FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jeremy Levin

Research Profile

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
Lourdes Toral-Barza; Wei-Guo Zhang; Xinyi Huang; Leonard A McDonald; Edward J Salaski; Laurel R Barbieri; Wei-Dong Ding; Girija Krishnamurthy; Yong Bo Hu; Judy Lucas; Valerie S Bernan; Ping Cai; Jeremy I Levin; Tarek S Mansour; James Gibbons; Robert T Abraham; Ker Yu
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Adrian Huang; Diane Joseph-McCarthy; Frank Lovering; Linhong Sun; Weiheng Wang; Weixin Xu; Yi Zhu; Junqing Cui; Yuhua Zhang; Jeremy I Levin
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Jeffrey S Condon; Diane Joseph-McCarthy; Jeremy I Levin; Henry-Georges Lombart; Frank Lovering; Linhong Sun; Weiheng Wang; Weixin Xu; Yuhua Zhang
Identification of potent and selective TACE inhibitors via the S1 pocket.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jeremy Levin (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2007: Lourdes Toral-Barza; Wei-Guo Zhang; Xinyi Huang; Leonard A McDonald; Edward J Salaski; Laurel R Barbieri; Wei-Dong Ding; Girija Krishnamurthy; Yong Bo Hu; Judy Lucas; Valerie S Bernan; Ping Cai; Jeremy I Levin; Tarek S Mansour; James Gibbons; Robert T Abraham; Ker Yu
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Molecular cancer therapeutics 2007;6(11):3028-38.
2007: Adrian Huang; Diane Joseph-McCarthy; Frank Lovering; Linhong Sun; Weiheng Wang; Weixin Xu; Yi Zhu; Junqing Cui; Yuhua Zhang; Jeremy I Levin
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Bioorganic & medicinal chemistry 2007;15(18):6170-81.
2007: Jeffrey S Condon; Diane Joseph-McCarthy; Jeremy I Levin; Henry-Georges Lombart; Frank Lovering; Linhong Sun; Weiheng Wang; Weixin Xu; Yuhua Zhang
Identification of potent and selective TACE inhibitors via the S1 pocket.
Bioorganic & medicinal chemistry letters 2007;17(1):34-9.
2006: Kaapjoo Park; Alexis Aplasca; Mila T Du; LinHong Sun; Yi Zhu; Yuhua Zhang; Jeremy I Levin
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(15):3927-31.
2006: Jeremy I Levin; James M Chen; Leif M Laakso; Mila Du; J Schmid; Weixin Xu; Terri Cummons; Jun Xu; Guixian Jin; Dauphine Barone; Jerauld S Skotnicki
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2006;16(6):1605-9.
2005: Yonghan Hu; Jason S Xiang; Martin J DiGrandi; Xuemei Du; Manus Ipek; Leif M Laakso; Jianchang Li; Wei Li; Thomas S Rush; Jean Schmid; Jerauld S Skotnicki; Steve Tam; Jennifer R Thomason; Qin Wang; Jeremy I Levin
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorganic & medicinal chemistry 2005;13(24):6629-44.
2005: Jianchang Li; Thomas S Rush; Wei Li; Dianne DeVincentis; Xuemei Du; Yonghan Hu; Jennifer R Thomason; Jason S Xiang; Jerauld S Skotnicki; Steve Tam; Kristina M Cunningham; Priya S Chockalingam; Elisabeth A Morris; Jeremy I Levin
Synthesis and SAR of highly selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(22):4961-6.
2005: Jeremy I Levin; James M Chen; Leif M Laakso; Mila Du; X Du; Aranapakam M Venkatesan; Vincent P Sandanayaka; Arie Zask; Jun Xu; Weixin Xu; Y Zhang; Jerauld S Skotnicki
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2005;15(19):4345-9.
2005: Junjun Wu; Thomas S Rush; Rajeev Hotchandani; Xuemei Du; Mary Geck; Elisabeth Collins; Zhang B Xu; Jerauld S Skotnicki; Jeremy I Levin; Frank Lovering
Identification of potent and selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):4105-9.
2004: Aranapakam M Venkatesan; Jamie M Davis; George T Grosu; Jannie Baker; Arie Zask; Jeremy I Levin; John W Ellingboe; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Guixian Jin; Weixin Xu; Diane Joseph McCarthy; Dauphine Barone
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(25):6255-69.
2004: Jeremy I Levin; Frances C Nelson; Efren Delos Santos; Mila T Du; Gloria MacEwan; James M Chen; Semiramis Ayral-Kaloustian; Jun Xu; Guixian Jin; Terri Cummons; Dauphine Barone
Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
Bioorganic & medicinal chemistry letters 2004;14(16):4147-51.
2004: Jeremy I Levin
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
Current topics in medicinal chemistry 2004;4(12):1289-310.
2003: Jerauld S Skotnicki; Martin J DiGrandi; Jeremy I Levin
Design strategies for the identification of MMP-13 and Tace inhibitors.
Current opinion in drug discovery & development 2003;6(5):742-59.
2003: Jeremy I Levin; James M Chen; Kinwang Cheung; Derek Cole; C Crago; E Delos Santos; Xumei Du; Gulnaz Khafizova; Gloria MacEwan; Chuan Niu; Edward J Salaski; Arie Zask; Terri Cummons; Amy Sung; Jun Xu; Yuhua Zhang; Weixin Xu; Semiramis Ayral-Kaloustian; Guixian Jin; Rebecca Cowling; Dauphine Barone; Ken Mohler; Roy A Black; Jerauld S Skotnicki
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2003;13(16):2799-803.
2003: Venkatesan Aranapakam; Jamie M Davis; George T Grosu; Jannie Baker; John W Ellingboe; Arie Zask; Jeremy I Levin; Vincent P Sandanayaka; Mila Du; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling; Jeff Tillett; Weiguang Zhao; Joseph McDevitt; Zhang B Xu
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
2003: Arie Zask; Y Gu; J Donald Albright; Xumei Du; M Hogan; Jeremy I Levin; James M Chen; Loran M Killar; Amy Sung; John F DiJoseph; Michele A Sharr; Catherine E Roth; S Skala; Guixian Jin; Rebecca Cowling; Ken Mohler; Dauphine Barone; Roy Black; CJ March; Jerauld S Skotnicki
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
2003: Jeremy I Levin; Mila T Du
Sulfonate ester hydroxamic acids as potent and selective inhibitors of TACE enzyme.
Drug design and discovery 2003;18(4):123-6.
2002: Franklin J Moy; Pranab K Chanda; James Chen; Scott Cosmi; Wade Edris; Jeremy I Levin; Thomas S Rush; James Wilhelm; Robert Powers
Impact of mobility on structure-based drug design for the MMPs.
Journal of the American Chemical Society 2002;124(43):12658-9.
2002: Frances C Nelson; Efren Delos Santos; Jeremy I Levin; James M Chen; Jerauld S Skotnicki; John F DiJoseph; Michele A Sharr; Amy Sung; Loran M Killar; Rebecca Cowling; Guixian Jin; Catherine E Roth; J Donald Albright
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
2002: Jeremy I Levin; James M Chen; Mila T Du; Frances C Nelson; Loran M Killar; S Skala; Amy Sung; Guixian Jin; Rebecca Cowling; Dauphine Barone; CJ March; Ken Mohler; Roy A Black; Jerauld S Skotnicki
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Bioorganic & medicinal chemistry letters 2002;12(8):1199-202.
2002: James M Chen; Guixian Jin; Amy Sung; Jeremy I Levin
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups.
Bioorganic & medicinal chemistry letters 2002;12(8):1195-8.
2001: Jeremy I Levin; James M Chen; Mila T Du; Frances C Nelson; T Wehr; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; Catherine E Roth; Guixian Jin; Rebecca Cowling; L Di; M Sherman; Zhang B Xu; CJ March; Ken Mohler; Roy A Black; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Jeremy I Levin; J Chen; Mila Du; M Hogan; S Kincaid; Frances C Nelson; Aranapakam M Venkatesan; T Wehr; Arie Zask; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; C Roth; Guixian Jin; Rebecca Cowling; Ken Mohler; Roy A Black; CJ March; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Jeremy I Levin; Y Gu; Frances C Nelson; Arie Zask; John F DiJoseph; Michele A Sharr; Amy Sung; Guixian Jin; Rebecca Cowling; Pranab K Chanda; Scott Cosmi; C L Hsiao; Wade Edris; James Wilhelm; Loran M Killar; Jerauld S Skotnicki
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
2001: Jeremy I Levin; Mila T Du; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Franklin J Moy; Robert Powers; Guixian Jin; Rebecca Cowling; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.
2000: Franklin J Moy; Pranab K Chanda; J M Chen; Scott Cosmi; Wade Edris; Jeremy I Levin; Robert Powers
High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
Journal of molecular biology 2000;302(3):671-89.
2000: Franklin J Moy; Pranab K Chanda; Scott Cosmi; Wade Edris; Jeremy I Levin; Robert Powers
Letter to the editor: 1H, 15N, 13C, and 13CO assignments and secondary structure determination of collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
Journal of biomolecular NMR 2000;17(3):269-70.
1999: Jerauld S Skotnicki; Arie Zask; F C Nelson; J Donald Albright; Jeremy I Levin
Design and synthetic considerations of matrix metalloproteinase inhibitors.
Annals of the New York Academy of Sciences 1999;878():61-72.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Jerauld S Skotnicki; J Donald Albright
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2657-62.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Michele A Sharr; Jerauld S Skotnicki; Dinesh V Patel; Xiao-Yi Xiao; L Shi; M Navre; DA Campbell
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(10):1163-8.
1998: DA Campbell; Xiao-Yi Xiao; D Harris; S Ida; R Mortezaei; K Ngu; L Shi; D Tien; Y Wang; M Navre; Dinesh V Patel; Michele A Sharr; John F DiJoseph; Loran M Killar; C L Leone; Jeremy I Levin; Jerauld S Skotnicki
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(10):1157-62.