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Junan Li

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Junan Li; David E Schuller; Thomas J Knobloch; Laura Kresty; Jas C Lang; Zhaoxia Zhang; Christopher M Weghorst
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
Junan Li; Ming-Jye Poi; Ming-Daw Tsai
Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.
Yi Guo; Chunhua Yuan; Feng Tian; Kun Huang; Christopher M Weghorst; Ming-Daw Tsai; Junan Li
Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.

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All Publications

2011: Junan Li; David E Schuller; Thomas J Knobloch; Laura Kresty; Jas C Lang; Zhaoxia Zhang; Christopher M Weghorst
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
Anticancer research 2011;31(9):2683-92.
2011: Junan Li; Ming-Jye Poi; Ming-Daw Tsai
Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.
Biochemistry 2011;50(25):5566-82.
2010: Yi Guo; Chunhua Yuan; Feng Tian; Kun Huang; Christopher M Weghorst; Ming-Daw Tsai; Junan Li
Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.
Journal of molecular biology 2010;399(1):168-81.
2010: Yi Guo; Chunhua Yuan; Christopher M Weghorst; Junan Li
IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16.
Biochemical and biophysical research communications 2010;393(3):504-8.
2009: Yi Guo; Anjali Mahajan; Chunhua Yuan; Sang Hoon Joo; Christopher M Weghorst; Ming-Daw Tsai; Junan Li
Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins.
Biochemistry 2009;48(19):4050-62.
2008: Laura Kresty; Susan R Mallery; Thomas J Knobloch; Junan Li; Mary Lloyd; Bruce C Casto; Christopher M Weghorst
Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(11):3179-87.
2008: Junan Li; Blake Warner; Bruce C Casto; Thomas J Knobloch; Christopher M Weghorst
Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors.
Molecular carcinogenesis 2008;47(10):733-8.
2008: Peter Muscarella; Mark Bloomston; Alexander R Brewer; Anjali Mahajan; Wendy L Frankel; E Christopher Ellison; William B Farrar; Christopher M Weghorst; Junan Li
Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens.
Gene expression 2008;14(4):207-16.
2007: Anjali Mahajan; Yi Guo; Chunhua Yuan; Christopher M Weghorst; Ming-Daw Tsai; Junan Li
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.
Journal of molecular biology 2007;373(4):990-1005.
2006: Junan Li; Anjali Mahajan; Ming-Daw Tsai
Ankyrin repeat: a unique motif mediating protein-protein interactions.
Biochemistry 2006;45(51):15168-78.
2006: Junan Li; Jiuxiang Zhu; W Scott Melvin; Tanios S Bekaii-Saab; Ching-Shih Chen; Peter Muscarella
A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2006;10(2):207-14.
2005: Junan Li; Peter Muscarella; Sang Hoon Joo; Thomas J Knobloch; W Scott Melvin; Christopher M Weghorst; Ming-Daw Tsai
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).
Biochemistry 2005;44(40):13246-56.
2004: Chunhua Yuan; Junan Li; Anjali Mahajan; Ming-Jye Poi; In-Ja L Byeon; Ming-Daw Tsai
Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship.
Biochemistry 2004;43(38):12152-61.
2004: Junan Li; W Scott Melvin; Ming-Daw Tsai; Peter Muscarella
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner.
Biochemistry 2004;43(14):4394-9.
2004: Junan Li; Christopher M Weghorst; Masahiro Tsutsumi; Ming-Jye Poi; Thomas J Knobloch; Bruce C Casto; W Scott Melvin; Ming-Daw Tsai; Peter Muscarella
Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.
Carcinogenesis 2004;25(2):263-8.
2003: Junan Li; Sang Hoon Joo; Ming-Daw Tsai
An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4.
Biochemistry 2003;42(46):13476-83.
2003: Junan Li; Hongyuan Li; Ming-Daw Tsai
Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity.
Biochemistry 2003;42(22):6921-8.
2003: Junan Li; Dongyan Qin; Thomas J Knobloch; Ming-Daw Tsai; Christopher M Weghorst; W Scott Melvin; Peter Muscarella
Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.
Biochemical and biophysical research communications 2003;304(2):241-7.
2002: Junan Li; Ming-Daw Tsai
Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb.
Biochemistry 2002;41(12):3977-83.
2001: Ming-Jye Poi; T Yen; Junan Li; Huijuan Song; James C Lang; David E Schuller; Dennis K Pearl; Bruce C Casto; Ming-Daw Tsai; Christopher M Weghorst
Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.
Molecular carcinogenesis 2001;30(1):26-36.
2000: Chunhua Yuan; TL Selby; Junan Li; In-Ja L Byeon; Ming-Daw Tsai
Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.
Protein science : a publication of the Protein Society 2000;9(6):1120-8.
2000: Junan Li; Ming-Jye Poi; Dongyan Qin; TL Selby; In-Ja L Byeon; Ming-Daw Tsai
Tumor suppressor INK4: quantitative structure-function analyses of p18INK4C as an inhibitor of cyclin-dependent kinase 4.
Biochemistry 2000;39(4):649-57.
1999: Chunhua Yuan; Junan Li; TL Selby; In-Ja L Byeon; Ming-Daw Tsai
Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
Journal of molecular biology 1999;294(1):201-11.
1999: Junan Li; In-Ja L Byeon; K Ericson; Ming-Jye Poi; Paul E O'Maille; TL Selby; Ming-Daw Tsai
Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A.
Biochemistry 1999;38(10):2930-40.
1998: In-Ja L Byeon; Junan Li; K Ericson; TL Selby; A Tevelev; H J Kim; Paul E O'Maille; Ming-Daw Tsai
Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.
Molecular cell 1998;1(3):421-31.