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Yechezkel Barenholz

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TOP 3
Oren Regev; Daniel Zucker; Yechezkel Barenholz; Sivan Peretz; Yaelle Bavli-Felsen
Can carbon nanotube-liposome conjugates address the issues associated with carbon nanotubes in drug delivery?
Yechezkel Barenholz
Nanomedicine: Shake up the drug containers.
Noam Emanuel; Yosef Rosenfeld; David Segal; Yaakov H Applbaum; Or Cohen; Yechezkel Barenholz
A lipid-and-polymer-based novel local drug delivery system--BonyPid™: from physicochemical aspects to therapy of bacterially infected bones.

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2013: Oren Regev; Daniel Zucker; Yechezkel Barenholz; Sivan Peretz; Yaelle Bavli-Felsen
Can carbon nanotube-liposome conjugates address the issues associated with carbon nanotubes in drug delivery?
Future medicinal chemistry 2013;5(5):503-5.
2012: Yechezkel Barenholz
Nanomedicine: Shake up the drug containers.
Nature nanotechnology 2012;7(8):483-4.
2012: Noam Emanuel; Yosef Rosenfeld; David Segal; Yaakov H Applbaum; Or Cohen; Yechezkel Barenholz
A lipid-and-polymer-based novel local drug delivery system--BonyPid™: from physicochemical aspects to therapy of bacterially infected bones.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):353-61.
2012: János Szebeni; Miklós Tóth; Rudolf Urbanics; Péter Bedőcs; Rolf Bünger; László Rosivall; Yechezkel Barenholz
Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: a porcine model.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):382-7.
2012: Michal Bachar; Yechezkel Barenholz; Simcha Even-Chen; Amitai Mandelbaum; Hadas Perlstein; Irina Portnaya; Dganit Danino
Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled β-casein micelles.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):164-71.
2012: Faina Karchemski; Yechezkel Barenholz; Daniel Zucker; Oren Regev
Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):339-45.
2012: Rivka Cohen; Gilbert J Grant; Hiba Kanaan; Yechezkel Barenholz
Prolonged analgesia from Bupisome and Bupigel formulations: from design and fabrication to improved stability.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):346-52.
2012: Rina Ulmansky; Moshe Baru; Michal Harel; Galia Katzavian; Yaakov Naparstek; Alex Sigal; Keren Turjeman; Yechezkel Barenholz
Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):299-305.
2012: Ahuva Cern; Alexander Golbraikh; Aleck Sedykh; Alexander Tropsha; Yechezkel Barenholz; Amiram Goldblum
Quantitative structure-property relationship modeling of remote liposome loading of drugs.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):147-57.
2012: Daniel Zucker; Alexander V Andriyanov; Uri Raviv; Ariel Steiner; Yechezkel Barenholz
Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):281-9.
2012: Simcha Even-Chen; Rivka Cohen; Yechezkel Barenholz
Factors affecting DNA binding and stability of association to cationic liposomes.
Chemistry and physics of lipids 2012;165(4):414-23.
2012: János Szebeni; Miklós Tóth; Rudolf Urbanics; Zsóka Weiszhár; György Báthori; Péter Bedocs; Rolf Bünger; Rivka Cohen; Olga Garbuzenko; László Rosivall; Zoltán Rozsnyay; Yechezkel Barenholz
Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(2):176-84.
2011: Mirela Nadler-Milbauer; Lior Apter; Yechezkel Barenholz; Sue Haupt; Ygal Haupt; Tamara Minko; Abraham Rubinstein
Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer.
Journal of drug targeting 2011;19(10):859-73.
2011: Janos Szebeni; Alberto Gabizon; Franco Muggia; Yechezkel Barenholz
Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention.
Advanced drug delivery reviews 2011;63(12):1020-30.
2011: Ronit Goldberg; Avi Schroeder; Gilad Silbert; Keren Turjeman; Yechezkel Barenholz; Jacob Klein
Boundary lubricants with exceptionally low friction coefficients based on 2D close-packed phosphatidylcholine liposomes.
Advanced materials (Deerfield Beach, Fla.) 2011;23(31):3517-21.
2011: Ronit Goldberg; Avi Schroeder; Yechezkel Barenholz; Jacob Klein
Interactions between adsorbed hydrogenated soy phosphatidylcholine (HSPC) vesicles at physiologically high pressures and salt concentrations.
Biophysical journal 2011;100(10):2403-11.
2011: Yechezkel Barenholz; Cecilia Bombelli; Maria Grazia Bonicelli; Pietro di Profio; Luisa Giansanti; Giovanna Mancini; Fabrizio Pascale
Influence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes.
Journal of colloid and interface science 2011;356(1):46-53.
2011: Orli Even-Or; Aviva Joseph; Noga Itskovitz-Cooper; Sarit Samira; Eli Rochlin; Hagit Eliyahu; Itzik Goldwaser; Shobana Balasingam; Alexander James Mann; Rob Lambkin-Williams; Eli Kedar; Yechezkel Barenholz
A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity.
Vaccine 2011;29(13):2474-86.
2011: Yuval Avnir; Alberto Gabizon; Pablo Kizelsztein; Alex Sigal; Deborah Tulchinsky; Keren Turjeman; Dinah Tzemach; Yechezkel Barenholz
Fabrication principles and their contribution to the superior in vivo therapeutic efficacy of nano-liposomes remote loaded with glucocorticoids.
PloS one 2011;6(10):e25721.
2011: Efrat Harel; Elena Khazanov; Mirela Nadler Milbauer; Aviram Nissan; Abraham Rubinstein; Yechezkel Barenholz; Boaz Tirosh
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one 2011;6(9):e24202.
2010: Avi Schroeder; Keren Turjeman; Josh E Schroeder; Meir Leibergall; Yechezkel Barenholz
Using liposomes to target infection and inflammation induced by foreign body injuries or medical implants.
Expert opinion on drug delivery 2010;7(10):1175-89.
2010: Daniel Zucker; Yechezkel Barenholz
Optimization of vincristine-topotecan combination--paving the way for improved chemotherapy regimens by nanoliposomes.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(3):326-33.
2010: Orli Even-Or; Sarit Samira; Eli Rochlin; Shobana Balasingam; Alexander James Mann; Rob Lambkin-Williams; Jack Spira; Itzhak Goldwaser; Ronald Ellis; Yechezkel Barenholz
Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine.
Vaccine 2010;28(39):6527-41.
2010: Elena Khazanov; Noam Emmanuel; Abdel Kareem Azab; Yechezkel Barenholz; Eylon Yavin; Abraham Rubinstein
Specific detection of gastric alpha-antitrypsin by immobilized trypsin on polyHEMA films.
Molecular pharmaceutics 2010;7(4):944-52.
2010: Elyad M Davidson; Yechezkel Barenholz; Rivka Cohen; Simon Haroutiunian; Leonid Kagan; Yehuda Ginosar
High-dose bupivacaine remotely loaded into multivesicular liposomes demonstrates slow drug release without systemic toxic plasma concentrations after subcutaneous administration in humans.
Anesthesia and analgesia 2010;110(4):1018-23.
2010: Sarit Sivan; Avi Schroeder; Gabi Verberne; Yulia Merkher; Dvora Diminsky; Aba Priev; Alice Maroudas; Gregory Halperin; Dorrit Nitzan; Izhak Etsion; Yechezkel Barenholz
Liposomes act as effective biolubricants for friction reduction in human synovial joints.
Langmuir : the ACS journal of surfaces and colloids 2010;26(2):1107-16.
2010: Judith H Waknine-Grinberg; Nicholas Hunt; Annael Bentura-Marciano; James A McQuillan; Ho-Wai Chan; Wing-Chi Chan; Yechezkel Barenholz; Richard K Haynes; Jacob Golenser
Artemisone effective against murine cerebral malaria.
Malaria journal 2010;9():227.
2009: Avi Schroeder; Joseph Kost; Yechezkel Barenholz
Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes.
Chemistry and physics of lipids 2009;162(1-2):1-16.
2009: Daniel Zucker; David Marcus; Yechezkel Barenholz; Amiram Goldblum
Liposome drugs' loading efficiency: a working model based on loading conditions and drug's physicochemical properties.
Journal of controlled release : official journal of the Controlled Release Society 2009;139(1):73-80.
2009: Pablo Kizelsztein; Haim Ovadia; Olga Garbuzenko; Alex Sigal; Yechezkel Barenholz
Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2009;213(1-2):20-5.
2009: Boaz Tirosh; Nadine Khatib; Yechezkel Barenholz; Aviram Nissan; Abraham Rubinstein
Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa.
Molecular pharmaceutics 2009;6(4):1083-91.
2009: Avi Schroeder; Reuma Honen; Keren Turjeman; Alberto Gabizon; Joseph Kost; Yechezkel Barenholz
Ultrasound triggered release of cisplatin from liposomes in murine tumors.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):63-8.
2009: Judith Hannah Waknine-Grinberg; Joseph El-On; Vivian Barak; Yechezkel Barenholz; Jacob Golenser
The immunomodulatory effect of Sambucol on leishmanial and malarial infections.
Planta medica 2009;75(6):581-6.
2008: Avi Schroeder; Alex Sigal; Keren Turjeman; Yechezkel Barenholz
Using PEGylated nano-liposomes to target tissue invaded by a foreign body.
Journal of drug targeting 2008;16(7):591-5.
2008: Elena Khazanov; Aba Priev; Joris P Shillemans; Yechezkel Barenholz
Physicochemical and biological characterization of ceramide-containing liposomes: paving the way to ceramide therapeutic application.
Langmuir : the ACS journal of surfaces and colloids 2008;24(13):6965-80.
2008: Yuval Avnir; Rina Ulmansky; Veronica Wasserman; Simcha Even-Chen; Maya Broyer; Yechezkel Barenholz; Yaakov Naparstek
Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: a novel approach to treating autoimmune arthritis.
Arthritis and rheumatism 2008;58(1):119-29.
2007: Julia Boktov; Danielle Hirsch-Lerner; Yechezkel Barenholz
Characterization of the interplay between the main factors contributing to lipoplex-mediated transfection in cell cultures.
The journal of gene medicine 2007;9(10):884-93.
2007: Hagit Eliyahu; Aviva Joseph; J P Schillemans; Tony Azzam; Abraham J Domb; Yechezkel Barenholz
Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically.
Biomaterials 2007;28(14):2339-49.
2007: Avi Schroeder; Yuval Avnir; Sarah Weisman; Yousef Najajreh; Alberto Gabizon; Yeshayahu Talmon; Joseph Kost; Yechezkel Barenholz
Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.
Langmuir : the ACS journal of surfaces and colloids 2007;23(7):4019-25.
2007: Veronica Wasserman; Pablo Kizelsztein; Olga Garbuzenko; Ron Kohen; Haim Ovadia; Rinat Tabakman; Yechezkel Barenholz
The antioxidant tempamine: in vitro antitumor and neuroprotective effects and optimization of liposomal encapsulation and release.
Langmuir : the ACS journal of surfaces and colloids 2007;23(4):1937-47.
2007: Janos Szebeni; Carl R Alving; Laszlo Rosivall; Rolf Bünger; Lajos Baranyi; Peter Bedocs; Miklós Tóth; Yechezkel Barenholz
Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles.
Journal of liposome research 2007;17(2):107-17.
2006: Elena Khazanov; Dmitri Simberg; Yechezkel Barenholz
Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice.
The journal of gene medicine 2006;8(8):998-1007.
2006: Yousef Najajreh; Yael Ardeli-Tzaraf; Jana Kasparkova; Pavla Heringova; Dmitri Prilutski; Liliana Balter; Seba Jawbry; Elena Khazanov; Jose Manuel Perez; Yechezkel Barenholz; Viktor Brabec; Dan Gibson
Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles.
Journal of medicinal chemistry 2006;49(15):4674-83.
2006: Yousef Najajreh; Elena Khazanov; Seba Jawbry; Yael Ardeli-Tzaraf; Jose Manuel Perez; Jana Kasparkova; Viktor Brabec; Yechezkel Barenholz; Dan Gibson
Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies.
Journal of medicinal chemistry 2006;49(15):4665-73.
2006: Leslie Ann Mitchell; Aviva Joseph; Eli Kedar; Yechezkel Barenholz; Eithan Galun
Mucosal immunization against hepatitis A: antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid.
Vaccine 2006;24(25):5300-10.
2006: Aviva Joseph; Noga Itskovitz-Cooper; Sarit Samira; Orli Flasterstein; Hagit Eliyahu; Dmitri Simberg; Itzik Goldwaser; Yechezkel Barenholz; Eli Kedar
A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice.
Vaccine 2006;24(18):3990-4006.
2006: Tareq Taha Jubeh; Mirela Nadler-Milbauer; Yechezkel Barenholz; Abraham Rubinstein
Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD.
Journal of drug targeting 2006;14(3):155-63.
2006: Hagit Eliyahu; Shahar Siani; Tony Azzam; Abraham J Domb; Yechezkel Barenholz
Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates.
Biomaterials 2006;27(8):1646-55.
2006: Hagit Eliyahu; Aviva Joseph; Tony Azzam; Yechezkel Barenholz; Abraham J Domb
Dextran-spermine-based polyplexes--evaluation of transgene expression and of local and systemic toxicity in mice.
Biomaterials 2006;27(8):1636-45.
2006: Victor M Meidan; Judith Glezer; Sharona Salomon; Yechezkel Sidi; Yechezkel Barenholz; Jack S Cohen; Gila Lilling
Specific lipoplex-mediated antisense against Bcl-2 in breast cancer cells: a comparison between different formulations.
Journal of liposome research 2006;16(1):27-43.
2005: Yuval Avnir; Yechezkel Barenholz
pH determination by pyranine: medium-related artifacts and their correction.
Analytical biochemistry 2005;347(1):34-41.
2005: Dmitri Simberg; Aryeh Weiss; Yechezkel Barenholz
Reversible mode of binding of serum proteins to DOTAP/cholesterol Lipoplexes: a possible explanation for intravenous lipofection efficiency.
Human gene therapy 2005;16(9):1087-96.
2005: Danielle Hirsch-Lerner; Ming Zhang; Hagit Eliyahu; Marylin E Ferrari; Carl J Wheeler; Yechezkel Barenholz
Effect of "helper lipid" on lipoplex electrostatics.
Biochimica et biophysica acta 2005;1714(2):71-84.
2005: Moshe Baru; Lea Carmel-Goren; Yechezkel Barenholz; Inbal Dayan; Savely Ostropolets; Igal Slepoy; Nira Gvirtzer; Vladimir Fukson; Jack Spira
Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy.
Thrombosis and haemostasis 2005;93(6):1061-8.
2005: Olga Garbuzenko; Yechezkel Barenholz; Aba Priev
Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer.
Chemistry and physics of lipids 2005;135(2):117-29.
2005: Yousef Najajreh; Dmitri Prilutski; Yael Ardeli-Tzaraf; Jose Manuel Perez; Elena Khazanov; Yechezkel Barenholz; Jana Kasparkova; Viktor Brabec; Dan Gibson
Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand.
Angewandte Chemie (International ed. in English) 2005;44(19):2885-7.
2005: Olga Garbuzenko; Samuel Zalipsky; Masoud Qazen; Yechezkel Barenholz
Electrostatics of PEGylated micelles and liposomes containing charged and neutral lipopolymers.
Langmuir : the ACS journal of surfaces and colloids 2005;21(6):2560-8.
2005: Hagit Eliyahu; Arik Makovitzki; Tony Azzam; Amir Zlotkin; Aviva Joseph; Dan Gazit; Yechezkel Barenholz; Abraham J Domb
Novel dextran-spermine conjugates as transfecting agents: comparing water-soluble and micellar polymers.
Gene therapy 2005;12(6):494-503.
2005: Hagit Eliyahu; Yechezkel Barenholz; Abraham J Domb
Polymers for DNA delivery.
Molecules (Basel, Switzerland) 2005;10(1):34-64.
2005: Tareq Taha Jubeh; Sivan Antler; Susan Haupt; Yechezkel Barenholz; Abraham Rubinstein
Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine.
Molecular pharmaceutics 2005;2(1):2-11.
2004: Eliahu Kalmanzon; Yocheved Rahamim; Shmuel Carmeli; Yechezkel Barenholz; Eliahu Zlotkin
Endogenous regulation of the functional duality of pahutoxin, a marine trunkfish surfactant.
Toxicon : official journal of the International Society on Toxinology 2004;44(8):939-42.
2004: Sarah Weisman; Danielle Hirsch-Lerner; Yechezkel Barenholz; Yeshayahu Talmon
Nanostructure of cationic lipid-oligonucleotide complexes.
Biophysical journal 2004;87(1):609-14.
2004: Gilbert J Grant; Yechezkel Barenholz; Elijah M Bolotin; Mylarrao Bansinath; Herman Turndorf; Boris Piskoun; Elyad M Davidson
A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia.
Anesthesiology 2004;101(1):133-7.
2004: Tareq Taha Jubeh; Yechezkel Barenholz; Abraham Rubinstein
Differential adhesion of normal and inflamed rat colonic mucosa by charged liposomes.
Pharmaceutical research 2004;21(3):447-53.
2004: Dmitri Simberg; Sarah Weisman; Yeshayahu Talmon; Yechezkel Barenholz
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection.
Critical reviews in therapeutic drug carrier systems 2004;21(4):257-317.
2004: Yechezkel Barenholz
Sphingomyelin and cholesterol: from membrane biophysics and rafts to potential medical applications.
Sub-cellular biochemistry 2004;37():167-215.
2004: Amram Samuni; Yechezkel Barenholz
Use of nitroxides to protect liposomes against oxidative damage.
Methods in enzymology 2004;387():299-314.
2003: Dmitri Simberg; Sarah Weisman; Yeshayahu Talmon; Alexander Faerman; Tzipora Shoshani; Yechezkel Barenholz
The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection.
The Journal of biological chemistry 2003;278(41):39858-65.
2003: Arie Ben-Yehuda; Aviva Joseph; Yechezkel Barenholz; Evelyne Zeira; Simcha Even-Chen; Igal Louria-Hayon; Ilan Babai; Zichria Zakay-Rones; Evgenia Greenbaum; Ilia Galprin; Reinhard Glück; Rinaldo Zurbriggen; Eli Kedar
Immunogenicity and safety of a novel IL-2-supplemented liposomal influenza vaccine (INFLUSOME-VAC) in nursing-home residents.
Vaccine 2003;21(23):3169-78.
2003: Eliahu Kalmanzon; Yocheved Rahamim; Yechezkel Barenholz; Shmuel Carmeli; Eliahu Zlotkin
Receptor-mediated toxicity of pahutoxin, a marine trunkfish surfactant.
Toxicon : official journal of the International Society on Toxinology 2003;42(1):63-71.
2003: Ayelet Barenholz; Fanny Fishel; Elisheva Yakir; Shimon Gatt; Yechezkel Barenholz; Herve Bercovier
Liposomes enhance bioremediation of oil-contaminated soil.
Journal of liposome research 2003;13(2):173-86.
2003: Arie Ben-Yehuda; Aviva Joseph; Evelyne Zeira; Simcha Even-Chen; Igal Louria-Hayon; Ilan Babai; Zichria Zakay-Rones; Evgenia Greenbaum; Yechezkel Barenholz; Eli Kedar
Immunogenicity and safety of a novel liposomal influenza subunit vaccine (INFLUSOME-VAC) in young adults.
Journal of medical virology 2003;69(4):560-7.
2003: Yechezkel Barenholz
Relevancy of drug loading to liposomal formulation therapeutic efficacy.
Journal of liposome research 2003;13(1):1-8.
2003: Amram Samuni; Yechezkel Barenholz
Site-activity relationship of nitroxide radical's antioxidative effect.
Free radical biology & medicine 2003;34(2):177-85.
2003: Hilary Shmeeda; Simcha Even-Chen; Reuma Honen; Rivka Cohen; Carmela Weintraub; Yechezkel Barenholz
Enzymatic assays for quality control and pharmacokinetics of liposome formulations: comparison with nonenzymatic conventional methodologies.
Methods in enzymology 2003;367():272-92.
2003: Alberto Gabizon; Hilary Shmeeda; Yechezkel Barenholz
Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies.
Clinical pharmacokinetics 2003;42(5):419-36.
2002: Elena Khazanov; Yechezkel Barenholz; Dan Gibson; Yousef Najajreh
Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization.
Journal of medicinal chemistry 2002;45(24):5196-204.
2002: Aviva Joseph; Igal Louria-Hayon; Alla Plis-Finarov; Evelyne Zeira; Zichria Zakay-Rones; Eyal Raz; Tomoko Hayashi; Kenji Takabayashi; Yechezkel Barenholz; Eli Kedar
Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines.
Vaccine 2002;20(27-28):3342-54.
2002: Hilary Shmeeda; Pavel Kaspler; Judith Shleyer; Reuma Honen; Michal Horowitz; Yechezkel Barenholz
Heat acclimation in rats: modulation via lipid polyunsaturation.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(2):R389-99.
2002: Hagit Eliyahu; N Servel; Abraham J Domb; Yechezkel Barenholz
Lipoplex-induced hemagglutination: potential involvement in intravenous gene delivery.
Gene therapy 2002;9(13):850-8.
2002: Tony Azzam; Hagit Eliyahu; Lior Shapira; Michal Linial; Yechezkel Barenholz; Abraham J Domb
Polysaccharide-oligoamine based conjugates for gene delivery.
Journal of medicinal chemistry 2002;45(9):1817-24.
2002: Janos Szebeni; Lajos Baranyi; Sandor Savay; János Milosevits; R Bunger; P Laverman; Josbert M Metselaar; Gert Storm; Asher Chanan-Khan; Leonard Liebes; Franco M Muggia; R Cohen; Yechezkel Barenholz; Carl R Alving
Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies.
Journal of liposome research 2002;12(1-2):165-72.
2001: Victor M Meidan; J Glezer; N Amariglio; Jack S Cohen; Yechezkel Barenholz
Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation.
Biochimica et biophysica acta 2001;1568(3):177-82.
2001: Dmitri Simberg; Dganit Danino; Yeshayahu Talmon; A Minsky; Marylin E Ferrari; Carl J Wheeler; Yechezkel Barenholz
Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity.
The Journal of biological chemistry 2001;276(50):47453-9.
2001: Ilan Babai; Yechezkel Barenholz; Zichria Zakay-Rones; Evgenia Greenbaum; Sarit Samira; Igal Louria Hayon; M Rochman; Eli Kedar
A novel liposomal influenza vaccine (INFLUSOME-VAC) containing hemagglutinin-neuraminidase and IL-2 or GM-CSF induces protective anti-neuraminidase antibodies cross-reacting with a wide spectrum of influenza A viral strains.
Vaccine 2001;20(3-4):505-15.
2001: M Kerner; Oded Meyuhas; Danielle Hirsch-Lerner; Laura J Rosen; Z Min; Yechezkel Barenholz
Interplay in lipoplexes between type of pDNA promoter and lipid composition determines transfection efficiency of human growth hormone in NIH3T3 cells in culture.
Biochimica et biophysica acta 2001;1532(1-2):128-36.
2001: Janos Szebeni; Carl R Alving; Sandor Savay; Yechezkel Barenholz; Aba Priev; Dganit Danino; Yeshayahu Talmon
Formation of complement-activating particles in aqueous solutions of Taxol: possible role in hypersensitivity reactions.
International immunopharmacology 2001;1(4):721-35.
2001: Gilbert J Grant; Yechezkel Barenholz; Boris Piskoun; Mylarrao Bansinath; Herman Turndorf; E M Bolotin
DRV liposomal bupivacaine: preparation, characterization, and in vivo evaluation in mice.
Pharmaceutical research 2001;18(3):336-43.
2001: Eliahu Kalmanzon; R Aknin-Herrman; Yocheved Rahamim; Shmuel Carmeli; Yechezkel Barenholz; Eliahu Zlotkin
Cooperative cocktail in a chemical defence mechanism of a trunkfish.
Cellular & molecular biology letters 2001;6(4):971-84.
2000: Simcha Even-Chen; Yechezkel Barenholz
DOTAP cationic liposomes prefer relaxed over supercoiled plasmids.
Biochimica et biophysica acta 2000;1509(1-2):176-88.
2000: Victor M Meidan; Jack S Cohen; N Amariglio; Danielle Hirsch-Lerner; Yechezkel Barenholz
Interaction of oligonucleotides with cationic lipids: the relationship between electrostatics, hydration and state of aggregation.
Biochimica et biophysica acta 2000;1464(2):251-61.
2000: Amram Samuni; A Lipman; Yechezkel Barenholz
Damage to liposomal lipids: protection by antioxidants and cholesterol-mediated dehydration.
Chemistry and physics of lipids 2000;105(2):121-34.
2000: Eli Kedar; H Gur; Ilan Babai; Sarit Samira; Simcha Even-Chen; Yechezkel Barenholz
Delivery of cytokines by liposomes: hematopoietic and immunomodulatory activity of interleukin-2 encapsulated in conventional liposomes and in long-circulating liposomes.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(1):131-45.
1999: Danielle Hirsch-Lerner; Yechezkel Barenholz
Hydration of lipoplexes commonly used in gene delivery: follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry.
Biochimica et biophysica acta 1999;1461(1):47-57.
1999: D Samet; Yechezkel Barenholz
Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells.
Chemistry and physics of lipids 1999;102(1-2):65-77.
1999: Yechezkel Barenholz; TE Thompson
Sphingomyelin: biophysical aspects.
Chemistry and physics of lipids 1999;102(1-2):29-34.
1999: NJ Zuidam; Yechezkel Barenholz; A Minsky
Chiral DNA packaging in DNA-cationic liposome assemblies.
FEBS letters 1999;457(3):419-22.
1999: D Diminsky; N Moav; M Gorecki; Yechezkel Barenholz
Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles.
Vaccine 1999;18(1-2):3-17.
1999: N Naslavsky; Hilary Shmeeda; Gilgi Friedlander; A Yanai; A H Futerman; Yechezkel Barenholz; Albert Taraboulos
Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions.
The Journal of biological chemistry 1999;274(30):20763-71.
1999: NJ Zuidam; Danielle Hirsch-Lerner; S Margulies; Yechezkel Barenholz
Lamellarity of cationic liposomes and mode of preparation of lipoplexes affect transfection efficiency.
Biochimica et biophysica acta 1999;1419(2):207-20.
1999: NJ Zuidam; Yechezkel Barenholz
Characterization of DNA-lipid complexes commonly used for gene delivery.
International journal of pharmaceutics 1999;183(1):43-6.
1999: S Bandak; A Ramu; Yechezkel Barenholz; Alberto Gabizon
Reduced UV-induced degradation of doxorubicin encapsulated in polyethyleneglycol-coated liposomes.
Pharmaceutical research 1999;16(6):841-6.
1999: Ilan Babai; Sarit Samira; Yechezkel Barenholz; Zichria Zakay-Rones; Eli Kedar
A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice.
Vaccine 1999;17(9-10):1239-50.
1999: Ilan Babai; Sarit Samira; Yechezkel Barenholz; Zichria Zakay-Rones; Eli Kedar
A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. I. Vaccine characterization and efficacy studies in mice.
Vaccine 1999;17(9-10):1223-38.
1999: V Korablyov; Ari Zimran; Yechezkel Barenholz
Cerebroside-beta-glucosidase encapsulation in liposomes for Gaucher's disease treatment revisited.
Pharmaceutical research 1999;16(3):466-9.
1999: A Cabanes; Simcha Even-Chen; J Zimberoff; Yechezkel Barenholz; Eli Kedar; Alberto Gabizon
Enhancement of antitumor activity of polyethylene glycol-coated liposomal doxorubicin with soluble and liposomal interleukin 2.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):687-93.
1999: Oren Tirosh; Jehoshua Katzhendler; Yechezkel Barenholz; Ron Kohen
Low-density lipoprotein oxidation and its prevention by amidothionophosphate antioxidants.
Antioxidants & redox signaling 1999;1(3):325-38.
1999: Oren Tirosh; Y Katzhendler; Yechezkel Barenholz; Ron Kohen
Antioxidant activity of amidothionophosphates.
Methods in enzymology 1999;299():293-300.
1998: S Clerc; Yechezkel Barenholz
A quantitative model for using acridine orange as a transmembrane pH gradient probe.
Analytical biochemistry 1998;259(1):104-11.
1998: Danielle Hirsch-Lerner; Yechezkel Barenholz
Probing DNA-cationic lipid interactions with the fluorophore trimethylammonium diphenyl-hexatriene (TMADPH).
Biochimica et biophysica acta 1998;1370(1):17-30.
1998: Oren Tirosh; Yechezkel Barenholz; Jehoshua Katzhendler; Aba Priev
Hydration of polyethylene glycol-grafted liposomes.
Biophysical journal 1998;74(3):1371-9.
1998: NJ Zuidam; Yechezkel Barenholz
Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery.
Biochimica et biophysica acta 1998;1368(1):115-28.
1997: NJ Zuidam; Yechezkel Barenholz
Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin.
Biochimica et biophysica acta 1997;1329(2):211-22.
1997: Oren Tirosh; Ron Kohen; Jehoshua Katzhendler; A Alon; Yechezkel Barenholz
Oxidative stress effect on the integrity of lipid bilayers is modulated by cholesterol level of bilayers.
Chemistry and physics of lipids 1997;87(1):17-22.
1997: Eli Kedar; O Palgi; G Golod; Ilan Babai; Yechezkel Barenholz
Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNF-alpha show improved pharmacokinetics and biological activity and reduced toxicity in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1997;20(3):180-93.
1997: D Diminsky; R Schirmbeck; J Reimann; Yechezkel Barenholz
Comparison between hepatitis B surface antigen (HBsAg) particles derived from mammalian cells (CHO) and yeast cells (Hansenula polymorpha): composition, structure and immunogenicity.
Vaccine 1997;15(6-7):637-47.
1997: Leah Bar; Yechezkel Barenholz; TE Thompson
Effect of sphingomyelin composition on the phase structure of phosphatidylcholine-sphingomyelin bilayers.
Biochemistry 1997;36(9):2507-16.
1997: M Eckstein; Yechezkel Barenholz; Leah Bar; Esther Segal
Liposomes containing Candida albicans ribosomes as a prophylactic vaccine against disseminated candidiasis in mice.
Vaccine 1997;15(2):220-4.
1997: Amram Samuni; Yechezkel Barenholz; Daniel Crommelin; NJ Zuidam
Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides.
Free radical biology & medicine 1997;23(7):972-9.
1997: Amram Samuni; Yechezkel Barenholz
Stable nitroxide radicals protect lipid acyl chains from radiation damage.
Free radical biology & medicine 1997;22(7):1165-74.
1996: D Glick; Yechezkel Barenholz
IgG immunoglobulins induce activation of the sphingomyelin cycle in HL-60 cells.
FEBS letters 1996;394(3):237-40.
1996: N Emanuel; Eli Kedar; E M Bolotin; N I Smorodinsky; Yechezkel Barenholz
Targeted delivery of doxorubicin via sterically stabilized immunoliposomes: pharmacokinetics and biodistribution in tumor-bearing mice.
Pharmaceutical research 1996;13(6):861-8.
1996: N Emanuel; Eli Kedar; E M Bolotin; N I Smorodinsky; Yechezkel Barenholz
Preparation and characterization of doxorubicin-loaded sterically stabilized immunoliposomes.
Pharmaceutical research 1996;13(3):352-9.
1996: Yechezkel Barenholz; T Cohen; E Haas; Michael Ottolenghi
Lateral organization of pyrene-labeled lipids in bilayers as determined from the deviation from equilibrium between pyrene monomers and excimers.
The Journal of biological chemistry 1996;271(6):3085-90.
1996: Oren Tirosh; Y Katzhendler; Yechezkel Barenholz; Isaac Ginsburg; Ron Kohen
Antioxidant properties of amidothionophosphates: novel antioxidant molecules.
Free radical biology & medicine 1996;20(3):421-32.
1995: S Clerc; Yechezkel Barenholz
Loading of amphipathic weak acids into liposomes in response to transmembrane calcium acetate gradients.
Biochimica et biophysica acta 1995;1240(2):257-65.
1995: H Shmeeda; D Petkova; Yechezkel Barenholz
Cholesterol distribution in rat heart myocytes.
The American journal of physiology 1995;268(2 Pt 2):H759-66.
1995: M Y Levy; Itzhack Polacheck; Yechezkel Barenholz; Simon Benita
Efficacy evaluation of a novel submicron miconazole emulsion in a murine cryptococcosis model.
Pharmaceutical research 1995;12(2):223-30.
1994: H Shmeeda; D Petkova; Yechezkel Barenholz
Cholesterol homeostasis in cultures of rat heart myocytes: relationship to cellular hypertrophy.
The American journal of physiology 1994;267(5 Pt 2):H1689-97.
1994: Eli Kedar; E Braun; Y Rutkowski; N Emanuel; Yechezkel Barenholz
Delivery of cytokines by liposomes. II. Interleukin-2 encapsulated in long-circulating sterically stabilized liposomes: immunomodulatory and anti-tumor activity in mice.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1994;16(2):115-24.
1994: Eli Kedar; Y Rutkowski; E Braun; N Emanuel; Yechezkel Barenholz
Delivery of cytokines by liposomes. I. Preparation and characterization of interleukin-2 encapsulated in long-circulating sterically stabilized liposomes.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1994;16(1):47-59.
1994: Alberto Gabizon; R Catane; Beatrice Uziely; B Kaufman; T Safra; R Cohen; F Martin; A Huang; Yechezkel Barenholz
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.
Cancer research 1994;54(4):987-92.
1993: G Haran; R Cohen; L K Bar; Yechezkel Barenholz
Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases.
Biochimica et biophysica acta 1993;1151(2):201-15.
1993: V Borenstain-Ben Yashar; Yechezkel Barenholz; E Hy-Am; Eliezer A Rachmilewitz; Amiram Eldor
Phosphatidylserine in the outer leaflet of red blood cells from beta-thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes.
American journal of hematology 1993;44(1):63-5.
1993: S Amselem; R Cohen; Yechezkel Barenholz
In vitro tests to predict in vivo performance of liposomal dosage forms.
Chemistry and physics of lipids 1993;64(1-3):219-37.
1993: V Borenstain; Yechezkel Barenholz
Characterization of liposomes and other lipid assemblies by multiprobe fluorescence polarization.
Chemistry and physics of lipids 1993;64(1-3):117-27.
1993: Yechezkel Barenholz; S Amselem; Dorit Goren; R Cohen; D Gelvan; Amram Samuni; E B Golden; Alberto Gabizon
Stability of liposomal doxorubicin formulations: problems and prospects.
Medicinal research reviews 1993;13(4):449-91.
1993: Alberto Gabizon; Yechezkel Barenholz; M Bialer
Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs.
Pharmaceutical research 1993;10(5):703-8.
1993: Yechezkel Barenholz; R Pal; R R Wagner
Metabolic labeling of viral membrane lipids by fluorescent fatty acids: studying virus fusion with target membranes.
Methods in enzymology 1993;220():288-312.
1993: M Y Levy; Itzhack Polacheck; Yechezkel Barenholz; Simon Benita
Efficacy evaluation of a novel submicron amphotericin B emulsion in murine candidiasis.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1993;31(3):207-18.
1993: Amiram Eldor; J Maclouf; F Lellouche; V Ben-Yashar; Yechezkel Barenholz; R Durst; E Hy-Am; Ada Goldfarb; Eliezer A Rachmilewitz
A chronic hypercoagulable state and life-long platelet activation in beta thalassemia major.
The Southeast Asian journal of tropical medicine and public health 1993;24 Suppl 1():92-5.
1992: A T Horowitz; Yechezkel Barenholz; Alberto Gabizon
In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release.
Biochimica et biophysica acta 1992;1109(2):203-9.
1991: Alberto Gabizon; R Chisin; S Amselem; S Druckmann; R Cohen; Dorit Goren; I Fromer; Tamar Peretz; A Sulkes; Yechezkel Barenholz
Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin.
British journal of cancer 1991;64(6):1125-32.
1991: V Ben-Yashar; Yechezkel Barenholz
Characterization of the core and surface of human plasma lipoproteins. A study based on the use of five fluorophores.
Chemistry and physics of lipids 1991;60(1):1-14.
1991: Yechezkel Barenholz; T Cohen; R Korenstein; Michael Ottolenghi
Organization and dynamics of pyrene and pyrene lipids in intact lipid bilayers. Photo-induced charge transfer processes.
Biophysical journal 1991;60(1):110-24.
1990: S Amselem; Alberto Gabizon; Yechezkel Barenholz
Optimization and upscaling of doxorubicin-containing liposomes for clinical use.
Journal of pharmaceutical sciences 1990;79(12):1045-52.
1990: Dorit Goren; Alberto Gabizon; Yechezkel Barenholz
The influence of physical characteristics of liposomes containing doxorubicin on their pharmacological behavior.
Biochimica et biophysica acta 1990;1029(2):285-94.
1989: Alberto Gabizon; Tamar Peretz; A Sulkes; S Amselem; Rami Ben-Yosef; N Ben-Baruch; R Catane; S Biran; Yechezkel Barenholz
Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study.
European journal of cancer & clinical oncology 1989;25(12):1795-803.
1989: V Ben-Yashar; Yechezkel Barenholz
The interaction of cholesterol and cholest-4-en-3-one with dipalmitoylphosphatidylcholine. Comparison based on the use of three fluorophores.
Biochimica et biophysica acta 1989;985(3):271-8.
1989: S Druckmann; Alberto Gabizon; Yechezkel Barenholz
Separation of liposome-associated doxorubicin from non-liposome-associated doxorubicin in human plasma: implications for pharmacokinetic studies.
Biochimica et biophysica acta 1989;980(3):381-4.
1988: Alberto Gabizon; Dorit Goren; Yechezkel Barenholz
Investigations on the antitumor efficacy of liposome-associated doxorubicin in murine tumor models.
Israel journal of medical sciences 1988;24(9-10):512-7.
1987: V Ben Yashar; M Menashe; R L Biltonen; M L Johnson; Yechezkel Barenholz
Interaction of trans-parinaric acid with phosphatidylcholine bilayers: comparison with the effect of other fluorophores.
Biochimica et biophysica acta 1987;904(1):117-24.
1985: Alberto Gabizon; Dorit Goren; Z Fuks; A Meshorer; Yechezkel Barenholz
Superior therapeutic activity of liposome-associated adriamycin in a murine metastatic tumour model.
British journal of cancer 1985;51(5):681-9.
1983: Alberto Gabizon; Dorit Goren; Z Fuks; Yechezkel Barenholz; A Dagan; A Meshorer
Enhancement of adriamycin delivery to liver metastatic cells with increased tumoricidal effect using liposomes as drug carriers.
Cancer research 1983;43(10):4730-5.
1982: Alberto Gabizon; A Dagan; Dorit Goren; Yechezkel Barenholz; Z Fuks
Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.
Cancer research 1982;42(11):4734-9.