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Richard Lewis

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Richard S Lewis
Store-operated calcium channels: new perspectives on mechanism and function.
Paul J Hoover; Richard S Lewis
Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).
Elizabeth D Covington; Minnie M Wu; Richard S Lewis
Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.

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All Publications

2011: Richard S Lewis
Store-operated calcium channels: new perspectives on mechanism and function.
Cold Spring Harbor perspectives in biology 2011;3(12):.
2011: Paul J Hoover; Richard S Lewis
Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13299-304.
2010: Elizabeth D Covington; Minnie M Wu; Richard S Lewis
Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.
Molecular biology of the cell 2010;21(11):1897-907.
2009: Lauren I Richie Ehrlich; David Y Oh; Irving L Weissman; Richard S Lewis
Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.
Immunity 2009;31(6):986-98.
2009: Franklin M Mullins; Chan Young Park; Ricardo E Dolmetsch; Richard S Lewis
STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(36):15495-500.
2009: Chan Young Park; Paul J Hoover; Franklin M Mullins; Priti Bachhawat; Elizabeth D Covington; Stefan Raunser; Thomas Walz; K Christopher Garcia; Ricardo E Dolmetsch; Richard S Lewis
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
Cell 2009;136(5):876-90.
2008: Riina M Luik; Bin Wang; Murali Prakriya; Minnie M Wu; Richard S Lewis
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.
Nature 2008;454(7203):538-42.
2007: Minnie M Wu; Riina M Luik; Richard S Lewis
Some assembly required: constructing the elementary units of store-operated Ca2+ entry.
Cell calcium 2007;42(2):163-72.
2007: Richard S Lewis
The molecular choreography of a store-operated calcium channel.
Nature 2007;446(7133):284-7.
2007: Riina M Luik; Richard S Lewis
New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells.
Trends in molecular medicine 2007;13(3):103-7.
2006: Riina M Luik; Minnie M Wu; JoAnn Buchanan; Richard S Lewis
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.
The Journal of cell biology 2006;174(6):815-25.
2006: Minnie M Wu; JoAnn Buchanan; Riina M Luik; Richard S Lewis
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane.
The Journal of cell biology 2006;174(6):803-13.
2006: Murali Prakriya; Richard S Lewis
Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode.
The Journal of general physiology 2006;128(3):373-86.
2006: Stefan Feske; Yousang Gwack; Murali Prakriya; Sonal Srikanth; Sven-Holger Puppel; Bogdan Tanasa; Patrick G Hogan; Richard S Lewis; Mark Daly; Anjana Rao
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Nature 2006;441(7090):179-85.
2005: Nirav R Bhakta; Richard S Lewis
Real-time measurement of signaling and motility during T cell development in the thymus.
Seminars in immunology 2005;17(6):411-20.
2005: Stefan Feske; Murali Prakriya; Anjana Rao; Richard S Lewis
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients.
The Journal of experimental medicine 2005;202(5):651-62.
2005: Nirav R Bhakta; David Y Oh; Richard S Lewis
Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.
Nature immunology 2005;6(2):143-51.
2004: Jonathan B Rothbard; Theodore C Jessop; Richard S Lewis; Bryce A Murray; Paul A Wender
Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells.
Journal of the American Chemical Society 2004;126(31):9506-7.
2004: Diana M Bautista; Richard S Lewis
Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells.
The Journal of physiology 2004;556(Pt 3):805-17.
2003: Richard S Lewis
Calcium oscillations in T-cells: mechanisms and consequences for gene expression.
Biochemical Society transactions 2003;31(Pt 5):925-9.
2003: Murali Prakriya; Richard S Lewis
CRAC channels: activation, permeation, and the search for a molecular identity.
Cell calcium 2003;33(5-6):311-21.
2002: Diana M Bautista; Markus Hoth; Richard S Lewis
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells.
The Journal of physiology 2002;541(Pt 3):877-94.
2002: Philippe Bousso; Nirav R Bhakta; Richard S Lewis; Ellen A Robey
Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.
Science (New York, N.Y.) 2002;296(5574):1876-80.
2002: Murali Prakriya; Richard S Lewis
Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels.
The Journal of general physiology 2002;119(5):487-507.
2001: Murali Prakriya; Richard S Lewis
Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.
The Journal of physiology 2001;536(Pt 1):3-19.
2001: Richard S Lewis
Calcium signaling mechanisms in T lymphocytes.
Annual review of immunology 2001;19():497-521.
2000: Markus Hoth; D C Button; Richard S Lewis
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10607-12.
1998: L J Holsinger; ISabella Graef; W Swat; T Chi; Diana M Bautista; L Davidson; Richard S Lewis; F W Alt; Gerald R Crabtree
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Current biology : CB 1998;8(10):563-72.
1998: Ricardo E Dolmetsch; K Xu; Richard S Lewis
Calcium oscillations increase the efficiency and specificity of gene expression.
Nature 1998;392(6679):933-6.
1998: James I Healy; Ricardo E Dolmetsch; Richard S Lewis; Christopher C Goodnow
Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes.
Novartis Foundation symposium 1998;215():137-44; discussion 144-5, 186-90.
1997: Markus Hoth; C M Fanger; Richard S Lewis
Mitochondrial regulation of store-operated calcium signaling in T lymphocytes.
The Journal of cell biology 1997;137(3):633-48.
1997: Ricardo E Dolmetsch; Richard S Lewis; Christopher C Goodnow; James I Healy
Differential activation of transcription factors induced by Ca2+ response amplitude and duration.
Nature 1997;386(6627):855-8.
1997: James I Healy; Ricardo E Dolmetsch; Luika Timmerman; Jason G Cyster; M L Thomas; Gerald R Crabtree; Richard S Lewis; Christopher C Goodnow
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.
Immunity 1997;6(4):419-28.
1996: michael sjaastad; Richard S Lewis; W James Nelson
Mechanisms of integrin-mediated calcium signaling in MDCK cells: regulation of adhesion by IP3- and store-independent calcium influx.
Molecular biology of the cell 1996;7(7):1025-41.
1996: A Zweifach; Richard S Lewis
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
The Journal of general physiology 1996;107(5):597-610.
1996: Richard S Lewis; Ricardo E Dolmetsch; A Zweifach
Positive and negative regulation of depletion-activated calcium channels by calcium.
Society of General Physiologists series 1996;51():241-54.
1995: C M Fanger; M Hoth; Gerald R Crabtree; Richard S Lewis
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
The Journal of cell biology 1995;131(3):655-67.
1995: A T Serafini; Richard S Lewis; N A Clipstone; R J Bram; C Fanger; S Fiering; Leonore A Herzenberg; Gerald R Crabtree
Isolation of mutant T lymphocytes with defects in capacitative calcium entry.
Immunity 1995;3(2):239-50.
1995: A Zweifach; Richard S Lewis
Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.
The Journal of biological chemistry 1995;270(24):14445-51.
1995: A Zweifach; Richard S Lewis
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.
The Journal of general physiology 1995;105(2):209-26.
1994: michael sjaastad; B Angres; Richard S Lewis; W James Nelson
Feedback regulation of cell-substratum adhesion by integrin-mediated intracellular Ca2+ signaling.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8214-8.
1994: Ricardo E Dolmetsch; Richard S Lewis
Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.
The Journal of general physiology 1994;103(3):365-88.
1993: A Zweifach; Richard S Lewis
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6295-9.