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Chengwen Li

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Chengwen Li; M J Manco-Johnson; P E Monahan; N Narkbunnam; R Jude Samulski; Aravind Asokan; G Hu; Linda J Jacobson
Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.
Ping-Jie Xiao; Chengwen Li; Aaron Neumann; R Jude Samulski
Quantitative 3D tracing of gene-delivery viral vectors in human cells and animal tissues.
Chengwen Li; Marc Scott Weinberg; Pingjie Xiao; Steven James Gray; R Jude Samulski
Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins.

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2012: Chengwen Li; M J Manco-Johnson; P E Monahan; N Narkbunnam; R Jude Samulski; Aravind Asokan; G Hu; Linda J Jacobson
Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.
Gene therapy 2012;19(3):288-94.
2012: Ping-Jie Xiao; Chengwen Li; Aaron Neumann; R Jude Samulski
Quantitative 3D tracing of gene-delivery viral vectors in human cells and animal tissues.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(2):317-28.
2011: Chengwen Li; Marc Scott Weinberg; Pingjie Xiao; Steven James Gray; R Jude Samulski
Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14258-63.
2011: Kevin S Goudy; Mark C Johnson; Alaina Garland; Chengwen Li; R Jude Samulski; Bo Wang; Roland Tisch
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
European journal of immunology 2011;41(5):1480-90.
2011: Boris Kantor; Matthew Bayer; Hong Ma; Jude Samulski; Chengwen Li; Thomas J McCown; Tal Kafri
Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(3):547-56.
2010: Jarrod S Johnson; Chengwen Li; Nina DiPrimio; Marc S Weinberg; Thomas J McCown; R Jude Samulski
Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction.
Journal of virology 2010;84(17):8888-902.
2010: Aravind Asokan; Julia C Conway; Jana L Phillips; Chengwen Li; Julia Hegge; Rebecca Sinnott; Swati Yadav; Nina DiPrimio; Hyun-Joo Nam; Mavis Agbandje-McKenna; Scott McPhee; Jon Wolff; R Jude Samulski
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle.
Nature biotechnology 2010;28(1):79-82.
2009: Chengwen Li; Matt Hirsch; Nina DiPrimio; Aravind Asokan; Kevin Goudy; Roland Tisch; R Jude Samulski
Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.
Journal of virology 2009;83(13):6817-24.
2009: Chengwen Li; Kevin Goudy; Matt Hirsch; Aravind Asokan; Yun Fan; Jeff Alexander; Junjiang Sun; Paul E Monahan; David Seiber; John Sidney; Alessandro Sette; Roland Tisch; Jeffrey Frelinger; R Jude Samulski
Cellular immune response to cryptic epitopes during therapeutic gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10770-4.
2009: F Curtis Hewitt; Chengwen Li; Steven J Gray; Shelley Cockrell; Michael Washburn; R Jude Samulski
Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors.
Journal of virology 2009;83(8):3919-29.
2009: Matthew L Hirsch; Francesca Storici; Chengwen Li; Vivian W Choi; R Jude Samulski
AAV recombineering with single strand oligonucleotides.
PloS one 2009;4(11):e7705.
2009: Chengwen Li; M Hirsch; P Carter; Aravind Asokan; X Zhou; Zhijian Wu; R Jude Samulski
A small regulatory element from chromosome 19 enhances liver-specific gene expression.
Gene therapy 2009;16(1):43-51.
2008: Xiaohuai Zhou; Xinghua Zeng; Zhenghong Fan; Chengwen Li; Thomas J McCown; R Jude Samulski; Xiao Xiao
Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):494-9.
2007: Chengwen Li; Matthew Hirsch; Aravind Asokan; Brian Zeithaml; Hong Ma; Tal Kafri; R Jude Samulski
Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo.
Journal of virology 2007;81(14):7540-7.
2005: Chengwen Li; Dawn E Bowles; Terry Van Dyke; R Jude Samulski
Adeno-associated virus vectors: potential applications for cancer gene therapy.
Cancer gene therapy 2005;12(12):913-25.
2005: Chengwen Li; R Jude Samulski
Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production.
Virology 2005;335(1):10-21.
2000: Hengjun Chao; Y Liu; J Rabinowitz; Chengwen Li; R Jude Samulski; Christopher E Walsh
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):619-23.