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Shihua Li

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TOP 3
Xiao-Jiang Li; Shihua Li
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models.
Austin Cape; Xingxing Chen; Jun He; He Li; Shihua Li; Yung-Feng Lin; Ashley O'Neill; Chuan-En Wang; Xing-Shun Xu; Hong Yi; Xiao-Jiang Li
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
Shihua Li; Xiao-Jiang Li
A huntingtin-HAP1-PCM1 pathway in ciliogenesis.

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All Publications

2012: Xiao-Jiang Li; Shihua Li
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models.
Journal of genetics and genomics = Yi chuan xue bao 2012;39(6):239-45.
2012: Austin Cape; Xingxing Chen; Jun He; He Li; Shihua Li; Yung-Feng Lin; Ashley O'Neill; Chuan-En Wang; Xing-Shun Xu; Hong Yi; Xiao-Jiang Li
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
Cellular and molecular life sciences : CMLS 2012;69(8):1305-17.
2012: Shihua Li; Xiao-Jiang Li
A huntingtin-HAP1-PCM1 pathway in ciliogenesis.
Expert review of proteomics 2012;9(1):17-9.
2011: Shanshan Huang; Xiao-Jiang Li; Joseph J Ling; Su Yang; Shihua Li
Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.
Brain : a journal of neurology 2011;134(Pt 7):1943-58.
2010: Xingshun Xu; Hao Yang; Yung-Feng Lin; Xiang Li; Austin Cape; Kerry J Ressler; Shihua Li; Xiao-Jiang Li
Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):19126-31.
2010: Dongshan Yang; Chuan-En Wang; Bentian Zhao; Wei Li; Zhen Ouyang; Zhaoming Liu; Huaqiang Yang; Pei Fan; Ashley O'Neill; Weiwang Gu; Hong Yi; Shihua Li; Liangxue Lai; Xiao-Jiang Li
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs.
Human molecular genetics 2010;19(20):3983-94.
2010: Xiang Li; Chuan-En Wang; Shanshan Huang; Xingshun Xu; Xiao-Jiang Li; He Li; Shihua Li
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Human molecular genetics 2010;19(12):2445-55.
2010: Yung-Feng Lin; Xingshun Xu; Austin Cape; Shihua Li; Xiao-Jiang Li
Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.
The Journal of biological chemistry 2010;285(21):15941-9.
2010: Jennifer Bradford; Ji-Yeon Shin; Meredith Roberts; Chuan-En Wang; Guoqing Sheng; Shihua Li; Xiao-Jiang Li
Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
The Journal of biological chemistry 2010;285(14):10653-61.
2010: Jennifer W Bradford; Shihua Li; Xiao-Jiang Li
Polyglutamine toxicity in non-neuronal cells.
Cell research 2010;20(4):400-7.
2010: Chuan-En Wang; Shihua Li; Xiao-Jiang Li
Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.
Molecular brain 2010;3():33.
2010: Xiao-Jiang Li; Adam L Orr; Shihua Li
Impaired mitochondrial trafficking in Huntington's disease.
Biochimica et biophysica acta 2010;1802(1):62-5.
2009: Jennifer Bradford; Ji-Yeon Shin; Meredith Roberts; Chuan-En Wang; Xiao-Jiang Li; Shihua Li
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22480-5.
2009: Anjali G Shah; Meyer J Friedman; Shanshan Huang; Meredith Roberts; Xiao-Jiang Li; Shihua Li
Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.
Human molecular genetics 2009;18(21):4141-52.
2009: Meyer J Friedman; Shihua Li; Xiao-Jiang Li
Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection.
The Journal of biological chemistry 2009;284(41):27944-51.
2009: Lauren S Havel; Shihua Li; Xiao-Jiang Li
Nuclear accumulation of polyglutamine disease proteins and neuropathology.
Molecular brain 2009;2():21.
2008: Suzanne Tydlacka; Chuan-En Wang; Xuejun Wang; Shihua Li; Xiao-Jiang Li
Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(49):13285-95.
2008: Chuan-En Wang; Suzanne Tydlacka; Adam L Orr; Shang-Hsun Yang; Graham Kyrenia Rona; Michael R Hayden; Shihua Li; Anthony W S Chan; Xiao-Jiang Li
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
Human molecular genetics 2008;17(17):2738-51.
2008: Adam L Orr; Shanshan Huang; Meredith A Roberts; John C Reed; Shihua Li; Xiao-Jiang Li
Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.
The Journal of biological chemistry 2008;283(23):16027-36.
2008: Meyer J Friedman; Chuan-En Wang; Xiao-Jiang Li; Shihua Li
Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity.
The Journal of biological chemistry 2008;283(13):8283-90.
2008: Adam L Orr; Shihua Li; Chuan-En Wang; He Li; Jianjun Wang; Juan Rong; Xingshun Xu; Pier Giorgio Mastroberardino; J Timothy Greenamyre; Xiao-Jiang Li
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(11):2783-92.
2007: Meyer J Friedman; Anjali G Shah; Zhi-Hui Fang; Elizabeth G Ward; Stephen Warren; Shihua Li; Xiao-Jiang Li
Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration.
Nature neuroscience 2007;10(12):1519-28.
2007: Xiao-Jiang Li; Meyer Friedman; Shihua Li
Interacting proteins as genetic modifiers of Huntington disease.
Trends in genetics : TIG 2007;23(11):531-3.
2007: Juan Rong; Shihua Li; Guoqing Sheng; Meng Wu; Brian Coblitz; Min Li; Haian Fu; Xiao-Jiang Li
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
The Journal of biological chemistry 2007;282(7):4748-56.
2006: Shihua Li; Xiao-Jiang Li
Multiple pathways contribute to the pathogenesis of Huntington disease.
Molecular neurodegeneration 2006;1():19.