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Yuk Leung

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Yi-Hung Chen; Chi-Li Gong; Yue-Hsiung Kuo; Min-Fan Tsai; Yuan-Kun Tu; King-Chuen Wu; Chin-Tsang Yang; Chia-Chia Chao; Yuk M Leung
Coumarsabin hastens C-type inactivation gating of voltage-gated K⁺ channels.
Yu-Wen Chen; Ching-Hsia Hung; Yuk M Leung; Ja-Ping Shieh; Yu-Chung Chen; Jhi-Joung Wang
Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats.
Yu-Wen Chen; Chin-Chen Chu; Yuk M Leung; Yu-Chung Chen; Jhi-Joung Wang
Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.

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2013: Yi-Hung Chen; Chi-Li Gong; Yue-Hsiung Kuo; Min-Fan Tsai; Yuan-Kun Tu; King-Chuen Wu; Chin-Tsang Yang; Chia-Chia Chao; Yuk M Leung
Coumarsabin hastens C-type inactivation gating of voltage-gated K⁺ channels.
European journal of pharmacology 2013;704(1-3):41-8.
2012: Yu-Wen Chen; Ching-Hsia Hung; Yuk M Leung; Ja-Ping Shieh; Yu-Chung Chen; Jhi-Joung Wang
Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats.
European journal of pharmacology 2012;693(1-3):25-30.
2012: Yu-Wen Chen; Chin-Chen Chu; Yuk M Leung; Yu-Chung Chen; Jhi-Joung Wang
Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.
European journal of pharmacology 2012;693(1-3):31-6.
2012: Dah-Yuu Lu; Chih-Hsin Tang; Wei-Lan Yeh; Chih-Shiang Chang; Chi-Wai Cheung; Yuk M Leung; Ju-Fang Liu; Kar-Lok Wong
The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2012;19(12):1093-100.
2012: Chi-Li Gong; Chang-Shin Kuo; Chia-Chia Chao; Ka-Shun Cheng; Min-Fan Tsai; Kar-Lok Wong; Yuk M Leung
Inhibitory effects of magnolol on voltage-gated Na+ and K+ channels of NG108-15 cells.
European journal of pharmacology 2012;682(1-3):73-8.
2011: Yuk M Leung; Chien-Fang Huang; Chia-Chia Chao; Dah-Yuu Lu; Chang-Shin Kuo; Tzu-Hurng Cheng; Li-Yun Chang; Chun-Hsiao Chou
Voltage-gated K+ channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells.
Journal of cellular physiology 2011;226(4):1090-8.
2010: Dah-Yuu Lu; Yuk M Leung; Chi-Wai Cheung; Yun-Ru Chen; Kar-Lok Wong
Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells.
Biochemical pharmacology 2010;80(8):1201-9.
2010: Yuk M Leung; Bor-Tsang Wu; Yu-Chung Chen; Ching-Hsia Hung; Yu-Wen Chen
Diphenidol inhibited sodium currents and produced spinal anesthesia.
Neuropharmacology 2010;58(7):1147-52.
2010: Yuk M Leung
Voltage-gated K+ channel modulators as neuroprotective agents.
Life sciences 2010;86(21-22):775-80.
2010: Yuk M Leung; Kar-Lok Wong; Chia-Huei Lin; Chia-Chia Chao; Chun-Hsiao Chou; Li-Yun Chang; Siao-Wei Chen; Tzu-Hurng Cheng; Yueh-Hsiung Kuo
Dependence of 6beta-acetoxy-7alpha-hydroxyroyleanone block of Kv1.2 channels on C-type inactivation.
Cellular and molecular life sciences : CMLS 2010;67(1):147-56.
2009: Dah-Yuu Lu; Wei-Hsuan Yu; Wei-Lan Yeh; Chih-Hsin Tang; Yuk M Leung; Kar-Lok Wong; Yuh-Fung Chen; Chih-Ho Lai; Wen-Mei Fu
Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells.
Journal of cellular physiology 2009;220(1):163-73.
2009: Dah-Yuu Lu; Chih-Hsin Tang; Wei-Lan Yeh; Kar-Lok Wong; Chih-Peng Lin; Yi-Hung Chen; Chih-Ho Lai; Yuh-Fung Chen; Yuk M Leung; Wen-Mei Fu
SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia.
European journal of pharmacology 2009;613(1-3):146-54.
2009: Chun-Hsiao Chou; Chi-Li Gong; Chia-Chia Chao; Chia-Huei Lin; chiu-yin kwan; Ching-Liang Hsieh; Yuk M Leung
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
Journal of natural products 2009;72(5):830-4.
2008: Herbert Y Gaisano; Yuk M Leung
Pancreatic islet alpha cell commands itself: secrete more glucagon!
Cell metabolism 2008;7(6):474-5.
2008: Chia-Chia Chao; Jeffrey Shieh; Sheng-Chu Kuo; Bor-Tsang Wu; Mann-Jen Hour; Yuk M Leung
HMJ-53A accelerates slow inactivation gating of voltage-gated K+ channels in mouse neuroblastoma N2A cells.
Neuropharmacology 2008;54(7):1128-35.
2008: Yuk M Leung; Chiu-Yin Kwan
Dual vascular effects of leptin via endothelium: hypothesis and perspective.
The Chinese journal of physiology 2008;51(1):1-6.
2008: Yan He; Chadwick L Elias; Ya-Chi Huang; Xiaodong Gao; Yuk M Leung; Youhou Kang; Huanli Xie; John A Chaddock; Robert G Tsushima; Herbert Y Gaisano
Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.
Pancreas 2008;36(1):10-7.
2007: Le Min; Yuk M Leung; Alejandra Tomas; Robert T Watson; Herbert Y Gaisano; Philippe A Halban; Jeffrey Pessin; June Chunqiu Hou
Dynamin is functionally coupled to insulin granule exocytosis.
The Journal of biological chemistry 2007;282(46):33530-6.
2007: Edwin P Kwan; Xiaodong Gao; Yuk M Leung; Herbert Y Gaisano
Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.
Pancreas 2007;35(3):e45-54.
2007: Yuk M Leung; Edwin P Kwan; Betty Ng; Youhou Kang; Herbert Y Gaisano
SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.
Endocrine reviews 2007;28(6):653-63.
2007: Ishtiaq Ahmed; Laura I Cosen-Binker; Yuk M Leung; Herbert Y Gaisano; Nicholas E Diamant
Modulation of the K(v)4.3 channel by syntaxin 1A.
Biochemical and biophysical research communications 2007;358(3):789-95.
2007: Fuzhen Xia; Yuk M Leung; Gregory Gaisano; Xiaodong Gao; Yi Chen; Jocelyn E Manning Fox; Alpana Bhattacharjee; Michael B Wheeler; Herbert Y Gaisano; Robert G Tsushima
Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.
Endocrinology 2007;148(5):2157-67.
2007: Leila Neshatian; Yuk M Leung; Youhou Kang; Xiaodong Gao; Huanli Xie; Robert G Tsushima; Herbert Y Gaisano; Nicholas E Diamant
Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(5):G1233-42.
2006: Youhou Kang; Betty Ng; Yuk M Leung; Yan He; Huanli Xie; David Lodwick; Robert I Norman; Andrew Tinker; Robert G Tsushima; Herbert Y Gaisano
Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation.
The Journal of biological chemistry 2006;281(28):19019-28.
2006: Yuk M Leung; Ishtiaq Ahmed; Laura Sheu; Robert G Tsushima; Nicholas E Diamant; Herbert Y Gaisano
Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties.
Biochemical and biophysical research communications 2006;345(1):340-4.
2006: Yan He; Youhou Kang; Yuk M Leung; Fuzhen Xia; Xiaodong Gao; Huanli Xie; Herbert Y Gaisano; Robert G Tsushima
Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.
The Biochemical journal 2006;396(2):363-9.
2006: Yuk M Leung; Ishtiaq Ahmed; Laura Sheu; Xiaodong Gao; Manami Hara; Robert G Tsushima; Nicholas E Diamant; Herbert Y Gaisano
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.
Endocrinology 2006;147(5):2155-62.
2005: Yuk M Leung; Ishtiaq Ahmed; Laura Sheu; Robert G Tsushima; Nicholas E Diamant; Manami Hara; Herbert Y Gaisano
Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse.
Endocrinology 2005;146(11):4766-75.
2005: Patrick P L Lam; Yuk M Leung; Laura Sheu; James Ellis; Robert G Tsushima; Lucy Osborne; Herbert Y Gaisano
Transgenic mouse overexpressing syntaxin-1A as a diabetes model.
Diabetes 2005;54(9):2744-54.
2005: Yuk M Leung; Youhou Kang; Fuzhen Xia; Laura Sheu; Xiaodong Gao; Huanli Xie; Robert G Tsushima; Herbert Y Gaisano
Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels.
The Biochemical journal 2005;387(Pt 1):195-202.
2004: Ningren Cui; Youhou Kang; Yan He; Yuk M Leung; Huanli Xie; Ewa A Pasyk; Xiaodong Gao; Laura Sheu; John B Hansen; Philip Wahl; Robert G Tsushima; Herbert Y Gaisano
H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.
The Journal of biological chemistry 2004;279(51):53259-65.
2004: Youhou Kang; Yuk M Leung; Jocelyn E Manning Fox; Fuzhen Xia; Huanli Xie; Laura Sheu; Robert G Tsushima; Peter E Light; Herbert Y Gaisano
Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.
The Journal of biological chemistry 2004;279(45):47125-31.
2003: Yuk M Leung; Youhou Kang; Xiaodong Gao; Fuzhen Xia; Huanli Xie; Laura Sheu; Sharon Tsuk; Ilana Lotan; Robert G Tsushima; Herbert Y Gaisano
Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.
The Journal of biological chemistry 2003;278(19):17532-8.
2002: Yuk M Leung; Laura Sheu; Edwin P Kwan; Guotang Wang; Robert G Tsushima; Herbert Y Gaisano
Visualization of sequential exocytosis in rat pancreatic islet beta cells.
Biochemical and biophysical research communications 2002;292(4):980-6.
2002: Yuk M Leung; Tony K Kwan; Chiu-Yin Kwan; Edwin E Daniel
Calyculin A-induced endothelial cell shape changes are independent of [Ca(2+)](i) elevation and may involve actin polymerization.
Biochimica et biophysica acta 2002;1589(2):93-103.
2001: Chiu-Yin Kwan; Yuk M Leung; Tony K Kwan; Edwin E Daniel
Tetrandrine inhibits Ca2+ release-activated Ca2+ channels in vascular endothelial cells.
Life sciences 2001;68(7):841-7.
2000: Yuk M Leung; Chiu-Yin Kwan; Edwin E Daniel
Block of inwardly rectifying K+ currents by extracellular Mg2+ and Ba2+ in bovine pulmonary artery endothelial cells.
Canadian journal of physiology and pharmacology 2000;78(9):751-6.
1999: Yuk M Leung; Chiu-Yin Kwan
Current perspectives in the pharmacological studies of store-operated Ca2+ entry blockers.
Japanese journal of pharmacology 1999;81(3):253-8.
1998: Yuk M Leung; Y Xion; YJ Ou; Chiu-Yin Kwan
Perturbation by lysophosphatidylcholine of membrane permeability in cultured vascular smooth muscle and endothelial cells.
Life sciences 1998;63(11):965-73.
1997: YJ Ou; Yuk M Leung; SJ Huang; Chiu-Yin Kwan
Dual effects of extracellular Ca2+ on cardiotoxin-induced cytotoxicity and cytosolic Ca2+ changes in cultured single cells of rabbit aortic endothelium.
Biochimica et biophysica acta 1997;1330(1):29-38.
1997: Yuk M Leung; Chiu-Yin Kwan; T T Loh
Spontaneous Mn2+ entry is specifically inhibited by calyculin A in human leukemic HL-60 cells.
European journal of pharmacology 1997;331(2-3):337-40.
1997: Yuk M Leung; YJ Ou; Chiu-Yin Kwan; T T Loh
Specific interaction between tetrandrine and Quillaja saponins in promoting permeabilization of plasma membrane in human leukemic HL-60 cells.
Biochimica et biophysica acta 1997;1325(2):318-28.
1996: Yuk M Leung; M Berdik; Chiu-Yin Kwan; TT Loh
Effects of tetrandrine and closely related bis-benzylisoquinoline derivatives on cytosolic Ca2+ in human leukaemic HL-60 cells: a structure-activity relationship study.
Clinical and experimental pharmacology & physiology 1996;23(8):653-9.
1996: Yuk M Leung; C Y Kwan; TT Loh
Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway.
Biochemical pharmacology 1996;51(5):605-12.
1996: Yuk M Leung; Chiu-Yin Kwan; TT Loh
Capacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1996;17(2):97-101.
1994: Yuk M Leung; Chiu-Yin Kwan; TT Loh
Dual effects of tetrandrine on cytosolic calcium in human leukaemic HL-60 cells: intracellular calcium release and calcium entry blockade.
British journal of pharmacology 1994;113(3):767-74.
1994: Yuk M Leung; Chiu-Yin Kwan; TT Loh
Cytosolic calcium pre-elevation amplifies agonist-induced calcium release in human leukaemic HL-60 cells.
The Biochemical journal 1994;302 ( Pt 1)():87-94.
1993: Yuk M Leung; W H Zhu; TT Loh
Apotransferrin can elevate intracellular free calcium ion and stimulate mitogenesis in human leukemic HL60 cells.
Biological signals 1993;2(3):117-25.