren; Andrew J Copp; Nicholas D E Greene
Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(26):2759-63.
2011: Sigrun Lange; Kit-Yi Leung; Anthony P Nicholas; Paul R Thompson; Bertrand Vernay; Corey P Causey; Stefanie Gögel; Nicholas D E Greene; Patrizia Ferretti
Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.
Developmental biology 2011;355(2):205-14.
2011: Timothy Me Scales; Pascal Derkinderen; Kit-Yi Leung; Helen L Byers; Malcolm A Ward; Caroline Price; Ian N Bird; Timothy Perera; Stuart Kellie; Ritchie Williamson; Brian H Anderton; C Hugh Reynolds
Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.
Molecular neurodegeneration 2011;6():12.
2010: Matthew J Lovell; Mohammed Yasin; Kate L Lee; King Kenneth Cheung; Yasunori Shintani; Massimo Collino; Ahila Sivarajah; Kit-Yi Leung; Kunihiko Takahashi; Amar Kapoor; Muhammad M Yaqoob; Ken Suzuki; Mark F Lythgoe; John Martin; Patricia B Munroe; Chris Thiemermann; Anthony Mathur
Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway.
Atherosclerosis 2010;213(1):67-76.
2010: Sandra C P De Castro; Kit-Yi Leung; Dawn Savery; Katie Burren; Rima Rozen; Andrew J Copp; Nicholas D E Greene
Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.
Birth defects research. Part A, Clinical and molecular teratology 2010;88(8):612-8.
2010: Stefanie Gögel; Sigrun Lange; Kit-Yi Leung; Nicholas D E Greene; Patrizia Ferretti
Post-translational regulation of Crmp in developing and regenerating chick spinal cord.
Developmental neurobiology 2010;70(6):456-71.
2009: Ross Laxton; Yanhua Hu; Johan Duchene; Feng Zhang; Zhongyi Zhang; Kit-Yi Leung; Qingzhong Xiao; Ramona S Scotland; Conrad P Hodgkinson; Katherine Smith; Johann Willeit; Carlos López-Otín; Iain A Simpson; Stefan Kiechl; Amrita Ahluwalia; Qingbo Xu; Shu Ye
A role of matrix metalloproteinase-8 in atherosclerosis.
Circulation research 2009;105(9):921-9.
2009: Felix M Munkonge; Vaksha Amin; Stephen C Hyde; Anne-Marie Green; Ian A Pringle; Deborah R Gill; Joel W S Smith; Robert P Hooley; Stefania Xenariou; Malcolm A Ward; Nicola Leeds; Kit-Yi Leung; Mario Chan; Elizabeth Hillery; Duncan M Geddes; Uta Griesenbach; Edith H Postel; David A Dean; Michael J Dunn; Eric W F W Alton
Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.
The Journal of biological chemistry 2009;284(39):26978-87.
2008: David John Gillott; Abdallah Eldib; Elisabetta Iammarrone; Kit-Yi Leung; Alan Russell Thornhill; Jurgis Gediminas Grudzinskas
Glycolytic enzyme expression in human granulosa cells.
Fertility and sterility 2008;90(4 Suppl):1405-10.
2008: Jesmond Dalli; lucy norling; Derek Renshaw; Dianne Cooper; Kit-Yi Leung; Mauro Perretti
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles.
Blood 2008;112(6):2512-9.
2008: Inmaculada Cuchillo-Ibanez; Anjan Seereeram; Helen L Byers; Kit-Yi Leung; Malcolm A Ward; Brian H Anderton; Diane P Hanger
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3186-95.
2008: David John Gillott; Hazem M Al-Rumaih; Kit-Yi Leung; Abdallah Eldib; J Gedis Grudzinskas
Specific isoforms of leucine-rich alpha2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with spontaneous pregnancy.
Fertility and sterility 2008;90(3):761-8.
2008: Sadani Cooray; Isabel Almiro Do Vale; Kit-Yi Leung; Tom R Webb; J Paul Chapple; Michaela Egertová; Michael Cheetham; Maurice R Elphick; Adrian J L Clark
The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.
Endocrinology 2008;149(4):1935-41.
2007: Simone Ferrero; David John Gillott; Valentino Remorgida; Paola Anserini; Kit-Yi Leung; Nicola Ragni; J Gedis Grudzinskas
Proteomic analysis of peritoneal fluid in women with endometriosis.
Journal of proteome research 2007;6(9):3402-11.
2007: Diane P Hanger; Helen L Byers; Selina Wray; Kit-Yi Leung; Malcolm J Saxton; Anjan Seereeram; C Hugh Reynolds; Malcolm A Ward; Brian H Anderton
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
The Journal of biological chemistry 2007;282(32):23645-54.
2007: Yong Ji; Géraldine Ferracci; Alice Warley; Malcolm Ward; Kit-Yi Leung; Salma Samsuddin; Christian Lévêque; Lindsay Queen; Vikash Reebye; Pallavi Pal; Eugenia Gkaliagkousi; Michael Seager; Albert Ferro
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8839-44.
2007: Nicholas D E Greene; Abiodun Bamidele; ManKin Choy; Sandra C P de Castro; Robin Wait; Kit-Yi Leung; Shajna Begum; David G Gadian; Rod C Scott; Mark F Lythgoe
Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus.
Proteomics 2007;7(8):1336-44.
2005: Kit-Yi Leung; Pierre Lescuyer; James Campbell; Helen L Byers; Laure Allard; jean-charles sanchez; Malcolm A Ward
A novel strategy using MASCOT Distiller for analysis of cleavable isotope-coded affinity tag data to quantify protein changes in plasma.
Proteomics 2005;5(12):3040-4.
2005: Pascal Derkinderen; Timothy M E Scales; Diane P Hanger; Kit-Yi Leung; Helen L Byers; Malcolm A Ward; Christof Lenz; Caroline Price; Ian N Bird; Timothy Perera; Stuart Kellie; Ritchie Williamson; Wendy Noble; Richard A Van Etten; Karelle Leroy; Jean-Pierre Brion; C Hugh Reynolds; Brian H Anderton
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(28):6584-93.
2004: Gerhard M Schmid; Véronique Converset; Nadia Walter; Matthew V Sennitt; Kit-Yi Leung; Helen Byers; Malcolm Ward; Denis F Hochstrasser; Michael A Cawthorne; jean-charles sanchez
Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice.
Proteomics 2004;4(8):2270-82.
2004: Laure Allard; Pierre Lescuyer; Jennifer Burgess; Kit-Yi Leung; Malcolm Ward; Nadia Walter; Pierre R Burkhard; Garry L Corthals; Denis F Hochstrasser; jean-charles sanchez
ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke.
Proteomics 2004;4(8):2242-51.
2003: Philip Eaton; Miriam E Jones; Emma McGregor; Michael J Dunn; Nicola Leeds; Helen L Byers; Kit-Yi Leung; Malcolm A Ward; Julian R Pratt; Michael J Shattock
Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S290-6.
2002: Nicholas D E Greene; Kit-Yi Leung; Robin Wait; Shajna Begum; Michael J Dunn; Andrew J Copp
Differential protein expression at the stage of neural tube closure in the mouse embryo.
The Journal of biological chemistry 2002;277(44):41645-51.
2001: Kit-Yi Leung; Nicholas D E Greene; Patricia B Munroe; Sara E Mole
Identification of a transactivation motif in the CLN3 protein.
IUBMB life 2001;51(5):295-8.
2001: Kit-Yi Leung; Nicholas D E Greene; Patricia B Munroe; Sara E Mole
Analysis of CLN3-protein interactions using the yeast two-hybrid system.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2001;5 Suppl A():89-93.
1999: John B P Stephenson; Nicholas D E Greene; Kit-Yi Leung; Patricia B Munroe; Sara E Mole; R Mark Gardiner; Peter E M Taschner; M O'Regan; K Naismith; Yanick J Crow; Hannah M Mitchison
The molecular basis of GROD-storing neuronal ceroid lipofuscinoses in Scotland.
Molecular genetics and metabolism 1999;66(4):245-7.
1998: Patricia B Munroe; Nicholas D E Greene; Kit-Yi Leung; Sara E Mole; R Mark Gardiner; Hannah M Mitchison; John B P Stephenson; Yanick J Crow
Sharing of PPT mutations between distinct clinical forms of neuronal ceroid lipofuscinoses in patients from Scotland.
Journal of medical genetics 1998;35(9):790.