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Min Li-Weber

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Min Li-Weber
Targeting apoptosis pathways in cancer by Chinese medicine.
Gernot Polier; Peter Proksch; Nigel Ribeiro; Hendrik Schmidt; Frédéric Thuaud; Wolfgang W Müller; Jennifer Neumann; Laurent Désaubry; Christoph Gelhaus; Marco Giaisi; Ottmar Janssen; Rebecca Köhler; Peter H Krammer; Matthias Leippe; Min Li-Weber
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.
Marco Giaisi; Rebecca Köhler; Peter H Krammer; Simone Fulda; Min Li-Weber
Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.

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All Publications

2013: Min Li-Weber
Targeting apoptosis pathways in cancer by Chinese medicine.
Cancer letters 2013;332(2):304-12.
2012: Gernot Polier; Peter Proksch; Nigel Ribeiro; Hendrik Schmidt; Frédéric Thuaud; Wolfgang W Müller; Jennifer Neumann; Laurent Désaubry; Christoph Gelhaus; Marco Giaisi; Ottmar Janssen; Rebecca Köhler; Peter H Krammer; Matthias Leippe; Min Li-Weber
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.
Chemistry & biology 2012;19(9):1093-104.
2012: Marco Giaisi; Rebecca Köhler; Peter H Krammer; Simone Fulda; Min Li-Weber
Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.
International journal of cancer. Journal international du cancer 2012;131(4):1003-8.
2012: Christian Kliem; Rebecca Köhler; Peter H Krammer; Marco Giaisi; Anette Merling; Min Li-Weber
Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.
The Journal of biological chemistry 2012;287(13):10200-9.
2011: M Bleumink; R Köhler; Marco Giaisi; Peter Proksch; Peter H Krammer; Min Li-Weber
Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression.
Cell death and differentiation 2011;18(2):362-70.
2011: Sherif S Ebada; Neil Lajkiewicz; Min Li-Weber; John A Porco; Peter Proksch
Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae).
Progress in the chemistry of organic natural products 2011;94():1-58.
2011: G Polier; N Ribeiro; L Desaubry; J Ding; Thomas Efferth; D Eick; Marco Giaisi; R Köhler; B V Konkimalla; P H Krammer; Min Li-Weber
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.
Cell death & disease 2011;2():e182.
2010: Michael Lohoff; Marco Giaisi; Rebecca Köhler; Bärbel Casper; Peter H Krammer; Min Li-Weber
Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4.
The Journal of biological chemistry 2010;285(3):1643-52.
2009: J Y Zhu; Marco Giaisi; R Köhler; W W Müller; A Mühleisen; Peter Proksch; Peter H Krammer; Min Li-Weber
Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.
Cell death and differentiation 2009;16(9):1289-99.
2009: Min Li-Weber
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.
Cancer treatment reviews 2009;35(1):57-68.
2008: Daniel Hebenstreit; Marco Giaisi; Monika K Treiber; Xiao-Bin Zhang; Huai-Feng Mi; Jutta Horejs-Hoeck; Kristian G Andersen; Peter H Krammer; Albert Duschl; Min Li-Weber
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.
The Journal of biological chemistry 2008;283(33):22490-7.
2008: Sven Baumann; Stefanie C Fas; Marco Giaisi; Wolfgang W Müller; Anette Merling; Karsten Gülow; Lutz Edler; Peter H Krammer; Min Li-Weber
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.
Blood 2008;111(4):2354-63.
2007: Jia Y Zhu; Inna N Lavrik; Ulrich Mahlknecht; Marco Giaisi; Peter Proksch; Peter H Krammer; Min Li-Weber
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities.
International journal of cancer. Journal international du cancer 2007;121(8):1839-46.
2007: Thomas Efferth; Marco Giaisi; Anette Merling; Peter H Krammer; Min Li-Weber
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.
PloS one 2007;2(8):e693.
2006: Stefanie C Fas; Sven Baumann; Jia Yun Zhu; Marco Giaisi; Monika K Treiber; Ulrich Mahlknecht; Peter H Krammer; Min Li-Weber
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.
Blood 2006;108(12):3700-6.
2006: Andreas Krueger; Stefanie C Fas; Marco Giaisi; Marc Bleumink; Anette Merling; Christine Stumpf; Sven Baumann; Denise Holtkotte; Valerie Bosch; Peter H Krammer; Min Li-Weber
HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).
Blood 2006;107(10):3933-9.
2005: Tom M Ganten; Ronald Koschny; Tobias L Haas; Jaromir Sykora; Min Li-Weber; Kerstin Herzer; Henning Walczak
Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.
Hepatology (Baltimore, Md.) 2005;42(3):588-97.
2005: Min Li-Weber; Monika K Treiber; Marco Giaisi; Katalin Palfi; Nadja Stephan; Simone Parg; Peter H Krammer
Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2132-43.
2005: Peter Proksch; Marco Giaisi; Monika K Treiber; Katalin Palfi; Anette Merling; Herbert Spring; Peter H Krammer; Min Li-Weber
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7075-84.
2005: Karsten Gülow; Marcin Kaminski; Katalin Darvas; Dorothee Süss; Min Li-Weber; Peter H Krammer
HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5249-60.
2005: Min Li-Weber; Katalin Palfi; Marco Giaisi; Peter H Krammer
Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.
Cell death and differentiation 2005;12(4):408-9.
2004: Bysani Chandrasekar; Kirankumar Vemula; Rama Mohan Surabhi; Min Li-Weber; Laurie B Owen-Schaub; Liselotte E Jensen; Srinivas Mummidi
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
The Journal of biological chemistry 2004;279(19):20221-33.
2004: Min Li-Weber; Marco Giaisi; Sven Baumann; Katalin Pálfi; Peter H Krammer
NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells.
European journal of immunology 2004;34(4):1111-8.
2003: Min Li-Weber; Peter H Krammer
Regulation of IL4 gene expression by T cells and therapeutic perspectives.
Nature reviews. Immunology 2003;3(7):534-43.
2003: Min Li-Weber; Peter H Krammer
Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system.
Seminars in immunology 2003;15(3):145-57.
2002: Min Li-Weber; Marco Giaisi; Monika K Treiber; Peter H Krammer
The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.
European journal of immunology 2002;32(12):3587-97.
2002: Bernd Elser; Michael Lohoff; Sonja Kock; Marco Giaisi; Sabine Kirchhoff; Peter H Krammer; Min Li-Weber
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.
Immunity 2002;17(6):703-12.
2002: Min Li-Weber; Marco Giaisi; Sven Baumann; Monika K Treiber; Peter H Krammer
The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.
Cell death and differentiation 2002;9(11):1256-65.
2002: Min Li-Weber; Markus A Weigand; Marco Giaisi; Dorothee Süss; Monika K Treiber; Sven Baumann; Elena Ritsou; Raoul Breitkreutz; Peter H Krammer
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.
The Journal of clinical investigation 2002;110(5):681-90.
2002: Min Li-Weber; Marco Giaisi; Monika K Treiber; Peter H Krammer
Vitamin E inhibits IL-4 gene expression in peripheral blood T cells.
European journal of immunology 2002;32(9):2401-8.
2002: Sabine Kirchhoff; Thorsten Sebens; Sven Baumann; Andreas Krueger; Rainer Zawatzky; Min Li-Weber; Edgar Meinl; Frank Neipel; Bernhard Fleckenstein; Peter H Krammer
Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1226-34.
2001: Min Li-Weber; Marco Giaisi; Peter H Krammer
Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene.
European journal of immunology 2001;31(12):3694-703.
2001: Min Li-Weber; Marco Giaisi; Katerina Chlichlia; Khashayarsha Khazaie; Peter H Krammer
Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells.
European journal of immunology 2001;31(9):2623-32.
2001: A Ehret; Min Li-Weber; R Frank; Peter H Krammer
The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat.
European journal of immunology 2001;31(6):1790-9.
2000: Sabine Kirchhoff; W W Müller; Min Li-Weber; Peter H Krammer
Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.
European journal of immunology 2000;30(10):2765-74.
2000: Steffen P Hehner; Min Li-Weber; Marco Giaisi; Wulf Dröge; Peter H Krammer; M Lienhard Schmitz
Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3829-36.
2000: Min Li-Weber; O Laur; K Dern; Peter H Krammer
T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.
European journal of immunology 2000;30(2):661-70.
1999: Min Li-Weber; O Laur; Peter H Krammer
Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
European journal of immunology 1999;29(9):3017-27.
1998: Min Li-Weber; M Giasi; Peter H Krammer
Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.
The Journal of biological chemistry 1998;273(49):32460-6.
1998: Min Li-Weber; O Laur; A Hekele; Johannes F Coy; Henning Walczak; Peter H Krammer
A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation.
European journal of immunology 1998;28(8):2373-83.
1998: Min Li-Weber; P Salgame; C Hu; IV Davydov; O Laur; S Klevenz; Peter H Krammer
Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1380-9.
1997: Min Li-Weber; O Laur; IV Davydov; C Hu; P Salgame; Peter H Krammer
What controls tissue-specific expression of the IL-4 gene?
Immunobiology 1997;198(1-3):170-8.
1997: Min Li-Weber; P Salgame; C Hu; Peter H Krammer
Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter.
Gene 1997;188(2):253-60.
1997: Min Li-Weber; P Salgame; C Hu; IV Davydov; Peter H Krammer
Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1194-200.
1995: I V Davydov; Peter H Krammer; Min Li-Weber
Nuclear factor-IL6 activates the human IL-4 promoter in T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5273-9.
1995: I V Davydov; D Bohmann; Peter H Krammer; Min Li-Weber
Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.
Gene 1995;161(2):271-5.
1995: Min Li-Weber; I V Davydov; Peter H Krammer
NF-Y, IRF-2, and C/EBP proteins are involved in regulation of human IL-4 gene expression.
Immunobiology 1995;193(2-4):263-7.
1994: Min Li-Weber; I V Davydov; H Krafft; Peter H Krammer
The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4122-33.
1994: M O Westendorp; Min Li-Weber; R W Frank; Peter H Krammer
Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Journal of virology 1994;68(7):4177-85.
1993: Min Li-Weber; H Krafft; Peter H Krammer
A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1371-82.
1992: A Oehm; I Behrmann; Werner Falk; M Pawlita; G Maier; C Klas; Min Li-Weber; S Richards; J Dhein; B C Trauth
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
The Journal of biological chemistry 1992;267(15):10709-15.
1992: Min Li-Weber; A Eder; H Krafft-Czepa; Peter H Krammer
T cell-specific negative regulation of transcription of the human cytokine IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1913-8.