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Nancy Lewin

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Noemi Kedei; Nancy E Lewin; Langston Lim; Poonam Mannan; Yam B Poudel; Arnab Rudra; Julia Selezneva; Peter M Blumberg; Derek C Braun; Jinqiu Chen; Thomas J Cummins; Susan H Garfield; Tamás Géczy; Madeleine R Heldman; Michelle A Herrmann; Gary E Keck
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Gary E Keck; Noemi Kedei; Nancy E Lewin; Yam B Poudel; Arnab Rudra; Jeffrey C Stephens; Peter M Blumberg
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Tamas Geczy; Ji-Hye Kang; Noemi Kedei; Nancy E Lewin; Langston Lim; Poonam Mannan; Victor E Marquez; Megan L Peach; Julia Selezneva; Dina M Sigano; Christopher J Valle; Wonhee Woo; Saïd El Kazzouli; Susan H Garfield; Peter M Blumberg
Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.

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All Publications

2013: Noemi Kedei; Nancy E Lewin; Langston Lim; Poonam Mannan; Yam B Poudel; Arnab Rudra; Julia Selezneva; Peter M Blumberg; Derek C Braun; Jinqiu Chen; Thomas J Cummins; Susan H Garfield; Tamás Géczy; Madeleine R Heldman; Michelle A Herrmann; Gary E Keck
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
ACS chemical biology 2013;8(4):767-77.
2012: Gary E Keck; Noemi Kedei; Nancy E Lewin; Yam B Poudel; Arnab Rudra; Jeffrey C Stephens; Peter M Blumberg
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Bioorganic & medicinal chemistry letters 2012;22(12):4084-8.
2012: Tamas Geczy; Ji-Hye Kang; Noemi Kedei; Nancy E Lewin; Langston Lim; Poonam Mannan; Victor E Marquez; Megan L Peach; Julia Selezneva; Dina M Sigano; Christopher J Valle; Wonhee Woo; Saïd El Kazzouli; Susan H Garfield; Peter M Blumberg
Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.
The Journal of biological chemistry 2012;287(16):13137-58.
2011: Noga Gal; Susan H Garfield; Peter M Blumberg; Saïd El Kazzouli; Noemi Kedei; Sofiya Kolusheva; Nancy E Lewin; Langston Lim; Poonam Mannan; Victor E Marquez; Taiyabah A Naeem; Dina M Sigano; Andrea Telek; Raz Jelinek
N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity.
Chembiochem : a European journal of chemical biology 2011;12(15):2331-40.
2011: Noemi Kedei; Emanuel Lubart; Nancy E Lewin; Andrea Telek; Langston Lim; Poonam Mannan; Susan H Garfield; Matthew B Kraft; Gary E Keck; Sofiya Kolusheva; Raz Jelinek; Peter M Blumberg
Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells.
Chembiochem : a European journal of chemical biology 2011;12(8):1242-51.
2010: Or Raifman; Sofiya Kolusheva; Said El Kazzouli; Dina M Sigano; Noemi Kedei; Nancy E Lewin; Ruben Lopez-Nicolas; Ana Ortiz-Espin; Juan C Gomez-Fernandez; Peter M Blumberg; Victor E Marquez; Senena Corbalan-Garcia; Raz Jelinek
Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities.
Chembiochem : a European journal of chemical biology 2010;11(14):2003-9.
2010: Gary E Keck; Yam B Poudel; Arnab Rudra; Jeffrey C Stephens; Noemi Kedei; Nancy E Lewin; Megan L Peach; Peter M Blumberg
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.
Angewandte Chemie (International ed. in English) 2010;49(27):4580-4.
2010: Ji-Hye Kang; Yerim Kim; Shin-Hye Won; Song-Kyu Park; Chang Woo Lee; Hwan Mook Kim; Nancy E Lewin; Nicholas A Perry; Larry V Pearce; Daniel J Lundberg; Robert J Surawski; Peter M Blumberg; Jeewoo Lee
Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents.
Bioorganic & medicinal chemistry letters 2010;20(3):1008-12.
2010: Or Raifman; Sofiya Kolusheva; Maria J Comin; Noemi Kedei; Nancy E Lewin; Peter M Blumberg; Victor E Marquez; Raz Jelinek
Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities.
The FEBS journal 2010;277(1):233-43.
2009: Maria Soledad Sosa; Nancy E Lewin; Sung-Hee Choi; Peter M Blumberg; Marcelo G Kazanietz
Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.
Biochemistry 2009;48(34):8171-8.
2009: Gary E Keck; Wei Li; Matthew B Kraft; Noemi Kedei; Nancy E Lewin; Peter M Blumberg
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
Organic letters 2009;11(11):2277-80.
2009: Maria J Comin; Gabriella Czifra; Noemi Kedei; Andrea Telek; Nancy E Lewin; Sofiya Kolusheva; Julia F Velasquez; Ryan Kobylarz; Raz Jelinek; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Journal of medicinal chemistry 2009;52(10):3274-83.
2009: Gary E Keck; Yam B Poudel; Dennie S Welch; Matthew B Kraft; Anh P Truong; Jeffrey C Stephens; Noemi Kedei; Nancy E Lewin; Peter M Blumberg
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
Organic letters 2009;11(3):593-6.
2008: Dehui Duan; Dina M Sigano; James A Kelley; Christopher C Lai; Nancy E Lewin; Noemi Kedei; Megan L Peach; Jeewoo Lee; Thushara P Abeyweera; Susan A Rotenberg; Hee Kim; Young Ho Kim; Saïd El Kazzouli; Jae-Uk Chung; Howard A Young; Matthew R Young; Alyson Baker; Nancy H Colburn; Adriana Haimovitz-Friedman; Jean-Philip Truman; Damon Parrish; Jeffrey Deschamps; Nicholas A Perry; Robert J Surawski; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Journal of medicinal chemistry 2008;51(17):5198-220.
2008: Sung Hee Choi; Gabriella Czifra; Noemi Kedei; Nancy E Lewin; Jozsef Lazar; Yongmei Pu; Victor E Marquez; Peter M Blumberg
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.
The Journal of biological chemistry 2008;283(16):10543-9.
2007: Yongseok Choi; Yongmei Pu; Megan L Peach; Ji-Hye Kang; Nancy E Lewin; Dina M Sigano; Susan H Garfield; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Journal of medicinal chemistry 2007;50(15):3465-81.
2007: Krishnan Malolanarasimhan; Noemi Kedei; Dina M Sigano; James A Kelley; Christopher C Lai; Nancy E Lewin; Robert J Surawski; Vladimir A Pavlyukovets; Susan H Garfield; Stephen Wincovitch; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
Journal of medicinal chemistry 2007;50(5):962-78.
2006: Ji-Hye Kang; Samira Benzaria; Dina M Sigano; Nancy E Lewin; Yongmei Pu; Megan L Peach; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
Journal of medicinal chemistry 2006;49(11):3185-203.
2006: Jeewoo Lee; Ji-Hye Kang; Kee-Chung Han; Yerim Kim; Su Yeon Kim; Hae-Suk Youn; Inhee Mook-Jung; Hee Kim; Jee Hye Lo Han; Hee-Jin Ha; Young Ho Kim; Victor E Marquez; Nancy E Lewin; Larry V Pearce; Daniel J Lundberg; Peter M Blumberg
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Journal of medicinal chemistry 2006;49(6):2028-36.
2006: Jeewoo Lee; Ju-Hyun Lee; Su Yeon Kim; Nicholas A Perry; Nancy E Lewin; Jolene A Ayres; Peter M Blumberg
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.
Bioorganic & medicinal chemistry 2006;14(6):2022-31.
2005: Ji-Hye Kang; Megan L Peach; Yongmei Pu; Nancy E Lewin; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
Journal of medicinal chemistry 2005;48(18):5738-48.
2005: Yongmei Pu; Nicholas A Perry; Dazhi Yang; Nancy E Lewin; Noemi Kedei; Derek C Braun; Sung Hee Choi; Peter M Blumberg; Susan H Garfield; James C Stone; Dehui Duan; Victor E Marquez
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
The Journal of biological chemistry 2005;280(29):27329-38.
2004: Hirokazu Tamamura; Dina M Sigano; Nancy E Lewin; Megan L Peach; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).
Journal of medicinal chemistry 2004;47(20):4858-64.
2004: Ji-Hye Kang; Su Yeon Kim; Jeewoo Lee; Victor E Marquez; Nancy E Lewin; Larry V Pearce; Peter M Blumberg
Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.
Journal of medicinal chemistry 2004;47(16):4000-7.
2004: Ji-Hye Kang; Maqbool A Siddiqui; Dina M Sigano; Krzysztof Krajewski; Nancy E Lewin; Yongmei Pu; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Organic letters 2004;6(14):2413-6.
2004: Dehui Duan; Nancy E Lewin; Dina M Sigano; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.
Journal of medicinal chemistry 2004;47(12):3248-54.
2004: George R Pettit; Holger Hoffmann; Delbert L Herald; James McNulty; Alison Murphy; Kerianne C Higgs; Ernest Hamel; Nancy E Lewin; Larry V Pearce; Peter M Blumberg; Robin K Pettit; John C Knight
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.
The Journal of organic chemistry 2004;69(7):2251-6.
2004: George R Pettit; Holger Hoffmann; Delbert L Herald; Peter M Blumberg; Ernest Hamel; Jean M Schmidt; Yung Chang; Robin K Pettit; Nancy E Lewin; Larry V Pearce
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
Journal of medicinal chemistry 2004;47(7):1775-82.
2004: Hirokazu Tamamura; Dina M Sigano; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.
Journal of medicinal chemistry 2004;47(3):644-55.
2003: Jayalakshmi Sridhar; Zhi-Liang Wei; Ireneusz Nowak; Nancy E Lewin; Jolene A Ayres; Larry V Pearce; Peter M Blumberg; Alan P Kozikowski
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
Journal of medicinal chemistry 2003;46(19):4196-204.
2003: Yongseok Choi; Ji-Hye Kang; Nancy E Lewin; Peter M Blumberg; Jeewoo Lee; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Journal of medicinal chemistry 2003;46(13):2790-3.
2003: Ji-Hye Kang; Hye-Eun Chung; Su Yeon Kim; Yerim Kim; Jeewoo Lee; Nancy E Lewin; Larry V Pearce; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorganic & medicinal chemistry 2003;11(12):2529-39.
2003: Dina M Sigano; Megan L Peach; Kassoum Nacro; Yongseok Choi; Nancy E Lewin; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
Journal of medicinal chemistry 2003;46(9):1571-9.
2003: Alan P Kozikowski; Ireneusz Nowak; Pavel A Petukhov; René Etcheberrigaray; Ali Mohamed; Mathew Tan; Nancy E Lewin; Henry Hennings; Larry L Pearce; Peter M Blumberg
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.
Journal of medicinal chemistry 2003;46(3):364-73.
2003: Nancy E Lewin; Peter M Blumberg
[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins.
Methods in molecular biology (Clifton, N.J.) 2003;233():129-56.
2002: George R Pettit; Sylvie Ducki; Rui Tan; Roberta S Gardella; James B McMahon; Michael R Boyd; George R Pettit; Peter M Blumberg; Nancy E Lewin; Dennis L Doubek; Larry P Tackett; Michael D Williams
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
2002: Zhi-Liang Wei; Sukumar Sakamuri; Pavel A Petukhov; Clifford George; Nancy E Lewin; Peter M Blumberg; Alan P Kozikowski
Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.
Organic letters 2002;4(13):2169-72.
2001: Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; L L Pearce; Nancy E Lewin; S Yan; Samira Benzaria; Marc C Nicklaus; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Journal of medicinal chemistry 2001;44(25):4309-12.
2001: Lei Shao; Nancy E Lewin; Patricia S Lorenzo; Zengjian Hu; Istvan J Enyedy; Susan H Garfield; James C Stone; F J Marner; Peter M Blumberg; Shaomeng Wang
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.
Journal of medicinal chemistry 2001;44(23):3872-80.
2001: Kassoum Nacro; Dina M Sigano; S Yan; Marc C Nicklaus; L L Pearce; Nancy E Lewin; Susan H Garfield; Peter M Blumberg; Victor E Marquez
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
Journal of medicinal chemistry 2001;44(12):1892-904.
2001: Jeewoo Lee; Kee-Chung Han; S Y Lee; Su Yeon Kim; Ji-Hye Kang; Nancy E Lewin; L S Best; Peter M Blumberg; Victor E Marquez
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco (Società chimica italiana : 1989) 2001;56(3):203-10.
2000: H Tamamura; B Bienfait; Kassoum Nacro; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.
Journal of medicinal chemistry 2000;43(17):3209-17.
2000: Kassoum Nacro; B Bienfait; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.
Bioorganic & medicinal chemistry letters 2000;10(7):653-5.
2000: Kassoum Nacro; B Bienfait; Jeewoo Lee; Kee-Chung Han; Ji-Hye Kang; Samira Benzaria; Nancy E Lewin; Dipak Bhattacharyya; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Journal of medicinal chemistry 2000;43(5):921-44.
1999: Maria Jose Caloca; M L Garcia-Bermejo; Peter M Blumberg; Nancy E Lewin; Elisabeth Kremmer; H Mischak; Shulin Wang; Kassoum Nacro; B Bienfait; Victor E Marquez; Marcelo G Kazanietz
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11854-9.
1999: Shaomeng Wang; M Liu; Nancy E Lewin; Patricia S Lorenzo; D Bhattacharrya; Lixin Qiao; Alan P Kozikowski; Peter M Blumberg
Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations.
Journal of medicinal chemistry 1999;42(18):3436-46.
1999: Victor E Marquez; Kassoum Nacro; Samira Benzaria; Jeewoo Lee; R Sharma; K Teng; GW Milne; B Bienfait; Shulin Wang; Nancy E Lewin; Peter M Blumberg
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Pharmacology & therapeutics 1999;82(2-3):251-61.
1998: Samira Benzaria; B Bienfait; Kassoum Nacro; Shulin Wang; Nancy E Lewin; M Beheshti; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
Bioorganic & medicinal chemistry letters 1998;8(23):3403-8.
1998: Victor E Marquez; R Sharma; Shulin Wang; Nancy E Lewin; Peter M Blumberg; I S Kim; Jeewoo Lee
Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.
Bioorganic & medicinal chemistry letters 1998;8(13):1757-62.
1998: Tamás Bíró; Chaya Brodie; S Modarres; Nancy E Lewin; Peter Acs; Peter M Blumberg
Specific vanilloid responses in C6 rat glioma cells.
Brain research. Molecular brain research 1998;56(1-2):89-98.
1998: Tamás Bíró; Marcus Maurer; S Modarres; Nancy E Lewin; Chaya Brodie; Geza Acs; Peter Acs; R Paus; Peter M Blumberg
Characterization of functional vanilloid receptors expressed by mast cells.
Blood 1998;91(4):1332-40.
1997: Maria Jose Caloca; N Fernandez; Nancy E Lewin; D Ching; rama modali; Peter M Blumberg; Marcelo G Kazanietz
Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters.
The Journal of biological chemistry 1997;272(42):26488-96.
1997: Alan P Kozikowski; Shaomeng Wang; Dawei Ma; J Yao; S Ahmad; R I Glazer; K Bogi; Peter Acs; S Modarres; Nancy E Lewin; Peter M Blumberg
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Journal of medicinal chemistry 1997;40(9):1316-26.
1996: J Lee; Nancy E Lewin; Peter Acs; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.
Journal of medicinal chemistry 1996;39(25):4912-9.
1996: J Lee; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures.
Bioorganic & medicinal chemistry 1996;4(8):1299-305.
1996: Z Szallasi; L Du; R Levine; Nancy E Lewin; P N Nguyen; M D Williams; George R Pettit; Peter M Blumberg
The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
Cancer research 1996;56(9):2105-11.
1996: J Lee; R Sharma; Shulin Wang; GW Milne; Nancy E Lewin; Z Szallasi; Peter M Blumberg; C George; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.
Journal of medicinal chemistry 1996;39(1):36-45.
1996: J Lee; Shulin Wang; GW Milne; R Sharma; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):29-35.
1996: R Sharma; J Lee; Shulin Wang; GW Milne; Nancy E Lewin; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):19-28.
1995: Marcelo G Kazanietz; Shulin Wang; GW Milne; Nancy E Lewin; H L Liu; Peter M Blumberg
Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis.
The Journal of biological chemistry 1995;270(37):21852-9.
1995: Geza Acs; J Lee; Victor E Marquez; Shulin Wang; GW Milne; L Du; Nancy E Lewin; Peter M Blumberg
Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.
Journal of neurochemistry 1995;65(1):301-18.
1995: Alan P Kozikowski; Dawei Ma; L Du; Nancy E Lewin; P M Bumberg
Effect of alteration of the heterocyclic nucleus of ILV on its isoform selectivity for PKC. Palladium catalyzed route to benzofuran analogues of ILV.
Farmaco (Società chimica italiana : 1989) 1995;50(6):425-30.
1995: Marcelo G Kazanietz; Nancy E Lewin; J D Bruns; Peter M Blumberg
Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity.
The Journal of biological chemistry 1995;270(18):10777-83.
1995: Peter M Blumberg; Geza Acs; Peter Acs; L B Areces; Marcelo G Kazanietz; Nancy E Lewin; Z Szallasi
Protein kinase C in cell signaling: strategies for the development of selective inhibitors.
Agents and actions. Supplements 1995;47():87-100.
1994: Shulin Wang; Daniel W Zaharevitz; R Sharma; Victor E Marquez; Nancy E Lewin; L Du; Peter M Blumberg; GW Milne
The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies.
Journal of medicinal chemistry 1994;37(26):4479-89.
1994: Marcelo G Kazanietz; Nancy E Lewin; F Gao; George R Pettit; Peter M Blumberg
Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1994;46(2):374-9.
1994: Peter M Blumberg; Geza Acs; L B Areces; Marcelo G Kazanietz; Nancy E Lewin; Z Szallasi
Protein kinase C in signal transduction and carcinogenesis.
Progress in clinical and biological research 1994;387():3-19.
1992: Kirk R Gustafson; John H Cardellina; James B McMahon; RJ Gulakowski; J Ishitoya; Z Szallasi; Nancy E Lewin; P M Blumberg; O S Weislow; John A Beutler
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
Journal of medicinal chemistry 1992;35(11):1978-86.
1992: Nancy E Lewin; M L Dell'Aquila; George R Pettit; Peter M Blumberg; B S Warren
Binding of [3H]bryostatin 4 to protein kinase C.
Biochemical pharmacology 1992;43(9):2007-14.