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Stewart Leung

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Chemicals & Drugs

Physiology

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T Charis Wagner; Sharlene Velichko; David Vogel; M R Sandhya Rani; Stewart Leung; Richard M Ransohoff; George R Stark; H Daniel Perez; Ed Croze
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.
M R Sandhya Rani; Douglas W Leaman; Yulong Han; Stewart Leung; Ed Croze; Eleanor N Fish; Alan Wolfman; Richard M Ransohoff
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.
Nywana Sizemore; Stewart Leung; George R Stark
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.

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2002: T Charis Wagner; Sharlene Velichko; David Vogel; M R Sandhya Rani; Stewart Leung; Richard M Ransohoff; George R Stark; H Daniel Perez; Ed Croze
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.
The Journal of biological chemistry 2002;277(2):1493-9.
1999: M R Sandhya Rani; Douglas W Leaman; Yulong Han; Stewart Leung; Ed Croze; Eleanor N Fish; Alan Wolfman; Richard M Ransohoff
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.
The Journal of biological chemistry 1999;274(45):32507-11.
1999: Nywana Sizemore; Stewart Leung; George R Stark
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.
Molecular and cellular biology 1999;19(7):4798-805.
1998: Xiaoxia Li; Stewart Leung; C Burns; George R Stark
Cooperative binding of Stat1-2 heterodimers and ISGF3 to tandem DNA elements.
Biochimie 1998;80(8-9):703-10.
1997: Xiaoxia Li; Stewart Leung; I M Kerr; George R Stark
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
Molecular and cellular biology 1997;17(4):2048-56.
1996: Douglas W Leaman; Stewart Leung; Xiaoxia Li; George R Stark
Regulation of STAT-dependent pathways by growth factors and cytokines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(14):1578-88.
1996: M R Sandhya Rani; G R Foster; Stewart Leung; Douglas W Leaman; George R Stark; Richard M Ransohoff
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.
The Journal of biological chemistry 1996;271(37):22878-84.
1996: Stewart Leung; Xiaoxia Li; George R Stark
STATs find that hanging together can be stimulating.
Science (New York, N.Y.) 1996;273(5276):750-1.
1996: Xiaoxia Li; Stewart Leung; S Qureshi; J E Darnell; George R Stark
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.
The Journal of biological chemistry 1996;271(10):5790-4.
1995: Stewart Leung; S A Qureshi; Ian M Kerr; J E Darnell; George R Stark
Role of STAT2 in the alpha interferon signaling pathway.
Molecular and cellular biology 1995;15(3):1312-7.