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Thomas Leung
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Research Profile (preview)
Chemicals & Drugs
Concepts & Ideas
Genes & Molecular Sequences
Anatomy
Living Beings
Phenomena
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Network (preview)
22
Manser, Ed
20
Lim, Louis
13
Tan, Ivan
8
Chen, Xiang-qun
5
Zhao, Zhuo-Shen
3
Monfries, Clinton
3
Ng, Chong Han
3
Dong, Jing-Ming
2
Hall, Christine
2
Loo, Tsui-Han
1
SundarRaj, Nirmala
1
Tan, L
1
Teo, Mabel
1
Harden, Nicholas
1
Jacobs, Tom
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Publications
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All Publications
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2006: Yong Jeffery; Tan Ivan; Lim Louis; Leung Thomas
Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
The Journal of biological chemistry 2006;281(42):31202-11.
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2005: Hall Christine; Lim Louis; Leung Thomas
C1, see them all.
Trends in biochemical sciences 2005;30(4):169-71.
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2004: Brown Matthew; Jacobs Tom; Eickholt Britta; Ferrari Giovanna; Teo Mabel; Monfries Clinton; Qi Robert Z; Leung Thomas; Lim Louis; Hall Christine
Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(41):8994-9004.
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2004: Anderson Susan; DiCesare Lisa; Tan Ivan; Leung Thomas; SundarRaj Nirmala
Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblasts.
Experimental cell research 2004;298(2):574-83.
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2004: Ng Yvonne; Tan Ivan; Lim Louis; Leung Thomas
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
The Journal of biological chemistry 2004;279(33):34156-64.
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2003: Tan Ivan; Cheong Albert; Lim Louis; Leung Thomas
Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity.
Gene 2003;304():107-15.
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2002: Chan Wing; Kozma Robert; Yasui Yoshihiro; Inagaki Masaki; Leung Thomas; Manser Ed; Lim Louis
Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase.
European journal of cell biology 2002;81(12):692-701.
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2002: Leung Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.
FEBS letters 2002;532(3):445-9.
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2002: Dong Jing-Ming; Leung Thomas; Manser Edward; Lim Louis
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
European journal of cell biology 2002;81(4):231-42.
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2002: Chen Xiang-qun; Tan Ivan; Ng Chong Han; Hall Christine; Lim Louis; Leung Thomas
Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies.
The Journal of biological chemistry 2002;277(15):12680-8.
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2002: Tan Ivan; Lim Louis; Leung Thomas
Introduction of dominant inhibitory proteins directed against ROK and MRCK kinases.
Methods in molecular biology (Clifton, N.J.) 2002;189():111-9.
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2001: Tan I; Ng C H; Lim L; Leung T
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
The Journal of biological chemistry 2001;276(24):21209-16.
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2001: Tan I; Seow K T; Lim L; Leung T
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Molecular and cellular biology 2001;21(8):2767-78.
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1999: Chen X Q; Tan I; Leung T; Lim L
The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.
The Journal of biological chemistry 1999;274(28):19901-5.
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1998: Sin W C; Chen X Q; Leung T; Lim L
RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network.
Molecular and cellular biology 1998;18(11):6325-39.
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1998: Dong J M; Leung T; Manser E; Lim L
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha.
The Journal of biological chemistry 1998;273(35):22554-62.
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1998: Zhao Z S; Manser E; Chen X Q; Chong C; Leung T; Lim L
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.
Molecular and cellular biology 1998;18(4):2153-63.
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1998: Manser E; Loo T H; Koh C G; Zhao Z S; Chen X Q; Tan L; Tan I; Leung T; Lim L
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.
Molecular cell 1998;1(2):183-92.
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1998: Leung T; Chen X Q; Tan I; Manser E; Lim L
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Molecular and cellular biology 1998;18(1):130-40.
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1998: Manser E; Leung T; Lim L
Identification and characterization of small GTPase-associated kinases.
Methods in molecular biology (Clifton, N.J.) 1998;84():295-305.
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1997: Manser E; Huang H Y; Loo T H; Chen X Q; Dong J M; Leung T; Lim L
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
Molecular and cellular biology 1997;17(3):1129-43.
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1996: Lim L; Manser E; Leung T; Hall C
Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
European journal of biochemistry / FEBS 1996;242(2):171-85.
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1996: Leung T; Chen X Q; Manser E; Lim L
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.
Molecular and cellular biology 1996;16(10):5313-27.
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1996: Harden N; Lee J; Loh H Y; Ong Y M; Tan I; Leung T; Manser E; Lim L
A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures.
Molecular and cellular biology 1996;16(5):1896-908.
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1995: Leung T; Manser E; Tan L; Lim L
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes.
The Journal of biological chemistry 1995;270(49):29051-4.
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1995: Zhao Z S; Leung T; Manser E; Lim L
Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24.
Molecular and cellular biology 1995;15(10):5246-57.
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1995: Manser E; Chong C; Zhao Z S; Leung T; Michael G; Hall C; Lim L
Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family.
The Journal of biological chemistry 1995;270(42):25070-8.
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1995: Manser E; Leung T; Lim L
Purification and assay of kinases that interact with Rac/Cdc42.
Methods in enzymology 1995;256():215-27.
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1995: Manser E; Leung T; Lim L
Identification of GTPase-activating proteins by nitrocellulose overlay assay.
Methods in enzymology 1995;256():130-9.
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1994: Leung T; How B E; Manser E; Lim L
Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.
The Journal of biological chemistry 1994;269(17):12888-92.
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1994: Manser E; Leung T; Salihuddin H; Zhao Z S; Lim L
A brain serine/threonine protein kinase activated by Cdc42 and Rac1.
Nature 1994;367(6458):40-6.
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1993: Tan E C; Leung T; Manser E; Lim L
The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.
The Journal of biological chemistry 1993;268(36):27291-8.
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1993: Manser E; Leung T; Salihuddin H; Tan L; Lim L
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.
Nature 1993;363(6427):364-7.
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1993: Leung T; How B E; Manser E; Lim L
Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.
The Journal of biological chemistry 1993;268(6):3813-6.
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1992: Manser E; Leung T; Monfries C; Teo M; Hall C; Lim L
Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.
The Journal of biological chemistry 1992;267(23):16025-8.
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1990: Hall C; Monfries C; Smith P; Lim H H; Kozma R; Ahmed S; Vanniasingham V; Leung T; Lim L
Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.
Journal of molecular biology 1990;211(1):11-6.
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