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Megan Levings

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Katherine G Macdonald; Andrew I M Campbell; Jonathan M Han; Megan E Himmel; Qing Huang; Bernard Kan; Pascal M Lavoie; Megan K Levings
Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans".
Megan E Himmel; Katherine G MacDonald; Theodore S Steiner; Rosa V Garcia; Megan K Levings
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.
Alicia N McMurchy; Ignazio S Piras; Michela Riba; Maria Grazia Roncarolo; Elia Stupka; Rosa Bacchetta; Alessandro Bulfone; Davide Cittaro; Sara Di Nunzio; Jose Manuel Garcia-Manteiga; Jana Gillies; Maria Concetta Gizzi; Dejan Lazarevic; Megan K Levings
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells.

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2013: Katherine G Macdonald; Andrew I M Campbell; Jonathan M Han; Megan E Himmel; Qing Huang; Bernard Kan; Pascal M Lavoie; Megan K Levings
Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans".
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4440-1.
2013: Megan E Himmel; Katherine G MacDonald; Theodore S Steiner; Rosa V Garcia; Megan K Levings
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2001-8.
2013: Alicia N McMurchy; Ignazio S Piras; Michela Riba; Maria Grazia Roncarolo; Elia Stupka; Rosa Bacchetta; Alessandro Bulfone; Davide Cittaro; Sara Di Nunzio; Jose Manuel Garcia-Manteiga; Jana Gillies; Maria Concetta Gizzi; Dejan Lazarevic; Megan K Levings
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells.
Blood 2013;121(8):1265-75.
2013: Alicia N McMurchy; Megan K Levings
In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells.
Methods in molecular biology (Clifton, N.J.) 2013;946():115-32.
2012: Natasha R Ryz; Ho Pan Sham; Xiujuan Wu; Yiqun Zhang; Ganive Bhinder; Justin Chan; Jan P Dutz; Alexa Glesby; Tina Huang; Kevan Jacobson; Megan K Levings; Caixia Ma; Scott J Patterson; Bruce A Vallance
Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(12):G1299-311.
2012: Yu Yao; Megan K Levings; Theodore S Steiner
ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation.
European journal of immunology 2012;42(12):3310-21.
2012: Katherine G MacDonald; Paul C Orban; Megan K Levings
T regulatory cell therapy in transplantation: stability, localization and functional specialization.
Current opinion in organ transplantation 2012;17(4):343-8.
2012: Megan E Himmel; Paul C Orban; Theodore S Steiner; Yu Yao; Megan K Levings
Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers.
Immunology 2012;136(2):115-22.
2012: Richard Yu; Shengquan Zhang; Xuejun Zhang; Raewyn Broady; Jan P Dutz; Min Gao; Yuanshen Huang; Megan K Levings; Mingwan Su; Yang Wang; Shencai Wei; Aie Xu; Jie Yu; Youwen Zhou
Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin.
PloS one 2012;7(12):e51040.
2012: Jonathan M Han; Scott J Patterson; Megan K Levings
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.
Frontiers in immunology 2012;3():245.
2012: Ashish K Marwaha; Alicia N McMurchy; Nicole J Leung; Megan K Levings
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
Frontiers in immunology 2012;3():129.
2012: Ekaterina Yurchenko; Marina Tiemi Shio; Moshe Szyf; Maria Da Silva Martins; Tony C Huang; Megan K Levings; Martin Olivier; Ciriaco Piccirillo
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo.
PloS one 2012;7(4):e35572.
2011: Carla J Cohen; Sarah Q Crome; Elizabeth L Dai; Kate G MacDonald; Dixie L Mager; Megan K Levings
Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5615-26.
2011: Ekaterina Yurchenko; Megan K Levings; Ciriaco Piccirillo
CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation.
European journal of immunology 2011;41(12):3455-66.
2011: Joel Montane; Paul C Orban; Galina Soukhatcheva; Rusung Tan; Loraine Bischoff; Derek L Dai; Gijs Hardenberg; Timothy J Kieffer; Megan K Levings; C Bruce Verchere
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
The Journal of clinical investigation 2011;121(8):3024-8.
2011: Alicia N McMurchy; Andrew Bushell; Megan K Levings; Kathryn J Wood
Moving to tolerance: clinical application of T regulatory cells.
Seminars in immunology 2011;23(4):304-13.
2011: Scott J Patterson; Jonathan M Han; Rosa Garcia; Kiran Assi; Tianyan Gao; Audrey O'Neill; Alexandra C Newton; Megan K Levings
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5533-7.
2011: Adele Y Wang; Sarah Crome; Kristina M Jenkins; Jeffrey A Medin; Jonathan L Bramson; Megan K Levings
Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production.
Cancer immunology, immunotherapy : CII 2011;60(3):381-8.
2011: Megan E Himmel; Sarah Crome; Sabine Ivison; Ciriaco Piccirillo; Theodore S Steiner; Megan K Levings
Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils.
European journal of immunology 2011;41(2):306-12.
2011: Kiran Assi; Shoukat Dedhar; Megan K Levings; David Owen; Scott Patterson; Baljinder Salh
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.
BMC immunology 2011;12():42.
2011: Sabine M Ivison; Megan E Himmel; Matthew Mayer; Yu Yao; Arnawaz Kifayet; Megan K Levings; Theodore S Steiner
The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells.
Inflammatory bowel diseases 2011;17(1):319-33.
2010: Raewyn Broady; Jie Yu; Vickie Chow; Adisak Tantiworawit; Christine Kang; Kyra Berg; Magdalena Martinka; Mehran Ghoreishi; Jan P Dutz; Megan K Levings
Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells.
Blood 2010;116(25):5748-51.
2010: Alicia N McMurchy; Jana Gillies; Sarah E Allan; Laura Passerini; Eleonora Gambineri; Maria-Grazia Roncarolo; Rosa Bacchetta; Megan K Levings
Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.
The Journal of allergy and clinical immunology 2010;126(6):1242-51.
2010: Judith Maxwell Silverman; Joachim Clos; Eva Horakova; Adele Y Wang; Martina Wiesgigl; Isabelle Kelly; Miriam A Lynn; W Robert McMaster; Leonard J Foster; Megan K Levings; Neil E Reiner
Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5011-22.
2010: Mihoko Ladd; Ashish Sharma; Qing Huang; Adele Y Wang; Lixin Xu; Indira Genowati; Megan K Levings; Pascal M Lavoie
Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation.
Immunology 2010;131(2):289-99.
2010: Thomas Abraham; Sarah E Allan; Megan K Levings
Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space.
Micron (Oxford, England : 1993) 2010;41(6):633-40.
2010: Sabine M Ivison; Megan E Himmel; Gijs Hardenberg; Paige A J Wark; Arnawaz Kifayet; Megan K Levings; Theodore S Steiner
TLR5 is not required for flagellin-mediated exacerbation of DSS colitis.
Inflammatory bowel diseases 2010;16(3):401-9.
2010: Sarah Crome; A Y Wang; Megan K Levings
Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease.
Clinical and experimental immunology 2010;159(2):109-19.
2009: Sara Di Nunzio; Massimiliano Cecconi; Laura Passerini; Alicia N McMurchy; Udo Baron; Ivana Turbachova; Silvia Vignola; Erica Valencic; Alberto Tommasini; Anne Junker; Giantonio Cazzola; Sven Olek; Megan K Levings; Lucia Perroni; Maria-Grazia Roncarolo; Rosa Bacchetta
Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.
Blood 2009;114(19):4138-41.
2009: Megan K Levings; A W Thomson
MASTering Treg function to promote tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(10):2209-10.
2009: Natasha R Locke; Scott J Patterson; Melisa J Hamilton; Laura M Sly; Gerald Krystal; Megan K Levings
SHIP regulates the reciprocal development of T regulatory and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):975-83.
2009: Alicia N McMurchy; Megan K Levings
3rd Keystone Symposium on T regulatory cells.
Immunotherapy 2009;1(4):529-37.
2009: Sarah Crome; Adele Y Wang; Christine Y Kang; Megan K Levings
The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.
European journal of immunology 2009;39(6):1480-93.
2009: Alicia N McMurchy; Sara Di Nunzio; Maria Grazia Roncarolo; Rosa Bacchetta; Megan K Levings
Molecular regulation of cellular immunity by FOXP3.
Advances in experimental medicine and biology 2009;665():30-46.
2008: Sarah E Allan; George X Song-Zhao; Thomas Abraham; Alicia N McMurchy; Megan K Levings
Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3.
European journal of immunology 2008;38(12):3282-9.
2008: Raewyn Broady; Megan K Levings
Graft-versus-host disease: suppression by statins.
Nature medicine 2008;14(11):1155-6.
2008: Megan E Himmel; Gijs Hardenberg; Ciriaco Piccirillo; Theodore S Steiner; Megan K Levings
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.
Immunology 2008;125(2):145-53.
2008: Sarah E Allan; Raewyn Broady; Silvia Gregori; Megan E Himmel; Natasha Locke; Maria-Grazia Roncarolo; Rosa Bacchetta; Megan K Levings
CD4+ T-regulatory cells: toward therapy for human diseases.
Immunological reviews 2008;223():391-421.
2008: Laura Passerini; Sarah E Allan; Manuela Battaglia; Sara Di Nunzio; Alicia N Alstad; Megan K Levings; Maria-Grazia Roncarolo; Rosa Bacchetta
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.
International immunology 2008;20(3):421-31.
2008: Raewyn Broady; Jie Yu; Megan K Levings
Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells.
Journal of clinical apheresis 2008;23(2):82-91.
2008: Sarah E Allan; Alicia N Alstad; Natacha Merindol; Natasha K Crellin; Mario Amendola; Rosa Bacchetta; Luigi Naldini; Maria-Grazia Roncarolo; Hugo Soudeyns; Megan K Levings
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):194-202.
2007: Natasha K Crellin; Rosa V Garcia; Megan K Levings
Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells.
Journal of immunological methods 2007;324(1-2):92-104.
2007: Sarah E Allan; Sarah Crome; Natasha K Crellin; Laura Passerini; Theodore S Steiner; Rosa Bacchetta; Maria-Grazia Roncarolo; Megan K Levings
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.
International immunology 2007;19(4):345-54.
2007: Natasha K Crellin; Rosa V Garcia; Megan K Levings
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.
Blood 2007;109(5):2014-22.
2007: Silvia Gregori; Rosa Bacchetta; Laura Passerini; Megan K Levings; Maria-Grazia Roncarolo
Isolation, expansion, and characterization of human natural and adaptive regulatory T cells.
Methods in molecular biology (Clifton, N.J.) 2007;380():83-105.
2006: Carmen Gianfrani; Megan K Levings; Claudia Sartirana; Giuseppe Mazzarella; Gianvincenzo Barba; Delia Zanzi; Alessandra Camarca; Gaetano Iaquinto; Nicola Giardullo; Salvatore Auricchio; Riccardo Troncone; Maria-Grazia Roncarolo
Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):4178-86.
2006: Maria-Grazia Roncarolo; Silvia Gregori; Manuela Battaglia; Rosa Bacchetta; Katharina Fleischhauer; Megan K Levings
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.
Immunological reviews 2006;212():28-50.
2006: Rosa Bacchetta; Laura Passerini; Eleonora Gambineri; Minyue Dai; Sarah E Allan; Lucia Perroni; Franca Dagna Bricarelli; Claudia Sartirana; Susanne Matthes-Martin; Anita Lawitschka; Chiara Azzari; Steven F Ziegler; Megan K Levings; Maria-Grazia Roncarolo
Defective regulatory and effector T cell functions in patients with FOXP3 mutations.
The Journal of clinical investigation 2006;116(6):1713-22.
2006: Megan K Levings; Sarah Allan; Eva d'Hennezel; Ciriaco Piccirillo
Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity.
Advances in immunology 2006;92():119-55.
2005: Natasha K Crellin; Rosa V Garcia; Omeed Hadisfar; Sarah E Allan; Theodore S Steiner; Megan K Levings
Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8051-9.
2005: Sarah E Allan; Laura Passerini; Rosa Bacchetta; Natasha K Crellin; Minyue Dai; Paul C Orban; Steven F Ziegler; Maria-Grazia Roncarolo; Megan K Levings
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.
The Journal of clinical investigation 2005;115(11):3276-84.
2005: Megan K Levings; Silvia Gregori; Eleonora Tresoldi; Sabrina Cazzaniga; Chiara Bonini; Maria-Grazia Roncarolo
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells.
Blood 2005;105(3):1162-9.
2005: Megan K Levings; M G Roncarolo
Phenotypic and functional differences between human CD4+CD25+ and type 1 regulatory T cells.
Current topics in microbiology and immunology 2005;293():303-26.
2005: Virginia M Salvati; Giuseppe Mazzarella; Carmen Gianfrani; Megan K Levings; Rosita Stefanile; Beatrice De Giulio; Gaetano Iaquinto; Nicola Giardullo; Salvatore Auricchio; Maria-Grazia Roncarolo; Riccardo Troncone
Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa.
Gut 2005;54(1):46-53.
2003: Maria-Grazia Roncarolo; Silvia Gregori; Megan K Levings
Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells.
Novartis Foundation symposium 2003;252():115-27; discussion 127-31, 203-10.
2002: Megan K Levings; Rosa Bacchetta; Ute Schulz; Maria-Grazia Roncarolo
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.
International archives of allergy and immunology 2002;129(4):263-76.
2002: Megan K Levings; Romina Sangregorio; Claudia Sartirana; Anna Lisa Moschin; Manuela Battaglia; Paul C Orban; Maria-Grazia Roncarolo
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.
The Journal of experimental medicine 2002;196(10):1335-46.
2002: Rosa Bacchetta; Claudia Sartirana; Megan K Levings; Claudio Bordignon; Satwant Narula; Maria-Grazia Roncarolo
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines.
European journal of immunology 2002;32(8):2237-45.
2001: Maria-Grazia Roncarolo; Rosa Bacchetta; Claudio Bordignon; S Narula; Megan K Levings
Type 1 T regulatory cells.
Immunological reviews 2001;182():68-79.
2001: Megan K Levings; Romina Sangregorio; Maria-Grazia Roncarolo
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.
The Journal of experimental medicine 2001;193(11):1295-302.
2001: Megan K Levings; Romina Sangregorio; F Galbiati; S Squadrone; Rene de Waal Malefyt; Maria-Grazia Roncarolo
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5530-9.
2001: Maria-Grazia Roncarolo; Megan K Levings; Catia Traversari
Differentiation of T regulatory cells by immature dendritic cells.
The Journal of experimental medicine 2001;193(2):F5-9.
2000: Maria-Grazia Roncarolo; Megan K Levings
The role of different subsets of T regulatory cells in controlling autoimmunity.
Current opinion in immunology 2000;12(6):676-83.
1999: Paul C Orban; Megan K Levings; John W Schrader
Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis.
Blood 1999;94(5):1614-22.
1999: Megan K Levings; D C Bessette; John W Schrader
Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase.
Blood 1999;93(11):3694-702.
1999: Megan K Levings; John W Schrader
IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5224-9.
1997: Melanie J Welham; Heather K Bone; Megan K Levings; L Learmonth; L M Wang; Kevin B Leslie; J H Pierce; John W Schrader
Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells.
The Journal of biological chemistry 1997;272(2):1377-81.