Jeremy Levin

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Toral-Barza Lourdes; Zhang Wei-Guo; Huang Xinyi; McDonald Leonard A; Salaski Edward J; Barbieri Laurel R; Ding Wei-Dong; Krishnamurthy Girija; Hu Yong Bo; Lucas Judy; Bernan Valerie S; Cai Ping; Levin Jeremy I; Mansour Tarek S; Gibbons James J; Abraham Robert T; Yu Ker
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Huang Adrian; Joseph-McCarthy Diane; Lovering Frank; Sun Linhong; Wang Weiheng; Xu Weixin; Zhu Yi; Cui Junqing; Zhang Yuhua; Levin Jeremy I
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Condon Jeffrey S; Joseph-McCarthy Diane; Levin Jeremy I; Lombart Henry-Georges; Lovering Frank E; Sun Linhong; Wang Weiheng; Xu Weixin; Zhang Yuhua
Identification of potent and selective TACE inhibitors via the S1 pocket.

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All Publications

2007: Toral-Barza Lourdes; Zhang Wei-Guo; Huang Xinyi; McDonald Leonard A; Salaski Edward J; Barbieri Laurel R; Ding Wei-Dong; Krishnamurthy Girija; Hu Yong Bo; Lucas Judy; Bernan Valerie S; Cai Ping; Levin Jeremy I; Mansour Tarek S; Gibbons James J; Abraham Robert T; Yu Ker
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Molecular cancer therapeutics 2007;6(11):3028-38.
2007: Huang Adrian; Joseph-McCarthy Diane; Lovering Frank; Sun Linhong; Wang Weiheng; Xu Weixin; Zhu Yi; Cui Junqing; Zhang Yuhua; Levin Jeremy I
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Bioorganic & medicinal chemistry 2007;15(18):6170-81.
2007: Condon Jeffrey S; Joseph-McCarthy Diane; Levin Jeremy I; Lombart Henry-Georges; Lovering Frank E; Sun Linhong; Wang Weiheng; Xu Weixin; Zhang Yuhua
Identification of potent and selective TACE inhibitors via the S1 pocket.
Bioorganic & medicinal chemistry letters 2007;17(1):34-9.
2006: Park Kaapjoo; Aplasca Alexis; Du Mila T; Sun LinHong; Zhu Yi; Zhang Yuhua; Levin Jeremy I
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(15):3927-31.
2006: Levin J I; Chen J M; Laakso L M; Du M; Schmid J; Xu W; Cummons T; Xu J; Jin G; Barone D; Skotnicki J S
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2006;16(6):1605-9.
2005: Hu Yonghan; Xiang Jason S; DiGrandi Martin J; Du Xuemei; Ipek Manus; Laakso Leif M; Li Jianchang; Li Wei; Rush Thomas S; Schmid Jean; Skotnicki Jerauld S; Tam Steve; Thomason Jennifer R; Wang Qin; Levin Jeremy I
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorganic & medicinal chemistry 2005;13(24):6629-44.
2005: Li Jianchang; Rush Thomas S; Li Wei; DeVincentis Dianne; Du Xuemei; Hu Yonghan; Thomason Jennifer R; Xiang Jason S; Skotnicki Jerauld S; Tam Steve; Cunningham Kristina M; Chockalingam Priya S; Morris Elisabeth A; Levin Jeremy I
Synthesis and SAR of highly selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(22):4961-6.
2005: Levin J I; Chen J M; Laakso L M; Du M; Du X; Venkatesan A M; Sandanayaka V; Zask A; Xu J; Xu W; Zhang Y; Skotnicki J S
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2005;15(19):4345-9.
2005: Wu Junjun; Rush Thomas S; Hotchandani Rajeev; Du Xuemei; Geck Mary; Collins Elisabeth; Xu Zhang-Bao; Skotnicki Jerry; Levin Jeremy I; Lovering Frank E
Identification of potent and selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):4105-9.
2004: Venkatesan Aranapakam M; Davis Jamie M; Grosu George T; Baker Jannie; Zask Arie; Levin Jeremy I; Ellingboe John; Skotnicki Jerauld S; Dijoseph John F; Sung Amy; Jin Guixian; Xu Weixin; McCarthy Diane Joseph; Barone Dauphine
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(25):6255-69.
2004: Levin Jeremy I; Nelson Frances C; Delos Santos Efren; Du Mila T; MacEwan Gloria; Chen James M; Ayral-Kaloustian Semiramis; Xu Jun; Jin Guixian; Cummons Terri; Barone Dauphine
Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
Bioorganic & medicinal chemistry letters 2004;14(16):4147-51.
2004: Levin Jeremy I
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
Current topics in medicinal chemistry 2004;4(12):1289-310.
2003: Skotnicki Jerauld S; DiGrandi Martin J; Levin Jeremy I
Design strategies for the identification of MMP-13 and Tace inhibitors.
Current opinion in drug discovery & development 2003;6(5):742-59.
2003: Levin J I; Chen J M; Cheung K; Cole D; Crago C; Santos E Delos; Du X; Khafizova G; MacEwan G; Niu C; Salaski E J; Zask A; Cummons T; Sung A; Xu J; Zhang Y; Xu W; Ayral-Kaloustian S; Jin G; Cowling R; Barone D; Mohler K M; Black R A; Skotnicki J S
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2003;13(16):2799-803.
2003: Aranapakam Venkatesan; Davis Jamie M; Grosu George T; Baker Jannie; Ellingboe John; Zask Arie; Levin Jeremy I; Sandanayaka Vincent P; Du Mila; Skotnicki Jerauld S; DiJoseph John F; Sung Amy; Sharr Michele A; Killar Loran M; Walter Thomas; Jin Guixian; Cowling Rebecca; Tillett Jeff; Zhao Weiguang; McDevitt Joseph; Xu Zhang Bao
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
2003: Zask A; Gu Y; Albright J D; Du X; Hogan M; Levin J I; Chen J M; Killar L M; Sung A; DiJoseph J F; Sharr M A; Roth C E; Skala S; Jin G; Cowling R; Mohler K M; Barone D; Black R; March C; Skotnicki J S
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
2003: Levin Jeremy I; Du Mila T
Sulfonate ester hydroxamic acids as potent and selective inhibitors of TACE enzyme.
Drug design and discovery 2003;18(4):123-6.
2002: Moy Franklin J; Chanda Pranab K; Chen James; Cosmi Scott; Edris Wade; Levin Jeremy I; Rush Thomas S; Wilhelm James; Powers Robert
Impact of mobility on structure-based drug design for the MMPs.
Journal of the American Chemical Society 2002;124(43):12658-9.
2002: Nelson Frances C; Delos Santos Efren; Levin Jeremy I; Chen James M; Skotnicki Jerauld S; DiJoseph John F; Sharr Michele A; Sung Amy; Killar Loran M; Cowling Rebecca; Jin Guixian; Roth Catherine E; Albright J Donald
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
2002: Levin J I; Chen J M; Du M T; Nelson F C; Killar L M; Skala S; Sung A; Jin G; Cowling R; Barone D; March C J; Mohler K M; Black R A; Skotnicki J S
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Bioorganic & medicinal chemistry letters 2002;12(8):1199-202.
2002: Chen James M; Jin Guixian; Sung Amy; Levin Jeremy I
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups.
Bioorganic & medicinal chemistry letters 2002;12(8):1195-8.
2001: Levin J I; Chen J M; Du M T; Nelson F C; Wehr T; DiJoseph J F; Killar L M; Skala S; Sung A; Sharr M A; Roth C E; Jin G; Cowling R; Di L; Sherman M; Xu Z B; March C J; Mohler K M; Black R A; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Levin J I; Chen J; Du M; Hogan M; Kincaid S; Nelson F C; Venkatesan A M; Wehr T; Zask A; DiJoseph J; Killar L M; Skala S; Sung A; Sharr M; Roth C; Jin G; Cowling R; Mohler K M; Black R A; March C J; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Levin J I; Gu Y; Nelson F C; Zask A; DiJoseph J F; Sharr M A; Sung A; Jin G; Cowling R; Chanda P; Cosmi S; Hsiao C L; Edris W; Wilhelm J; Killar L M; Skotnicki J S
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
2001: Levin J I; Du M T; DiJoseph J F; Killar L M; Sung A; Walter T; Sharr M A; Roth C E; Moy F J; Powers R; Jin G; Cowling R; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.
2000: Moy F J; Chanda P K; Chen J M; Cosmi S; Edris W; Levin J I; Powers R
High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
Journal of molecular biology 2000;302(3):671-89.
2000: Moy F J; Chanda P K; Cosmi S; Edris W; Levin J I; Powers R
Letter to the editor: 1H, 15N, 13C, and 13CO assignments and secondary structure determination of collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
Journal of biomolecular NMR 2000;17(3):269-70.
1999: Skotnicki J S; Zask A; Nelson F C; Albright J D; Levin J I
Design and synthetic considerations of matrix metalloproteinase inhibitors.
Annals of the New York Academy of Sciences 1999;878():61-72.
1998: Levin J I; DiJoseph J F; Killar L M; Sung A; Walter T; Sharr M A; Roth C E; Skotnicki J S; Albright J D
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2657-62.
1998: Levin J I; DiJoseph J F; Killar L M; Sharr M A; Skotnicki J S; Patel D V; Xiao X Y; Shi L; Navre M; Campbell D A
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(10):1163-8.
1998: Campbell D A; Xiao X Y; Harris D; Ida S; Mortezaei R; Ngu K; Shi L; Tien D; Wang Y; Navre M; Patel D V; Sharr M A; DiJoseph J F; Killar L M; Leone C L; Levin J I; Skotnicki J S
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(10):1157-62.

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Jeremy Levin

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