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David Levy

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Lu Ting-Chi; Wang Zhao-Hui; Feng Xiaobei; Chuang Peter Y; Fang Wei; Shen Yuhong; Levy David E; Xiong Huabao; Chen Nan; He John Cijiang
Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy.
Gough Daniel J; Corlett Alicia; Schlessinger Karni; Wegrzyn Joanna; Larner Andrew C; Levy David E
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
Xu Jiangnan; Yang Yu; Qiu Guixing; Lal Girdhari; Wu Zhihong; Levy David E; Ochando Jordi C; Bromberg Jonathan S; Ding Yaozhong
c-Maf regulates IL-10 expression during Th17 polarization.

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2009: Lu Ting-Chi; Wang Zhao-Hui; Feng Xiaobei; Chuang Peter Y; Fang Wei; Shen Yuhong; Levy David E; Xiong Huabao; Chen Nan; He John Cijiang
Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy.
Kidney international 2009;76(1):63-71.
2009: Gough Daniel J; Corlett Alicia; Schlessinger Karni; Wegrzyn Joanna; Larner Andrew C; Levy David E
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
Science (New York, N.Y.) 2009;324(5935):1713-6.
2009: Xu Jiangnan; Yang Yu; Qiu Guixing; Lal Girdhari; Wu Zhihong; Levy David E; Ochando Jordi C; Bromberg Jonathan S; Ding Yaozhong
c-Maf regulates IL-10 expression during Th17 polarization.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6226-36.
2009: Spolski Rosanne; Kim Hyoung-Pyo; Zhu Wei; Levy David E; Leonard Warren J
IL-21 mediates suppressive effects via its induction of IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2859-67.
2009: Lal Girdhari; Zhang Nan; van der Touw William; Ding Yaozhong; Ju Wenjun; Bottinger Erwin P; Reid St Patrick; Levy David E; Bromberg Jonathan S
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):259-73.
2008: Chakraborty Papia; Wang Yaming; Wei Jen-Hsuan; van Deursen Jan; Yu Hongtao; Malureanu Liviu; Dasso Mary; Forbes Douglass J; Levy David E; Seemann Joachim; Fontoura Beatriz M A
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression.
Developmental cell 2008;15(5):657-67.
2008: Gough Daniel J; Levy David E; Johnstone Ricky W; Clarke Christopher J
IFNgamma signaling-does it mean JAK-STAT?
Cytokine & growth factor reviews 2008;19(5-6):383-94.
2007: MacDonald Margaret R; Machlin Erica S; Albin Owen R; Levy David E
The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses.
Journal of virology 2007;81(24):13509-18.
2007: Zhou Liang; Ivanov Ivaylo I; Spolski Rosanne; Min Roy; Shenderov Kevin; Egawa Takeshi; Levy David E; Leonard Warren J; Littman Dan R
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Nature immunology 2007;8(9):967-74.
2007: Tseng J-C; Zheng Y; Yee H; Levy D E; Meruelo D
Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity.
Gene therapy 2007;14(15):1166-74.
2007: Zeng Rong; Spolski Rosanne; Casas Esther; Zhu Wei; Levy David E; Leonard Warren J
The molecular basis of IL-21-mediated proliferation.
Blood 2007;109(10):4135-42.
2007: Satterly Neal; Tsai Pei-Ling; van Deursen Jan; Nussenzveig Daniel R; Wang Yaming; Faria Paula A; Levay Agata; Levy David E; Fontoura Beatriz M A
Influenza virus targets the mRNA export machinery and the nuclear pore complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1853-8.
2006: Wang Yaming; Zhu Wei; Levy David E
Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.
Methods (San Diego, Calif.) 2006;39(4):356-62.
2006: Wang Yaming; Levy David E
C. elegans STAT: evolution of a regulatory switch.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1641-52.
2006: Zhang Ling; Badgwell Donna B; Bevers Jack J; Schlessinger Karni; Murray Peter J; Levy David E; Watowich Stephanie S
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain.
Molecular and cellular biochemistry 2006;288(1-2):179-89.
2006: Levy David E; Inghirami Giorgio
STAT3: a multifaceted oncogene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10151-2.
2006: Faria Ana M C; Levay Agata; Wang Yaming; Kamphorst Alice O; Rosa Magda L P; Nussenzveig Daniel R; Balkan Wayne; Chook Yuh Min; Levy David E; Fontoura Beatriz M A
The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.
Immunity 2006;24(3):295-304.
2006: Prakash Arun; Levy David E
Regulation of IRF7 through cell type-specific protein stability.
Biochemical and biophysical research communications 2006;342(1):50-6.
2006: Huang Bo; Pan Ping-Ying; Li Qingsheng; Sato Alice I; Levy David E; Bromberg Jonathan; Divino Celia M; Chen Shu-Hsia
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.
Cancer research 2006;66(2):1123-31.
2006: Wang Yaming; Levy David E
C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.
Current biology : CB 2006;16(1):89-94.
2005: Inghirami Giorgio; Chiarle Roberto; Simmons William J; Piva Roberto; Schlessinger Karni; Levy David E
New and old functions of STAT3: a pivotal target for individualized treatment of cancer.
Cell cycle (Georgetown, Tex.) 2005;4(9):1131-3.
2005: Schlessinger Karni; Levy David E
Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.
Cancer research 2005;65(13):5828-34.
2005: Gimeno Ramon; Lee Chien-Kuo; Schindler Christian; Levy David E
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.
Molecular and cellular biology 2005;25(13):5456-65.
2005: Chiarle Roberto; Simmons William J; Cai Honjying; Dhall Girish; Zamo Alberto; Raz Regina; Karras James G; Levy David E; Inghirami Giorgio
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
Nature medicine 2005;11(6):623-9.
2005: Prakash Arun; Smith Eric; Lee Chien-Kuo; Levy David E
Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
The Journal of biological chemistry 2005;280(19):18651-7.
2005: Shen Yuhong; La Perle Krista M D; Levy David E; Darnell James E
Reduced STAT3 activity in mice mimics clinical disease syndromes.
Biochemical and biophysical research communications 2005;330(1):305-9.
2005: Yang Jinbo; Chatterjee-Kishore Moitreyee; Staugaitis Susan M; Nguyen Hannah; Schlessinger Karni; Levy David E; Stark George R
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.
Cancer research 2005;65(3):939-47.
2004: Chang Hao-Ming; Paulson Matthew; Holko Michelle; Rice Charles M; Williams Bryan R G; Marié Isabelle; Levy David E
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9578-83.
2004: Chesler David A; Dodard Cindy; Lee Grace Y; Levy David E; Reiss Carol Shoshkes
Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent.
Journal of neurovirology 2004;10(1):57-63.
2004: Shen Yuhong; Schlessinger Karni; Zhu Xuejun; Meffre Eric; Quimby Fred; Levy David E; Darnell J E
Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.
Molecular and cellular biology 2004;24(1):407-19.
2003: Levy David E; Marié Isabelle; Prakash Arun
Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.
Current opinion in immunology 2003;15(1):52-8.
2002: Levy David E; Darnell J E
Stats: transcriptional control and biological impact.
Nature reviews. Molecular cell biology 2002;3(9):651-62.
2002: Lee Chien-kuo; Raz Regina; Gimeno Ramon; Gertner Rachel; Wistinghausen Birte; Takeshita Kenichi; DePinho Ronald A; Levy David E
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
Immunity 2002;17(1):63-72.
2002: Levy David E; Lee Chien-kuo
What does Stat3 do?
The Journal of clinical investigation 2002;109(9):1143-8.
2002: Levy David E
Whence interferon? Variety in the production of interferon in response to viral infection.
The Journal of experimental medicine 2002;195(4):F15-8.
2002: Zamo Alberto; Chiarle Roberto; Piva Roberto; Howes Jennifer; Fan Yan; Chilosi Marco; Levy David E; Inghirami Giorgio
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death.
Oncogene 2002;21(7):1038-47.
2002: Enninga Jost; Levy David E; Blobel Günter; Fontoura Beatriz M A
Role of nucleoporin induction in releasing an mRNA nuclear export block.
Science (New York, N.Y.) 2002;295(5559):1523-5.
2002: Paulson Matthew; Press Carolyn; Smith Eric; Tanese Naoko; Levy David E
IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff.
Nature cell biology 2002;4(2):140-7.
2002: Levy David E; Marié Isabelle; Smith Eric; Prakash Arun
Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(1):87-93.
2001: Levy D E; García-Sastre A
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion.
Cytokine & growth factor reviews 2001;12(2-3):143-56.
2001: Smith E J; Marié I; Prakash A; García-Sastre A; Levy D E
IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.
The Journal of biological chemistry 2001;276(12):8951-7.
2000: Marié I; Smith E; Prakash A; Levy D E
Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain.
Molecular and cellular biology 2000;20(23):8803-14.
2000: Lee C K; Rao D T; Gertner R; Gimeno R; Frey A B; Levy D E
Distinct requirements for IFNs and STAT1 in NK cell function.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3571-7.
2000: Weiden M; Tanaka N; Qiao Y; Zhao B Y; Honda Y; Nakata K; Canova A; Levy D E; Rom W N; Pine R
Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2028-39.
2000: Levy D E; Gilliland D G
Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice.
Oncogene 2000;19(21):2505-10.
2000: Zong C S; Chan J; Levy D E; Horvath C; Sadowski H B; Wang L H
Mechanism of STAT3 activation by insulin-like growth factor I receptor.
The Journal of biological chemistry 2000;275(20):15099-105.
2000: Durbin J E; Fernandez-Sesma A; Lee C K; Rao T D; Frey A B; Moran T M; Vukmanovic S; García-Sastre A; Levy D E
Type I IFN modulates innate and specific antiviral immunity.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4220-8.
2000: Goodman A R; Levy D E; Reis L F; Vilcek J
Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages.
Journal of leukocyte biology 2000;67(3):387-95.
2000: Lee C K; Smith E; Gimeno R; Gertner R; Levy D E
STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1286-92.
1999: Lee C K; Gimeno R; Levy D E
Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes.
The Journal of experimental medicine 1999;190(10):1451-64.
1999: Paulson M; Pisharody S; Pan L; Guadagno S; Mui A L; Levy D E
Stat protein transactivation domains recruit p300/CBP through widely divergent sequences.
The Journal of biological chemistry 1999;274(36):25343-9.
1999: Raz R; Lee C K; Cannizzaro L A; d'Eustachio P; Levy D E
Essential role of STAT3 for embryonic stem cell pluripotency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2846-51.
1998: García-Sastre A; Egorov A; Matassov D; Brandt S; Levy D E; Durbin J E; Palese P; Muster T
Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.
Virology 1998;252(2):324-30.
1998: Zheng P; Guo Y; Niu Q; Levy D E; Dyck J A; Lu S; Sheiman L A; Liu Y
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation.
Nature 1998;396(6709):373-6.
1998: Marié I; Durbin J E; Levy D E
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.
The EMBO journal 1998;17(22):6660-9.
1998: García-Sastre A; Durbin R K; Zheng H; Palese P; Gertner R; Levy D E; Durbin J E
The role of interferon in influenza virus tissue tropism.
Journal of virology 1998;72(11):8550-8.
1998: Levy D E
Analysis of interferon-regulated proteins binding the interferon-alpha-stimulated response element.
Methods (San Diego, Calif.) 1998;15(3):167-74.
1998: Fernandez-Sesma A; Peluso R W; Bai X; Schulman J L; Levy D E; Moran T M
Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1841-9.
1997: Lee C K; Bluyssen H A; Levy D E
Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity.
The Journal of biological chemistry 1997;272(35):21872-7.
1997: Levy D E
The house that Jak/Stat built.
Cytokine & growth factor reviews 1997;8(1):81-90.
1997: Bluyssen H A; Levy D E
Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
The Journal of biological chemistry 1997;272(7):4600-5.
1996: Bluyssen A R; Durbin J E; Levy D E
ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.
Cytokine & growth factor reviews 1996;7(1):11-7.
1996: Durbin J E; Hackenmiller R; Simon M C; Levy D E
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.
Cell 1996;84(3):443-50.
1996: Leaman D W; Pisharody S; Flickinger T W; Commane M A; Schlessinger J; Kerr I M; Levy D E; Stark G R
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.
Molecular and cellular biology 1996;16(1):369-75.
1995: Bluyssen H A; Muzaffar R; Vlieststra R J; van der Made A C; Leung S; Stark G R; Kerr I M; Trapman J; Levy D E
Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5645-9.
1995: Raz R; Cheung K; Ling L; Levy D E
Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness.
Somatic cell and molecular genetics 1995;21(2):139-45.
1995: Levy D E; Raz R; Durbin J E; Bluyssen H; Muzaffar R; Pisharody S
Cytoplasmic transcription factors: mediators of cytokine signaling.
Agents and actions. Supplements 1995;47():79-85.
1994: Raz R; Durbin J E; Levy D E
Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.
The Journal of biological chemistry 1994;269(39):24391-5.
1993: Silvennoinen O; Schindler C; Schlessinger J; Levy D E
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
Science (New York, N.Y.) 1993;261(5129):1736-9.
1993: Parrington J; Rogers N C; Gewert D R; Pine R; Veals S A; Levy D E; Stark G R; Kerr I M
The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.
European journal of biochemistry / FEBS 1993;214(3):617-26.
1993: Veals S A; Santa Maria T; Levy D E
Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity.
Molecular and cellular biology 1993;13(1):196-206.
1992: Veals S A; Schindler C; Leonard D; Fu X Y; Aebersold R; Darnell J E; Levy D E
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.
Molecular and cellular biology 1992;12(8):3315-24.
1991: Kessler D S; Levy D E
Protein kinase activity required for an early step in interferon-alpha signaling.
The Journal of biological chemistry 1991;266(34):23471-6.
1991: Veals S A; Kessler D S; Josiah S; Leonard D G; Levy D E
Signal transduction pathway activating interferon-alpha-stimulated gene expression.
British journal of haematology 1991;79 Suppl 1():9-13.
1990: Fu X Y; Kessler D S; Veals S A; Levy D E; Darnell J E
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8555-9.
1990: Kessler D S; Veals S A; Fu X Y; Levy D E
Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.
Genes & development 1990;4(10):1753-65.
1990: Pine R; Decker T; Kessler D S; Levy D E; Darnell J E
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.
Molecular and cellular biology 1990;10(6):2448-57.
1990: Levy D E; Lew D J; Decker T; Kessler D S; Darnell J E
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.
The EMBO journal 1990;9(4):1105-11.
1989: Levy D E; Kessler D S; Pine R; Darnell J E
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.
Genes & development 1989;3(9):1362-71.
1989: Decker T; Lew D J; Cheng Y S; Levy D E; Darnell J E
Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.
The EMBO journal 1989;8(7):2009-14.
1988: Kessler D S; Pine R; Pfeffer L M; Levy D E; Darnell J E
Cells resistant to interferon are defective in activation of a promoter-binding factor.
The EMBO journal 1988;7(12):3779-83.
1988: Kessler D S; Levy D E; Darnell J E
Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8521-5.
1988: Levy D E; Kessler D S; Pine R; Reich N; Darnell J E
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.
Genes & development 1988;2(4):383-93.
1988: Pine R; Levy D E; Reich N; Darnell J E
Transcriptional stimulation by CaPO4-DNA precipitates.
Nucleic acids research 1988;16(4):1371-8.

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David Levy

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