FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Richard Lewis

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Living Beings

Anatomy

Procedures

High Pressure Liquid Chromatography

Phenomena

Magnetic Resonance Spectroscopy

Co-author Network

Publications

TOP 3
Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Daryl C Yang; Bryan G Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Artin Ghassemian; Richard J Lewis; Robert C Reid; Ching-I Anderson Wang; Mei-Kwan Yau; Paul F Alewood; David P Fairlie; Thomas Durek
Efficient chemical synthesis of human complement protein C3a.
Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Dary C Yang; Bryan Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Richard Lewis (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Daryl C Yang; Bryan G Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Molecular & cellular proteomics : MCP 2013;12(5):1488.
2013: Artin Ghassemian; Richard J Lewis; Robert C Reid; Ching-I Anderson Wang; Mei-Kwan Yau; Paul F Alewood; David P Fairlie; Thomas Durek
Efficient chemical synthesis of human complement protein C3a.
Chemical communications (Cambridge, England) 2013;49(23):2356-8.
2013: Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Dary C Yang; Bryan Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Molecular & cellular proteomics : MCP 2013;12(3):651-63.
2013: sebastien dutertre; Ai-hua Jin; Alun Jones; Quentin Kaas; Paul F Alewood; Richard J Lewis
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.
Molecular & cellular proteomics : MCP 2013;12(2):312-29.
2013: Lotten Ragnarsson; K Johan Rosengren; Ching-I A Wang; Åsa Andersson; Andreas Brust; Dewi Fajarningsih; Thea Monks; Richard J Lewis
Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor.
The Journal of biological chemistry 2013;288(3):1814-27.
2013: Ching-I A Wang; Richard J Lewis
Emerging opportunities for allosteric modulation of G-protein coupled receptors.
Biochemical pharmacology 2013;85(2):153-62.
2013: Silmara R Sousa; Irina Vetter; Lotten Ragnarsson; Richard J Lewis
Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells.
PloS one 2013;8(3):e59293.
2013: Silmara R Sousa; Irina Vetter; Richard J Lewis
Venom peptides as a rich source of cav2.2 channel blockers.
Toxins 2013;5(2):286-314.
2012: Ching-I A Wang; Soumya Ramu; Nausad H Shaikh; Richard J Lewis
A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.
Molecular pharmacology 2012;82(5):898-909.
2012: Irina Vetter; Viktorie Vlachová; John N Wood; Peter J Cabot; Lindon S Collins; Mirjam Eberhardt; Matthias Engel; Andreas Hess; Rachel Hinsbey; Angelika Lampert; Richard J Lewis; Peter W Reeh; Simon Sattler; Marina Sergejeva; Anastasia Sharov; Filip Touska; Katharina Zimmermann
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.
The EMBO journal 2012;31(19):3795-808.
2012: Jutty Rajan Prashanth; Richard J Lewis; sebastien dutertre
Towards an integrated venomics approach for accelerated conopeptide discovery.
Toxicon : official journal of the International Society on Toxinology 2012;60(4):470-7.
2012: Irina Vetter; David J Adams; Paul F Alewood; Zoltan Dekan; Oliver Knapp; Richard J Lewis
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels.
Biochemical pharmacology 2012;84(4):540-8.
2012: Zoltan Dekan; Richard J Lewis; Ching-I A Wang; Robert K Andrews; Paul F Alewood
Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability.
Organic & biomolecular chemistry 2012;10(30):5791-4.
2012: Irina Vetter; Joshua S Wingerd; Christine A Mozar; Paul F Alewood; MacDonald J Christie; Thomas Durek; Richard J Lewis
Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.
Biochemical pharmacology 2012;83(11):1562-71.
2012: Richard J Lewis; Irina Vetter; sebastien dutertre; MacDonald J Christie
Conus venom peptide pharmacology.
Pharmacological reviews 2012;64(2):259-98.
2012: Richard J Lewis
Discovery and development of the χ-conopeptide class of analgesic peptides.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):524-8.
2012: Christina I Schroeder; Linda Thomas; Denise A Adams; Paul F Alewood; Richard J Lewis; Marion L Loughnan; Katherine J Nielsen; David J Craik
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID.
Biopolymers 2012;98(4):345-56.
2012: Irina Vetter; Richard J Lewis
Therapeutic potential of cone snail venom peptides (conopeptides).
Current topics in medicinal chemistry 2012;12(14):1546-52.
2012: Christina I Schroeder; Linda Thomas; Denise Adams; Paul F Alewood; Richard J Lewis
N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels.
Biopolymers 2012;98(2):161-5.
2011: Zoltan Dekan; Richard J Lewis; Irina Vetter; David J Craik; Norelle L Daly; Paul F Alewood
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure.
Journal of the American Chemical Society 2011;133(40):15866-9.
2011: Marco C Inserra; Richard J Lewis
Venom Peptide modulators of the immune system.
Inflammation & allergy drug targets 2011;10(5):399-410.
2011: Irina Vetter; Richard J Lewis
Natural product ligands of TRP channels.
Advances in experimental medicine and biology 2011;704():41-85.
2011: Irina Vetter; Jasmine L Davis; Lachlan D Rash; Raveendra Anangi; Mehdi Mobli; Paul F Alewood; Richard J Lewis; Glenn F King
Venomics: a new paradigm for natural products-based drug discovery.
Amino acids 2011;40(1):15-28.
2010: Markus Muttenthaler; Asa Andersson; Aline D de Araujo; Zoltan Dekan; Richard J Lewis; Paul F Alewood
Modulating oxytocin activity and plasma stability by disulfide bond engineering.
Journal of medicinal chemistry 2010;53(24):8585-96.
2010: Truong D Nguyen-Huu; César Mattei; Peter J Wen; Andrea J Bourdelais; Richard J Lewis; Evelyne Benoit; Daniel G Baden; Jordi Molgó; Frédéric A Meunier
Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: mechanism of action and reversible inhibition by brevenal.
Toxicon : official journal of the International Society on Toxinology 2010;56(5):792-6.
2010: Brett Hamilton; Nigel Whittle; Glen Shaw; Geoff Eaglesham; Michael R Moore; Richard J Lewis
Human fatality associated with Pacific ciguatoxin contaminated fish.
Toxicon : official journal of the International Society on Toxinology 2010;56(5):668-73.
2010: Rodrigo A V Morales; Norelle L Daly; Irina Vetter; Mehdi Mobli; Ian A Napier; David J Craik; Richard J Lewis; MacDonald J Christie; Glenn F King; Paul F Alewood; Thomas Durek
Chemical synthesis and structure of the prokineticin Bv8.
Chembiochem : a European journal of chemical biology 2010;11(13):1882-8.
2010: Richard J Lewis; Mark Poli
Editorial: toxins in seafood.
Toxicon : official journal of the International Society on Toxinology 2010;56(2):107.
2010: Anton A Grishin; Ching-I A Wang; Markus Muttenthaler; Paul F Alewood; Richard J Lewis; David J Adams
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.
The Journal of biological chemistry 2010;285(29):22254-63.
2010: Ching-I Anderson Wang; Richard J Lewis
Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity.
Biochemical pharmacology 2010;79(8):1083-91.
2010: Markus Muttenthaler; Simon T Nevin; Anton A Grishin; Shyuan Thieu Ngo; Peng T Choy; Norelle L Daly; Shu-Hong Hu; Christopher J Armishaw; Ching-I A Wang; Richard J Lewis; Jennifer L Martin; Peter G Noakes; David J Craik; David J Adams; Paul F Alewood
Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.
Journal of the American Chemical Society 2010;132(10):3514-22.
2010: Irina Vetter; Richard J Lewis
Characterization of endogenous calcium responses in neuronal cell lines.
Biochemical pharmacology 2010;79(6):908-20.
2010: G Berecki; Leonid Motin; A Haythornthwaite; S Vink; P Bansal; R Drinkwater; C I Wang; M Moretta; Richard J Lewis; Paul F Alewood; M J Christie; D J Adams
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.
Molecular pharmacology 2010;77(2):139-48.
2009: Asa Andersson; Jonathan B Baell; Peter J Duggan; Janease E Graham; Richard J Lewis; Natalie G Lumsden; C Elisabet Tranberg; Kellie L Tuck; Aijun Yang
Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine.
Bioorganic & medicinal chemistry 2009;17(18):6659-70.
2009: Lai Y Chan; Conan K L Wang; Jodie M Major; Kathryn P Greenwood; Richard J Lewis; David J Craik; Norelle L Daly
Isolation and characterization of peptides from Momordica cochinchinensis seeds.
Journal of natural products 2009;72(8):1453-8.
2009: Jasmine Davis; Alun Jones; Richard J Lewis
Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS.
Peptides 2009;30(7):1222-7.
2009: Richard J Lewis; Aijun Yang; Alun Jones
Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh.
Toxicon : official journal of the International Society on Toxinology 2009;54(1):62-6.
2009: Marion L Loughnan; Annette Nicke; Nicole Lawrence; Richard J Lewis
Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily.
Biochemistry 2009;48(17):3717-29.
2009: Emma L Millard; Simon T Nevin; Marion L Loughnan; Annette Nicke; Richard J Clark; Paul F Alewood; Richard J Lewis; David J Adams; David J Craik; Norelle L Daly
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues.
The Journal of biological chemistry 2009;284(8):4944-51.
2009: Richard J Lewis
Conotoxin venom peptide therapeutics.
Advances in experimental medicine and biology 2009;655():44-8.
2009: Richard J Lewis
Conotoxins: molecular and therapeutic targets.
Progress in molecular and subcellular biology 2009;46():45-65.
2008: Hua Zhang; Jodie M Major; Richard J Lewis; Robert Capon
Phorbasins G-K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.
Organic & biomolecular chemistry 2008;6(20):3811-5.
2008: Ai-Hua Jin; Norelle L Daly; Simon T Nevin; Ching-I A Wang; sebastien dutertre; Richard J Lewis; David J Adams; David J Craik; Paul F Alewood
Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function.
Journal of medicinal chemistry 2008;51(18):5575-84.
2008: sebastien dutertre; Daniel Croker; Norelle L Daly; Asa Andersson; Markus Muttenthaler; Natalie G Lumsden; David J Craik; Paul F Alewood; gilles guillon; Richard J Lewis
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.
The Journal of biological chemistry 2008;283(11):7100-8.
2007: Joanne T Blanchfield; Oliver P Gallagher; Cecile Cros; Richard J Lewis; Paul F Alewood; Istvan Toth
Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue.
Biochemical and biophysical research communications 2007;361(1):97-102.
2007: sebastien dutertre; Chris Ulens; Regina Büttner; Alexander Fish; René Van Elk; Yvonne Kendel; Gene Hopping; Paul F Alewood; Christina Schroeder; Annette Nicke; August B Smit; Titia K Sixma; Richard J Lewis
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
The EMBO journal 2007;26(16):3858-67.
2007: Filip A Paczkowski; Iain A Sharpe; sebastien dutertre; Richard J Lewis
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.
The Journal of biological chemistry 2007;282(24):17837-44.
2007: Richard J Lewis; Christina I Schroeder; Jenny Ekberg; Katherine J Nielsen; Marion L Loughnan; Linda Thomas; Denise A Adams; Roger Drinkwater; David J Adams; Paul F Alewood
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.
Molecular pharmacology 2007;71(3):676-85.
2007: Leonid Motin; Takahiro Yasuda; Christina I Schroeder; Richard J Lewis; David J Adams
Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels.
The European journal of neuroscience 2007;25(2):435-44.
2006: Richard J Lewis
Ciguatera: Australian perspectives on a global problem.
Toxicon : official journal of the International Society on Toxinology 2006;48(7):799-809.
2006: Jenny Ekberg; Angelo Jayamanne; Christopher W Vaughan; S Aslan; Linda Thomas; J Mould; Roger Drinkwater; M D Baker; B Abrahamsen; J N Wood; David J Adams; MacDonald J Christie; Richard J Lewis
muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):17030-5.
2006: sebastien dutertre; Richard J Lewis
Toxin insights into nicotinic acetylcholine receptors.
Biochemical pharmacology 2006;72(6):661-70.
2006: Christina I Schroeder; Clinton J Doering; Gerald W Zamponi; Richard J Lewis
N-type calcium channel blockers: novel therapeutics for the treatment of pain.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(5):535-43.
2006: Marion L Loughnan; Annette Nicke; Alun Jones; Christina I Schroeder; Simon T Nevin; David J Adams; Paul F Alewood; Richard J Lewis
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum.
The Journal of biological chemistry 2006;281(34):24745-55.
2006: sebastien dutertre; Natalie G Lumsden; Paul F Alewood; Richard J Lewis
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail.
FEBS letters 2006;580(16):3860-6.
2006: Lotten Ragnarsson; T Yasuda; Richard J Lewis; Peter R Dodd; David J Adams
NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G.
Journal of neurochemistry 2006;96(1):283-91.
2005: Carsten Nielsen; Richard J Lewis; Dianne Alewood; Roger Drinkwater; Elka Palant; Margaret Patterson; Tony L Yaksh; Damon McCumber; Maree T Smith
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.
Pain 2005;118(1-2):112-24.
2005: sebastien dutertre; Annette Nicke; Richard J Lewis
Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor.
The Journal of biological chemistry 2005;280(34):30460-8.
2005: K Peter R Nilsson; Erica Lovelace; Christina E Caesar; Nahreen Tynngård; Paul F Alewood; Helena M Johansson; Iain A Sharpe; Richard J Lewis; Norelle L Daly; David J Craik
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.
Biopolymers 2005;80(6):815-23.
2005: Vicky W-W Tsai; Peter R Dodd; Richard J Lewis
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor.
Neuroscience 2005;130(2):457-64.
2005: Vicky W-W Tsai; Heather L Scott; Richard J Lewis; Peter R Dodd
The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease.
Neurotoxicity research 2005;7(1-2):125-41.
2004: Jorgen Mould; Takahiro Yasuda; Christina I Schroeder; Aaron M Beedle; Clinton J Doering; Gerald W Zamponi; David J Adams; Richard J Lewis
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels.
The Journal of biological chemistry 2004;279(33):34705-14.
2004: sebastien dutertre; Annette Nicke; Joel D A Tyndall; Richard J Lewis
Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors.
Journal of molecular recognition : JMR 2004;17(4):339-47.
2004: Norelle L Daly; Jenny Ekberg; Linda Thomas; David J Adams; Richard J Lewis; David J Craik
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.
The Journal of biological chemistry 2004;279(24):25774-82.
2004: sebastien dutertre; Richard J Lewis
Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors.
European journal of biochemistry / FEBS 2004;271(12):2327-34.
2004: Anna Kloda; John Clements; Richard J Lewis; David J Adams
Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors.
Molecular pharmacology 2004;65(6):1386-96.
2004: Takahiro Yasuda; Richard J Lewis; David J Adams
Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation.
The Journal of general physiology 2004;123(4):401-16.
2004: Marion L Loughnan; Annette Nicke; Alun Jones; David J Adams; Paul F Alewood; Richard J Lewis
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.
Journal of medicinal chemistry 2004;47(5):1234-41.
2004: Richard J Lewis
Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters.
IUBMB life 2004;56(2):89-93.
2004: Christina I Schroeder; Mark L Smythe; Richard J Lewis
Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.
Molecular diversity 2004;8(2):127-34.
2003: Annette Nicke; Marek Samochocki; Marion L Loughnan; Paramjit S Bansal; Alfred Maelicke; Richard J Lewis
Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors.
FEBS letters 2003;554(1-2):219-23.
2003: Ivannah Pottier; Brett Hamilton; Alun Jones; Richard J Lewis; Jean-Paul Vernoux
Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding.
Toxicon : official journal of the International Society on Toxinology 2003;42(6):663-72.
2003: Iain A Sharpe; Elka Palant; Christina I Schroeder; David M Kaye; David J Adams; Paul F Alewood; Richard J Lewis
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.
The Journal of biological chemistry 2003;278(41):40317-23.
2003: Lesley J Bryan-Lluka; Heinz Bönisch; Richard J Lewis
chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter.
The Journal of biological chemistry 2003;278(41):40324-9.
2003: Richard J Lewis; Maria L Garcia
Therapeutic potential of venom peptides.
Nature reviews. Drug discovery 2003;2(10):790-802.
2003: Iain A Sharpe; Linda Thomas; Marion L Loughnan; Leonid Motin; Elka Palant; Daniel E Croker; Dianne Alewood; Songhai Chen; Robert M Graham; Paul F Alewood; David J Adams; Richard J Lewis
Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.
The Journal of biological chemistry 2003;278(36):34451-7.
2003: Trudy J Milne; Giovanni Abbenante; Joel D A Tyndall; Judy Halliday; Richard J Lewis
Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily.
The Journal of biological chemistry 2003;278(33):31105-10.
2003: Joanne T Blanchfield; Julie L Dutton; Ron C Hogg; Oliver P Gallagher; David J Craik; Alun Jones; David J Adams; Richard J Lewis; Paul F Alewood; Istvan Toth
Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.
Journal of medicinal chemistry 2003;46(7):1266-72.
2003: David J Adams; Amanda B Smith; Christina I Schroeder; Takahiro Yasuda; Richard J Lewis
Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals.
The Journal of biological chemistry 2003;278(6):4057-62.
2003: Annette Nicke; Marion L Loughnan; Emma L Millard; Paul F Alewood; David J Adams; Norelle L Daly; David J Craik; Richard J Lewis
Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.
The Journal of biological chemistry 2003;278(5):3137-44.
2002: Ivannah Pottier; Jean-Paul Vernoux; Alun Jones; Richard J Lewis
Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies.
Food additives and contaminants 2002;19(11):1034-42.
2002: Brett Hamilton; Mira Hurbungs; Alun Jones; Richard J Lewis
Multiple ciguatoxins present in Indian Ocean reef fish.
Toxicon : official journal of the International Society on Toxinology 2002;40(9):1347-53.
2002: Katherine J Nielsen; Michael Watson; David J Adams; Anna K M Hammarström; Peter W Gage; Justine M Hill; David J Craik; Linda Thomas; Denise Adams; Paul F Alewood; Richard J Lewis
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels.
The Journal of biological chemistry 2002;277(30):27247-55.
2002: Ron C Hogg; Richard J Lewis; David J Adams
Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons.
The European journal of neuroscience 2002;16(2):242-8.
2002: Ivannah Pottier; Jean-Paul Vernoux; Alun Jones; Richard J Lewis
Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry.
Toxicon : official journal of the International Society on Toxinology 2002;40(7):929-39.
2002: Brett Hamilton; Mira Hurbungs; Jean-Paul Vernoux; Alun Jones; Richard J Lewis
Isolation and characterisation of Indian Ocean ciguatoxin.
Toxicon : official journal of the International Society on Toxinology 2002;40(6):685-93.
2002: Lotten Ragnarsson; Martin Mortensen; Peter R Dodd; Richard J Lewis
Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex.
Journal of neurochemistry 2002;81(4):765-79.
2002: Maree T Smith; Peter J Cabot; Fraser B Ross; Alan D Robertson; Richard J Lewis
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
Pain 2002;96(1-2):119-27.
2001: Iain A Sharpe; J Gehrmann; Marion L Loughnan; Linda Thomas; Denise A Adams; AR Atkins; Elka Palant; David J Craik; David J Adams; Paul F Alewood; Richard J Lewis
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
Nature neuroscience 2001;4(9):902-7.
2001: Ivannah Pottier; Jean-Paul Vernoux; Richard J Lewis
Ciguatera fish poisoning in the Caribbean islands and Western Atlantic.
Reviews of environmental contamination and toxicology 2001;168():99-141.
2001: Richard J Lewis
The changing face of ciguatera.
Toxicon : official journal of the International Society on Toxinology 2001;39(1):97-106.
2000: Richard J Lewis; Katherine J Nielsen; David J Craik; Marion L Loughnan; Denise A Adams; Iain A Sharpe; Tudor Luchian; David J Adams; T Bond; Linda Thomas; Alun Jones; J L Matheson; Roger Drinkwater; P R Andrews; Paul F Alewood
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
The Journal of biological chemistry 2000;275(45):35335-44.
2000: Justine M Hill; AR Atkins; Marion L Loughnan; Alun Jones; Denise A Adams; R C Martin; Richard J Lewis; David J Craik; Paul F Alewood
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis.
European journal of biochemistry / FEBS 2000;267(15):4642-8.
2000: Richard J Lewis
Ion channel toxins and therapeutics: from cone snail venoms to ciguatera.
Therapeutic drug monitoring 2000;22(1):61-4.
1999: Ron C Hogg; Les P Miranda; David J Craik; Richard J Lewis; Paul F Alewood; David J Adams
Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor.
The Journal of biological chemistry 1999;274(51):36559-64.
1999: Katherine J Nielsen; D Adams; Linda Thomas; T Bond; Paul F Alewood; David J Craik; Richard J Lewis
Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels.
Journal of molecular biology 1999;289(5):1405-21.
1999: Katherine J Nielsen; Denise A Adams; Paul F Alewood; Richard J Lewis; Linda Thomas; T Schroeder; David J Craik
Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus.
Biochemistry 1999;38(21):6741-51.
1999: Katherine J Nielsen; N Skjaerbaek; M Dooley; Denise A Adams; Martin Mortensen; Peter R Dodd; David J Craik; Paul F Alewood; Richard J Lewis
Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators.
Journal of medicinal chemistry 1999;42(3):415-26.
1999: Richard J Lewis; Alun Jones; Jean-Paul Vernoux
HPLC/tandem electrospray mass spectrometry for the determination of Sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fish.
Analytical chemistry 1999;71(1):247-50.
1998: Michael R Moore; Jack C Ng; Richard J Lewis
Environmental poisoning: presentation and management.
Therapeutic drug monitoring 1998;20(5):502-9.
1998: S H Hu; Marion L Loughnan; R Miller; C M Weeks; Robert H Blessing; Paul F Alewood; Richard J Lewis; Jennifer L Martin
The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods.
Biochemistry 1998;37(33):11425-33.
1998: Ron C Hogg; Richard J Lewis; David J Adams
Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones.
Neuroscience letters 1998;252(2):103-6.
1998: Marion L Loughnan; T Bond; AR Atkins; J Cuevas; David J Adams; Natalie M Broxton; Bruce G Livett; John Down; Alun Jones; Paul F Alewood; Richard J Lewis
alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors.
The Journal of biological chemistry 1998;273(25):15667-74.
1997: Martin Scanlon; D Naranjo; Linda Thomas; Paul F Alewood; Richard J Lewis; David J Craik
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA.
Structure (London, England : 1993) 1997;5(12):1585-97.
1997: PJ Fenner; Richard J Lewis; JA Williamson; M L Williams
A Queensland family with ciguatera after eating coral trout.
The Medical journal of Australia 1997;166(9):473-5.
1997: Richard J Lewis; Alun Jones
Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry.
Toxicon : official journal of the International Society on Toxinology 1997;35(2):159-68.
1997: N Skjaerbaek; Katherine J Nielsen; Richard J Lewis; Paul F Alewood; David J Craik
Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy.
The Journal of biological chemistry 1997;272(4):2291-9.
1996: Katherine J Nielsen; Linda Thomas; Richard J Lewis; Paul F Alewood; David J Craik
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.
Journal of molecular biology 1996;263(2):297-310.
1996: A Jones; J P Bingham; J Gehrmann; T Bond; Marion L Loughnan; AR Atkins; Richard J Lewis; Paul F Alewood
Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 1996;10(1):138-43.
1995: J A Brock; Elspeth M McLachlan; P Jobling; Richard J Lewis
Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1.
British journal of pharmacology 1995;116(4):2213-20.
1995: P A Hamblin; Elspeth M McLachlan; Richard J Lewis
Sub-nanomolar concentrations of ciguatoxin-1 excite preganglionic terminals in guinea pig sympathetic ganglia.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(2):236-46.
1995: M J Holmes; Richard J Lewis; A Jones; A W Hoy
Cooliatoxin, the first toxin from Coolia monotis (Dinophyceae).
Natural toxins 1995;3(5):355-62.
1994: Richard J Lewis; J P Bingham; A Jones; Paul F Alewood; P R Andrews
Drugs from the peptide venoms of marine cone shells.
Australasian biotechnology 1994;4(5):298-300.
1988: Richard J Lewis
Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles.
Toxicon : official journal of the International Society on Toxinology 1988;26(7):639-49.