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Arnold Levine

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Arnold J Levine; Benjamin Greenbaum
The maintenance of epigenetic states by p53: the guardian of the epigenome.
Xin Yu; Arnold J Levine; Alexei Vazquez; Darren R Carpizo
Allele-specific p53 mutant reactivation.
Zhaohui Feng; Arnold J Levine; Meihua Lin; Lianxin Liu; Jiabei Wang; Xiaowen Wang; Cen Zhang; Yuhan Zhao; Tongsen Zheng; Wenwei Hu
Chronic restraint stress attenuates p53 function and promotes tumorigenesis.

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All Publications

2012: Arnold J Levine; Benjamin Greenbaum
The maintenance of epigenetic states by p53: the guardian of the epigenome.
Oncotarget 2012;3(12):1503-4.
2012: Xin Yu; Arnold J Levine; Alexei Vazquez; Darren R Carpizo
Allele-specific p53 mutant reactivation.
Cancer cell 2012;21(5):614-25.
2012: Zhaohui Feng; Arnold J Levine; Meihua Lin; Lianxin Liu; Jiabei Wang; Xiaowen Wang; Cen Zhang; Yuhan Zhao; Tongsen Zheng; Wenwei Hu
Chronic restraint stress attenuates p53 function and promotes tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):7013-8.
2012: Wenwei Hu; Zhaohui Feng; Arnold J Levine
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.
Genes & cancer 2012;3(3-4):199-208.
2012: Benjamin D Greenbaum; Arnold J Levine; Olive T W Li; Leo L M Poon; Raul Rabadan
Viral reassortment as an information exchange between viral segments.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(9):3341-6.
2012: William A Freed-Pastor; Anita Langerød; Arnold J Levine; Wencheng Li; Scott W Lowe; Hideaki Mizuno; Sung-Hwan Moon; Timothy F Osborne; Alla Polotskaia; Jill Bargonetti; Anthony Barsotti; Mina J Bissell; Anne-Lise Børresen-Dale; Agustin Chicas; Ruth Rodriguez-Barrueco; Jose M Silva; Bin Tian; Xi Zhao; Carol Prives
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Cell 2012;148(1-2):244-58.
2012: Arnold J Levine
The evolution of the p53 family of genes.
Cell cycle (Georgetown, Tex.) 2012;11(2):214-5.
2012: Kshitij Wagh; Ming Yao; Gabriela Alexe; Aatish Bhatia; Michael Boemo; Lee Cronk; Shridar Ganesan; Arnold J Levine; Asad Naqvi; Vijay Ravikumar; Anupama Reddy; Michael Seiler; Gyan Bhanot
Lactase persistence and lipid pathway selection in the Maasai.
PloS one 2012;7(9):e44751.
2012: Erhan Bilal; Anne-Lise Børresen-Dale; VANESSA ALMENDRO; Nicola Barnard; Gyan Bhanot; Arnold J Levine; Hege Russnes; Inga H Rye; Deborah Toppmeyer; Kristen Vassallo; Shridar Ganesan
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers.
PloS one 2012;7(6):e38575.
2011: Elke K Markert; Alexei Vazquez; Hideaki Mizuno; Arnold J Levine
Molecular classification of prostate cancer using curated expression signatures.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(52):21276-81.
2011: Cen Zhang; Wenwei Hu; Arnold J Levine; Meihua Lin; Xiaowen Wang; Rui Wu; Bo Yang; Zhaohui Feng
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16259-64.
2011: Arnold J Levine
The paths to death and differentiation.
Cell death and differentiation 2011;18(9):1391-2.
2011: Zhaohui Feng; Amanda K Frank; Hey-Joo Kang; Arnold J Levine; Maureen E Murphy; Asad Naqvi; Zev Rosenwaks; Yvonne Sun; Haijian Wang; Cen Zhang; Wenwei Hu
Regulation of female reproduction by p53 and its family members.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(7):2245-55.
2011: Alexei Vazquez; Diptee Kulkarni; Lukasz F Grochola; Gareth Bond; Nicola Barnard; Deborah Toppmeyer; Arnold J Levine; Kim M Hirshfield
A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.
International journal of cancer. Journal international du cancer 2011;128(10):2335-43.
2011: Monica Nicolau; Arnold J Levine; Gunnar Carlsson
Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):7265-70.
2011: Arnold J Levine
Introduction: The Changing Directions of p53 Research.
Genes & cancer 2011;2(4):382-4.
2011: Arnold J Levine
Monographs editor.
Genes & cancer 2011;2(4):381.
2011: Arnold J Levine; Richard Tomasini; Frank D McKeon; Tak W Mak; Gerry Melino
The p53 family: guardians of maternal reproduction.
Nature reviews. Molecular cell biology 2011;12(4):259-65.
2011: Madhura S Mehta; Alexei Vazquez; Diptee A Kulkarni; John E Kerrigan; Gurinder Atwal; Shoichi Metsugi; Deborah Toppmeyer; Arnold J Levine; Kim M Hirshfield
Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.
Breast cancer research and treatment 2011;125(3):861-8.
2010: Hideaki Mizuno; Benjamin T Spike; Geoffrey M Wahl; Arnold J Levine
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22745-50.
2010: Arnold J Levine; Anna M Puzio-Kuter
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.
Science (New York, N.Y.) 2010;330(6009):1340-4.
2010: Vladimir A Belyi; Arnold J Levine; Anna Marie Skalka
Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old.
Journal of virology 2010;84(23):12458-62.
2010: David Lane; Arnold J Levine
p53 Research: the past thirty years and the next thirty years.
Cold Spring Harbor perspectives in biology 2010;2(12):a000893.
2010: Prashanth Ak; Arnold J Levine
p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3643-52.
2010: Sean M Post; Alfonso Quintás-Cardama; Vinod Pant; Tomoo Iwakuma; Amir Hamir; James G Jackson; Daniela R Maccio; Gareth Bond; David G Johnson; Arnold J Levine; Guillermina Lozano
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Cancer cell 2010;18(3):220-30.
2010: Zhaohui Feng; Arnold J Levine
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
Trends in cell biology 2010;20(7):427-34.
2010: Wenwei Hu; Chang S Chan; Rui Wu; Cen Zhang; Yvonne Sun; Jun S Song; Laura H Tang; Arnold J Levine; Zhaohui Feng
Negative regulation of tumor suppressor p53 by microRNA miR-504.
Molecular cell 2010;38(5):689-99.
2010: Elke K Markert; Nils Baas; Arnold J Levine; Alexei Vazquez
Higher order Boolean networks as models of cell state dynamics.
Journal of theoretical biology 2010;264(3):945-51.
2010: Vladimir A Belyi; Prashanth Ak; Elke Markert; Haijian Wang; Wenwei Hu; Anna Puzio-Kuter; Arnold J Levine
The origins and evolution of the p53 family of genes.
Cold Spring Harbor perspectives in biology 2010;2(6):a001198.
2010: Byeong-Seon Jeong; Wenwei Hu; Vladimir Belyi; Raul Rabadan; Arnold J Levine
Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(5):1347-53.
2010: Wenwei Hu; Cen Zhang; Rui Wu; Yvonne Sun; Arnold J Levine; Zhaohui Feng
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(16):7455-60.
2010: Chris R Harris; Arnold J Levine; Robin Normart; Elizabeth Stevenson; Carlos Cordon-Cardo; Shridar Ganesan; Bruce G Haffty; Qifeng Yang; Laura H Tang
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes.
Genes & cancer 2010;1(2):115-24.
2010: Vladimir A Belyi; Arnold J Levine; Anna Marie Skalka
Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.
PLoS pathogens 2010;6(7):e1001030.
2010: Huiqing Liu; Angela R Brannon; Anupama R Reddy; Gabriela Alexe; Michael W Seiler; Alexandra Arreola; Jay H Oza; Ming Yao; David Juan; Louis S Liou; Shridar Ganesan; Arnold J Levine; W K Rathmell; Gyan V Bhanot
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma.
BMC systems biology 2010;4():51.
2010: Hideaki Mizuno; Gurinder Singh Atwal; Haijian Wang; Arnold J Levine; Alexei Vazquez
Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome.
BMC genetics 2010;11():27.
2010: Kim M Hirshfield; Timothy R Rebbeck; Arnold J Levine
Germline mutations and polymorphisms in the origins of cancers in women.
Journal of oncology 2010;2010():297671.
2010: Alexei Vazquez; Lukasz F Grochola; Elisabeth E Bond; Arnold J Levine; Helge Taubert; Thomas H Müller; Peter Würl; Gareth Bond
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival.
Cancer research 2010;70(1):172-80.
2009: Wenwei Hu; Zhaohui Feng; Arnold J Levine
The regulation of human reproduction by p53 and its pathway.
Cell cycle (Georgetown, Tex.) 2009;8(22):3621-2.
2009: C R Harris; A Dewan; A Zupnick; R Normart; A Gabriel; C Prives; Arnold J Levine; J Hoh
p53 responsive elements in human retrotransposons.
Oncogene 2009;28(44):3857-65.
2009: Diptee A Kulkarni; Alexei Vazquez; Bruce G Haffty; Elisa Bandera; Wenwei Hu; Yvonne Y Sun; Deborah Toppmeyer; Arnold J Levine; Kim M Hirshfield
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.
Carcinogenesis 2009;30(11):1910-5.
2009: Vladimir A Belyi; Arnold J Levine
One billion years of p53/p63/p73 evolution.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17609-10.
2009: Anna M Puzio-Kuter; Arnold J Levine
Stem cell biology meets p53.
Nature biotechnology 2009;27(10):914-5.
2009: Arnold J Levine; Moshe Oren
The first 30 years of p53: growing ever more complex.
Nature reviews. Cancer 2009;9(10):749-58.
2009: Lukasz F Grochola; Alexei Vazquez; Elisabeth E Bond; Peter Würl; Helge Taubert; Thomas H Müller; Arnold J Levine; Gareth Bond
Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6301-8.
2009: Gurinder Singh Atwal; Tomas Kirchhoff; Elisabeth E Bond; Marco Montagna; Marco Monagna; Chiara Menin; Roberta Bertorelle; Maria Chiara Scaini; Frank Bartel; Anja Böhnke; Christina Pempe; Elise Gradhand; Steffen Hauptmann; Kenneth Offit; Arnold J Levine; Gareth Bond
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(25):10236-41.
2009: Hey-Joo Kang; Zhaohui Feng; Yvonne Sun; Gurinder Atwal; Maureen E Murphy; Timothy R Rebbeck; Zev Rosenwaks; Arnold J Levine; Wenwei Hu
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9761-6.
2009: Hong Shi; Si-jie Tan; Hua Zhong; Wenwei Hu; Arnold J Levine; Chun-jie Xiao; Yi Peng; Xue-bin Qi; Wei-hua Shou; Run-lin Z Ma; Yi Li; Bing Su; Xin Lu
Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.
American journal of human genetics 2009;84(4):534-41.
2009: Xin Yu; Todd Riley; Arnold J Levine
The regulation of the endosomal compartment by p53 the tumor suppressor gene.
The FEBS journal 2009;276(8):2201-12.
2009: Arnold J Levine
The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.
Virology 2009;384(2):285-93.
2009: Benjamin D Greenbaum; Raul Rabadan; Arnold J Levine
Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system.
PloS one 2009;4(6):e5969.
2009: Todd Riley; Xin Yu; Eduardo Sontag; Arnold J Levine
The p53HMM algorithm: using profile hidden markov models to detect p53-responsive genes.
BMC bioinformatics 2009;10():111.
2009: Robert Brewster; Gary S Grest; Arnold J Levine
Effects of cohesion on the surface angle and velocity profiles of granular material in a rotating drum.
Physical review. E, Statistical, nonlinear, and soft matter physics 2009;79(1 Pt 1):011305.
2009: Arnold J Levine; Zachary J Levine; Ali H Brivanlou
GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.
Developmental biology 2009;325(1):43-8.
2008: Alexei Vazquez; Elisabeth E Bond; Arnold J Levine; Gareth Bond
The genetics of the p53 pathway, apoptosis and cancer therapy.
Nature reviews. Drug discovery 2008;7(12):979-87.
2008: Arnold J Levine
Why do we not yet have a human immunodeficiency virus vaccine?
Journal of virology 2008;82(24):11998-2000.
2008: Gabriela Alexe; R Vijaya Satya; M Seiler; D Platt; T Bhanot; S Hui; Masashi Tanaka; Arnold J Levine; Gyan Bhanot
PCA and clustering reveal alternate mtDNA phylogeny of N and M clades.
Journal of molecular evolution 2008;67(5):465-87.
2008: Arnold J Levine; Evan Vosburgh
P53 mutations in lymphomas: position matters.
Blood 2008;112(8):2997-8.
2008: Michael Krasnitz; Arnold J Levine; Raul Rabadan
Anomalies in the influenza virus genome database: new biology or laboratory errors?
Journal of virology 2008;82(17):8947-50.
2008: Benjamin D Greenbaum; Arnold J Levine; Gyan Bhanot; Raul Rabadan
Patterns of evolution and host gene mimicry in influenza and other RNA viruses.
PLoS pathogens 2008;4(6):e1000079.
2008: Harlan Robins; Michael Krasnitz; Arnold J Levine
The computational detection of functional nucleotide sequence motifs in the coding regions of organisms.
Experimental biology and medicine (Maywood, N.J.) 2008;233(6):665-73.
2008: Todd Riley; Eduardo Sontag; Patricia Chen; Arnold J Levine
Transcriptional control of human p53-regulated genes.
Nature reviews. Molecular cell biology 2008;9(5):402-12.
2008: Eain Murphy; Jirí Vanícek; Harlan Robins; Thomas Shenk; Arnold J Levine
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5453-8.
2008: Wenwei Hu; Zhaohui Feng; Gurinder S Atwal; Arnold J Levine
p53: a new player in reproduction.
Cell cycle (Georgetown, Tex.) 2008;7(7):848-52.
2008: Zhaohui Feng; Wenwei Hu; Gunaretnam Rajagopal; Arnold J Levine
The tumor suppressor p53: cancer and aging.
Cell cycle (Georgetown, Tex.) 2008;7(7):842-7.
2008: Glenn A Marsh; Raúl Rabadán; Arnold J Levine; Peter Palese
Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging.
Journal of virology 2008;82(5):2295-304.
2008: Raul Rabadan; Arnold J Levine; Michael Krasnitz
Non-random reassortment in human influenza A viruses.
Influenza and other respiratory viruses 2008;2(1):9-22.
2008: Yaoxing Huang; Michael Krasnitz; Raul Rabadan; Daniela M Witten; Yang Song; Arnold J Levine; David D Ho; Harlan Robins
A recoding method to improve the humoral immune response to an HIV DNA vaccine.
PloS one 2008;3(9):e3214.
2008: Gurinder Singh Atwal; Raúl Rabadán; Guillermina Lozano; Louise C Strong; Mariëlle W G Ruijs; Marjanka K Schmidt; Laura J van't Veer; Heli Nevanlinna; Johanna Tommiska; Kristiina Aittomäki; Gaelle Bougeard; Thierry Frebourg; Arnold J Levine; Gareth Bond
An information-theoretic analysis of genetics, gender and age in cancer patients.
PloS one 2008;3(4):e1951.
2007: Arnold J Levine; Wenwei Hu; Zhaohui Feng; German Gil
Reconstructing signal transduction pathways: challenges and opportunities.
Annals of the New York Academy of Sciences 2007;1115():32-50.
2007: Wenwei Hu; Zhaohui Feng; Angelika K Teresky; Arnold J Levine
p53 regulates maternal reproduction through LIF.
Nature 2007;450(7170):721-4.
2007: Gabriela Alexe; Gul S Dalgin; Daniel Scanfeld; Pablo Tamayo; Jill P Mesirov; Charles DeLisi; Lyndsay Harris; Nicola Barnard; Maritza Martel; Arnold J Levine; Shridar Ganesan; Gyan Bhanot
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates.
Cancer research 2007;67(22):10669-76.
2007: Zhaohui Feng; Wenwei Hu; Angelika K Teresky; Eva Hernando; Carlos Cordon-Cardo; Arnold J Levine
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16633-8.
2007: Arnold J Levine; Ali H Brivanlou
Proposal of a model of mammalian neural induction.
Developmental biology 2007;308(2):247-56.
2007: Zhaohui Feng; Wenwei Hu; Elisa de Stanchina; Angelika K Teresky; Shengkan Jin; Scott W Lowe; Arnold J Levine
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer research 2007;67(7):3043-53.
2007: Wenwei Hu; Zhaohui Feng; Lan Ma; John Wagner; JJ Rice; Gustavo Stolovitzky; Arnold J Levine
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.
Cancer research 2007;67(6):2757-65.
2007: Gurinder Singh Atwal; Gareth Bond; Sally Metsuyanim; Moshe Papa; Eitan Friedman; Tal Distelman-Menachem; Edna Ben-Asher; Doron Lancet; David A Ross; John J Sninsky; Tomas J White; Arnold J Levine; Ronit Yarden
Haplotype structure and selection of the MDM2 oncogene in humans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4524-9.
2007: Gareth Bond; Arnold J Levine
A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans.
Oncogene 2007;26(9):1317-23.
2007: Buyong Ma; Arnold J Levine
Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.
Nucleic acids research 2007;35(22):7733-47.
2007: Buyong Ma; Yongping Pan; Jie Zheng; Arnold J Levine; Ruth Nussinov
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets.
Nucleic acids research 2007;35(9):2986-3001.
2006: Raul Rabadan; Arnold J Levine; Harlan Robins
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes.
Journal of virology 2006;80(23):11887-91.
2006: Gareth Bond; Chiara Menin; Roberta Bertorelle; Pia Alhopuro; Lauri A Aaltonen; Arnold J Levine
MDM2 SNP309 accelerates colorectal tumour formation in women.
Journal of medical genetics 2006;43(12):950-2.
2006: Arnold J Levine; W Hu; Z Feng
The P53 pathway: what questions remain to be explored?
Cell death and differentiation 2006;13(6):1027-36.
2006: Gareth Bond; Kim M Hirshfield; Tomas Kirchhoff; Gabriella Alexe; Elisabeth E Bond; Harlan Robins; Frank Bartel; Helge Taubert; Peter Wuerl; William N Hait; Deborah Toppmeyer; Kenneth Offit; Arnold J Levine
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.
Cancer research 2006;66(10):5104-10.
2006: Arnold J Levine; Ali H Brivanlou
GDF3 at the crossroads of TGF-beta signaling.
Cell cycle (Georgetown, Tex.) 2006;5(10):1069-73.
2006: Xin Yu; Sandra Harris; Arnold J Levine
The regulation of exosome secretion: a novel function of the p53 protein.
Cancer research 2006;66(9):4795-801.
2006: Yongping Pan; Buyong Ma; Arnold J Levine; Ruth Nussinov
Comparison of the human and worm p53 structures suggests a way for enhancing stability.
Biochemistry 2006;45(12):3925-33.
2006: Megan Cully; Han You; Arnold J Levine; Tak W Mak
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.
Nature reviews. Cancer 2006;6(3):184-92.
2006: Arnold J Levine; Zhaohui Feng; Tak W Mak; Han You; Shengkan Jin
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
Genes & development 2006;20(3):267-75.
2006: Z Feng; Shengkan Jin; Andrew Zupnick; J Hoh; Elisa de Stanchina; Scott W Lowe; Carol Prives; Arnold J Levine
p53 tumor suppressor protein regulates the levels of huntingtin gene expression.
Oncogene 2006;25(1):1-7.
2006: Gyan Bhanot; Gabriela Alexe; Babu Venkataraghavan; Arnold J Levine
A robust meta-classification strategy for cancer detection from MS data.
Proteomics 2006;6(2):592-604.
2006: Arnold J Levine; Ali H Brivanlou
GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos.
Development (Cambridge, England) 2006;133(2):209-16.
2005: Harlan Robins; Michael Krasnitz; Hagar Barak; Arnold J Levine
A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities.
Journal of bacteriology 2005;187(24):8370-4.
2005: Sandra Harris; German Gil; Harlan Robins; Wenwei Hu; Kim M Hirshfield; Elisabeth E Bond; Gareth Bond; Arnold J Levine
Detection of functional single-nucleotide polymorphisms that affect apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16297-302.
2005: Lan Ma; John Wagner; JJ Rice; Wenwei Hu; Arnold J Levine; Gustavo Stolovitzky
A plausible model for the digital response of p53 to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14266-71.
2005: John Wagner; Lan Ma; JJ Rice; Wenwei Hu; Arnold J Levine; Gustavo Stolovitzky
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback.
Systems biology 2005;152(3):109-18.
2005: Nicoleta C Arva; Tamara R Gopen; Kathryn E Talbott; Latoya E Campbell; Agustin Chicas; David E White; Gareth Bond; Arnold J Levine; Jill Bargonetti
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.
The Journal of biological chemistry 2005;280(29):26776-87.
2005: Gareth Bond; Wenwei Hu; Arnold J Levine
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect.
Cancer research 2005;65(13):5481-4.
2005: Zhaohui Feng; Haiyan Zhang; Arnold J Levine; Shengkan Jin
The coordinate regulation of the p53 and mTOR pathways in cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8204-9.
2005: Buyong Ma; Yongping Pan; Kannan Gunasekaran; ozlem keskin; R Babu Venkataraghavan; Arnold J Levine; Ruth Nussinov
The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins.
Physical biology 2005;2(2):S56-66.
2005: Sandra Harris; Arnold J Levine
The p53 pathway: positive and negative feedback loops.
Oncogene 2005;24(17):2899-908.
2005: Buyong Ma; Yongping Pan; Kannan Gunasekaran; R Babu Venkataraghavan; Arnold J Levine; Ruth Nussinov
Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):3988-93.
2005: Daylon James; Arnold J Levine; Daniel Besser; Ali Hemmati-Brivanlou
TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
Development (Cambridge, England) 2005;132(6):1273-82.
2005: Yongping Pan; Buyong Ma; R Babu Venkataraghavan; Arnold J Levine; Ruth Nussinov
In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.
Biochemistry 2005;44(5):1423-32.
2005: Gareth Bond; Wenwei Hu; Arnold J Levine
MDM2 is a central node in the p53 pathway: 12 years and counting.
Current cancer drug targets 2005;5(1):3-8.
2005: Sandra Harris; G Gil; W Hu; H Robins; Elisabeth E Bond; Kim M Hirshfield; Z Feng; X Yu; A K Teresky; Gareth Bond; Arnold J Levine
Single-nucleotide polymorphisms in the p53 pathway.
Cold Spring Harbor symposia on quantitative biology 2005;70():111-9.
2005: Gabriela Alexe; Gyan Bhanot; Babu Venkataraghavan; Ram RAMASWAMY; Jorge Lepre; Arnold J Levine; Gustavo Stolovitzky
A robust meta-classification strategy for cancer diagnosis from gene expression data.
Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference 2005;():322-5.
2005: Gyan Bhanot; Gabriela Alexe; Arnold J Levine; Gustavo Stolovitzky
Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories.
Genome informatics. International Conference on Genome Informatics 2005;16(1):233-44.
2004: Gareth Bond; Wenwei Hu; Elisabeth E Bond; Harlan Robins; Stuart G Lutzker; Nicoleta C Arva; Jill Bargonetti; Frank Bartel; Helge Taubert; Peter Wuerl; Kenan Onel; Linwah Yip; Shih-Jen Hwang; Louise C Strong; Guillermina Lozano; Arnold J Levine
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Cell 2004;119(5):591-602.
2004: WenYong Chen; Timothy K Cooper; Cynthia A Zahnow; Michael Overholtzer; Zhiquan Zhao; Marc Ladanyi; Judith E Karp; Nalan Gokgoz; Jay S Wunder; Irene L Andrulis; Arnold J Levine; Joseph L Mankowski; Stephen B Baylin
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Cancer cell 2004;6(4):387-98.
2004: Joshua B Plotkin; Harlan Robins; Arnold J Levine
Tissue-specific codon usage and the expression of human genes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12588-91.
2004: Archontoula Stoffel; Arnold J Levine
Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53.
Cell cycle (Georgetown, Tex.) 2004;3(8):1017-20.
2004: Archontoula Stoffel; Mira Chaurushiya; Bhuvanesh Singh; Arnold J Levine
Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9079-84.
2004: Galit Lahav; Nitzan Rosenfeld; Alex Sigal; Naama Geva-Zatorsky; Arnold J Levine; Michael B Elowitz; Uri Alon
Dynamics of the p53-Mdm2 feedback loop in individual cells.
Nature genetics 2004;36(2):147-50.
2004: Arnold J Levine; Cathy A Finlay; Philip W Hinds
P53 is a tumor suppressor gene.
Cell 2004;116(2 Suppl):S67-9, 1 p following S69.
2003: Zhenyu Yue; Shengkan Jin; Chingwen Yang; Arnold J Levine; Nathaniel Heintz
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15077-82.
2003: Michael Overholtzer; Pulivarthi H Rao; Reyna Favis; Xin-Yan Lu; Michael B Elowitz; Francis Barany; Marc Ladanyi; Richard Gorlick; Arnold J Levine
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11547-52.
2003: Lilian Soon; Ting-An Yie; Anita Shvarts; Arnold J Levine; Fei Su; Kam-Meng Tchou-Wong
Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.
The Journal of biological chemistry 2003;278(13):11465-70.
2003: Arnold J Levine; Ignacio Munoz-Sanjuan; Esther Bell; Alison J North; Ali H Brivanlou
Fluorescent labeling of endothelial cells allows in vivo, continuous characterization of the vascular development of Xenopus laevis.
Developmental biology 2003;254(1):50-67.
2003: Shengkan Jin; Markus Kalkum; Michael Overholtzer; Archontoula Stoffel; Brian T Chait; Arnold J Levine
CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.
Genes & development 2003;17(3):359-67.
2002: Michael B Elowitz; Arnold J Levine; Eric D Siggia; Peter S Swain
Stochastic gene expression in a single cell.
Science (New York, N.Y.) 2002;297(5584):1183-6.
2002: Elena N Pugacheva; Alexander V Ivanov; Julia E Kravchenko; Boris P Kopnin; Arnold J Levine; Peter Chumakov
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Oncogene 2002;21(30):4595-600.
2002: Josephine Hoh; Shengkan Jin; T Parrado; Joanne Edington; Arnold J Levine; Jurg Ott
The p53MH algorithm and its application in detecting p53-responsive genes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8467-72.
2002: Bhuvanesh Singh; Pabbathi G Reddy; Andy Goberdhan; Christine Walsh; Su Dao; Ivan Ngai; Ting-Chao Chou; Pornchai O-Charoenrat; Arnold J Levine; Pulivarthi H Rao; Archontoula Stoffel
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.
Genes & development 2002;16(8):984-93.
2002: Fei Su; Michael Overholtzer; Daniel Besser; Arnold J Levine
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
Genes & development 2002;16(1):46-57.
2001: Shengkan Jin; Arnold J Levine
The p53 functional circuit.
Journal of cell science 2001;114(Pt 23):4139-40.
2001: Arnold J Levine
Cancer research in the 21st century.
The Keio journal of medicine 2001;50(3):129-33.
2001: W Tao; Diane Pennica; L Xu; Robert F Kalejta; Arnold J Levine
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
Genes & development 2001;15(14):1796-807.
2001: DA Notterman; Uri Alon; A J Sierk; Arnold J Levine
Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays.
Cancer research 2001;61(7):3124-30.
2001: Anna A Sablina; Peter Chumakov; Arnold J Levine; Boris P Kopnin
p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling.
Oncogene 2001;20(8):899-909.
2001: J C Venter; M D Adams; E W Myers; P W Li; R J Mural; G G Sutton; Hamilton O Smith; M Yandell; C A Evans; R A Holt; J D Gocayne; P Amanatides; R M Ballew; D H Huson; Jennifer Wortman; Q Zhang; C D Kodira; X H Zheng; L Chen; M Skupski; G. SUBRAMANIAN; P D Thomas; J Zhang; G L Gabor Miklos; C Nelson; S Broder; andrew clark; J Nadeau; Victor A McKusick; N Zinder; Arnold J Levine; Richard J Roberts; M Simon; C Slayman; M Hunkapiller; R Bolanos; A Delcher; I Dew; D Fasulo; M Flanigan; L Florea; A Halpern; S Hannenhalli; S Kravitz; S Levy; C Mobarry; K Reinert; K Remington; J Abu-Threideh; E Beasley; K Biddick; V Bonazzi; R Brandon; M Cargill; I Chandramouliswaran; R Charlab; K Chaturvedi; Z Deng; V Di Francesco; P Dunn; K Eilbeck; C Evangelista; A E Gabrielian; W Gan; W Ge; F Gong; Z Gu; P Guan; T J Heiman; M E Higgins; R R Ji; Z Ke; K A Ketchum; Z Lai; Y Lei; Z Li; J Li; Y Liang; X Lin; F Lu; G V Merkulov; N Milshina; H M Moore; A K Naik; V A Narayan; B Neelam; D Nusskern; D B Rusch; Steven L Salzberg; W Shao; B Shue; J Sun; Z Wang; A Wang; X Wang; J Wang; M Wei; R Wides; C Xiao; C Yan; A Yao; J Ye; M Zhan; W Zhang; H Zhang; Q Zhao; L Zheng; F Zhong; W Zhong; S Zhu; Shaying Zhao; D Gilbert; S Baumhueter; G Spier; C Carter; A Cravchik; T Woodage; F Ali; H An; A Awe; D Baldwin; H Baden; M Barnstead; I Barrow; K Beeson; D Busam; A Carver; A Center; M L Cheng; L Curry; S Danaher; L Davenport; R Desilets; S Dietz; K Dodson; L Doup; S Ferriera; N Garg; A Gluecksmann; B Hart; J Haynes; C Haynes; C Heiner; S Hladun; Damon Hostin; J Houck; T Howland; C Ibegwam; J Johnson; F Kalush; L Kline; S Koduru; A Love; F Mann; D May; S McCawley; T McIntosh; I McMullen; M Moy; L Moy; B Murphy; K Nelson; C Pfannkoch; E Pratts; V Puri; H Qureshi; M Reardon; R Rodriguez; Y H Rogers; D Romblad; B Ruhfel; R Scott; C Sitter; M Smallwood; E Stewart; R Strong; Edward Suh; R Thomas; N N Tint; S Tse; C Vech; Gaofeng Wang; J Wetter; S Williams; M Williams; S Windsor; E Winn-Deen; K Wolfe; J Zaveri; K Zaveri; Josep F Abril; R Guigó; M J Campbell; K V Sjolander; B Karlak; A Kejariwal; H Mi; B Lazareva; T Hatton; A Narechania; K Diemer; A Muruganujan; N Guo; S Sato; V Bafna; S Istrail; R Lippert; R Schwartz; B Walenz; S Yooseph; D Allen; A Basu; J Baxendale; L Blick; M Caminha; J Carnes-Stine; P Caulk; Y H Chiang; M Coyne; C Dahlke; A Mays; M Dombroski; M Donnelly; D Ely; S Esparham; C Fosler; H Gire; S Glanowski; K Glasser; A Glodek; M Gorokhov; K Graham; B Gropman; M Harris; J Heil; S Henderson; J Hoover; D Jennings; C Jordan; J Jordan; J Kasha; L Kagan; C Kraft; A Levitsky; M Lewis; X Liu; J Lopez; D Ma; W Majoros; J McDaniel; S Murphy; M Newman; T Nguyen; N Nguyen; M Nodell; S Pan; J Peck; M Peterson; W Rowe; R Sanders; J Scott; M Simpson; T Smith; A Sprague; T Stockwell; R Turner; E Venter; M Wang; M Wen; D Wu; M Wu; A Xia; A Zandieh; X Zhu
The sequence of the human genome.
Science (New York, N.Y.) 2001;291(5507):1304-51.
2001: Michael Berger; Ronit Vogt Sionov; Arnold J Levine; Ygal Haupt
A role for the polyproline domain of p53 in its regulation by Mdm2.
The Journal of biological chemistry 2001;276(6):3785-90.
2001: James M Pipas; Arnold J Levine
Role of T antigen interactions with p53 in tumorigenesis.
Seminars in cancer biology 2001;11(1):23-30.
2001: L T Ziemer; Diane Pennica; Arnold J Levine
Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene.
Molecular and cellular biology 2001;21(2):562-74.
2000: Bert Vogelstein; D Lane; Arnold J Levine
Surfing the p53 network.
Nature 2000;408(6810):307-10.
2000: R Lev Bar-Or; Ruth Maya; Lee Segel; Uri Alon; Arnold J Levine; Moshe Oren
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11250-5.
2000: Sabrina Strano; Eliana Munarriz; Mario Rossi; B Cristofanelli; Y Shaul; Luisa Castagnoli; Arnold J Levine; Ada Sacchi; Gianni Cesareni; Moshe Oren; Giovanni Blandino
Physical and functional interaction between p53 mutants and different isoforms of p73.
The Journal of biological chemistry 2000;275(38):29503-12.
2000: AJ Muller; AK Teresky; Arnold J Levine
A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8421-6.
2000: Shengkan Jin; S Martinek; W S Joo; Jennifer Wortman; Nebojsa Mirkovic; Andrej Sali; M D Yandell; Nikola P Pavletich; Michael W Young; Arnold J Levine
Identification and characterization of a p53 homologue in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7301-6.
2000: R Zhao; Kurt Gish; M Murphy; Y Yin; DA Notterman; W H Hoffman; Ed Tom; David H Mack; Arnold J Levine
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.
Genes & development 2000;14(8):981-93.
2000: L Xu; R B Corcoran; J W Welsh; Diane Pennica; Arnold J Levine
WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.
Genes & development 2000;14(5):585-95.
2000: Michael B A Oldstone; Arnold J Levine
Virology in the next millennium.
Cell 2000;100(1):139-42.
2000: R Zhao; Kurt Gish; M Murphy; Y Yin; DA Notterman; W H Hoffman; Ed Tom; David H Mack; Arnold J Levine
The transcriptional program following p53 activation.
Cold Spring Harbor symposia on quantitative biology 2000;65():475-82.
1999: A E Casau; J E Vaughan; G Lozano; Arnold J Levine
Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.
Journal of virology 1999;73(12):9976-83.
1999: J Ahn; Maureen Murphy; S Kratowicz; A Wang; Arnold J Levine; Donna L George
Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.
Oncogene 1999;18(43):5954-8.
1999: Maureen Murphy; J Ahn; K K Walker; William H Hoffman; R M Evans; Arnold J Levine; Donna L George
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
Genes & development 1999;13(19):2490-501.
1999: AJ Muller; K B Heiden; AK Teresky; Arnold J Levine
Genetic mapping of the embryonal carcinoma transplantation resistance locus Gt(B6) to mouse Chromosome 8.
Immunogenetics 1999;49(11-12):949-56.
1999: C C Zhang; Jin-Ming Yang; Judy Bash-Babula; Eileen White; M Murphy; Arnold J Levine; William N Hait
DNA damage increases sensitivity to vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4.
Cancer research 1999;59(15):3663-70.
1999: Todd D Schell; Lawrence M Mylin; I Georgoff; A K Teresky; Arnold J Levine; Satvir S Tevethia
Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice.
Journal of virology 1999;73(7):5981-93.
1999: W Tao; Arnold J Levine
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6937-41.
1999: Uri Alon; Naama Barkai; DA Notterman; Kurt Gish; S Ybarra; D Mack; Arnold J Levine
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6745-50.
1999: W Tao; Arnold J Levine
Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3077-80.
1999: Michael H G Kubbutat; Robert L Ludwig; Arnold J Levine; Karen H Vousden
Analysis of the degradation function of Mdm2.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(2):87-92.
1999: Giovanni Blandino; Arnold J Levine; Moshe Oren
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy.
Oncogene 1999;18(2):477-85.
1999: DA Freedman; L Wu; Arnold J Levine
Functions of the MDM2 oncoprotein.
Cellular and molecular life sciences : CMLS 1999;55(1):96-107.
1999: DA Freedman; Arnold J Levine
Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.
Cancer research 1999;59(1):1-7.
1998: Diane Pennica; T A Swanson; J W Welsh; M A Roy; David A Lawrence; Asuka Morimoto; J Brush; Lisa Anne Taneyhill; B Deuel; M Lew; C Watanabe; R L Cohen; M F Melhem; G G Finley; Philip Quirke; Audrey D Goddard; Kenneth J Hillan; Austin Gurney; D Botstein; Arnold J Levine
WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14717-22.
1998: Z Lai; DA Freedman; Arnold J Levine; George L McLendon
Metal and RNA binding properties of the hdm2 RING finger domain.
Biochemistry 1998;37(48):17005-15.
1998: Z Lai; DA Freedman; Arnold J Levine; George L McLendon
Metal and RNA binding properties of the hdm2 RING finger domain.
Biochemistry 1998;37(48):7005-15.
1998: DA Freedman; Arnold J Levine
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6.
Molecular and cellular biology 1998;18(12):7288-93.
1998: DA Notterman; S Young; B Wainger; Arnold J Levine
Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity.
Oncogene 1998;17(21):2743-51.
1998: Matthias Theobald; Thomas Ruppert; Ulrike Kuckelkorn; J Hernandez; A Häussler; Edite Antunes Ferreira; Ulrike Liewer; Judith A Biggs; Arnold J Levine; Christoph Huber; Ulrich H Koszinowski; Peter-M Kloetzel; Linda A Sherman
The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope.
The Journal of experimental medicine 1998;188(6):1017-28.
1998: AJ Muller; S Chatterjee; AK Teresky; Arnold J Levine
The gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine chromosome 1.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(9):773-4.
1998: X Zeng; Arnold J Levine; Hua lu
Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6681-6.
1998: H Lu; Y Taya; M Ikeda; Arnold J Levine
Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6399-402.
1998: Charles Epstein; E F Attiyeh; D A Hobson; A L Silver; James R Broach; Arnold J Levine
p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors.
Oncogene 1998;16(16):2115-22.
1998: C C Zhang; Jin-Ming Yang; Eileen White; M Murphy; Arnold J Levine; William N Hait
The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.
Oncogene 1998;16(12):1617-24.
1998: J Roth; M Dobbelstein; DA Freedman; Thomas Shenk; Arnold J Levine
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
The EMBO journal 1998;17(2):554-64.
1998: L C Bullions; Arnold J Levine
The role of beta-catenin in cell adhesion, signal transduction, and cancer.
Current opinion in oncology 1998;10(1):81-7.
1997: H Lu; Robert P Fisher; P Bailey; Arnold J Levine
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro.
Molecular and cellular biology 1997;17(10):5923-34.
1997: L Chen; Vincent Marechal; J Moreau; Arnold J Levine; Jiandong Chen
Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.
The Journal of biological chemistry 1997;272(36):22966-73.
1997: L C Bullions; DA Notterman; L S Chung; Arnold J Levine
Expression of wild-type alpha-catenin protein in cells with a mutant alpha-catenin gene restores both growth regulation and tumor suppressor activities.
Molecular and cellular biology 1997;17(8):4501-8.
1997: M Dobbelstein; J Roth; W T Kimberly; Arnold J Levine; Thomas Shenk
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence.
The EMBO journal 1997;16(14):4276-84.
1997: L Wu; Arnold J Levine
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.
Molecular medicine (Cambridge, Mass.) 1997;3(7):441-51.
1997: EM Ruaro; Licio Collavin; Giannino Del Sal; R Haffner; M Oren; Arnold J Levine; Claudio Schneider
A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4675-80.
1997: DA Freedman; Charles Epstein; J C Roth; Arnold J Levine
A genetic approach to mapping the p53 binding site in the MDM2 protein.
Molecular medicine (Cambridge, Mass.) 1997;3(4):248-59.
1997: Vincent Marechal; B Elenbaas; Lisa Anne Taneyhill; J Piette; M Mechali; Jean-Claude Nicolas; Arnold J Levine; J Moreau
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.
Oncogene 1997;14(12):1427-33.
1997: Arnold J Levine
p53, the cellular gatekeeper for growth and division.
Cell 1997;88(3):323-31.
1997: James R Broach; Arnold J Levine
Oncogenes and cell proliferation.
Current opinion in genetics & development 1997;7(1):1-6.
1997: S Hayashi; Bonnee Rubinfeld; B Souza; Paul Polakis; Eric Wieschaus; Arnold J Levine
A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):242-7.
1996: K K Walker; Arnold J Levine
Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15335-40.
1996: M Murphy; A Hinman; Arnold J Levine
Wild-type p53 negatively regulates the expression of a microtubule-associated protein.
Genes & development 1996;10(23):2971-80.
1996: P H Kussie; S Gorina; Vincent Marechal; B Elenbaas; J Moreau; Arnold J Levine; Nikola P Pavletich
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science (New York, N.Y.) 1996;274(5289):948-53.
1996: B Elenbaas; M Dobbelstein; J Roth; Thomas Shenk; Arnold J Levine
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain.
Molecular medicine (Cambridge, Mass.) 1996;2(4):439-51.
1996: Stuart G Lutzker; Arnold J Levine
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation.
Nature medicine 1996;2(7):804-10.
1996: Joanna Beatrice Wilson; J L Bell; Arnold J Levine
Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice.
The EMBO journal 1996;15(12):3117-26.
1996: J Roth; D Dittmer; D Rea; J Tartaglia; E Paoletti; Arnold J Levine
p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4781-6.
1996: Jiandong Chen; X Wu; J Lin; Arnold J Levine
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.
Molecular and cellular biology 1996;16(5):2445-52.
1996: J Lin; C Reichner; X Wu; Arnold J Levine
Analysis of wild-type and mutant p21WAF-1 gene activities.
Molecular and cellular biology 1996;16(4):1786-93.
1996: Giannino Del Sal; M Murphy; E Ruaro; D Lazarevic; Arnold J Levine; Claudio Schneider
Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.
Oncogene 1996;12(1):177-85.
1996: Stuart G Lutzker; Arnold J Levine
Apoptosis and cancer chemotherapy.
Cancer treatment and research 1996;87():345-56.
1995: Matthias Theobald; Judith A Biggs; D Dittmer; Arnold J Levine; Linda A Sherman
Targeting p53 as a general tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):11993-7.
1995: Giannino Del Sal; E M Ruaro; R Utrera; C N Cole; Arnold J Levine; Claudio Schneider
Gas1-induced growth suppression requires a transactivation-independent p53 function.
Molecular and cellular biology 1995;15(12):7152-60.
1995: Arnold J Levine; M C Wu; A Chang; A Silver; E F Attiyeh; J Lin; Charles Epstein
The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype.
Annals of the New York Academy of Sciences 1995;768():111-28.
1995: P Sabbatini; J Lin; Arnold J Levine; Eileen White
Essential role for p53-mediated transcription in E1A-induced apoptosis.
Genes & development 1995;9(17):2184-92.
1995: Roger J A Grand; Philip Lecane; D Owen; M L Grant; Sally Roberts; Arnold J Levine; Phillip H Gallimore
The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.
Virology 1995;210(2):323-34.
1995: Z X Xiao; Jiandong Chen; Arnold J Levine; N Modjtahedi; J Xing; William R Sellers; David M Livingston
Interaction between the retinoblastoma protein and the oncoprotein MDM2.
Nature 1995;375(6533):694-8.
1995: J Lin; A K Teresky; Arnold J Levine
Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.
Oncogene 1995;10(12):2387-90.
1995: Wendy C Weinberg; Christopher G Azzoli; K Chapman; Arnold J Levine; Stuart H Yuspa
p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein.
Oncogene 1995;10(12):2271-9.
1995: J H Bayle; B Elenbaas; Arnold J Levine
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5729-33.
1995: H Lu; Arnold J Levine
Human TAFII31 protein is a transcriptional coactivator of the p53 protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5154-8.
1995: G Riou; Michel BARROIS; sandrine prost; M J Terrier; Christine Theodore; Arnold J Levine
The p53 and mdm-2 genes in human testicular germ-cell tumors.
Molecular carcinogenesis 1995;12(3):124-31.
1995: Jiandong Chen; J Lin; Arnold J Levine
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene.
Molecular medicine (Cambridge, Mass.) 1995;1(2):142-52.
1995: Nobuo Horikoshi; A Usheva; Jiandong Chen; Arnold J Levine; roberto weinmann; Thomas Shenk
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.
Molecular and cellular biology 1995;15(1):227-34.
1995: L Wu; J H Bayle; B Elenbaas; Nikola P Pavletich; Arnold J Levine
Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids.
Molecular and cellular biology 1995;15(1):497-504.
1994: Vincent Marechal; B Elenbaas; J Piette; Jean-Claude Nicolas; Arnold J Levine
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.
Molecular and cellular biology 1994;14(11):7414-20.
1994: M E Perry; Arnold J Levine
P53 and mdm-2: interactions between tumor suppressor gene and oncogene products.
The Mount Sinai journal of medicine, New York 1994;61(4):291-9.
1994: Arnold J Levine; A Chang; D Dittmer; DA Notterman; A Silver; K Thorn; D Welsh; M Wu
The p53 tumor suppressor gene.
The Journal of laboratory and clinical medicine 1994;123(6):817-23.
1994: J Lin; Jiandong Chen; B Elenbaas; Arnold J Levine
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
Genes & development 1994;8(10):1235-46.
1994: X Wu; Arnold J Levine
p53 and E2F-1 cooperate to mediate apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3602-6.
1994: Arnold J Levine
The road to the discovery of the p53 protein. The Steiner Cancer Prize Award Lecture.
International journal of cancer. Journal international du cancer 1994;56(6):775-6.
1994: Arnold J Levine; M E Perry; A Chang; A Silver; D Dittmer; M Wu; D Welsh
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.
British journal of cancer 1994;69(3):409-16.
1994: R S Quartin; C N Cole; J M Pipas; Arnold J Levine
The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
Journal of virology 1994;68(3):1334-41.
1994: Carlos Cordon-Cardo; E Latres; Marija Drobnjak; M R Oliva; D Pollack; James M Woodruff; Vincent Marechal; Jiandong Chen; Murray F Brennan; Arnold J Levine
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.
Cancer research 1994;54(3):794-9.
1994: H Lu; J Lin; Jiandong Chen; Arnold J Levine
The regulation of p53-mediated transcription and the roles of hTAFII31 and mdm-2.
Harvey lectures 1994;90():81-93.
1994: D C Olson; Arnold J Levine
The properties of p53 proteins selected for the loss of suppression of transformation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(1):61-71.
1994: Arnold J Levine
The origins of the small DNA tumor viruses.
Advances in cancer research 1994;65():141-68.
1994: J Lin; X Wu; Jiandong Chen; A Chang; Arnold J Levine
Functions of the p53 protein in growth regulation and tumor suppression.
Cold Spring Harbor symposia on quantitative biology 1994;59():215-23.
1993: M E Perry; J Piette; J A Zawadzki; D Harvey; Arnold J Levine
The mdm-2 gene is induced in response to UV light in a p53-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11623-7.
1993: G Riou; Monique G Lê; Jean-Paul Travagli; Arnold J Levine; Ute M Moll
Poor prognosis of p53 gene mutation and nuclear overexpression of p53 protein in inflammatory breast carcinoma.
Journal of the National Cancer Institute 1993;85(21):1765-7.
1993: Varda Rotter; D Schwartz; E Almon; Naomi Goldfinger; A Kapon; A Meshorer; L A Donehower; Arnold J Levine
Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9075-9.
1993: D C Olson; V Marechal; Jamil Momand; Jiandong Chen; C Romocki; Arnold J Levine
Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.
Oncogene 1993;8(9):2353-60.
1993: G P Zambetti; Arnold J Levine
A comparison of the biological activities of wild-type and mutant p53.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(10):855-65.
1993: X Wu; J H Bayle; D Olson; Arnold J Levine
The p53-mdm-2 autoregulatory feedback loop.
Genes & development 1993;7(7A):1126-32.
1993: Jiandong Chen; V Marechal; Arnold J Levine
Mapping of the p53 and mdm-2 interaction domains.
Molecular and cellular biology 1993;13(7):4107-14.
1993: D Dittmer; S Pati; G Zambetti; S Chu; A K Teresky; M Moore; C Finlay; Arnold J Levine
Gain of function mutations in p53.
Nature genetics 1993;4(1):42-6.
1993: Arnold J Levine
11th Ernst Klenk Lecture. The p53 tumor suppressor gene and product.
Biological chemistry Hoppe-Seyler 1993;374(4):227-35.
1993: E Almon; Naomi Goldfinger; A Kapon; D Schwartz; Arnold J Levine; Varda Rotter
Testicular tissue-specific expression of the p53 suppressor gene.
Developmental biology 1993;156(1):107-16.
1993: Arnold J Levine
Normal and neoplastic growth and development. AACR special conference in cancer research.
Cancer research 1993;53(4):929-30.
1993: Joanna Beatrice Wilson; M W Ferguson; N A Jenkins; L F Lock; N G Copeland; Arnold J Levine
Transgenic mouse model of X-linked cleft palate.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(2):67-76.
1993: M E Perry; Arnold J Levine
Tumor-suppressor p53 and the cell cycle.
Current opinion in genetics & development 1993;3(1):50-4.
1993: Arnold J Levine
The tumor suppressor genes.
Annual review of biochemistry 1993;62():623-51.
1993: R S Quartin; Arnold J Levine
A comparison of the properties of human p53 mutant alleles.
Advances in experimental medicine and biology 1993;330():55-65.
1992: E Seto; A Usheva; G P Zambetti; Jamil Momand; Nobuo Horikoshi; roberto weinmann; Arnold J Levine; Thomas Shenk
Wild-type p53 binds to the TATA-binding protein and represses transcription.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12028-32.
1992: Satvir S Tevethia; M Epler; I Georgoff; A Teresky; M Marlow; Arnold J Levine
Antibody response to human papovavirus JC (JCV) and simian virus 40 (SV40) T antigens in SV40 T antigen-transgenic mice.
Virology 1992;190(1):459-64.
1992: A Lustig; Arnold J Levine
One hundred years of virology.
Journal of virology 1992;66(8):4629-31.
1992: Ute M Moll; G Riou; Arnold J Levine
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7262-6.
1992: G P Zambetti; J Bargonetti; K Walker; Carol Prives; Arnold J Levine
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.
Genes & development 1992;6(7):1143-52.
1992: Jamil Momand; G P Zambetti; D C Olson; D George; Arnold J Levine
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.
Cell 1992;69(7):1237-45.
1992: Arnold J Levine
The p53 tumor-suppressor gene.
The New England journal of medicine 1992;326(20):1350-2.
1992: G P Zambetti; D Olson; M Labow; Arnold J Levine
A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3952-6.
1992: M Moore; A K Teresky; Arnold J Levine; M Seiberg
p53 mutations are not selected for in simian virus 40 T-antigen-induced tumors from transgenic mice.
Journal of virology 1992;66(2):641-9.
1992: Arnold J Levine
The p53 tumour suppressor gene and product.
Cancer surveys 1992;12():59-79.
1992: Joanna Beatrice Wilson; Arnold J Levine
The oncogenic potential of Epstein-Barr virus nuclear antigen 1 in transgenic mice.
Current topics in microbiology and immunology 1992;182():375-84.
1991: D M Harvey; Arnold J Levine
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.
Genes & development 1991;5(12B):2375-85.
1991: G Shaulsky; Naomi Goldfinger; M S Tosky; Arnold J Levine; Varda Rotter
Nuclear localization is essential for the activity of p53 protein.
Oncogene 1991;6(11):2055-65.
1991: T Chittenden; A Frey; Arnold J Levine
Regulated replication of an episomal simian virus 40 origin plasmid in COS7 cells.
Journal of virology 1991;65(11):5944-51.
1991: E A Montalvo; Yigong Shi; Thomas Shenk; Arnold J Levine
Negative regulation of the BZLF1 promoter of Epstein-Barr virus.
Journal of virology 1991;65(7):3647-55.
1991: S B Baim; M A Labow; Arnold J Levine; Thomas Shenk
A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5072-6.
1991: Arnold J Levine; Jamil Momand; C A Finlay
The p53 tumour suppressor gene.
Nature 1991;351(6326):453-6.
1991: Peter M Howley; Arnold J Levine; F P Li; David M Livingston; A S Rabson
Lack of SV40 DNA in tumors from scientists working with SV40 virus.
The New England journal of medicine 1991;324(7):494.
1991: J Martinez; I Georgoff; J Martinez; Arnold J Levine
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.
Genes & development 1991;5(2):151-9.
1991: G Lozano; Arnold J Levine
Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences.
Molecular carcinogenesis 1991;4(1):3-9.
1991: Scott E Kern; Kenneth W Kinzler; S J Baker; J M Nigro; V Rotter; Arnold J Levine; P Friedman; C Prives; Bert Vogelstein
Mutant p53 proteins bind DNA abnormally in vitro.
Oncogene 1991;6(1):131-6.
1991: S J Oh; T Chittenden; Arnold J Levine
Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication.
Journal of virology 1991;65(1):514-9.
1991: G P Zambetti; R S Quartin; J Martinez; I Georgoff; Jamil Momand; D Dittmer; C A Finlay; Arnold J Levine
Regulation of transformation and the cell cycle by p53.
Cold Spring Harbor symposia on quantitative biology 1991;56():219-25.
1990: Martin Scheffner; B A Werness; Jon M Huibregtse; Arnold J Levine; Peter M Howley
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.
Cell 1990;63(6):1129-36.
1990: Philip W Hinds; C A Finlay; R S Quartin; S J Baker; Eric R Fearon; Bert Vogelstein; Arnold J Levine
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(12):571-80.
1990: Arnold J Levine
The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses.
Virology 1990;177(2):419-26.
1990: M A Labow; S B Baim; Thomas Shenk; Arnold J Levine
Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells.
Molecular and cellular biology 1990;10(7):3343-56.
1990: Joanna Beatrice Wilson; W Weinberg; R Johnson; S Yuspa; Arnold J Levine
Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6.
Cell 1990;61(7):1315-27.
1990: Arnold J Levine; Jamil Momand
Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products.
Biochimica et biophysica acta 1990;1032(1):119-36.
1990: B A Werness; Arnold J Levine; Peter M Howley
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
Science (New York, N.Y.) 1990;248(4951):76-9.
1990: Arnold J Levine
Tumor suppressor genes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1990;12(2):60-6.
1989: A B Frey; Arnold J Levine
p53-plus-ras-transformed rat embryo fibroblasts express tumor-specific transplantation antigen activity which is shared by independently transformed cells.
Journal of virology 1989;63(12):5440-4.
1989: M Seiberg; Y Aloni; Arnold J Levine
Comparison of human and monkey cells for the ability to attenuate transcripts that begin at the adenovirus major late promoter.
Journal of virology 1989;63(9):4093-6.
1989: H J Cho; M Seiberg; I Georgoff; A K Teresky; J R Marks; Arnold J Levine
Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.
Journal of neuroscience research 1989;24(1):115-22.
1989: T Chittenden; S Lupton; Arnold J Levine
Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication.
Journal of virology 1989;63(7):3016-25.
1989: C A Finlay; Philip W Hinds; Arnold J Levine
The p53 proto-oncogene can act as a suppressor of transformation.
Cell 1989;57(7):1083-93.
1989: M Seiberg; Y Aloni; Arnold J Levine
The adenovirus type 2 DNA-binding protein interacts with the major late promoter attenuated RNA.
Journal of virology 1989;63(3):1134-41.
1989: J R Marks; J Lin; Philip W Hinds; D Miller; Arnold J Levine
Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
Journal of virology 1989;63(2):790-7.
1989: Philip W Hinds; C Finlay; Arnold J Levine
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.
Journal of virology 1989;63(2):739-46.
1989: K M Wong; Arnold J Levine
Characterization of proteins encoded by the Epstein-Barr virus transactivator gene BMLF1.
Virology 1989;168(1):101-11.
1989: Arnold J Levine
The p53 tumor suppressor gene and gene product.
Princess Takamatsu symposia 1989;20():221-30.
1988: C F Clarke; K Cheng; A B Frey; R Stein; Philip W Hinds; Arnold J Levine
Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.
Molecular and cellular biology 1988;8(3):1206-15.
1988: Arnold J Levine
Oncogenes of DNA tumor viruses.
Cancer research 1988;48(3):493-6.
1988: C A Finlay; Philip W Hinds; T H Tan; D Eliyahu; M Oren; Arnold J Levine
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.
Molecular and cellular biology 1988;8(2):531-9.
1988: J Marks; J Lin; D Miller; G Lozano; J Herbert; Arnold J Levine
The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice.
Progress in clinical and biological research 1988;284():163-86.
1987: M Seiberg; M Kessler; Arnold J Levine; Y Aloni
Human RNA polymerase II can prematurely terminate transcription of the adenovirus type 2 late transcription unit at a precise site that resembles a prokaryotic termination signal.
Virus genes 1987;1(1):97-116.
1987: Philip W Hinds; C A Finlay; A B Frey; Arnold J Levine
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.
Molecular and cellular biology 1987;7(8):2863-9.
1987: Arnold J Levine
Virus vector-mediated gene transfer.
Microbiological sciences 1987;4(8):245-50.
1987: H Lübbert; B J Hoffman; Terrance Snutch; Terry Van Dyke; Arnold J Levine; P R Hartig; H A Lester; N Davidson
cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4332-6.
1987: Terry Van Dyke; C Finlay; D Miller; J Marks; G Lozano; Arnold J Levine
Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice.
Journal of virology 1987;61(6):2029-32.
1986: P Ostapchuk; J F Diffley; J T Bruder; B Stillman; Arnold J Levine; Patrick Hearing
Interaction of a nuclear factor with the polyomavirus enhancer region.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8550-4.
1986: K A Yagaloff; G Lozano; Terry Van Dyke; Arnold J Levine; P R Hartig
Serotonin 5-HT1C receptors are expressed at high density on choroid plexus tumors from transgenic mice.
Brain research 1986;385(2):389-94.
1986: K M Wong; Arnold J Levine
Identification and mapping of Epstein-Barr virus early antigens and demonstration of a viral gene activator that functions in trans.
Journal of virology 1986;60(1):149-56.
1986: T H Tan; J Wallis; Arnold J Levine
Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex.
Journal of virology 1986;59(3):574-83.
1985: S Lupton; Arnold J Levine
Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.
Molecular and cellular biology 1985;5(10):2533-42.
1985: J C Hearing; Arnold J Levine
The Epstein-Barr virus nuclear antigen (BamHI K antigen) is a single-stranded DNA binding phosphoprotein.
Virology 1985;145(1):105-16.
1985: J C Hearing; A Lewis; Arnold J Levine
Structure of the Epstein-Barr virus nuclear antigen as probed with monoclonal antibodies.
Virology 1985;142(1):215-20.
1985: Terry Van Dyke; C Finlay; Arnold J Levine
A comparison of several lines of transgenic mice containing the SV40 early genes.
Cold Spring Harbor symposia on quantitative biology 1985;50():671-8.
1984: J C Hearing; J C Nicolas; Arnold J Levine
Identification of Epstein-Barr virus sequences that encode a nuclear antigen expressed in latently infected lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4373-7.
1984: R L Brinster; H Y Chen; A Messing; Terry Van Dyke; Arnold J Levine; R D Palmiter
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors.
Cell 1984;37(2):367-79.
1984: D Pennica; D V Goeddel; J S Hayflick; N C Reich; C W Anderson; Arnold J Levine
The amino acid sequence of murine p53 determined from a c-DNA clone.
Virology 1984;134(2):477-82.
1984: B Nowak; A Gmeiner; P Sarnow; Arnold J Levine; Bernhard Fleckenstein
Physical mapping of human cytomegalovirus genes: identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide.
Virology 1984;134(1):91-102.
1984: N C Reich; Arnold J Levine
Growth regulation of a cellular tumour antigen, p53, in nontransformed cells.
Nature 1984;308(5955):199-201.
1984: P Sarnow; P Hearing; C W Anderson; D N Halbert; Thomas Shenk; Arnold J Levine
Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells.
Journal of virology 1984;49(3):692-700.
1984: B Nowak; C Sullivan; P Sarnow; R Thomas; F Bricout; J C Nicolas; Bernhard Fleckenstein; Arnold J Levine
Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins.
Virology 1984;132(2):325-38.
1983: R Thomas; L Kaplan; N Reich; D P Lane; Arnold J Levine
Characterization of human p53 antigens employing primate specific monoclonal antibodies.
Virology 1983;131(2):502-17.
1983: N C Reich; M Oren; Arnold J Levine
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.
Molecular and cellular biology 1983;3(12):2143-50.
1983: N C Reich; P Sarnow; E Duprey; Arnold J Levine
Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein.
Virology 1983;128(2):480-4.
1983: J C Nicolas; P Sarnow; M Girard; Arnold J Levine
Host range temperature-conditional mutants in the adenovirus DNA binding protein are defective in the assembly of infectious virus.
Virology 1983;126(1):228-39.
1983: J C Nicolas; C S Young; F Suarez; M Girard; Arnold J Levine
Detection, rescue, and mapping of mutations in the adenovirus DNA binding protein gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(6):1674-7.
1983: Arnold J Levine; N Reich; R Thomas
The regulation of a cellular protein, p53, in normal and transformed cells.
Progress in clinical and biological research 1983;119():159-69.
1983: M Oren; Arnold J Levine
Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(1):56-9.
1982: P Sarnow; P Hearing; C W Anderson; N Reich; Arnold J Levine
Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix.
Journal of molecular biology 1982;162(3):565-83.
1982: R Robinson; T Schutzbank; M Oren; Arnold J Levine
Regulation of the levels of cellular transcripts by SV40 large T antigen.
Annals of the New York Academy of Sciences 1982;397():221-8.
1982: J C Nicolas; D Ingrand; P Sarnow; Arnold J Levine
A mutation in the adenovirus type 5 DNA binding protein that fails to autoregulate the production of the DNA binding protein.
Virology 1982;122(2):481-5.
1982: T Schutzbank; R Robinson; M Oren; Arnold J Levine
SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion.
Cell 1982;30(2):481-90.
1982: P Sarnow; C A Sullivan; Arnold J Levine
A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells.
Virology 1982;120(2):510-7.
1982: M Oren; N C Reich; Arnold J Levine
Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny.
Molecular and cellular biology 1982;2(4):443-9.
1982: N C Reich; Arnold J Levine
Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA.
Virology 1982;117(1):286-90.
1982: P Sarnow; Y S Ho; J Williams; Arnold J Levine
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.
Cell 1982;28(2):387-94.
1982: Arnold J Levine; Murray F Brennan; A Ramu; Richard I Fisher; P A Pizzo; D L Glaubiger
Controlled clinical trials of nutritional intervention as an adjunct to chemotherapy, with a comment on nutrition and drug resistance.
Cancer research 1982;42(2 Suppl):774s-781s.
1982: Arnold J Levine
The nature of the host range restriction of SV40 and polyoma viruses in embryonal carcinoma cells.
Current topics in microbiology and immunology 1982;101():1-30.
1982: Arnold J Levine
Transformation-associated tumor antigens.
Advances in cancer research 1982;37():75-109.
1982: T Schutzbank; Arnold J Levine
Cells transformed by a wide variety of agents express higher abundance levels of some cellular RNA species.
Journal of cellular biochemistry 1982;19(3):259-65.
1981: J Logan; J C Nicolas; W C Topp; M Girard; Thomas Shenk; Arnold J Levine
Transformation by adenovirus early region 2A temperature-sensitive mutants and their revertants.
Virology 1981;115(2):419-22.
1981: J C Nicolas; Arnold J Levine
Multiplicity-dependent host range restriction of human adenovirus in human embryonal carcinoma cells.
Virology 1981;113(2):787-9.
1981: M Oren; Arnold J Levine
Immunoselection of simian virus 40 large T antigen messenger rnas from transformed cells.
Virology 1981;113(2):790-3.
1981: W Maltzman; M Oren; Arnold J Levine
The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells.
Virology 1981;112(1):145-56.
1981: J P Rabek; V A Zakian; Arnold J Levine
The SV40 A gene product suppresses the adenovirus H5ts125 defect in DNA replication.
Virology 1981;109(2):290-302.
1981: K Sekikawa; Arnold J Levine
Isolation and characterization of polyoma host range mutants that replicate in nullipotential embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):1100-4.
1981: M Oren; W Maltzman; Arnold J Levine
Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.
Molecular and cellular biology 1981;1(2):101-10.
1981: J C Nicolas; F Suarez; Arnold J Levine; M Girard
Temperature-independent revertants of adenovirus H5ts125 and H5ts107 mutants in the DNA binding protein: isolation of a new class of host range temperature conditional revertants.
Virology 1981;108(2):521-4.
1980: E A Garber; M M Seidman; Arnold J Levine
Intracellular SV40 nucleoprotein complexes: synthesis to encapsidation.
Virology 1980;107(2):389-401.
1980: H R Axelrod; Arnold J Levine
Expression of SV40 tumor antigen in SV40 transformed teratocarcinoma-derived cell lines.
Journal of cellular physiology 1980;104(2):249-52.
1980: S R Ross; Arnold J Levine; R S Galos; J Williams; Thomas Shenk
Early viral proteins in HeLa cells infected with adenovirus type 5 host range mutants.
Virology 1980;103(2):475-92.
1980: H Ariga; H Klein; Arnold J Levine; M S Horwitz
A cleavage product of the adenovirus DNA binding protein is active in DNA replication in vitro.
Virology 1980;101(1):307-10.
1980: S R Ross; S J Flint; Arnold J Levine
Identification of the adenovirus early proteins and their genomic map positions.
Virology 1980;100(2):419-32.
1980: R F Balint; D I Linzer; G Khoury; Arnold J Levine
The expression of SV40 large T-antigen in embryonal carcinoma--SV40 transformed somatic cell hybrids.
Virology 1980;100(2):492-4.
1980: D I Linzer; W Maltzman; Arnold J Levine
Characterization of a murine cellular SV40 T antigen in SV40-transformed cells and uninfected embryonal carcinoma cells.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 1,():215-24.
1979: S Ross; Arnold J Levine
The genomic map position of the adenovirus type 2 glycoprotein.
Virology 1979;99(2):427-30.
1979: D I Linzer; W Maltzman; Arnold J Levine
The SV40 A gene product is required for the production of a 54,000 MW cellular tumor antigen.
Virology 1979;98(2):308-18.
1979: M M Seidman; Arnold J Levine; H Weintraub
The asymmetric segregation of parental nucleosomes during chrosome replication.
Cell 1979;18(2):439-49.
1979: S Segal; Arnold J Levine; G Khoury
Evidence for non-spliced SV40 RNA in undifferentiated murine teratocarcinoma stem cells.
Nature 1979;280(5720):335-8.
1979: D I Linzer; Arnold J Levine
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.
Cell 1979;17(1):43-52.
1979: M Seidman; E Garber; Arnold J Levine
Parameters affecting the stability of SV40 virions during the extraction of nucleoprotein complexes.
Virology 1979;95(1):256-9.
1979: W Maltzman; D I Linzer; F Brown; A K Teresky; M Rosenstraus; Arnold J Levine
Permanent teratocarcinoma-derived cell lines stabilized by transformation with SV40 and SV40tsA mutant viruses.
International review of cytology. Supplement 1979;(10):173-89.
1978: E A Garber; M M Seidman; Arnold J Levine
The detection and characterization of multiple forms of SV40 nucleoprotein complexes.
Virology 1978;90(2):305-16.
1978: Arnold J Levine
Approaches to mapping the temporal events in the cell cycle using conditional lethal mutants.
Journal of cellular physiology 1978;95(3):387-92.
1978: E Postel; H Klein; Arnold J Levine
The fidelity of phosphorylation of the adenovirus DNA-binding protein by an in vitro nuclear protein kinase from virus-infected cells.
Virology 1978;86(1):291-4.
1977: W Topp; J D Hall; D Rifkin; Arnold J Levine; R Pollack
The characterization of SV40-transformed cell lines derived from mouse teratocarcinoma: growth properties and differentiated characteristics.
Journal of cellular physiology 1977;93(2):269-76.
1977: A D Levinson; Arnold J Levine
The group C adenovirus tumor antigens: identification in infected and transformed cells and a peptide map analysis.
Cell 1977;11(4):871-9.
1977: A D Levinson; E H Postel; Arnold J Levine
In vivo and in vitro phosphorylation of the adenovirus type 5 single strand-specific DNA-binding protein.
Virology 1977;79(1):144-59.
1977: A Levinson; Arnold J Levine
The isolation and identification of the adenovirus group C tumor antigens.
Virology 1977;76(1):1-11.
1976: Arnold J Levine
Summation: molecular mechanisms of gene regulation--session 1.
Cancer research 1976;36(11 Pt. 2):4295-6.
1976: W Topp; J D Hall; M Marsden; A K Teresky; D Rifkin; Arnold J Levine; R Pollack
In vitro differentiation of teratomas and the distribution of creatine phosphokinase and plasminogen activator in teratocarcinoma-derived cells.
Cancer research 1976;36(11 Pt. 2):4217-23.
1976: Arnold J Levine
SV40 and adenovirus early functions involved in DNA replication and transformation.
Biochimica et biophysica acta 1976;458(3):213-41.
1976: E H Postel; Arnold J Levine
The requirement of simian virus 40 gene A product for the stimulation of cellular thymidine kinase activity after viral infection.
Virology 1976;73(1):206-15.
1976: Arnold J Levine; P C van der Vliet; B Rosenwirth; C Anderson; J Rabek; A Levinson; S Anderson
Characterization of an adenovirus early protein required for viral DNA replication: a single strand specific DNA binding proteins.
Molecular and cellular biochemistry 1976;11(2):79-95.
1976: A Levinson; Arnold J Levine; S Anderson; M Osborn; B Rosenwirth; K Weber
The relationship between group C adenovirus tumor antigen and the adenovirus single-strand DNA-binding protein.
Cell 1976;7(4):575-84.
1976: B Rosenwirth; C Anderson; Arnold J Levine
Tryptic fingerprint analysis of adenovirus types 2, 5 and 12 DNA-Binding proteins.
Virology 1976;69(2):617-25.
1976: K Shiroki; H Shimojo; Arnold J Levine; K Sekikawa; J Rabek
Suppression of the temperature-sensitive character of adenovirus 12 early mutants in monkey cells transformed by an adenovirus 7-simian virus 40 hybrid.
Virology 1976;69(2):431-7.
1976: Arnold J Levine; P C van der Vliet; J S Sussenbach
The replication of papovavirus and adenovirus DNA.
Current topics in microbiology and immunology 1976;73():67-124.
1975: P J Laipis; A Sen; Arnold J Levine; C Mulder
DNA replication in SV40 infected cells X. The structure of the 16 S gap circle intermediate in SV40 DNA synthesis.
Virology 1975;68(1):115-23.
1975: B Rosenwirth; K Shiroki; Arnold J Levine; H Shimojo
Isolation and characterization of adenovirus type 12 DNA binding proteins.
Virology 1975;67(1):14-23.
1975: P C Van Der Vliet; Arnold J Levine; M J Ensinger; H S Ginsberg
Thermolabile DNA binding proteins from cells infected with a temperature-sensitive mutant of adenovrius defective in viral DNA synthesis.
Journal of virology 1975;15(2):348-54.
1975: E H Postel; Arnold J Levine
Studies on the regulation of deoxypyrimidine kinases in normal, SV40-transformed and SV40- and adenovirus-infected mouse cells in culture.
Virology 1975;63(2):404-20.
1975: A Sen; P J Laipis; Arnold J Levine
DNA replication in SV40-infected cells. XI. The properties of SV40 DNA and nucleoprotein complex synthesized in the presence of cycloheximide.
Intervirology 1975;5(3-4):122-36.
1975: Arnold J Levine; P C Van Der Vliet; B Rosenwirth; J Rabek; G Frenkel; M Ensinger
Adenovirus-infected, cell-specific, DNA-binding proteins.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():559-66.
1974: A K Teresky; M Marsden; E L Kuff; Arnold J Levine
Morphological criteria for the in vitro differentiation of embryoid bodies produced by a transplantable teratoma of mice.
Journal of cellular physiology 1974;84(2):319-32.
1974: Arnold J Levine; M Torosian; A J Sarokhan; A K Teresky
Biochemical criteria for the in vitro differentiation of embryoid bodies produced by a transplantable teratoma of mice. The production of acetylcholine esterase and creatine phosphokinase by teratoma cells.
Journal of cellular physiology 1974;84(2):311-7.
1974: A Sen; R Hancock; Arnold J Levine
The properties and origin of the proteins in the SV40 nucleoprotein complex.
Virology 1974;61(1):11-21.
1974: A Sen; Arnold J Levine
SV40 nucleoprotein complex activity unwinds superhelical turns in SV40 DNA.
Nature 1974;249(455):343-4.
1974: J L Melnick; A C Allison; J S Butel; W Eckhart; B E Eddy; S Kit; Arnold J Levine; J A Miles; Joseph S Pagano; L Sachs; V Vonka
Papovaviridae.
Intervirology 1974;3(1-2):106-20.
1974: Arnold J Levine
The replication of papovavirus DNA.
Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progrès en virologie médicale 1974;17(0):1-37.
1973: P C van der Vliet; Arnold J Levine
DNA-binding proteins specific for cells infected by adenovirus.
Nature: New biology 1973;246(154):170-4.
1973: P J Laipis; Arnold J Levine
DNA replication in SV40-infected cells. IX. The inhibition of a gap-filling step during discontinuous synthesis of SV40 DNA.
Virology 1973;56(2):580-94.
1973: E M Ritzi; Arnold J Levine
The fragmentation of cellular DNA and the formation of pseudovirions during SV 40 infection of African green monkey kidney cells.
The Journal of general virology 1973;20(3):353-67.
1973: K D Noonan; Arnold J Levine; M M Burger
Cell cycle-dependent changes in the surface membrane as detected with (3H)concanavalin A.
The Journal of cell biology 1973;58(2):491-7.
1973: Rudolf Jaenisch; Arnold J Levine
DNA replication of SV40-infected cells. VII. Formation of SV40 catenated and circular dimers.
Journal of molecular biology 1973;73(2):199-212.
1972: Arnold J Levine; M M Burger
A working hypothesis explaining the maintenance of the transformed state by SV40 and polyoma.
Journal of theoretical biology 1972;37(3):436-46.
1972: A Mayer; Arnold J Levine
DNA replication in SV40-infected cells. 8. The distribution of replicating molecules at different stages of replication in SV40-infected cells.
Virology 1972;50(2):328-38.
1972: Rudolf Jaenisch; Arnold J Levine
DNA replication in SV40-infected cells. VI. The effect of cycloheximide on the formation of SV40 oligomeric DNA.
Virology 1972;48(2):373-9.
1972: D R Dubbs; S Kit; Rudolf Jaenisch; Arnold J Levine
Isolation of simian virus 40 recombinants from cells infected with oligomeric forms of simian virus 40 deoxyribonucleic acid.
Journal of virology 1972;9(4):717-9.
1971: Rudolf Jaenisch; Arnold J Levine
Infection of primary African green monkey cells with SV40 monomeric and dimeric DNA.
Journal of molecular biology 1971;61(3):735-8.
1971: Rudolf Jaenisch; A Mayer; Arnold J Levine
Replicating SV40 molecules containing closed circular template DNA strands.
Nature: New biology 1971;233(37):72-5.
1971: J R Sheppard; Arnold J Levine; M M Burger
Cell-surface changes after infection with oncogenic viruses: requirement for synthesis of host DNA.
Science (New York, N.Y.) 1971;172(3990):1345-6.
1971: Rudolf Jaenisch; Arnold J Levine
DNA replication in SV40-infected cells. V. Circular and catenated oligomers of SV40 DNA.
Virology 1971;44(3):480-93.
1971: T O Fox; Arnold J Levine
Relationship between virus-induced cellular deoxyribonucleic acid synthesis and transformation by simian virus 40.
Journal of virology 1971;7(4):473-7.
1971: Arnold J Levine
Induction of mitochondrial DNA synthesis in monkey cells infected by simian virus 40 and (or) treated with calf serum.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(4):717-20.
1971: H S Kang; T B Eshbach; D A White; Arnold J Levine
Deoxyribonucleic acid replication in simian virus 40-infected cells. IV. Two different requirements for protein synthesis during simian virus 40 deoxyribonucleic acid replication.
Journal of virology 1971;7(1):112-20.
1970: Arnold J Levine; H S Kang; F E Billheimer
DNA replication in SV40 infected cells. I. Analysis of replicating SV40 DNA.
Journal of molecular biology 1970;50(2):549-68.
1970: E Ritzi; Arnold J Levine
Deoxyribonucleic acid replication in simian virus 40-infected cells. 3. Comparison of simian virus 40 lytic infection in three different monkey kidney cell lines.
Journal of virology 1970;5(6):686-92.
1970: Arnold J Levine; A K Teresky
Deoxyribonucleic acid replication in simian virus 40-infected cells. II. Detection and characterization of simian virus 40 pseudovirions.
Journal of virology 1970;5(4):451-7.
1969: Arnold J Levine; R L Sinsheimer
Isolation of a chloramphenicol-resistant protein from lambda-infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1969;62(4):1226-8.
1969: Arnold J Levine; R L Sinsheimer
The process of infection with bacteriophage phiX174. XXVII. Synthesis of a viral-specific chloramphenicol-resistant protein in phiX174-infected cells.
Journal of molecular biology 1969;39(3):655-68.
1968: Arnold J Levine; R L Sinsheimer
The process of infection with bacteriophage phi-X174. XIX. Isolation and characterization of a chloramphenicol-resistant protein from phi-X-infected cells.
Journal of molecular biology 1968;32(3):567-78.
1967: Arnold J Levine; H S Ginsberg
Mechanism by which fiber antigen inhibits multiplication of type 5 adenovirus.
Journal of virology 1967;1(4):747-57.