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Virgilio Lew

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Alex J Crick; Jurij Kotar; Virgilio L Lew; Sheel M Shah; Teresa Tiffert; Pietro Cicuta
An automated live imaging platform for studying merozoite egress-invasion in malaria cultures.
Yizhou Wang; Mary Williams; Cornelia Eisenach; Adrian Hills; Rucha Karnik; Virgilio L Lew; Maria Papanatsiou; Michael R Blatt
Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.
Adrian Hills; Anna Amtmann; Michael R Blatt; Zhong-Hua Chen; Virgilio L Lew
OnGuard, a computational platform for quantitative kinetic modeling of guard cell physiology.

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2013: Alex J Crick; Jurij Kotar; Virgilio L Lew; Sheel M Shah; Teresa Tiffert; Pietro Cicuta
An automated live imaging platform for studying merozoite egress-invasion in malaria cultures.
Biophysical journal 2013;104(5):997-1005.
2012: Yizhou Wang; Mary Williams; Cornelia Eisenach; Adrian Hills; Rucha Karnik; Virgilio L Lew; Maria Papanatsiou; Michael R Blatt
Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.
Plant physiology 2012;160(4):1956-67.
2012: Adrian Hills; Anna Amtmann; Michael R Blatt; Zhong-Hua Chen; Virgilio L Lew
OnGuard, a computational platform for quantitative kinetic modeling of guard cell physiology.
Plant physiology 2012;159(3):1026-42.
2012: Zhong-Hua Chen; Adrian Hills; Virgilio L Lew; Anna Amtmann; Ulrike Bätz; Michael R Blatt
Systems dynamic modeling of the stomatal guard cell predicts emergent behaviors in transport, signaling, and volume control.
Plant physiology 2012;159(3):1235-51.
2011: Rachel V Seear; Virgilio L Lew
IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent.
Cell calcium 2011;50(5):444-8.
2011: Teresa Tiffert; Virgilio L Lew
Elevated intracellular Ca2+ reveals a functional membrane nucleotide pool in intact human red blood cells.
The Journal of general physiology 2011;138(4):381-91.
2011: Virgilio L Lew
Malaria: surprising mechanism of merozoite egress revealed.
Current biology : CB 2011;21(9):R314-6.
2011: Jakob M A Mauritz; Rachel Seear; Alessandro Esposito; Clemens F Kaminski; Jeremy N Skepper; Alice Warley; Virgilio L Lew; Teresa Tiffert
X-ray microanalysis investigation of the changes in Na, K, and hemoglobin concentration in plasmodium falciparum-infected red blood cells.
Biophysical journal 2011;100(6):1438-45.
2010: Pawel Swietach; Teresa Tiffert; Jakob M A Mauritz; Rachel Seear; Alessandro Esposito; Clemens F Kaminski; Virgilio L Lew; Richard D Vaughan-Jones
Hydrogen ion dynamics in human red blood cells.
The Journal of physiology 2010;588(Pt 24):4995-5014.
2010: Jakob M A Mauritz; Alessandro Esposito; Teresa Tiffert; Jeremy N Skepper; Alice Warley; Young-Zoon Yoon; Pietro Cicuta; Virgilio L Lew; Jochen Guck; Clemens F Kaminski
Biophotonic techniques for the study of malaria-infected red blood cells.
Medical & biological engineering & computing 2010;48(10):1055-63.
2010: Alessandro Esposito; Jean-Baptiste Choimet; Jeremy N Skepper; Jakob M A Mauritz; Virgilio L Lew; Clemens F Kaminski; Teresa Tiffert
Quantitative imaging of human red blood cells infected with Plasmodium falciparum.
Biophysical journal 2010;99(3):953-60.
2010: Doron Kabaso; Roie Shlomovitz; Thorsten Auth; Virgilio L Lew; Nir S Gov
Curling and local shape changes of red blood cell membranes driven by cytoskeletal reorganization.
Biophysical journal 2010;99(3):808-16.
2010: Jakob M A Mauritz; Teresa Tiffert; Rachel Seear; Franziska Lautenschläger; Alessandro Esposito; Virgilio L Lew; Jochen Guck; Clemens F Kaminski
Detection of Plasmodium falciparum-infected red blood cells by optical stretching.
Journal of biomedical optics 2010;15(3):030517.
2010: Agnieszka Dyrda; Urszula Cytlak; Anna Ciuraszkiewicz; Agnieszka Lipinska; Anne Cueff; Guillaume Bouyer; Stéphane Egée; Poul Bennekou; Virgilio L Lew; Serge L Y Thomas
Local membrane deformations activate Ca2+-dependent K+ and anionic currents in intact human red blood cells.
PloS one 2010;5(2):e9447.
2010: Anne Cueff; Rachel Seear; Agnieszka Dyrda; Guillaume Bouyer; Stéphane Egée; Alessandro Esposito; Jeremy Skepper; Teresa Tiffert; Virgilio L Lew; Serge L Y Thomas
Effects of elevated intracellular calcium on the osmotic fragility of human red blood cells.
Cell calcium 2010;47(1):29-36.
2009: Young-Zoon Yoon; Ha Hong; Aidan Brown; Dong Chung Kim; Dae Joon Kang; Virgilio L Lew; Pietro Cicuta
Flickering analysis of erythrocyte mechanical properties: dependence on oxygenation level, cell shape, and hydration level.
Biophysical journal 2009;97(6):1606-15.
2009: Jakob M A Mauritz; Alessandro Esposito; Hagai Ginsburg; Clemens F Kaminski; Teresa Tiffert; Virgilio L Lew
The homeostasis of Plasmodium falciparum-infected red blood cells.
PLoS computational biology 2009;5(4):e1000339.
2009: Robert M Bookchin; Zipora Etzion; Virgilio L Lew; Teresa Tiffert
Preserved function of the plasma membrane calcium pump of red blood cells from diabetic subjects with high levels of glycated haemoglobin.
Cell calcium 2009;45(3):260-3.
2008: Zenghui Liu; Weijun Weng; Robert M Bookchin; Virgilio L Lew; Frank A Ferrone
Free energy of sickle hemoglobin polymerization: a scaled-particle treatment for use with dextran as a crowding agent.
Biophysical journal 2008;94(9):3629-34.
2008: Alessandro Esposito; Teresa Tiffert; Jakob M A Mauritz; Simon Schlachter; Lawrence H Bannister; Clemens F Kaminski; Virgilio L Lew
FRET imaging of hemoglobin concentration in Plasmodium falciparum-infected red cells.
PloS one 2008;3(11):e3780.
2007: Virgilio L Lew; Teresa Tiffert
Is invasion efficiency in malaria controlled by pre-invasion events?
Trends in parasitology 2007;23(10):481-4.
2007: Virgilio L Lew; Nuala Daw; Zipora Etzion; Teresa Tiffert; Adaeze Muoma; Laura Vanagas; Robert M Bookchin
Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells.
Blood 2007;110(4):1334-42.
2007: Teresa Tiffert; Nuala Daw; Zipora Etzion; Robert M Bookchin; Virgilio L Lew
Age decline in the activity of the Ca2+-sensitive K+ channel of human red blood cells.
The Journal of general physiology 2007;129(5):429-36.
2005: Virgilio L Lew
Malaria: endless fascination with merozoite release.
Current biology : CB 2005;15(18):R760-1.
2005: Teresa Tiffert; Virgilio L Lew; Hagai Ginsburg; Miriam Krugliak; Laure Croisille; Narla Mohandas
The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum.
Blood 2005;105(12):4853-60.
2005: Virgilio L Lew; Robert M Bookchin
Ion transport pathology in the mechanism of sickle cell dehydration.
Physiological reviews 2005;85(1):179-200.
2005: Virgilio L Lew; Teresa Tiffert; Zipora Etzion; Deisy Perdomo; Nuala Daw; Lynn Macdonald; Robert M Bookchin
Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells.
Blood 2005;105(1):361-7.
2004: Virgilio L Lew; Lynn Macdonald; Hagai Ginsburg; Miriam Krugliak; Teresa Tiffert
Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis.
Blood cells, molecules & diseases 2004;32(3):353-9.
2004: Serge L Y Thomas; Virgilio L Lew
Plasmodium falciparum and the permeation pathway of the host red blood cell.
Trends in parasitology 2004;20(3):122-5.
2003: Virgilio L Lew; Nuala Daw; Deisy Perdomo; Zipora Etzion; Robert M Bookchin; Teresa Tiffert
Distribution of plasma membrane Ca2+ pump activity in normal human red blood cells.
Blood 2003;102(12):4206-13.
2003: Virgilio L Lew; Teresa Tiffert; Hagai Ginsburg
Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells.
Blood 2003;101(10):4189-94.
2002: Virgilio L Lew; Teresa Tiffert; Hagai Ginsburg
Do azoles and chloroquine share similar mechanisms of antimalarial action?
Trends in parasitology 2002;18(4):156.
2002: Virgilio L Lew; Zipora Etzion; Robert M Bookchin
Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization.
Blood 2002;99(7):2578-85.
2002: Robert M Bookchin; Virgilio L Lew
Sickle red cell dehydration: mechanisms and interventions.
Current opinion in hematology 2002;9(2):107-10.
2001: Teresa Tiffert; Virgilio L Lew
Kinetics of inhibition of the plasma membrane calcium pump by vanadate in intact human red cells.
Cell calcium 2001;30(5):337-42.
2001: JE Raftos; Amanda J Edgley; Robert M Bookchin; Zipora Etzion; Virgilio L Lew; Teresa Tiffert
Normal Ca2+ extrusion by the Ca2+ pump of intact red blood cells exposed to high glucose concentrations.
American journal of physiology. Cell physiology 2001;280(6):C1449-54.
2001: Teresa Tiffert; Nuala Daw; Deisy Perdomo; Virgilio L Lew
A fast and simple screening test to search for specific inhibitors of the plasma membrane calcium pump.
The Journal of laboratory and clinical medicine 2001;137(3):199-207.
2000: Robert M Bookchin; Zipora Etzion; M Sorette; N Mohandas; J N Skepper; Virgilio L Lew
Identification and characterization of a newly recognized population of high-Na+, low-K+, low-density sickle and normal red cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8045-50.
2000: Teresa Tiffert; Virgilio L Lew; Deisy Perdomo; Hagai Ginsburg
Effect of ferriprotoporphyrin IX and non-heme iron on the Ca(2+) pump of intact human red cells.
The Journal of membrane biology 2000;175(2):107-13.
2000: Teresa Tiffert; Henry M Staines; J Clive Ellory; Virgilio L Lew
Functional state of the plasma membrane Ca2+ pump in Plasmodium falciparum-infected human red blood cells.
The Journal of physiology 2000;525 Pt 1():125-34.
2000: Teresa Tiffert; Hagai Ginsburg; Miriam Krugliak; B C Elford; Virgilio L Lew
Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):331-6.
1999: Henry M Staines; William Chang; J Clive Ellory; Teresa Tiffert; Kiaran Kirk; Virgilio L Lew
Passive Ca(2+) transport and Ca(2+)-dependent K(+) transport in Plasmodium falciparum-infected red cells.
The Journal of membrane biology 1999;172(1):13-24.
1999: JE Raftos; Virgilio L Lew; P W Flatman
Refinement and evaluation of a model of Mg2+ buffering in human red cells.
European journal of biochemistry / FEBS 1999;263(3):635-45.
1999: Robert M Bookchin; Tania C Balazs; Z Wang; Robert Josephs; Virgilio L Lew
Polymer structure and solubility of deoxyhemoglobin S in the presence of high concentrations of volume-excluding 70-kDa dextran. Effects of non-s hemoglobins and inhibitors.
The Journal of biological chemistry 1999;274(10):6689-97.
1999: Virgilio L Lew; Austin R Hockaday
The effects of transport perturbations on the homeostasis of erythrocytes.
Novartis Foundation symposium 1999;226():37-50; discussion 50-4.
1997: Teresa Tiffert; Virgilio L Lew
Apparent Ca2+ dissociation constant of Ca2+ chelators incorporated non-disruptively into intact human red cells.
The Journal of physiology 1997;505 ( Pt 2)():403-10.
1997: Virgilio L Lew; O E Ortiz; Robert M Bookchin
Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability.
The Journal of clinical investigation 1997;99(11):2727-35.
1997: Teresa Tiffert; Virgilio L Lew
Cytoplasmic calcium buffers in intact human red cells.
The Journal of physiology 1997;500 ( Pt 1)():139-54.
1997: JE Raftos; Robert M Bookchin; Virgilio L Lew
Measurement of the distribution of anion exchange function in normal human red cells.
The Journal of physiology 1997;499 ( Pt 1)():17-25.
1996: Robert M Bookchin; Virgilio L Lew
Pathophysiology of sickle cell anemia.
Hematology/oncology clinics of North America 1996;10(6):1241-53.
1996: Zipora Etzion; Virgilio L Lew; Robert M Bookchin
K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemia red blood cells.
The American journal of physiology 1996;271(4 Pt 1):C1111-21.
1996: J E Raftos; Robert M Bookchin; Virgilio L Lew
Distribution of chloride permeabilities in normal human red cells.
The Journal of physiology 1996;491 ( Pt 3)():773-7.
1995: J E Raftos; Virgilio L Lew
Effect of intracellular magnesium on calcium extrusion by the plasma membrane calcium pump of intact human red cells.
The Journal of physiology 1995;489 ( Pt 1)():63-72.
1995: Virgilio L Lew; T Balazs; Robert M Bookchin
Osmotic effects of water compartments in protein polymers.
Cell biochemistry and function 1995;13(3):173-6.
1995: Virgilio L Lew; J E Raftos; M Sorette; Robert M Bookchin; N Mohandas
Generation of normal human red cell volume, hemoglobin content, and membrane area distributions by "birth" or regulation?
Blood 1995;86(1):334-41.
1994: Robert M Bookchin; T Balazs; Virgilio L Lew
Measurement of the hemoglobin concentration in deoxyhemoglobin S polymers and characterization of the polymer water compartment.
Journal of molecular biology 1994;244(1):100-9.
1993: Zipora Etzion; Teresa Tiffert; Robert M Bookchin; Virgilio L Lew
Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells.
The Journal of clinical investigation 1993;92(5):2489-98.
1993: Virgilio L Lew; Zipora Etzion; Robert M Bookchin; R daCosta; H Väänänen; M Sassaroli; J Eisinger
The distribution of intracellular calcium chelator (fura-2) in a population of intact human red cells.
Biochimica et biophysica acta 1993;1148(1):152-6.
1993: Teresa Tiffert; Zipora Etzion; Robert M Bookchin; Virgilio L Lew
Effects of deoxygenation on active and passive Ca2+ transport and cytoplasmic Ca2+ buffering in normal human red cells.
The Journal of physiology 1993;464():529-44.
1993: A C Pereira; D Samellas; Teresa Tiffert; Virgilio L Lew
Inhibition of the calcium pump by high cytosolic Ca2+ in intact human red blood cells.
The Journal of physiology 1993;461():63-73.
1993: Robert M Bookchin; T Balazs; Virgilio L Lew
Composition of the hemoglobin S polymer.
American journal of hematology 1993;42(1):118-21.
1992: Virgilio L Lew; Robert M Bookchin
Role of reticulocyte transport heterogeneity in the generation of mature sickle cells with different volumes.
Biochemical Society transactions 1992;20(4):797-800.
1991: Virgilio L Lew; Robert M Bookchin
Osmotic effects of protein polymerization: analysis of volume changes in sickle cell anemia red cells following deoxy-hemoglobin S polymerization.
The Journal of membrane biology 1991;122(1):55-67.
1991: Virgilio L Lew; C J Freeman; O E Ortiz; Robert M Bookchin
A mathematical model of the volume, pH, and ion content regulation in reticulocytes. Application to the pathophysiology of sickle cell dehydration.
The Journal of clinical investigation 1991;87(1):100-12.
1991: Robert M Bookchin; O E Ortiz; Virgilio L Lew
Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia.
The Journal of clinical investigation 1991;87(1):113-24.
1990: O E Ortiz; Virgilio L Lew; Robert M Bookchin
Deoxygenation permeabilizes sickle cell anaemia red cells to magnesium and reverses its gradient in the dense cells.
The Journal of physiology 1990;427():211-26.
1990: Virgilio L Lew; C J Freeman; O E Ortiz; Robert M Bookchin
Applications of integrated cell models: novel predictions on the behaviour of red cells and reticulocytes.
Biomedica biochimica acta 1990;49(8-9):737-41.
1989: Robert M Bookchin; O E Ortiz; C J Freeman; Virgilio L Lew
Predictions and tests of a new integrated reticulocyte model: implications for dehydration of sickle cells.
Progress in clinical and biological research 1989;319():615-27.
1988: Georges Dagher; Virgilio L Lew
Maximal calcium extrusion capacity and stoichiometry of the human red cell calcium pump.
The Journal of physiology 1988;407():569-86.
1988: J García-Sancho; Virgilio L Lew
Properties of the residual calcium pools in human red cells exposed to transient calcium loads.
The Journal of physiology 1988;407():541-56.
1988: J García-Sancho; Virgilio L Lew
Heterogeneous calcium and adenosine triphosphate distribution in calcium-permeabilized human red cells.
The Journal of physiology 1988;407():523-39.
1988: J García-Sancho; Virgilio L Lew
Detection and separation of human red cells with different calcium contents following uniform calcium permeabilization.
The Journal of physiology 1988;407():505-22.
1988: Robert M Bookchin; O E Ortiz; O Shalev; S Tsurel; E A Rachmilewitz; Austin R Hockaday; Virgilio L Lew
Calcium transport and ultrastructure of red cells in beta-thalassemia intermedia.
Blood 1988;72(5):1602-7.
1988: Teresa Tiffert; Jerry L Spivak; Virgilio L Lew
Magnitude of calcium influx required to induce dehydration of normal human red cells.
Biochimica et biophysica acta 1988;943(2):157-65.
1988: Virgilio L Lew; Austin R Hockaday; C J Freeman; Robert M Bookchin
Mechanism of spontaneous inside-out vesiculation of red cell membranes.
The Journal of cell biology 1988;106(6):1893-901.
1987: C J Freeman; Robert M Bookchin; O E Ortiz; Virgilio L Lew
K-permeabilized human red cells lose an alkaline, hypertonic fluid containing excess K over diffusible anions.
The Journal of membrane biology 1987;96(3):235-41.
1987: Robert M Bookchin; O E Ortiz; Virgilio L Lew
Activation of calcium-dependent potassium channels in deoxygenated sickled red cells.
Progress in clinical and biological research 1987;240():193-200.
1986: Teresa Tiffert; Virgilio L Lew
Effect of changes in the rate of ionophore A23187-induced calcium influx on the pump-leak steady-state distribution of calcium in inosine-fed human red cells.
Biochimica et biophysica acta 1986;860(2):429-33.
1986: O E Ortiz; Virgilio L Lew; Robert M Bookchin
Calcium accumulated by sickle cell anemia red cells does not affect their potassium (86Rb+) flux components.
Blood 1986;67(3):710-5.
1986: Virgilio L Lew; Robert M Bookchin
Volume, pH, and ion-content regulation in human red cells: analysis of transient behavior with an integrated model.
The Journal of membrane biology 1986;92(1):57-74.
1985: Robert M Bookchin; E F Roth; Virgilio L Lew
Near-normal circulatory survival of rabbit red cells exposed to high levels of Ca and ionophore in vitro.
Blood 1985;66(1):220-3.
1985: Virgilio L Lew; Austin R Hockaday; M I Sepulveda; A P Somlyo; A V Somlyo; O E Ortiz; Robert M Bookchin
Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles.
Nature 1985;315(6020):586-9.
1985: Virgilio L Lew; J Garcia-Sancho
Use of the ionophore A23187 to measure and control cytoplasmic Ca2+ levels in intact red cells.
Cell calcium 1985;6(1-2):15-23.
1985: Robert M Bookchin; Virgilio L Lew; E F Roth
Elevated red cell calcium: innocent bystander or kiss of death?
Progress in clinical and biological research 1985;195():369-80.
1984: Teresa Tiffert; J Garcia-Sancho; Virgilio L Lew
Irreversible ATP depletion caused by low concentrations of formaldehyde and of calcium-chelator esters in intact human red cells.
Biochimica et biophysica acta 1984;773(1):143-56.
1984: Robert M Bookchin; O E Ortiz; Virgilio L Lew
Silent intracellular calcium in sickle cell anemia red cells.
Progress in clinical and biological research 1984;165():17-28.
1983: Robert M Bookchin; Virgilio L Lew
Red cell membrane abnormalities in sickle cell anemia.
Progress in hematology 1983;13():1-23.
1982: Virgilio L Lew; Roger Y Tsien; C Miner; Robert M Bookchin
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator.
Nature 1982;298(5873):478-81.
1981: P W Flatman; Virgilio L Lew
The magnesium dependence of sodium-pump-mediated sodium-potassium and sodium-sodium exchange in intact human red cells.
The Journal of physiology 1981;315():421-46.
1981: Robert M Bookchin; Virgilio L Lew
Effect of a 'sickling pulse' on calcium and potassium transport in sickle cell trait red cells.
The Journal of physiology 1981;312():265-80.
1981: Robert M Bookchin; C Raventos; Virgilio L Lew
Abnormal vesiculation and calcium transport by 'one-step' inside-out vesicles from sickle cell anemia red cells. Comparisons with transport by intact cells.
Progress in clinical and biological research 1981;55():163-82.
1980: Virgilio L Lew; Robert M Bookchin
A Ca2+-refractory state of the Ca-sensitive K+ permeability mechanism in sickle cell anaemia red cells.
Biochimica et biophysica acta 1980;602(1):196-200.
1980: P W Flatman; Virgilio L Lew
Excess magnesium converts red cell (sodium+potassium) ATPase to the potassium phosphatase.
The Journal of physiology 1980;307():1-8.
1980: P W Flatman; Virgilio L Lew
Magnesium buffering in intact human red blood cells measured using the ionophore A23187.
The Journal of physiology 1980;305():13-30.
1980: Robert M Bookchin; Virgilio L Lew
Progressive inhibition of the Ca pump and Ca:Ca exchange in sickle red cells.
Nature 1980;284(5756):561-3.
1969: I M Glynn; Virgilio L Lew
Affinities or apparent affinities of the transport adenosine triphosphatase system.
The Journal of general physiology 1969;54(1):289-305.