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David Barford

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Chemicals & Drugs

Procedures

X-Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Physiology

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Co-Publications
Name
17
Johnson, Louise
10
Tonks, Nicholas
9
Roe, Mark
9
Acharya, Ravi
6
Komander, David
6
Oikonomakos, Nikos
5
Passmore, Lori
4
Parker, James
4
Salmeen, Annette
4
Yang, Jing
4
Cohen, Patricia
4
Flint, AJ
4
Good, Valerie
3
Cliff, Matthew
3
Myers, Michael

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Publications

TOP 3
Yang Jing; Zhang Ziguo; Roe S Mark; Marshall Christopher J; Barford David
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Komander David; Reyes-Turcu Francisca; Licchesi Julien D F; Odenwaelder Peter; Wilkinson Keith D; Barford David
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.
Brennan Damian F; Barford David
Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases.

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All Publications

2009: Yang Jing; Zhang Ziguo; Roe S Mark; Marshall Christopher J; Barford David
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Science (New York, N.Y.) 2009;325(5946):1398-402.
2009: Komander David; Reyes-Turcu Francisca; Licchesi Julien D F; Odenwaelder Peter; Wilkinson Keith D; Barford David
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.
EMBO reports 2009;10(5):466-73.
2009: Brennan Damian F; Barford David
Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases.
Trends in biochemical sciences 2009;34(3):108-14.
2009: Parker James S; Parizotto Eneida A; Wang Muhan; Roe S Mark; Barford David
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein.
Molecular cell 2009;33(2):204-14.
2008: Komander David; Garg Ritu; Wan Paul T C; Ridley Anne J; Barford David
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
The EMBO journal 2008;27(23):3175-85.
2008: Komander David; Patel Manishha; Laurin Mélanie; Fradet Nadine; Pelletier Ariane; Barford David; Côté Jean-François
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling.
Molecular biology of the cell 2008;19(11):4837-51.
2008: Komander David; Lord Christopher J; Scheel Hartmut; Swift Sally; Hofmann Kay; Ashworth Alan; Barford David
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.
Molecular cell 2008;29(4):451-64.
2008: Gold Matthew G; Smith F Donelson; Scott John D; Barford David
AKAP18 contains a phosphoesterase domain that binds AMP.
Journal of molecular biology 2008;375(5):1329-43.
2008: Komander David; Barford David
Structure of the A20 OTU domain and mechanistic insights into deubiquitination.
The Biochemical journal 2008;409(1):77-85.
2007: Adami Alessandra; García-Alvarez Begoña; Arias-Palomo Ernesto; Barford David; Llorca Oscar
Structure of TOR and its complex with KOG1.
Molecular cell 2007;27(3):509-16.
2007: Yang Jing; Roe S Mark; Prickett Todd D; Brautigan David L; Barford David
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.
Biochemistry 2007;46(30):8807-15.
2007: Yang Jing; Groen Arnoud; Lemeer Simone; Jans Anne; Slijper Monique; Roe S Mark; den Hertog Jeroen; Barford David
Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide.
Biochemistry 2007;46(3):709-19.
2006: Gold Matthew G; Barford David; Komander David
Lining the pockets of kinases and phosphatases.
Current opinion in structural biology 2006;16(6):693-701.
2006: Gold Matthew G; Lygren Birgitte; Dokurno Pawel; Hoshi Naoto; McConnachie George; Taskén Kjetil; Carlson Cathrine R; Scott John D; Barford David
Molecular basis of AKAP specificity for PKA regulatory subunits.
Molecular cell 2006;24(3):383-95.
2006: Parker James S; Barford David
Argonaute: A scaffold for the function of short regulatory RNAs.
Trends in biochemical sciences 2006;31(11):622-30.
2006: Cliff Matthew J; Harris Richard; Barford David; Ladbury John E; Williams Mark A
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
Structure (London, England : 1993) 2006;14(3):415-26.
2006: Parker J S; Roe S M; Barford D
Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes.
Cold Spring Harbor symposia on quantitative biology 2006;71():45-50.
2005: Garnett Mathew J; Rana Sareena; Paterson Hugh; Barford David; Marais Richard
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.
Molecular cell 2005;20(6):963-9.
2005: Passmore Lori A; Booth Christopher R; Vénien-Bryan Catherine; Ludtke Steven J; Fioretto Céline; Johnson Louise N; Chiu Wah; Barford David
Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation.
Molecular cell 2005;20(6):855-66.
2005: Passmore Lori A; Barford David
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition.
EMBO reports 2005;6(9):873-8.
2005: Salmeen Annette; Barford David
Functions and mechanisms of redox regulation of cysteine-based phosphatases.
Antioxidants & redox signaling 2005;7(5-6):560-77.
2005: Parker James S; Roe S Mark; Barford David
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex.
Nature 2005;434(7033):663-6.
2005: Groen Arnoud; Lemeer Simone; van der Wijk Thea; Overvoorde John; Heck Albert J R; Ostman Arne; Barford David; Slijper Monique; den Hertog Jeroen
Differential oxidation of protein-tyrosine phosphatases.
The Journal of biological chemistry 2005;280(11):10298-304.
2005: Cliff Matthew J; Williams Mark A; Brooke-Smith John; Barford David; Ladbury John E
Molecular recognition via coupled folding and binding in a TPR domain.
Journal of molecular biology 2005;346(3):717-32.
2005: Yang Jing; Roe S Mark; Cliff Matthew J; Williams Mark A; Ladbury John E; Cohen Patricia T W; Barford David
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
The EMBO journal 2005;24(1):1-10.
2005: Passmore Lori A; Barford David; Harper J Wade
Purification and assay of the budding yeast anaphase-promoting complex.
Methods in enzymology 2005;398():195-219.
2004: Barford David
The role of cysteine residues as redox-sensitive regulatory switches.
Current opinion in structural biology 2004;14(6):679-86.
2004: Parker James S; Roe S Mark; Barford David
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity.
The EMBO journal 2004;23(24):4727-37.
2004: Passmore Lori A; Barford David
Getting into position: the catalytic mechanisms of protein ubiquitylation.
The Biochemical journal 2004;379(Pt 3):513-25.
2004: Wan Paul T C; Garnett Mathew J; Roe S Mark; Lee Sharlene; Niculescu-Duvaz Dan; Good Valerie M; Jones C Michael; Marshall Christopher J; Springer Caroline J; Barford David; Marais Richard;
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
Cell 2004;116(6):855-67.
2003: Gray Christopher H; Barford David
Getting in the ring: proline-directed substrate specificity in the cell cycle proteins Cdc14 and CDK2-cyclinA3.
Cell cycle (Georgetown, Tex.) 2003;2(6):500-2.
2003: Gray Christopher H; Good Valerie M; Tonks Nicholas K; Barford David
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase.
The EMBO journal 2003;22(14):3524-35.
2003: Salmeen Annette; Andersen Jannik N; Myers Michael P; Meng Tzu-Ching; Hinks John A; Tonks Nicholas K; Barford David
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Nature 2003;423(6941):769-73.
2003: Passmore Lori A; McCormack Elizabeth A; Au Shannon W N; Paul Angela; Willison Keith R; Harper J Wade; Barford David
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.
The EMBO journal 2003;22(4):786-96.
2002: Pearl Laurence H; Barford David
Regulation of protein kinases in insulin, growth factor and Wnt signalling.
Current opinion in structural biology 2002;12(6):761-7.
2002: Yang Jing; Cron Peter; Good Valerie M; Thompson Vivienne; Hemmings Brian A; Barford David
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Nature structural biology 2002;9(12):940-4.
2002: Yang Jing; Cron Peter; Thompson Vivienne; Good Valerie M; Hess Daniel; Hemmings Brian A; Barford David
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.
Molecular cell 2002;9(6):1227-40.
2002: Au Shannon W N; Leng Xiaohong; Harper J Wade; Barford David
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Journal of molecular biology 2002;316(4):955-68.
2002: Johnson Louise N; De Moliner Erika; Brown Nick R; Song Haiwei; Barford David; Endicott Jane A; Noble Martin E M
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.
Pharmacology & therapeutics 2002;93(2-3):113-24.
2002: Barford David
Protein tyrosine phosphatases: X-ray crystallographic observation of cysteinyl-phosphate reaction intermediate.
Methods in enzymology 2002;354():237-51.
2001: Myers M P; Andersen J N; Cheng A; Tremblay M L; Horvath C M; Parisien J P; Salmeen A; Barford D; Tonks N K
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
The Journal of biological chemistry 2001;276(51):47771-4.
2001: Barford D
The mechanism of protein kinase regulation by protein phosphatases.
Biochemical Society transactions 2001;29(Pt 4):385-91.
2001: Yang J; Dokurno P; Tonks N K; Barford D
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.
The EMBO journal 2001;20(14):3645-56.
2001: Song H; Hanlon N; Brown N R; Noble M E; Johnson L N; Barford D
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Molecular cell 2001;7(3):615-26.
2000: Salmeen A; Andersen J N; Myers M P; Tonks N K; Barford D
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Molecular cell 2000;6(6):1401-12.
2000: Song H; Mugnier P; Das A K; Webb H M; Evans D R; Tuite M F; Hemmings B A; Barford D
The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis.
Cell 2000;100(3):311-21.
1999: Barford D
Colworth Medal Lecture. Structural studies of reversible protein phosphorylation and protein phosphatases.
Biochemical Society transactions 1999;27(6):751-66.
1999: Groves M R; Barford D
Topological characteristics of helical repeat proteins.
Current opinion in structural biology 1999;9(3):383-9.
1999: Groves M R; Hanlon N; Turowski P; Hemmings B A; Barford D
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell 1999;96(1):99-110.
1998: Groves M R; Yao Z J; Roller P P; Burke T R; Barford D
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry 1998;37(51):17773-83.
1998: Pannifer A D; Flint A J; Tonks N K; Barford D
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
The Journal of biological chemistry 1998;273(17):10454-62.
1998: Barford D; Neel B G
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
Structure (London, England : 1993) 1998;6(3):249-54.
1998: Das A K; Cohen P W; Barford D
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.
The EMBO journal 1998;17(5):1192-9.
1998: Hanlon N; Barford D
Purification and crystallization of the CDK-associated protein phosphatase KAP expressed in Escherichia coli.
Protein science : a publication of the Protein Society 1998;7(2):508-11.
1998: Barford D; Das A K; Egloff M P
The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
Annual review of biophysics and biomolecular structure 1998;27():133-64.
1997: Hoffmann K M; Tonks N K; Barford D
The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu.
The Journal of biological chemistry 1997;272(44):27505-8.
1997: Egloff M P; Johnson D F; Moorhead G; Cohen P T; Cohen P; Barford D
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.
The EMBO journal 1997;16(8):1876-87.
1997: Flint A J; Tiganis T; Barford D; Tonks N K
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1680-5.
1997: Johnson L N; Barford D; Owen D J; Noble M E; Garman E F
From phosphorylase to phosphorylase kinase.
Advances in second messenger and phosphoprotein research 1997;31():11-28.
1996: Das A K; Helps N R; Cohen P T; Barford D
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
The EMBO journal 1996;15(24):6798-809.
1996: Burke T R; Ye B; Yan X; Wang S; Jia Z; Chen L; Zhang Z Y; Barford D
Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
Biochemistry 1996;35(50):15989-96.
1996: Barford D
Molecular mechanisms of the protein serine/threonine phosphatases.
Trends in biochemical sciences 1996;21(11):407-12.
1995: Barford D
Protein phosphatases.
Current opinion in structural biology 1995;5(6):728-34.
1995: Egloff M P; Cohen P T; Reinemer P; Barford D
Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.
Journal of molecular biology 1995;254(5):942-59.
1995: Jia Z; Barford D; Flint A J; Tonks N K
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science (New York, N.Y.) 1995;268(5218):1754-8.
1995: Kole H K; Akamatsu M; Ye B; Yan X; Barford D; Roller P P; Burke T R
Protein-tyrosine phosphatase inhibition by a peptide containing the phosphotyrosyl mimetic, L-O-malonyltyrosine.
Biochemical and biophysical research communications 1995;209(3):817-22.
1994: Johnson L N; Barford D
Electrostatic effects in the control of glycogen phosphorylase by phosphorylation.
Protein science : a publication of the Protein Society 1994;3(10):1726-30.
1994: Barford D; Keller J C; Flint A J; Tonks N K
Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coli.
Journal of molecular biology 1994;239(5):726-30.
1994: Barford D; Flint A J; Tonks N K
Crystal structure of human protein tyrosine phosphatase 1B.
Science (New York, N.Y.) 1994;263(5152):1397-404.
1994: Barford D; Keller J C
Co-crystallization of the catalytic subunit of the serine/threonine specific protein phosphatase 1 from human in complex with microcystin LR.
Journal of molecular biology 1994;235(2):763-6.
1993: Johnson L N; Snape P; Martin J L; Acharya K R; Barford D; Oikonomakos N G
Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b.
Journal of molecular biology 1993;232(1):253-67.
1993: Taguchi J E; Heyes S J; Barford D; Johnson L N; Dobson C M
Solid state 31P cross-polarization/magic angle sample spinning nuclear magnetic resonance of crystalline glycogen phosphorylase b.
Biophysical journal 1993;64(2):492-501.
1993: Johnson L N; Barford D
The effects of phosphorylation on the structure and function of proteins.
Annual review of biophysics and biomolecular structure 1993;22():199-232.
1992: Leonidas D D; Oikonomakos N G; Papageorgiou A C; Acharya K R; Barford D; Johnson L N
Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate.
Protein science : a publication of the Protein Society 1992;1(9):1112-22.
1992: Barford D; Johnson L N
The molecular mechanism for the tetrameric association of glycogen phosphorylase promoted by protein phosphorylation.
Protein science : a publication of the Protein Society 1992;1(4):472-93.
1992: Johnson L N; Hu S H; Barford D
Catalytic mechanism of glycogen phosphorylase.
Faraday discussions 1992;(93):131-42.
1991: Barford D; Hu S H; Johnson L N
Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
Journal of molecular biology 1991;218(1):233-60.
1990: Johnson L N; Barford D
Glycogen phosphorylase. The structural basis of the allosteric response and comparison with other allosteric proteins.
The Journal of biological chemistry 1990;265(5):2409-12.
1989: Barford D; Johnson L N
The allosteric transition of glycogen phosphorylase.
Nature 1989;340(6235):609-16.
1988: Barford D; Schwabe J W; Oikonomakos N G; Acharya K R; Hajdu J; Papageorgiou A C; Martin J L; Knott J C; Vasella A; Johnson L N
Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane.
Biochemistry 1988;27(18):6733-41.
1988: Hajdu J; Acharya K R; Stuart D I; Barford D; Johnson L N
Catalysis in enzyme crystals.
Trends in biochemical sciences 1988;13(3):104-9.
1988: Johnson L N; Cheetham J; McLaughlin P J; Acharya K R; Barford D; Phillips D C
Protein-oligosaccharide interactions: lysozyme, phosphorylase, amylases.
Current topics in microbiology and immunology 1988;139():81-134.
1987: Oikonomakos N G; Johnson L N; Acharya K R; Stuart D I; Barford D; Hajdu J; Varvill K M; Melpidou A E; Papageorgiou T; Graves D J
Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
Biochemistry 1987;26(25):8381-9.
1987: Johnson L N; Acharya K R; Stuart D I; Barford D; Oikonomakos N G; Hajdu J; Varvill K M
Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
Biochemical Society transactions 1987;15(5):1001-5.
1987: Hajdu J; Acharya K R; Stuart D I; McLaughlin P J; Barford D; Oikonomakos N G; Klein H; Johnson L N
Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
The EMBO journal 1987;6(2):539-46.
1986: Hajdu J; Acharya K R; Stuart D I; McLaughlin P J; Barford D; Klein H; Johnson L N
Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b.
Biochemical Society transactions 1986;14(3):538-41.

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