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Jada Lewis

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Ashley Cannon; Monica Castanedes-Casey; Simon D'Alton; Dennis W Dickson; Ian M Farnham; John Howard; Michael Jurasic; Joshua Knight; Wen-Lang Lin; Leonard Petrucelli; Linda Rousseau; Matthew R Sarkisian; Brittany Scott; Charles A Wuertzer; Baoli Yang; Xin Yu; Yongjie Zhang; Rachel Bailey; Jada Lewis
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Jennifer Gass; Karen Jansen-West; Wing C Lee; Jada Lewis; Christopher D Link; Anders Nykjaer; Casey Cook; Nicole Finch; Rosa Rademakers; Caroline Stetler; Leonard Petrucelli
Progranulin regulates neuronal outgrowth independent of sortilin.
Ya-Fei Xu; Yong-Jie Zhang; Caroline Stetler; Xiangkun Cao; Dennis W Dickson; Jada Lewis; Wen-Lang Lin; Leonard Petrucelli
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

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All Publications

2012: Ashley Cannon; Monica Castanedes-Casey; Simon D'Alton; Dennis W Dickson; Ian M Farnham; John Howard; Michael Jurasic; Joshua Knight; Wen-Lang Lin; Leonard Petrucelli; Linda Rousseau; Matthew R Sarkisian; Brittany Scott; Charles A Wuertzer; Baoli Yang; Xin Yu; Yongjie Zhang; Rachel Bailey; Jada Lewis
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Acta neuropathologica 2012;123(6):807-23.
2012: Jennifer Gass; Karen Jansen-West; Wing C Lee; Jada Lewis; Christopher D Link; Anders Nykjaer; Casey Cook; Nicole Finch; Rosa Rademakers; Caroline Stetler; Leonard Petrucelli
Progranulin regulates neuronal outgrowth independent of sortilin.
Molecular neurodegeneration 2012;7():33.
2011: Ya-Fei Xu; Yong-Jie Zhang; Caroline Stetler; Xiangkun Cao; Dennis W Dickson; Jada Lewis; Wen-Lang Lin; Leonard Petrucelli
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.
Molecular neurodegeneration 2011;6():73.
2010: Ya-Fei Xu; Tania F Gendron; Yong-Jie Zhang; Wen-Lang Lin; Simon D'Alton; Hong Sheng; Monica Castanedes Casey; Jimei Tong; Joshua Knight; Xin Yu; Rosa Rademakers; Kevin Boylan; Michael Hutton; Eileen McGowan; dennis dickson; Jada Lewis; Leonard Petrucelli
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(32):10851-9.
2010: Zeshan Ahmed; Hong Sheng; Ya-Fei Xu; Wen-Lang Lin; Amy E Innes; Jennifer Gass; Xin Yu; Charles A Wuertzer; Harold Hou; Shuichi Chiba; Keitaro Yamanouchi; Malcolm Leissring; Leonard Petrucelli; Masugi Nishihara; Michael Hutton; Eileen McGowan; dennis dickson; Jada Lewis
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
The American journal of pathology 2010;177(1):311-24.
2010: todd golde; Leonard Petrucelli; Jada Lewis
Targeting Abeta and tau in Alzheimer's disease, an early interim report.
Experimental neurology 2010;223(2):252-66.
2009: Casey Cook; Jennifer Gass; Judith Dunmore; Jimei Tong; Julie Taylor; Jason Eriksen; Eileen McGowan; Jada Lewis; Jennifer Johnston; Leonard Petrucelli
Aging is not associated with proteasome impairment in UPS reporter mice.
PloS one 2009;4(6):e5888.
2009: Chad A Dickey; Clara Kraft; Umesh Jinwal; John Koren; Amelia Johnson; Laura Anderson; Lori Lebson; Daniel Lee; dennis dickson; Rohan de Silva; Lester I Binder; Dave Morgan; Jada Lewis
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy.
The American journal of pathology 2009;174(1):228-38.
2008: Dave Morgan; Sanjay Munireddy; Jennifer Alamed; Jason DeLeon; David M Diamond; Paula Bickford; Michael Hutton; Jada Lewis; Eileen McGowan; Marcia N Gordon
Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice.
Journal of Alzheimer's disease : JAD 2008;15(4):605-14.
2008: Irving E Vega; Edwin E Traverso; Yancy Ferrer-Acosta; Eduardo Matos; Migdalisel Colon; John Gonzalez; dennis dickson; Michael Hutton; Jada Lewis; Shu H Yen
A novel calcium-binding protein is associated with tau proteins in tauopathy.
Journal of neurochemistry 2008;106(1):96-106.
2008: Tara L Spires-Jones; Alix de Calignon; Toshifumi Matsui; Cindy Zehr; Rose Pitstick; Hai-Yan Wu; Jennifer D Osetek; Phillip B Jones; Brian J Bacskai; Mel B Feany; George A Carlson; Karen K. Hsiao Ashe; Jada Lewis; Bradley T Hyman
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(4):862-7.
2008: Jada Lewis; Heather L Melrose; David Bumcrot; Andrew Hope; Cynthia Zehr; Sarah J Lincoln; Adam Braithwaite; Zhen He; Sina Ogholikhan; Kelly M Hinkle; Caroline Kent; Ivanka Toudjarska; Klaus Charisse; Ravi Braich; Rajendra K Pandey; Michael G Heckman; Demetrius M Maraganore; Julia Crook; Matthew J Farrer
In vivo silencing of alpha-synuclein using naked siRNA.
Molecular neurodegeneration 2008;3():19.
2008: Jason Eriksen; Cynthia Zehr; Jada Lewis
Biologic models of neurodegenerative disorders.
Handbook of clinical neurology 2008;89():173-88.
2007: Tristan Bolmont; Florence Clavaguera; Melanie Meyer-Luehmann; Martin C Herzig; Rebecca Radde; Matthias Staufenbiel; Jada Lewis; Michael Hutton; Markus Tolnay; Mathias Jucker
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
The American journal of pathology 2007;171(6):2012-20.
2007: Zdenek Berger; Hanno M Roder; Amanda Hanna; Aaron Carlson; Vijayaraghavan Rangachari; Mei Yue; Zbigniew K Wszolek; Karen K. Hsiao Ashe; Joshua Knight; dennis dickson; Cathy Andorfer; Terrone L Rosenberry; Jada Lewis; Michael Hutton; Christopher Janus
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3650-62.
2006: Omi Katsuse; Wen-Lang Lin; Jada Lewis; Michael Hutton; dennis dickson
Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice.
Neuroscience letters 2006;409(2):95-9.
2006: Sylvie Le Corre; Hans W Klafki; Nikolaus Plesnila; Gabriele Hübinger; Axel Obermeier; Heidi Sahagún; Barbara Monse; Pierfausto Seneci; Jada Lewis; Jason Eriksen; Cynthia Zehr; Mei Yue; Eileen McGowan; dennis dickson; Michael Hutton; Hanno M Roder
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9673-8.
2005: Wen-Lang Lin; Cynthia Zehr; Jada Lewis; Michael Hutton; Shu-Hui C. Yen; dennis dickson
Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau.
Journal of neurocytology 2005;34(6):397-410.
2005: Martin Ramsden; Linda Kotilinek; Colleen Forster; Jennifer Paulson; Eileen McGowan; Karen SantaCruz; Aaron Guimaraes; Mei Yue; Jada Lewis; George Carlson; Michael Hutton; Karen K. Hsiao Ashe
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10637-47.
2005: Karen SantaCruz; Jada Lewis; Tara L Spires; J Paulson; Linda Kotilinek; Martin Ingelsson; A Guimaraes; Michael DeTure; M Ramsden; Eileen McGowan; Colleen Forster; Mei Yue; Jennifer Orne; Christopher Janus; Ami Mariash; M Kuskowski; Bradley T Hyman; Michael Hutton; Karen K. Hsiao Ashe
Tau suppression in a neurodegenerative mouse model improves memory function.
Science (New York, N.Y.) 2005;309(5733):476-81.
2005: Wendy Noble; Emmanuel Planel; Cindy Zehr; Vicki Olm; Jordana Meyerson; Farhana Suleman; Kate Gaynor; Lili Wang; John LaFrancois; Boris Feinstein; Mark Burns; Pavan Krishnamurthy; Yi Wen; Ratan Bhat; Jada Lewis; dennis dickson; karen duff
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6990-5.
2005: Robyn A Halverson; Jada Lewis; Shanti Frausto; Michael Hutton; Nancy A Muma
Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(5):1226-33.
2004: Naruhiko Sahara; Irving E Vega; Takashi Ishizawa; Jada Lewis; Eileen McGowan; Michael Hutton; dennis dickson; Shu-Hui C. Yen
Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins.
Journal of neurochemistry 2004;90(4):829-38.
2004: Gary W Arendash; Jada Lewis; Ralph E Leighty; Eileen McGowan; Jennifer R Cracchiolo; Michael Hutton; Marcos F Garcia
Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.
Brain research 2004;1012(1-2):29-41.
2004: Cynthia Zehr; Jada Lewis; Eileen McGowan; Julia Crook; Wen-Lang Lin; Kate Godwin; Joshua Knight; dennis dickson; Michael Hutton
Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice.
Neurobiology of disease 2004;15(3):553-62.
2004: Leonard Petrucelli; dennis dickson; Kathryn Kehoe; Julie Taylor; Heather Snyder; Andrew Grover; Michael De Lucia; Eileen McGowan; Jada Lewis; Guy Prihar; Jungsu Kim; Wolfgang H Dillmann; Susan E Browne; Alexis Hall; Richard Voellmy; Yoshio Tsuboi; Ted M Dawson; Benjamin Wolozin; John Hardy; Michael Hutton
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Human molecular genetics 2004;13(7):703-14.
2004: Marcos F Garcia; Marcia N Gordon; Michael Hutton; Jada Lewis; Eileen McGowan; Chad A Dickey; Dave Morgan; Gary W Arendash
The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice.
Neuroreport 2004;15(1):73-7.
2004: Ronald L. Klein; Wen-Lang Lin; dennis dickson; Jada Lewis; Michael Hutton; karen duff; Edwin M Meyer; Michael A King
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology 2004;164(1):347-53.
2003: Wen-Lang Lin; Jada Lewis; Shu-Hui C. Yen; Michael Hutton; dennis dickson
Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.
Journal of neurocytology 2003;32(9):1091-105.
2003: Takashi Ishizawa; Naruhiko Sahara; Koichi Ishiguro; Jay Kersh; Eileen McGowan; Jada Lewis; Michael Hutton; dennis dickson; Shu-Hui C. Yen
Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice.
The American journal of pathology 2003;163(3):1057-67.
2003: Wen-Lang Lin; Jada Lewis; Shu-Hui C. Yen; Michael Hutton; dennis dickson
Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.
The American journal of pathology 2003;162(1):213-8.
2002: Naruhiko Sahara; Jada Lewis; Michael DeTure; Eileen McGowan; dennis dickson; Michael Hutton; Shu-Hui C. Yen
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Journal of neurochemistry 2002;83(6):1498-508.
2001: Michael Hutton; Jada Lewis; dennis dickson; Shu-Hui C. Yen; Eileen McGowan
Analysis of tauopathies with transgenic mice.
Trends in molecular medicine 2001;7(10):467-70.
2001: Jada Lewis; dennis dickson; Wen-Lang Lin; L Chisholm; A Corral; G Jones; Shu-Hui C. Yen; Naruhiko Sahara; Lisa Skipper; Debra Yager; Christopher B Eckman; John Hardy; Michael Hutton; Eileen McGowan
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science (New York, N.Y.) 2001;293(5534):1487-91.
2001: C W Wittmann; M F Wszolek; J M Shulman; Paul Salvaterra; Jada Lewis; Michael Hutton; Mel B Feany
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
Science (New York, N.Y.) 2001;293(5530):711-4.
2000: Jada Lewis; Eileen McGowan; J Rockwood; Heather L Melrose; Parimala Nacharaju; M van Slegtenhorst; Katrina Gwinn-Hardy; M Paul Murphy; Matt Baker; X Yu; karen duff; John Hardy; A Corral; Wen-Lang Lin; Shu-Hui C. Yen; dennis dickson; Peter Davies; Michael Hutton
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
2000: M van Slegtenhorst; Jada Lewis; Michael Hutton
The molecular genetics of the tauopathies.
Experimental gerontology 2000;35(4):461-71.
2000: Michael DeTure; Li-Wen Ko; S Yen; Parimala Nacharaju; Colin Easson; Jada Lewis; M van Slegtenhorst; Michael Hutton; Shu-Hui C. Yen
Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions.
Brain research 2000;853(1):5-14.
1999: Andrew Grover; Henry Houlden; Matt Baker; Jennifer Adamson; Jada Lewis; Guy Prihar; Stuart Pickering-Brown; karen duff; Michael Hutton
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
The Journal of biological chemistry 1999;274(21):15134-43.
1999: Parimala Nacharaju; Jada Lewis; Colin Easson; S Yen; J Hackett; Michael Hutton; Shu-Hui C. Yen
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.
FEBS letters 1999;447(2-3):195-9.
1998: Jada Lewis; B Yang; R Kim; Halina Sierakowska; Ryszard Kole; Oliver Smithies; Nobuyo Maeda
A common human beta globin splicing mutation modeled in mice.
Blood 1998;91(6):2152-6.
1998: J B Whitney; A Leder; Jada Lewis; R A Popp; C Paszty; E M Rubin; W R Shehee; T M Townes; Oliver Smithies
Rapid genotyping of mice with hemoglobinopathies and globin transgenes.
Biochemical genetics 1998;36(1-2):65-77.
1996: Jada Lewis
Alzheimer's disease then and now. Can we really explain the disparity in prevalence?
North Carolina medical journal 1996;57(3):158-9; discussion 159-60.
1996: Jada Lewis; B Yang; P Detloff; Oliver Smithies
Gene modification via "plug and socket" gene targeting.
The Journal of clinical investigation 1996;97(1):3-5.
1995: B Yang; Suzanne L Kirby; Jada Lewis; P J Detloff; Nobuyo Maeda; Oliver Smithies
A mouse model for beta 0-thalassemia.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11608-12.
1994: P J Detloff; Jada Lewis; Simon W M John; W R Shehee; Robert Langenbach; Nobuyo Maeda; Oliver Smithies
Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.
Molecular and cellular biology 1994;14(10):6936-43.
1993: Jada Lewis
Jonathan Swift and Alzheimer's disease.
Lancet 1993;342(8869):504.
1992: Jada Lewis
Vitamin A and Alzheimer's disease.
Neuroepidemiology 1992;11(3):163-8.