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Lee Bardwell

Research Profile

Chemicals & Drugs

Living Beings

Saccharomyces cerevisiae

Physiology

Phenomena

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Carlo Chan; Xinfeng Liu; Qing Nie; Liming Wang; Lee Bardwell; Germán Enciso
Protein scaffolds can enhance the bistability of multisite phosphorylation systems.
Lee Bardwell
Synthetic biology: modulating the MAP kinase module.
Ching-Shan Chou; Qing Nie; Lee Bardwell; Tau-Mu Yi
Noise filtering tradeoffs in spatial gradient sensing and cell polarization response.

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All Publications

2012: Carlo Chan; Xinfeng Liu; Qing Nie; Liming Wang; Lee Bardwell; Germán Enciso
Protein scaffolds can enhance the bistability of multisite phosphorylation systems.
PLoS computational biology 2012;8(6):e1002551.
2011: Lee Bardwell
Synthetic biology: modulating the MAP kinase module.
Current biology : CB 2011;21(7):R249-51.
2011: Ching-Shan Chou; Qing Nie; Lee Bardwell; Tau-Mu Yi
Noise filtering tradeoffs in spatial gradient sensing and cell polarization response.
BMC systems biology 2011;5():196.
2010: Behnam Compani; Trent Su; Ivan Chang; Jianlin Cheng; Kandarp H Shah; Thomas Whisenant; Yimeng Dou; Adriel Bergmann; Raymond Cheong; Barbara Wold; Lee Bardwell; Andre Levchenko; Pierre Baldi; Eric Mjolsness
A scalable and integrative system for pathway bioinformatics and systems biology.
Advances in experimental medicine and biology 2010;680():523-34.
2010: Thomas C Whisenant; David T Ho; Ryan W Benz; Jeffrey S Rogers; Robyn M Kaake; Elizabeth A Gordon; Lan Huang; Pierre Baldi; Lee Bardwell
Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.
PLoS computational biology 2010;6(8):.
2010: Seth Haney; Lee Bardwell; Qing Nie
Ultrasensitive responses and specificity in cell signaling.
BMC systems biology 2010;4():119.
2009: A Jane Bardwell; Erlynn Frankson; Lee Bardwell
Selectivity of docking sites in MAPK kinases.
The Journal of biological chemistry 2009;284(19):13165-73.
2008: Lee Bardwell
Signal transduction: turning a switch into a rheostat.
Current biology : CB 2008;18(19):R910-2.
2007: Lee Bardwell; Xiufen Zou; Qing Nie; Natalia L Komarova
Mathematical models of specificity in cell signaling.
Biophysical journal 2007;92(10):3425-41.
2006: Lee Bardwell
Mechanisms of MAPK signalling specificity.
Biochemical Society transactions 2006;34(Pt 5):837-41.
2006: Lee Bardwell; Kandarp Shah
Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates.
Methods (San Diego, Calif.) 2006;40(3):213-23.
2006: Lee Bardwell
G-protein signaling: a new branch in an old pathway.
Current biology : CB 2006;16(19):R853-5.
2006: David T Ho; A Jane Bardwell; Seema Grewal; Corey Iverson; Lee Bardwell
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
The Journal of biological chemistry 2006;281(19):13169-79.
2006: Seema Grewal; Douglas M Molina; Lee Bardwell
Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.
Cellular signalling 2006;18(1):123-34.
2005: Douglas M Molina; Seema Grewal; Lee Bardwell
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.
The Journal of biological chemistry 2005;280(51):42051-60.
2005: Laura J Flatauer; Sheena F Zadeh; Lee Bardwell
Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae.
Molecular and cellular biology 2005;25(5):1793-803.
2005: Lee Bardwell
A walk-through of the yeast mating pheromone response pathway.
Peptides 2005;26(2):339-50.
2005: Natalia L Komarova; Xiufen Zou; Qing Nie; Lee Bardwell
A theoretical framework for specificity in cell signaling.
Molecular systems biology 2005;1():2005.0023.
2004: Lee Bardwell
A walk-through of the yeast mating pheromone response pathway.
Peptides 2004;25(9):1465-76.
2004: Paul J Cullen; Walid Sabbagh; Ellie Graham; Molly M Irick; Erin K van Olden; Cassandra Neal; Jeffrey Delrow; Lee Bardwell; George F Sprague
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.
Genes & development 2004;18(14):1695-708.
2004: A Jane Bardwell; Mahsa Abdollahi; Lee Bardwell
Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.
The Biochemical journal 2004;378(Pt 2):569-77.
2004: Anasua B Kusari; Douglas M Molina; Walid Sabbagh; Chang S Lau; Lee Bardwell
A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.
The Journal of cell biology 2004;164(2):267-77.
2003: David T Ho; A Jane Bardwell; Mahsa Abdollahi; Lee Bardwell
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.
The Journal of biological chemistry 2003;278(35):32662-72.
2003: A Jane Bardwell; Mahsa Abdollahi; Lee Bardwell
Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.
The Biochemical journal 2003;370(Pt 3):1077-85.
2001: Walid Sabbagh; Laura J Flatauer; A Jane Bardwell; Lee Bardwell
Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.
Molecular cell 2001;8(3):683-91.
2001: A Jane Bardwell; Laura J Flatauer; Karen E Matsukuma; Jeremy Thorner; Lee Bardwell
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.
The Journal of biological chemistry 2001;276(13):10374-86.
1998: Lee Bardwell; Jeanette Gowen Cook; J X Zhu-Shimoni; D Voora; Jeremy Thorner
Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15400-5.
1998: Lee Bardwell; Jeanette Gowen Cook; D Voora; D M Baggott; A R Martinez; Jeremy Thorner
Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
Genes & development 1998;12(18):2887-98.
1997: Jeanette Gowen Cook; Lee Bardwell; Jeremy Thorner
Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway.
Nature 1997;390(6655):85-8.
1996: Jeanette Gowen Cook; Lee Bardwell; S J Kron; Jeremy Thorner
Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.
Genes & development 1996;10(22):2831-48.
1996: Lee Bardwell; Jeremy Thorner
A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs.
Trends in biochemical sciences 1996;21(10):373-4.
1996: Lee Bardwell; Jeanette Gowen Cook; E C Chang; B R Cairns; Jeremy Thorner
Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.
Molecular and cellular biology 1996;16(7):3637-50.
1994: Lee Bardwell; Jeanette Gowen Cook; Carla Inouye; Jeremy Thorner
Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae.
Developmental biology 1994;166(2):363-79.