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Thierry Levade

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Chemicals & Drugs

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Jose E Galgani; Thierry Levade; Justine Bertrand-Michel; Aude Dupuy; Karla Vasquez; Guillermo Watkins; Cedric Moro
Enhanced Skeletal Muscle Lipid Oxidative Efficiency in Insulin-Resistant vs Insulin-Sensitive Nondiabetic, Nonobese Humans.
S Caroline Sorli; Christian Touriol; Virginie Albinet; Carmen Bedia; Josefina Casas; Sandra Colié; Alexandre Dubrac; Gemma Fabriàs; Nicolas Guilbaud; Thierry Levade; Bruno Ségui; Nathalie Andrieu-Abadie
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells.
Emmanuel Mas; Bruno Ségui; Stéphane Carpentier; Marie Danjoux; Virginie Garcia; Thierry Levade
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.

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2013: Jose E Galgani; Thierry Levade; Justine Bertrand-Michel; Aude Dupuy; Karla Vasquez; Guillermo Watkins; Cedric Moro
Enhanced Skeletal Muscle Lipid Oxidative Efficiency in Insulin-Resistant vs Insulin-Sensitive Nondiabetic, Nonobese Humans.
The Journal of clinical endocrinology and metabolism 2013;98(4):E646-53.
2013: S Caroline Sorli; Christian Touriol; Virginie Albinet; Carmen Bedia; Josefina Casas; Sandra Colié; Alexandre Dubrac; Gemma Fabriàs; Nicolas Guilbaud; Thierry Levade; Bruno Ségui; Nathalie Andrieu-Abadie
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(2):489-98.
2013: Emmanuel Mas; Bruno Ségui; Stéphane Carpentier; Marie Danjoux; Virginie Garcia; Thierry Levade
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2013;45(2):147-54.
2013: Virginie Albinet; Nathalie Andrieu-Abadie; Marie-Lise Bats; Carmen Bedia; Virginie Garcia; Thorsten Hornemann; Frédérique Sabourdy; Bruno Ségui; Thierry Levade
Genetic disorders of simple sphingolipid metabolism.
Handbook of experimental pharmacology 2013;215():127-52.
2012: Jie Zhou; Flora Nolent; Yavuz Renda; Serenella Servidei; Marcel Tawk; Francesco Danilo Tiziano; Haluk Topaloglu; Julien Veillet; Nathalie Andrieu-Abadie; Monica Bayes; Enrico Bertini; Stéphane Carpentier; Francesc Castro-Giner; Virginie Garcia; Ivo Gut; Thierry Levade; Judith Melki
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
American journal of human genetics 2012;91(1):5-14.
2012: Stephanie Ballereau; Yves Genisson; Thierry Levade; Nathalie Andrieu-Abadie
Alteration of ceramide 1-O-functionalization as a promising approach for cancer therapy.
Anti-cancer agents in medicinal chemistry 2012;12(4):316-28.
2012: Elodie Lafont; Thierry Levade; Toshiro Okazaki; Klaus Schulze-Osthoff; Nathalie Andrieu-Abadie; Hervé Benoist; Romain Dupont; Bruno Ségui
Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis.
Biochimica et biophysica acta 2012;1821(4):684-93.
2012: Camille Attané; Alexandre Benani; Veronic Bezaire; Rémy Burcelin; Danièle Daviaud; Cédric Dray; Camille Foussal; Rocío Guzmán-Ruiz; Keiji Kuba; Sophie Le Gonidec; Thierry Levade; Luc Pénicaud; Josef Penninger; Chloé Rancoule; Mariano Ruiz-Gayo; Philippe Valet; Estelle Wanecq; Isabelle Castan-Laurell
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.
Diabetes 2012;61(2):310-20.
2012: Jérôme Stirnemann; Vassili Valayanopoulos; marie T vanier; Marie Vigan; Marc G Berger; Catherine Caillaud; Fabrice Camou; Christine de Roux-Serratrice; Thierry Billette de Villemeur; Dries Dobbelaere; Olivier Fain; Bruno Fantin; Roselyne Froissart; Bernard Grosbois; dalil hamroun; Djazia Heraoui; Pierre Kaminsky; Thierry Levade; Agathe Masseau; France Mentré; Cyril Mignot; Alain Robert; Christian Rose; Linda Rossi-Semerano; Frédéric Sedel; Nadia Belmatoug
The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients.
Orphanet journal of rare diseases 2012;7():77.
2012: Delphine Milhas; Nathalie Andrieu-Abadie; Hervé Benoist; Thierry Levade; Bruno Ségui
The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes.
International journal of molecular sciences 2012;13(7):8834-52.
2012: Corinne Ivaldi; Agnès Chapel; Jérôme Garin; Sylvie Kieffer-Jaquinod; Thierry Levade; Brent R Martin; Agnès Journet
Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.
PloS one 2012;7(5):e37187.
2011: Nadine Khadra; Laurence Bresson-Bepoldin; Michael D Cahalan; Benjamin Chaigne-Delalande; Thomas Ducret; Thierry Levade; Jean-François Moreau; Aubin Penna; Josy Reiffers; Bruno Ségui; Anne-Marie Vacher; Pierre Vacher; Patrick Legembre
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):19072-7.
2011: Carmen Bedia; Thierry Levade; Patrice Codogno
Regulation of autophagy by sphingolipids.
Anti-cancer agents in medicinal chemistry 2011;11(9):844-53.
2011: Carmen Bedia; Josefina Casas; Gemma Fabriàs; Nathalie Andrieu-Abadie; Thierry Levade
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.
The Journal of biological chemistry 2011;286(32):28200-9.
2011: Jagdeep S Walia; Anton Neschadim; Abdulfatah Alayoubi; Stéphane Carpentier; Fred Cheung; Xin Fan; David A Jaffray; Chyan-Jang Lee; Thierry Levade; Orlay Lopez-Perez; Melissa Madden; J Andrea McCart; Jeffrey A Medin
Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates.
Human gene therapy 2011;22(6):679-87.
2011: Sarah-Louise Cottinet; Anne-Marie Bergemer-Fouquet; Annick Toutain; Frédérique Sabourdy; Zoha Maakaroun-Vermesse; Thierry Levade; Alain Chantepie; F Labarthe
Danon disease: intrafamilial phenotypic variability related to a novel LAMP-2 mutation.
Journal of inherited metabolic disease 2011;34(2):515-22.
2011: Frédérique Sabourdy; Janick Selves; Leonardo Astudillo; Camille Laurent; Pierre Brousset; Marie-Bernadette Delisle; Nicole Therville; Nathalie Andrieu-Abadie; Bruno Ségui; Christian Recher; Thierry Levade
Is active acid sphingomyelinase required for the antiproliferative response to rituximab?
Blood 2011;117(13):3695-6.
2011: Guillaume Poiroux; Marguerite Pitié; Raphaël Culerrier; Bruno Ségui; Els J M Van Damme; Willy J Peumans; Jean Bernadou; Thierry Levade; Pierre Rougé; Annick Barre; Hervé Benoist
Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens.
Photochemistry and photobiology 2011;87(2):370-7.
2011: Guillaume Poiroux; Pierre Rougé; Bruno Ségui; Els J M Van Damme; Jean Bernadou; Raphaël Culerrier; Elodie Lafont; Thierry Levade; Willy J Peumans; Marguerite Pitié; Annick Barre; Hervé Benoist
Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy.
PloS one 2011;6(8):e23315.
2011: Iuliana Popa; Nicole Therville; Stéphane Carpentier; Thierry Levade; Olivier Cuvillier; Jacques Portoukalian
Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cells.
PloS one 2011;6(5):e19974.
2011: Bénédicte Héron; Yann Mikaeloff; Roseline Froissart; Guillaume Caridade; Irène Maire; Catherine Caillaud; Thierry Levade; Brigitte Chabrol; François Feillet; Hélène Ogier; Vassili Valayannopoulos; Helen Michelakakis; Dimitrios Zafeiriou; Lucy Lavery; Ed Wraith; Olivier Danos; Jean-Michel Heard; Marc Tardieu
Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece.
American journal of medical genetics. Part A 2011;155A(1):58-68.
2010: Carmen Bedia; Luz Camacho; José Luís Abad; Gemma Fabriàs; Thierry Levade
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease.
Journal of lipid research 2010;51(12):3542-7.
2010: Anne Montfort; Pascal G P Martin; Thierry Levade; Hervé Benoist; Bruno Ségui
FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.
Journal of leukocyte biology 2010;88(5):897-903.
2010: Volkan Seyrantepe; Pablo Lema; Aurore Caqueret; Larbi Dridi; Samar Bel-Hadj; Stephane Carpentier; Francine Boucher; Thierry Levade; Lionel Carmant; Roy A Gravel; Edith Hamel; Pascal Vachon; Graziella Di Cristo; Jacques L Michaud; Carlos R Morales; Alexey V Pshezhetsky
Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
PLoS genetics 2010;6(9):.
2010: Dani Nazzal; Nicole Therville; Houda Yacoub-Youssef; Virginie Garcia; Mogens Thomsen; Thierry Levade; Bruno Segui; Hervé Benoist
Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection.
The Journal of infectious diseases 2010;202(5):782-90.
2010: Elodie Lafont; D Milhas; S Carpentier; V Garcia; Z-X Jin; H Umehara; T Okazaki; K Schulze-Osthoff; Thierry Levade; H Benoist; Bruno Ségui
Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death.
Cell death and differentiation 2010;17(4):642-54.
2010: Ana G Barbeito; Thierry Levade; Marie B Delisle; Bernardino Ghetti; Ruben Vidal
Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy.
Molecular neurodegeneration 2010;5():50.
2010: Elodie Lafont; Delphine Milhas; Justin Teissié; Nicole Therville; Nathalie Andrieu-Abadie; Thierry Levade; Hervé Benoist; Bruno Ségui
Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.
PloS one 2010;5(10):e13638.
2009: Sandra Colié; Paul P Van Veldhoven; Blandine Kedjouar; Carmen Bedia; Virginie Albinet; Sonia-Caroline Sorli; Virginie Garcia; Mojgan Djavaheri-Mergny; Chantal Bauvy; Patrice Codogno; Thierry Levade; Nathalie Andrieu-Abadie
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.
Cancer research 2009;69(24):9346-53.
2009: Julien Baruteau; Thierry Levade; Isabelle Redonnet-Vernhet; Samir Mesli; Marie-Claude Bloom; Pierre Broué
Hypoketotic hypoglycemia with myolysis and hypoparathyroidism: an unusual association in medium chain acyl-CoA desydrogenase deficiency (MCADD).
Journal of pediatric endocrinology & metabolism : JPEM 2009;22(12):1175-7.
2009: Anne Montfort; Bénédicte de Badts; Victorine Douin-Echinard; Pascal G P Martin; Jason Iacovoni; Caroline Nevoit; Nicole Therville; Virginie Garcia; Marie-Antoinette Bertrand; Marie-Hélène Bessières; Marie-Claude Trombe; Thierry Levade; Hervé Benoist; Bruno Ségui
FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5369-78.
2009: James Wraith; Matthias R Baumgartner; Bruno Bembi; Athanasios Covanis; Thierry Levade; Eugen Mengel; Mercè Pineda; Frédéric Sedel; Meral Topçu; marie T vanier; Håkan Widner; Frits A Wijburg; Marc C Patterson
Recommendations on the diagnosis and management of Niemann-Pick disease type C.
Molecular genetics and metabolism 2009;98(1-2):152-65.
2009: Yahya Salma; Elodie Lafont; Nicole Therville; Stéphane Carpentier; Marie-José Bonnafé; Thierry Levade; Yves Génisson; Nathalie Andrieu-Abadie
The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism.
Biochemical pharmacology 2009;78(5):477-85.
2009: Claudine Tardy; Frédérique Sabourdy; Virginie Garcia; Anu Jalanko; Nicole Therville; Thierry Levade; Nathalie Andrieu-Abadie
Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis.
Biochimica et biophysica acta 2009;1793(7):1250-8.
2009: Frédérique Sabourdy; Helen Michelakakis; Aris Anastasakis; Virginie Garcia; Irene Mavridou; Michèle Nieto; Marie-Claude Pons; Constantinos Skiadas; Marina Moraitou; Panagiota Manta; Milan Elleder; Thierry Levade
Danon disease: further clinical and molecular heterogeneity.
Muscle & nerve 2009;39(6):837-44.
2009: Sophie Pattingre; Chantal Bauvy; Thierry Levade; Beth Levine; Patrice Codogno
Ceramide-induced autophagy: to junk or to protect cells?
Autophagy 2009;5(4):558-60.
2009: Hélène Autefage; Virginie Albinet; Virginie Garcia; Hortense Berges; Marie-Laure Nicolau; Nicole Therville; Marie-Françoise Altié; Catherine Caillaud; Thierry Levade; Nathalie Andrieu-Abadie
Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.
The Journal of biological chemistry 2009;284(17):11507-16.
2009: Emmanuelle Uro-Coste; Marie-Christine Arné-Bes; Jean-François Pellissier; Pascale Richard; Thierry Levade; François Heitz; Dominique Figarella-Branger; Marie-Bernadette Delisle
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation.
Neuromuscular disorders : NMD 2009;19(2):163-6.
2009: Sophie Pattingre; Chantal Bauvy; Stéphane Carpentier; Thierry Levade; Beth Levine; Patrice Codogno
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
The Journal of biological chemistry 2009;284(5):2719-28.
2009: Emmanuel Mas; Marie Danjoux; Virginie Garcia; Stéphane Carpentier; Bruno Ségui; Thierry Levade
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
PloS one 2009;4(11):e7929.
2009: Frédérique Sabourdy; Pierre Labauge; Hilde Monica Frostad Riise Stensland; Michèle Nieto; Violeta Latorre Garcés; dimitri renard; Giovanni Castelnovo; Nicolas de Champfleur; Thierry Levade
A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant.
BMC medical genetics 2009;10():84.
2009: Karine Palin; Rose-Marie Bluthé; Robert H McCusker; Thierry Levade; Françoise Moos; Robert Dantzer; Keith W Kelley
The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior.
Psychopharmacology 2009;201(4):549-56.
2008: Shobha Ramsubir; Takahiro Nonaka; Carmen Bedia Girbés; Stéphane Carpentier; Thierry Levade; Jeffrey A Medin
In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease.
Molecular genetics and metabolism 2008;95(3):133-41.
2008: Volkan Seyrantepe; Maryssa Canuel; Stéphane Carpentier; Karine Landry; Stéphanie Durand; Feng Liang; Jibin Zeng; Aurore Caqueret; Roy A Gravel; Sergio Marchesini; Claudia Zwingmann; Jacques Michaud; Carlos R Morales; Thierry Levade; Alexey V Pshezhetsky
Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.
Human molecular genetics 2008;17(11):1556-68.
2008: Frédérique Sabourdy; Blandine Kedjouar; S Caroline Sorli; Sandra Colié; Delphine Milhas; Yahya Salma; Thierry Levade
Functions of sphingolipid metabolism in mammals--lessons from genetic defects.
Biochimica et biophysica acta 2008;1781(4):145-83.
2008: Thomas Jouary; Cyril Goizet; Isabelle Coupry; Isabelle Redonnet-Vernhet; Thierry Levade; Ingrid Burgelin; Annick Toutain; Emmanuel Delaporte; Claire Douillard; Didier Lacombe; Alain Taieb; Benoît Arveiler
Detection of an intragenic deletion expands the spectrum of CTSC mutations in Papillon-Lefèvre syndrome.
The Journal of investigative dermatology 2008;128(2):322-5.
2008: Grégory Lavieu; Francesca Scarlatti; Giusy Sala; Stéphane Carpentier; Thierry Levade; Riccardo Ghidoni; Joëlle Botti; Patrice Codogno
Sphingolipids in macroautophagy.
Methods in molecular biology (Clifton, N.J.) 2008;445():159-73.
2007: Christophe Adamy; Paul Mulder; Lara Khouzami; Nathalie Andrieu-Abadie; Nicole Defer; Gabriele Candiani; Catherine Pavoine; Philippe Caramelle; Rachid Souktani; Philippe Le Corvoisier; Magali Perier; Matthias Kirsch; Thibaud Damy; Alain Berdeaux; Thierry Levade; Christian Thuillez; Luc Hittinger; Françoise Pecker
Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats.
Journal of molecular and cellular cardiology 2007;43(3):344-53.
2007: Maryline Moulin; Stéphane Carpentier; Thierry Levade; André-Patrick Arrigo
Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.
Apoptosis : an international journal on programmed cell death 2007;12(9):1703-20.
2007: Valérie Serriere-Lanneau; Fatima Teixeira-Clerc; Liying Li; Marlies Schippers; Willie de Wries; Boris Julien; Jeanne Tran Van Nhieu; Sylvie Manin; Klaas Poelstra; Jerold Chun; Stéphane Carpentier; Thierry Levade; Ariane Mallat; Sophie Lotersztajn
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(9):2005-13.
2007: Carmen Bedia; Josefina Casas; Virginie Garcia; Thierry Levade; Gemma Fabriàs
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases.
Chembiochem : a European journal of chemical biology 2007;8(6):642-8.
2007: Grégory Lavieu; Francesca Scarlatti; Giusy Sala; Thierry Levade; Riccardo Ghidoni; Joëlle Botti; Patrice Codogno
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
Autophagy 2007;3(1):45-7.
2006: Vanessa Faugeroux; Yves Génisson; Nathalie Andrieu-Abadie; Sandra Colié; Thierry Levade; Michel Baltas
C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors.
Organic & biomolecular chemistry 2006;4(24):4437-9.
2006: Bruno Ségui; Nathalie Andrieu-Abadie; Jean-Pierre Jaffrézou; Hervé Benoist; Thierry Levade
Sphingolipids as modulators of cancer cell death: potential therapeutic targets.
Biochimica et biophysica acta 2006;1758(12):2104-20.
2006: Christophe Verny; Adriana Prundean; Guillaume Nicolas; Vivien Pautot; Dominique Maugin; Thierry Levade; Dominique Bonneau; Frédéric Dubas
Refsum's disease may mimic familial Guillain Barre syndrome.
Neuromuscular disorders : NMD 2006;16(11):805-8.
2006: Santiago Grijalvo; Carmen Bedia; Gemma Triola; Josefina Casas; Amadeu Llebaria; Jordi Teixidó; Obdulia Rabal; Thierry Levade; Antonio Delgado; Gemma Fabriàs
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues.
Chemistry and physics of lipids 2006;144(1):69-84.
2006: Claudine Tardy; Patrice Codogno; Hélène Autefage; Thierry Levade; Nathalie Andrieu-Abadie
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle).
Biochimica et biophysica acta 2006;1765(2):101-25.
2006: Grégory Lavieu; Francesca Scarlatti; Giusy Sala; Stéphane Carpentier; Thierry Levade; Riccardo Ghidoni; Joëlle Botti; Patrice Codogno
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation.
The Journal of biological chemistry 2006;281(13):8518-27.
2006: T Granot; D Milhas; Stéphane Carpentier; Arie Dagan; Bruno Ségui; Shimon Gatt; Thierry Levade
Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs.
Leukemia 2006;20(3):392-9.
2006: Pierre Cochat; Aurélia Liutkus; Laurence Dubourg; Thierry Levade
[Current management of Fabry disease].
Néphrologie & thérapeutique 2006;2 Suppl 2():S167-71.
2006: Elisabeth Bonhoure; Dimitri Pchejetski; Nassera Aouali; Hamid Morjani; Thierry Levade; Takafumi Kohama; Olivier Cuvillier
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.
Leukemia 2006;20(1):95-102.
2005: Erwan Le Scolan; Dimitri Pchejetski; Yoshiko Banno; Nicole Denis; Patrick Mayeux; William Vainchenker; Thierry Levade; Françoise Moreau-Gachelin
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Blood 2005;106(5):1808-16.
2005: Delphine Milhas; Olivier Cuvillier; Nicole Therville; Patricia Clavé; Mogens Thomsen; Thierry Levade; Hervé Benoist; Bruno Ségui
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.
The Journal of biological chemistry 2005;280(20):19836-42.
2004: Claudine Tardy; Hélène Autefage; Virginie Garcia; Thierry Levade; Nathalie Andrieu-Abadie
Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts.
The Journal of biological chemistry 2004;279(51):52914-23.
2004: Claudine Tardy; Nathalie Andrieu-Abadie; Robert Salvayre; Thierry Levade
Lysosomal storage diseases: is impaired apoptosis a pathogenic mechanism?
Neurochemical research 2004;29(5):871-80.
2004: Sophie Malagarie-Cazenave; Bruno Ségui; Sophie Lévêque; Virginie Garcia; Stéphane Carpentier; Marie-Françoise Altié; Anne Brouchet; Valérie Gouazé; Nathalie Andrieu-Abadie; Yara Barreira; Hervé Benoist; Thierry Levade
Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice.
The Journal of biological chemistry 2004;279(18):18648-55.
2004: Michel Cailleret; Aïssata Amadou; Nathalie Andrieu-Abadie; Artur Nawrocki; Christophe Adamy; Bouziane Ait-Mamar; François Rocaries; Martin Best-Belpomme; Thierry Levade; Catherine Pavoine; Françoise Pecker
N-acetylcysteine prevents the deleterious effect of tumor necrosis factor-(alpha) on calcium transients and contraction in adult rat cardiomyocytes.
Circulation 2004;109(3):406-11.
2004: Marie-Cécile Nassogne; Chantal Lizarraga; Francisca N'Kuli; Françoise Van Bambeke; Roger Van Binst; Pierre Wallemacq; Paul Tulkens; Marie-Paule Mingeot-Leclercq; Thierry Levade; Pierre J Courtoy
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Toxicology and applied pharmacology 2004;194(2):101-10.
2003: Patrice Petit; Jacqueline Bréard; Valérie Montalescot; Noomen Ben El Hadj; Thierry Levade; Michel Popoff; Blandine Geny
Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of mitochondrial homeostasis in HL-60 cells.
Cellular microbiology 2003;5(11):761-71.
2003: Claudine Tardy; Jaana Tyynelä; Andrej Hasilik; Thierry Levade; Nathalie Andrieu-Abadie
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D.
Cell death and differentiation 2003;10(9):1090-100.
2003: Robert Jan Veldman; Catalin Mita; Olivier Cuvillier; Virginie Garcia; Karin Klappe; Jeffrey A Medin; John D Campbell; Stéphane Carpentier; Jan Willem Kok; Thierry Levade
The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1144-6.
2003: Olivier Cuvillier; Thierry Levade
Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(5):439-45.
2003: Julie Guillermet; Nathalie Saint-Laurent; Philippe Rochaix; Olivier Cuvillier; Thierry Levade; Andrew V Schally; Lucien Pradayrol; Louis Buscail; Christiane Susini; Corinne Bousquet
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):155-60.
2003: Olivier Cuvillier; Nathalie Andrieu-Abadie; Bruno Ségui; Sophie Malagarie-Cazenave; Claudine Tardy; Elisabeth Bonhoure; Thierry Levade
[Sphingolipid-mediated apoptotic signaling pathways].
Journal de la Société de biologie 2003;197(3):217-21.
2003: Nicolas Maestre; Christine Bezombes; Isabelle Plo; Thierry Levade; François Lavelle; Guy Laurent; Jean-Pierre Jaffrézou
Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel.
Journal of experimental therapeutics & oncology 2003;3(1):36-46.
2002: Nathalie Andrieu-Abadie; Thierry Levade
Sphingomyelin hydrolysis during apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):126-34.
2002: Sophie Malagarie-Cazenave; Nathalie Andrieu-Abadie; Bruno Ségui; Valérie Gouazé; Claudine Tardy; Olivier Cuvillier; Thierry Levade
Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death.
Expert reviews in molecular medicine 2002;4(28):1-15.
2002: Nathalie Auge; Virginie Garcia; Françoise Maupas-Schwalm; Thierry Levade; Robert Salvayre; Anne Negre-Salvayre
Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):1990-5.
2002: Laetitia Lacoste-Collin; Anne Gomez-Brouchet; Ghislaine Escourrou; Marie-Bernadette Delisle; Thierry Levade; Emmanuelle Uro-Coste
Expression of p27(Kip1) in bladder cancers: immunohistochemical study and prognostic value in a series of 95 cases.
Cancer letters 2002;186(1):115-20.
2002: Valerie Gouaze; Nathalie Andrieu-Abadie; Olivier Cuvillier; Sophie Malagarie-Cazenave; Marie-Francoise Frisach; Marc-Edouard Mirault; Thierry Levade
Glutathione peroxidase-1 protects from CD95-induced apoptosis.
The Journal of biological chemistry 2002;277(45):42867-74.
2002: Laetitia Lacoste-Collin; Virginie Garcia; Emmanuelle Uro-Coste; Marie-Christine Arné-Bes; Dominique Durand; Thierry Levade; Marie-Bernadette Delisle
Danon's disease (X-linked vacuolar cardiomyopathy and myopathy): a case with a novel Lamp-2 gene mutation.
Neuromuscular disorders : NMD 2002;12(9):882-5.
2002: Solène Grazide; Nicolas Maestre; Robert Jan Veldman; Christine Bezombes; Stéphane MADDENS; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1685-7.
2002: Thierry Levade; Sophie Malagarie-Cazenave; Valérie Gouazé; Bruno Ségui; Claudine Tardy; Susan Betito; Nathalie Andrieu-Abadie; Olivier Cuvillier
Ceramide in apoptosis: a revisited role.
Neurochemical research 2002;27(7-8):601-7.
2002: Jean-Pierre Jaffrézou; Guy Laurent; Thierry Levade
Ceramide in regulation of apoptosis. Implication in multitoxicant resistance.
Sub-cellular biochemistry 2002;36():269-84.
2001: Thierry Levade; Nathalie Augé; Robert Jan Veldman; Olivier Cuvillier; Anne Nègre-Salvayre; Robert Salvayre
Sphingolipid mediators in cardiovascular cell biology and pathology.
Circulation research 2001;89(11):957-68.
2001: Hamid Morjani; Nassera Aouali; R Belhoussine; Robert Jan Veldman; Thierry Levade; Michel Manfait
Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets.
International journal of cancer. Journal international du cancer 2001;94(2):157-65.
2001: Nathalie Andrieu-Abadie; Valérie Gouazé; Robert Salvayre; Thierry Levade
Ceramide in apoptosis signaling: relationship with oxidative stress.
Free radical biology & medicine 2001;31(6):717-28.
2001: Valérie Gouazé; Marc-Edouard Mirault; Stéphane Carpentier; Robert Salvayre; Thierry Levade; Nathalie Andrieu-Abadie
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.
Molecular pharmacology 2001;60(3):488-96.
2001: Bruno Ségui; Olivier Cuvillier; Sabine Adam-Klages; Virginie Garcia; Sophie Malagarie-Cazenave; S Lévêque; Sylvie Caspar-Bauguil; Jerome Coudert; Robert Salvayre; Martin Krönke; Thierry Levade
Involvement of FAN in TNF-induced apoptosis.
The Journal of clinical investigation 2001;108(1):143-51.
2001: Robert Jan Veldman; Nicolas Maestre; O M Aduib; Jeffrey A Medin; Robert Salvayre; Thierry Levade
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling.
The Biochemical journal 2001;355(Pt 3):859-68.
2001: Cristina Sánchez; Daniel Rueda; Bruno Ségui; Ismael Galve-Roperh; Thierry Levade; Manuel Guzmán
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.
Molecular pharmacology 2001;59(5):955-9.
2001: G Qin; T Takenaka; K Telsch; L Kelley; T Howard; Thierry Levade; Robert Deans; Bruce H Howard; H L Malech; R O Brady; Jeffrey A Medin
Preselective gene therapy for Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3428-33.
2001: Olivier Cuvillier; Victor E Nava; S K Murthy; Lisa C Edsall; Thierry Levade; Sheldon Milstien; Sarah Spiegel
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Cell death and differentiation 2001;8(2):162-71.
2001: Christine Bezombes; Bruno Ségui; Olivier Cuvillier; AP Bruno; Emmanuelle Uro-Coste; Valérie Gouazé; Nathalie Andrieu-Abadie; Stéphane Carpentier; Guy Laurent; Robert Salvayre; Jean-Pierre Jaffrézou; Thierry Levade
Lysosomal sphingomyelinase is not solicited for apoptosis signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):297-9.
2001: Jean-Pierre Jaffrézou; AP Bruno; A Moisand; Thierry Levade; Guy Laurent
Activation of a nuclear sphingomyelinase in radiation-induced apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):123-133.
2000: Julien Davaille; C Gallois; Aida Habib; Liying Li; Ariane Mallat; J Tao; Thierry Levade; Sophie Lotersztajn
Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway.
The Journal of biological chemistry 2000;275(44):34628-33.
2000: Isabelle Plo; Dominique Lautier; Thierry Levade; H Sekouri; Jean-Pierre Jaffrézou; Guy Laurent; Ali Bettaïeb
Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells.
The Biochemical journal 2000;351 Pt 2():459-67.
2000: Marie-Bernadette Delisle; Emmanuelle Uro-Coste; Robert Salvayre; Thierry Levade
[Lysosomal disorders. Diagnostic role of extra-cerebral biopsy].
Annales de pathologie 2000;20(5):527-32.
2000: Nathalie Augé; Anne Nègre-Salvayre; Robert Salvayre; Thierry Levade
Sphingomyelin metabolites in vascular cell signaling and atherogenesis.
Progress in lipid research 2000;39(3):207-29.
2000: C Gallois; Julien Davaille; Aida Habib; Ariane Mallat; J Tao; Thierry Levade; Sophie Lotersztajn
Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition.
Annals of the New York Academy of Sciences 2000;905():311-4.
2000: Bruno Ségui; Christine Bezombes; Emmanuelle Uro-Coste; Jeffrey A Medin; Nathalie Andrieu-Abadie; Nathalie Augé; A Brouchet; Guy Laurent; Robert Salvayre; Jean-Pierre Jaffrézou; Thierry Levade
Stress-induced apoptosis is not mediated by endolysosomal ceramide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(1):36-47.
1999: Bruno Ségui; Nathalie Andrieu-Abadie; Sabine Adam-Klages; O Meilhac; D Kreder; Virginie Garcia; AP Bruno; Jean-Pierre Jaffrézou; Robert Salvayre; Martin Krönke; Thierry Levade
CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.
The Journal of biological chemistry 1999;274(52):37251-8.
1999: Thierry Levade; Nathalie Andrieu-Abadie; Bruno Ségui; Nathalie Augé; M Chatelut; Jean-Pierre Jaffrézou; Robert Salvayre
Sphingomyelin-degrading pathways in human cells role in cell signalling.
Chemistry and physics of lipids 1999;102(1-2):167-78.
1999: Nathalie Andrieu-Abadie; J P Jaffrezou; Stéphane N Hatem; G Laurent; Thierry Levade; Jean-Jacques Mercadier
L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1501-10.
1999: Nathalie Augé; Mariana Nikolova-Karakashian; S Carpentier; Sampath Parthasarathy; Anne Nègre-Salvayre; Robert Salvayre; Alfred H Merrill; Thierry Levade
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase.
The Journal of biological chemistry 1999;274(31):21533-8.
1999: Jeffrey A Medin; T Takenaka; Stéphane Carpentier; V Garcia; JP Basile; B Segui; Nathalie Andrieu-Abadie; Nathalie Auge; Robert Salvayre; Thierry Levade
Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.
Human gene therapy 1999;10(8):1321-9.
1999: Thierry Levade; J P Jaffrézou
Signalling sphingomyelinases: which, where, how and why?
Biochimica et biophysica acta 1999;1438(1):1-17.
1999: Anne Gomez-Brouchet; cintas pascal; E Lagier; T Voisin; Marie-Bernadette Delisle; Nelly Fabre; G Gérand; R Salvayre; Thierry Levade
Adult Sandhoff disease presenting with chronic diarrhoea.
Journal of inherited metabolic disease 1999;22(2):187-8.
1999: Ali Bettaïeb; Isabelle Plo; Véronique Mansat-De Mas; Anne Quillet-Mary; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis.
Molecular pharmacology 1999;55(1):118-25.
1998: M Chatelut; Sylvie Caspar-Bauguil; J Tkaczuk; L Alibaud; MT Pieraggi; S Roudani; N Vacaresse; J Feunteun; Patrick Laharrague; Eliane Duchayne; Cécile Demur; M C Vincent; Jean-Claude Thiers; Robert Salvayre; Thierry Levade
Establishment and characterization of a human T-lymphocyte cell line immortalized by SV40 and with abnormal expression of TCR/CD3.
Scandinavian journal of immunology 1998;48(6):659-66.
1998: Isabelle Escargueil-Blanc; Nathalie Andrieu-Abadie; Sylvie Caspar-Bauguil; R Brossmer; Thierry Levade; Anne Nègre-Salvayre; Robert Salvayre
Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells.
The Journal of biological chemistry 1998;273(42):27389-95.
1998: Jean-Pierre Jaffrézou; Nicolas Maestre; V de Mas-Mansat; Christine Bezombes; Thierry Levade; Guy Laurent
Positive feedback control of neutral sphingomyelinase activity by ceramide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(11):999-1006.
1998: Ismael Galve-Roperh; Cristina Sánchez; Bruno Ségui; Amador Haro; Inés Díaz-Laviada; Thierry Levade
Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor-induced secretion of nerve growth factor in primary astrocyte cultures.
Journal of neurochemistry 1998;71(2):498-505.
1998: Nathalie Andrieu-Abadie; Stéphane Carpentier; Robert Salvayre; Thierry Levade
The tumour necrosis factor-sensitive pool of sphingomyelin is resynthesized in a distinct compartment of the plasma membrane.
The Biochemical journal 1998;333 ( Pt 1)():91-7.
1998: Nathalie Augé; Isabelle Escargueil-Blanc; I Lajoie-Mazenc; I Suc; Nathalie Andrieu-Abadie; MT Pieraggi; M Chatelut; Jean-Claude Thiers; Jean-Pierre Jaffrézou; Guy Laurent; Thierry Levade; Anne Nègre-Salvayre; Robert Salvayre
Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein.
The Journal of biological chemistry 1998;273(21):12893-900.
1998: Jean-Pierre Jaffrézou; Ali Bettaïeb; Thierry Levade; Guy Laurent
Antitumor agent-induced apoptosis in myeloid leukemia cells: a controlled suicide.
Leukemia & lymphoma 1998;29(5-6):453-63.
1998: B Liu; Nathalie Andrieu-Abadie; Thierry Levade; P Zhang; Lina M Obeid; Yusuf A Hannun
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
The Journal of biological chemistry 1998;273(18):11313-20.
1998: M Chatelut; M Leruth; Klaus Harzer; Arie Dagan; S Marchesini; Shimon Gatt; Robert Salvayre; Pierre J Courtoy; Thierry Levade
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue.
FEBS letters 1998;426(1):102-6.
1998: AP Bruno; Guy Laurent; D Averbeck; Cécile Demur; J Bonnet; Ali Bettaïeb; Thierry Levade; Jean-Pierre Jaffrézou
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation.
Cell death and differentiation 1998;5(2):172-82.
1998: I Redonnet-Vernhet; M Chatelut; Robert Salvayre; Thierry Levade
A novel lysosomal acid lipase gene mutation in a patient with cholesteryl ester storage disease.
Human mutation 1998;11(4):335-6.
1998: Christine Bezombes; Nicolas Maestre; Guy Laurent; Thierry Levade; Ali Bettaïeb; Jean-Pierre Jaffrézou
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(1):101-9.
1997: V Mansat; Guy Laurent; Thierry Levade; Ali Bettaïeb; Jean-Pierre Jaffrézou
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
Cancer research 1997;57(23):5300-4.
1997: Klaus Harzer; BC Paton; H Christomanou; M Chatelut; Thierry Levade; Masao Hiraiwa; John S O'Brien
Saposins (sap) A and C activate the degradation of galactosylceramide in living cells.
FEBS letters 1997;417(3):270-4.
1997: I Redonnet-Vernhet; M Chatelut; JP Basile; Robert Salvayre; Thierry Levade
Cholesteryl ester storage disease: relationship between molecular defects and in situ activity of lysosomal acid lipase.
Biochemical and molecular medicine 1997;62(1):42-9.
1997: V Mansat; Ali Bettaïeb; Thierry Levade; Guy Laurent; Jean-Pierre Jaffrézou
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(8):695-702.
1997: M Chatelut; Klaus Harzer; H Christomanou; J Feunteun; MT Pieraggi; BC Paton; Y Kishimoto; John S O'Brien; JP Basile; Jean-Claude Thiers; Robert Salvayre; Thierry Levade
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
Clinica chimica acta; international journal of clinical chemistry 1997;262(1-2):61-76.
1996: Thierry Levade; M Leruth; D Graber; A Moisand; S Vermeersch; Robert Salvayre; Pierre J Courtoy
In situ assay of acid sphingomyelinase and ceramidase based on LDL-mediated lysosomal targeting of ceramide-labeled sphingomyelin.
Journal of lipid research 1996;37(12):2525-38.
1996: I Redonnet-Vernhet; D J Mahuran; Robert Salvayre; F Dubas; Thierry Levade
Significance of two point mutations present in each HEXB allele of patients with adult GM2 gangliosidosis (Sandhoff disease) homozygosity for the Ile207-->Val substitution is not associated with a clinical or biochemical phenotype.
Biochimica et biophysica acta 1996;1317(2):127-33.
1996: Nathalie Augé; N Andrieu; Anne Nègre-Salvayre; Jean-Claude Thiers; Thierry Levade; Robert Salvayre
The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation.
The Journal of biological chemistry 1996;271(32):19251-5.
1996: I Redonnet-Vernhet; JK Ploos van Amstel; R P Jansen; R A Wevers; Robert Salvayre; Thierry Levade
Uneven X inactivation in a female monozygotic twin pair with Fabry disease and discordant expression of a novel mutation in the alpha-galactosidase A gene.
Journal of medical genetics 1996;33(8):682-8.
1996: Jean-Pierre Jaffrézou; Thierry Levade; Ali Bettaïeb; N Andrieu; Christine Bezombes; Nicolas Maestre; S Vermeersch; A Rousse; Guy Laurent
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
The EMBO journal 1996;15(10):2417-24.
1996: N Andrieu; Robert Salvayre; Thierry Levade
Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumor necrosis factor.
European journal of biochemistry / FEBS 1996;236(2):738-45.
1996: M Chatelut; J Feunteun; Klaus Harzer; A H Fensom; JP Basile; Robert Salvayre; Thierry Levade
A simple method for screening for Farber disease on cultured skin fibroblasts.
Clinica chimica acta; international journal of clinical chemistry 1996;245(1):61-71.
1995: N Andrieu; Robert Salvayre; Jean-Pierre Jaffrézou; Thierry Levade
Low temperatures and hypertonicity do not block cytokine-induced stimulation of the sphingomyelin pathway but inhibit nuclear factor-kappa B activation.
The Journal of biological chemistry 1995;270(41):24518-24.
1995: Thierry Levade; F Vidal; S Vermeersch; N Andrieu; S Gatt; Robert Salvayre
Degradation of fluorescent and radiolabelled sphingomyelins in intact cells by a non-lysosomal pathway.
Biochimica et biophysica acta 1995;1258(3):277-87.
1995: Thierry Levade; Herbert Enders; M Schliephacke; K Harzer
A family with combined Farber and Sandhoff, isolated Sandhoff and isolated fetal Farber disease: postnatal exclusion and prenatal diagnosis of Farber disease using lipid loading tests on intact cultured cells.
European journal of pediatrics 1995;154(8):643-8.
1995: Jean-Pierre Jaffrézou; G Chen; George E Durán; C Muller; C Bordier; Guy Laurent; Kevin Gang Chen; Thierry Levade
Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance.
Biochimica et biophysica acta 1995;1266(1):1-8.
1995: Thierry Levade; M C Tempesta; H W Moser; A H Fensom; K Harzer; Ann B Moser; Robert Salvayre
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease.
Biochemical and molecular medicine 1995;54(2):117-25.
1994: N Andrieu; Robert Salvayre; Thierry Levade
Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts.
The Biochemical journal 1994;303 ( Pt 2)():341-5.
1994: D Graber; Robert Salvayre; Thierry Levade
Accurate differentiation of neuronopathic and nonneuronopathic forms of Niemann-Pick disease by evaluation of the effective residual lysosomal sphingomyelinase activity in intact cells.
Journal of neurochemistry 1994;63(3):1060-8.
1994: Thierry Levade; D Graber; V Flurin; Marie-Bernadette Delisle; M T Pieraggi; M F Testut; JP Carrière; Robert Salvayre
Human beta-mannosidase deficiency associated with peripheral neuropathy.
Annals of neurology 1994;35(1):116-9.
1992: Jean-Pierre Jaffrézou; Thierry Levade; P Chatelain; Guy Laurent
Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)-benzenesulfonyl))indolizine.
Cancer research 1992;52(23):6440-6.
1992: Y Alomar; Anne Nègre-Salvayre; Thierry Levade; P Valdiguié; Robert Salvayre
Oxidized HDL are much less cytotoxic to lymphoblastoid cells than oxidized LDL.
Biochimica et biophysica acta 1992;1128(2-3):163-6.
1992: Jean-Pierre Jaffrézou; Thierry Levade; O Thurneyssen; M Chiron; C Bordier; Michel Attal; P Chatelain; Guy Laurent
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
Cancer research 1992;52(5):1352-9.
1991: Jean-Pierre Jaffrézou; J M Herbert; Thierry Levade; M N Gau; P Chatelain; Guy Laurent
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.
The Journal of biological chemistry 1991;266(29):19858-64.
1990: Jean-Pierre Jaffrézou; Thierry Levade; Emilienne Kuhlein; O Thurneyssen; M Chiron; H Grandjean; D Carrière; Guy Laurent
Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells.
Cancer research 1990;50(17):5558-66.
1990: A Negre-Salvayre; M Lopez; Thierry Levade; MT Pieraggi; Nicole Dousset; L Douste-Blazy; Robert Salvayre
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines.
Biochimica et biophysica acta 1990;1045(3):224-32.