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Pieter Leyssen

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Chemicals & Drugs

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Publications

TOP 3
Tine De Burghgraeve; Yannick Debing; Michael Jacobs; Suzanne J F Kaptein; Pieter Leyssen; Bruno Canard; Grégory Chatelain; Barbara Selisko; Arthur Van Aerschot; Johan Neyts
3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.
Jinzhi Tan; Stefan Anemüller; Bruno Coutard; Shyla George; Yuri Kusov; Céline Lacroix; Pieter Leyssen; Jeroen R Mesters; Johan Neyts; Helene Norder; Markus Perbandt; Rolf Hilgenfeld
3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.
Marcella Bassetto; Giampiero Colombano; Antonio Coluccia; Tine De Burghgraeve; Leen Delang; Valerio Gatti; Pieter Leyssen; Alberto Massarotti; Johan Neyts; Romano Silvestri; Giovanni Sorba; Gian Cesare Tron; Nicola Zonta; Andrea Brancale
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.

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All Publications

2013: Tine De Burghgraeve; Yannick Debing; Michael Jacobs; Suzanne J F Kaptein; Pieter Leyssen; Bruno Canard; Grégory Chatelain; Barbara Selisko; Arthur Van Aerschot; Johan Neyts
3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.
Antiviral research 2013;98(2):242-7.
2013: Jinzhi Tan; Stefan Anemüller; Bruno Coutard; Shyla George; Yuri Kusov; Céline Lacroix; Pieter Leyssen; Jeroen R Mesters; Johan Neyts; Helene Norder; Markus Perbandt; Rolf Hilgenfeld
3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.
Journal of virology 2013;87(8):4339-51.
2013: Marcella Bassetto; Giampiero Colombano; Antonio Coluccia; Tine De Burghgraeve; Leen Delang; Valerio Gatti; Pieter Leyssen; Alberto Massarotti; Johan Neyts; Romano Silvestri; Giovanni Sorba; Gian Cesare Tron; Nicola Zonta; Andrea Brancale
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.
Antiviral research 2013;98(1):12-8.
2013: Rachel Ulferts; Lonneke van der Linden; Bruno Canard; Bruno Coutard; Armando M De Palma; Kjerstin H W Lanke; Pieter Leyssen; Johan Neyts; Hendrik Jan Thibaut; Frank J M van Kuppeveld
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.
Antimicrobial agents and chemotherapy 2013;57(4):1952-6.
2013: Maria Letizia Barreca; Amartya Basu; U Helena Danielson; Nunzio Iraci; Neerja Kaushik-Basu; Ramalingam Krishnan; Pieter Leyssen; Giuseppe Manfroni; Johan Neyts; Jan Paeshuyse; Stefano Sabatini; Oriana Tabarrini; Johan Winquist; Violetta Cecchetti
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Journal of medicinal chemistry 2013;56(6):2270-82.
2012: Mélanie BOURJOT; Leen Delang; Françoise Guéritte; Pieter Leyssen; Johan Neyts; Van Hung Nguyen; Marc Litaudon
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.
Journal of natural products 2012;75(12):2183-7.
2012: Pierre-Marie Allard; Mélanie BOURJOT; Bruno Canard; Vincent Dumontet; Cécilia Eydoux; Françoise Guéritte; Jean-Claude Guillemot; Pieter Leyssen; Marie-Thérèse Martin; Cyril Poullain; Marc Litaudon
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.
Phytochemistry 2012;84():160-8.
2012: J Rocha-Pereira; I Costa; R Cunha; K Dallmeier; D Jochmans; Pieter Leyssen; Maria São José Nascimento; J Neyts
Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine.
Biochemical and biophysical research communications 2012;427(4):796-800.
2012: Mélanie BOURJOT; Bruno Canard; Cécilia Eydoux; Françoise Guéritte; Jean-Claude Guillemot; Pieter Leyssen; Philippe Rasoanaivo; Marc Litaudon
Chemical constituents of Anacolosa pervilleana and their antiviral activities.
Fitoterapia 2012;83(6):1076-80.
2012: J Rocha-Pereira; K Dallmeier; D Jochmans; Pieter Leyssen; Maria São José Nascimento; J Neyts
Favipiravir (T-705) inhibits in vitro norovirus replication.
Biochemical and biophysical research communications 2012;424(4):777-80.
2012: Dirk Jochmans; Pieter Leyssen; Johan Neyts
A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE.
Journal of virological methods 2012;183(2):176-9.
2012: Karlo Wittine; Jan Balzarini; Sandra Kraljević Pavelić; Pieter Leyssen; Damjan Makuc; Johan Neyts; Krešimir Pavelić; Janez Plavec; Mirela Sedić; Maja Stipković Babić; Mladen Mintas
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.
Bioorganic & medicinal chemistry 2012;20(11):3675-85.
2012: Mélanie Bourjot; Bruno Canard; Cécilia Eydoux; Françoise Guéritte; Jean-Claude Guillemot; Pieter Leyssen; Philippe Rasoanaivo; Marc Litaudon
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
Journal of natural products 2012;75(4):752-8.
2012: Michal Sála; Johan Neyts; Armando M De Palma; Milan Dejmek; Martin Dračínský; Hubert Hřebabecký; Pieter Leyssen; Radim Nencka
Novel substituted 9-norbornylpurines and their activities against RNA viruses.
Bioorganic & medicinal chemistry letters 2012;22(5):1963-8.
2012: Leire Aguado; María-José Camarasa; María-Dolores Canela; Pieter Leyssen; Johan Neyts; Eva-María Priego; Hendrik Jan Thibaut; María-Jesús Pérez-Pérez
Efficient synthesis and anti-enteroviral activity of 9-arylpurines.
European journal of medicinal chemistry 2012;49():279-88.
2012: Giuseppe Manfroni; Serena Massari; Francesco Meschini; Johan Neyts; Stefano Sabatini; Alberta Samuele; Maria Letizia Barreca; Nunzio Iraci; Pieter Leyssen; Giovanni Maga; Violetta Cecchetti
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Bioorganic & medicinal chemistry 2012;20(2):866-76.
2011: Michal Sála; Johan Neyts; Armando M De Palma; Milan Dejmek; Martin Dračínský; Hubert Hřebabecký; Pieter Leyssen; Helena Mertlíková-Kaiserová; Radim Nencka
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(14):4271-5.
2011: Hendrik Jan Thibaut; Pieter Leyssen; Gerhard Puerstinger; Alexandra Muigg; Johan Neyts; Armando Mirko De Palma
Towards the design of combination therapy for the treatment of enterovirus infections.
Antiviral research 2011;90(3):213-7.
2011: Matthew A Gregory; Michael Bobardt; Susan Obeid; Udayan Chatterji; Nigel J Coates; Teresa Foster; Philippe Gallay; Pieter Leyssen; Steven J Moss; Johan Neyts; Mohammad Nur-e-Alam; Jan Paeshuyse; Mahmood Piraee; Dipen Suthar; Tony Warneck; Ming-Qiang Zhang; Barrie Wilkinson
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
Antimicrobial agents and chemotherapy 2011;55(5):1975-81.
2011: Jih Ru Hwu; Shu-Yu Lin; Shwu-Chen Tsay; Erik De Clercq; Pieter Leyssen; Johan Neyts
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus.
Journal of medicinal chemistry 2011;54(7):2114-26.
2010: Hanane Elayadi; Michael Smietana; Christophe Pannecouque; Pieter Leyssen; Johan Neyts; Jean-Jacques Vasseur; Hassan B Lazrek
Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(24):7365-8.
2010: Stephane Priet; Ivan Zlatev; Ivan Barvik; Katrien Geerts; Pieter Leyssen; Johan Neyts; Helene Dutartre; Bruno Canard; Jean-Jacques Vasseur; François Morvan; Karine Alvarez
3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity.
Journal of medicinal chemistry 2010;53(18):6608-17.
2010: Michal Sála; Armando M De Palma; Hubert Hrebabecký; Radim Nencka; Martin Dracínský; Pieter Leyssen; Johan Neyts; Antonín Holý
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.
Bioorganic & medicinal chemistry 2010;18(12):4374-84.
2010: Yang Liu; Yi Xia; Wei Li; Mei Cong; Alain Maggiani; Pieter Leyssen; Fanqi Qu; Johan Neyts; Ling Peng
S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus.
Bioorganic & medicinal chemistry letters 2010;20(12):3610-3.
2009: Stéphane Betzi; Cécilia Eydoux; Cecile Bussetta; Marilyne Blemont; Pieter Leyssen; Claire Debarnot; Mohamed Ben-Rahou; jacques haiech; Marcel Hibert; Françoise Gueritte; David S Grierson; Jean-Louis Romette; Jean-Claude Guillemot; Johan Neyts; Karine Alvarez; Xavier Morelli; Hélène Dutartre; Bruno Canard
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.
Antiviral research 2009;84(1):48-59.
2009: Leen Delang; Jan Paeshuyse; Inge Vliegen; Pieter Leyssen; Susan Obeid; David Durantel; Fabien Zoulim; Anne Op de Beeck; Johan Neyts
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.
Hepatology (Baltimore, Md.) 2009;50(1):6-16.
2009: Sahar Kandil; Sonia Biondaro; Dimitrios Vlachakis; Anna-Claire Cummins; Antonio Coluccia; Colin Berry; Pieter Leyssen; Johan Neyts; Andrea Brancale
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach.
Bioorganic & medicinal chemistry letters 2009;19(11):2935-7.
2008: Jan Paeshuyse; Inge Vliegen; Lotte Coelmont; Pieter Leyssen; Oriana Tabarrini; Piet Herdewijn; Harald Mittendorfer; Johnny Easmon; Violetta Cecchetti; Ralf Bartenschlager; Gerhard Puerstinger; Johan Neyts
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Antimicrobial agents and chemotherapy 2008;52(9):3433-7.
2008: Pieter Leyssen; Erik De Clercq; Johan Neyts
Molecular strategies to inhibit the replication of RNA viruses.
Antiviral research 2008;78(1):9-25.
2007: Jan Paeshuyse; Jean-Michel Chezal; Matheus Froeyen; Pieter Leyssen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Carine Letellier; Tong Li; Harald Mittendorfer; Frank Koenen; Pierre Kerkhofs; Erik De Clercq; Piet Herdewijn; Gerhard Puerstinger; Alain Gueiffier; Olivier Chavignon; Jean-Claude Teulade; Johan Neyts
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Journal of virology 2007;81(20):11046-53.
2007: Armando De Palma; Ward Heggermont; Pieter Leyssen; Gerhard Pürstinger; Eva Wimmer; Erik De Clercq; Angela Rao; Anna-Maria Monforte; Alba Chimirri; Johan Neyts
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.
Biochemical and biophysical research communications 2007;353(3):628-32.
2006: Pieter Leyssen; Erik De Clercq; Johan Neyts
The anti-yellow fever virus activity of ribavirin is independent of error-prone replication.
Molecular pharmacology 2006;69(4):1461-7.
2006: Jan Paeshuyse; Pieter Leyssen; Eric Mabery; Nina Boddeker; Robert Vrancken; Matheus Froeyen; Israrul H Ansari; Hélène Dutartre; Jef Rozenski; Laura H V G Gil; Carine Letellier; Robert E Lanford; Bruno Canard; Frank Koenen; Pierre Kerkhofs; Ruben O Donis; Piet Herdewijn; Julia Watson; Erik De Clercq; Gerhard Puerstinger; Johan Neyts
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Journal of virology 2006;80(1):149-60.
2005: Pieter Leyssen; Jan Balzarini; Erik De Clercq; Johan Neyts
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.
Journal of virology 2005;79(3):1943-7.
2005: Erik De Clercq; Graciela Andrei; Jan Balzarini; Pieter Leyssen; Lieve Naesens; Johan Neyts; Christophe Pannecouque; Robert Snoeck; Chunxiao Ying; Dana Hocková; Antonín Holý
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2004: Johann Sellner; Pieter Leyssen; Sabine Heiland; Philipp R Rau; Johan Neyts; Francisco Martinez-Torres; Peter Schramm; Werner Hacke; Uta Meyding-Lamadé
In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging.
Journal of neurovirology 2004;10(4):255-9.
2004: Nathalie Charlier; Pieter Leyssen; Erik De Clercq; Johan Neyts
Rodent models for the study of therapy against flavivirus infections.
Antiviral research 2004;63(2):67-77.
2004: Nathalie Charlier; Richard Molenkamp; Pieter Leyssen; Jan Paeshuyse; Christian Drosten; Marcus Panning; Erik De Clercq; Peter J Bredenbeek; Johan Neyts
Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice.
Journal of virology 2004;78(14):7418-26.
2004: Johan Neyts; Pieter Leyssen; Erik Verbeken; Erik De Clercq
Efficacy of cidofovir in a murine model of disseminated progressive vaccinia.
Antimicrobial agents and chemotherapy 2004;48(6):2267-73.
2003: Pieter Leyssen; Romaric Croes; Philipp R Rau; Sabine Heiland; Erik Verbeken; Raphael Sciot; Jan Paeshuyse; Nathalie Charlier; Erik De Clercq; Uta Meyding-Lamadé; Johan Neyts
Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections.
Brain pathology (Zurich, Switzerland) 2003;13(3):279-90.
2003: Nathalie Charlier; Richard Molenkamp; Pieter Leyssen; Anne-Mieke Vandamme; Erik De Clercq; Peter J Bredenbeek; Johan Neyts
A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses.
Journal of virological methods 2003;108(1):67-74.
2003: Pieter Leyssen; Jan Paeshuyse; Nathalie Charlier; Alfons Van Lommel; Christian Drosten; Erik De Clercq; Johan Neyts
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.
Journal of neurovirology 2003;9(1):69-78.
2003: Pieter Leyssen; Christian Drosten; Marcus Paning; Nathalie Charlier; Jan Paeshuyse; Erik De Clercq; Johan Neyts
Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice.
Antimicrobial agents and chemotherapy 2003;47(2):777-82.
2003: Pieter Leyssen; Nathalie Charlier; Jan Paeshuyse; Erik De Clercq; Johan Neyts
Prospects for antiviral therapy.
Advances in virus research 2003;61():511-53.
2002: Nathalie Charlier; Pieter Leyssen; Jan Paeshuyse; Christian Drosten; Herbert Schmitz; Alfons Van Lommel; Erik De Clercq; Johan Neyts
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis.
The Journal of general virology 2002;83(Pt 8):1887-96.
2002: Nathalie Charlier; Pieter Leyssen; Cornelis W A Pleij; Philippe Lemey; Frédérique Billoir; Kristel Van Laethem; Anne-Mieke Vandamme; Erik De Clercq; Xavier de Lamballerie; Johan Neyts
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector.
The Journal of general virology 2002;83(Pt 8):1875-85.
2002: Chunxiao Ying; Jos F van Pelt; Alfons Van Lommel; Marc Van Ranst; Pieter Leyssen; Erik De Clercq; Johan Neyts
Sulphated and sulphonated polymers inhibit the initial interaction of hepatitis B virus with hepatocytes.
Antiviral chemistry & chemotherapy 2002;13(3):157-64.
2002: Pieter Leyssen; Nathalie Charlier; Philippe Lemey; Frédérique Billoir; Anne-Mieke Vandamme; Erik De Clercq; Xavier de Lamballerie; Johan Neyts
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector.
Virology 2002;293(1):125-40.
2001: Erik De Clercq; Graciela Andrei; Robert Snoeck; Leen De Bolle; Lieve Naesens; B Degrève; Jan Balzarini; Ying Zhang; Dominique Schols; Pieter Leyssen; Chunxiao Ying; Johan Neyts
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):271-85.
2001: Pieter Leyssen; Christian Drosten; H Schmitz; Johan Neyts
A novel model for the study of the therapy of flavivirus infections using the Modoc virus.
Virology 2001;279(1):27-37.
2000: Pieter Leyssen; Erik De Clercq; Johan Neyts
Perspectives for the treatment of infections with Flaviviridae.
Clinical microbiology reviews 2000;13(1):67-82, table of contents.