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Xiao-Jiang Li

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Xiao-Jiang Li; Shihua Li
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models.
Xiao-Jiang Li; Wei Li
Beyond mice: genetically modifying larger animals to model human diseases.
Austin Cape; Xingxing Chen; Jun He; He Li; Shihua Li; Yung-Feng Lin; Ashley O'Neill; Chuan-En Wang; Xing-Shun Xu; Hong Yi; Xiao-Jiang Li
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.

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All Publications

2012: Xiao-Jiang Li; Shihua Li
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models.
Journal of genetics and genomics = Yi chuan xue bao 2012;39(6):239-45.
2012: Xiao-Jiang Li; Wei Li
Beyond mice: genetically modifying larger animals to model human diseases.
Journal of genetics and genomics = Yi chuan xue bao 2012;39(6):237-8.
2012: Austin Cape; Xingxing Chen; Jun He; He Li; Shihua Li; Yung-Feng Lin; Ashley O'Neill; Chuan-En Wang; Xing-Shun Xu; Hong Yi; Xiao-Jiang Li
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
Cellular and molecular life sciences : CMLS 2012;69(8):1305-17.
2012: Hao Wang; Donghai Wu; Jing Xu; Chuan Yang; Jianzhong Yang; Liansha Huang; Zhenbo Huang; Hui Kong; Shihua Li; Xiao-Jiang Li; Tonghua Liu; Shaona Niu; Xiurong Rao; Guoqing Sheng
Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C receptor.
The Journal of biological chemistry 2012;287(3):2237-46.
2012: Shihua Li; Xiao-Jiang Li
A huntingtin-HAP1-PCM1 pathway in ciliogenesis.
Expert review of proteomics 2012;9(1):17-9.
2011: Madhuchhanda Mandal; Alison E Twelvetrees; Jing Wei; Jia Cheng; Lara J Duffney; Josef T Kittler; Shihua Li; Xiao-Jiang Li; Wenhua Liu; Eunice Y Yuen; Ping Zhong; Zhen Yan
Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin.
The Journal of biological chemistry 2011;286(39):33719-28.
2011: Shanshan Huang; Xiao-Jiang Li; Joseph J Ling; Su Yang; Shihua Li
Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.
Brain : a journal of neurology 2011;134(Pt 7):1943-58.
2011: Xiao-Jiang Li; Shihua Li
Proteasomal dysfunction in aging and Huntington disease.
Neurobiology of disease 2011;43(1):4-8.
2011: Lauren S Havel; Chuan-En Wang; Brandy Wade; Brenda Huang; Shihua Li; Xiao-Jiang Li
Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.
Human molecular genetics 2011;20(7):1424-37.
2011: Shao-Na Niu; Zhen-Bo Huang; Hao Wang; Xiu-Rong Rao; Hui Kong; Jing Xu; Xiao-Jiang Li; Chuan Yang; Guo-Qing Sheng
Brainstem Hap1-Ahi1 is involved in insulin-mediated feeding control.
FEBS letters 2011;585(1):85-91.
2010: Xingshun Xu; Hao Yang; Yung-Feng Lin; Xiang Li; Austin Cape; Kerry J Ressler; Shihua Li; Xiao-Jiang Li
Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):19126-31.
2010: Dongshan Yang; Chuan-En Wang; Bentian Zhao; Wei Li; Zhen Ouyang; Zhaoming Liu; Huaqiang Yang; Pei Fan; Ashley O'Neill; Weiwang Gu; Hong Yi; Shihua Li; Liangxue Lai; Xiao-Jiang Li
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs.
Human molecular genetics 2010;19(20):3983-94.
2010: Xiang Li; Chuan-En Wang; Shanshan Huang; Xingshun Xu; Xiao-Jiang Li; He Li; Shihua Li
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Human molecular genetics 2010;19(12):2445-55.
2010: Yung-Feng Lin; Xingshun Xu; Austin Cape; Shihua Li; Xiao-Jiang Li
Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.
The Journal of biological chemistry 2010;285(21):15941-9.
2010: Jennifer Bradford; Ji-Yeon Shin; Meredith Roberts; Chuan-En Wang; Guoqing Sheng; Shihua Li; Xiao-Jiang Li
Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
The Journal of biological chemistry 2010;285(14):10653-61.
2010: Jennifer W Bradford; Shihua Li; Xiao-Jiang Li
Polyglutamine toxicity in non-neuronal cells.
Cell research 2010;20(4):400-7.
2010: Linda Lin-yan Wu; Yongjun Fan; Shihua Li; Xiao-Jiang Li; Xin-Fu Zhou
Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.
The Journal of biological chemistry 2010;285(8):5614-23.
2010: Chuan-En Wang; Shihua Li; Xiao-Jiang Li
Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.
Molecular brain 2010;3():33.
2010: Xiao-Jiang Li; Adam L Orr; Shihua Li
Impaired mitochondrial trafficking in Huntington's disease.
Biochimica et biophysica acta 2010;1802(1):62-5.
2009: Jennifer Bradford; Ji-Yeon Shin; Meredith Roberts; Chuan-En Wang; Xiao-Jiang Li; Shihua Li
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22480-5.
2009: Anjali G Shah; Meyer J Friedman; Shanshan Huang; Meredith Roberts; Xiao-Jiang Li; Shihua Li
Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.
Human molecular genetics 2009;18(21):4141-52.
2009: Meyer J Friedman; Shihua Li; Xiao-Jiang Li
Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection.
The Journal of biological chemistry 2009;284(41):27944-51.
2009: Francesca Cicchetti; S Saporta; Robert A Hauser; Martin Parent; Martine Saint-Pierre; Paul Sanberg; Xiao-Jiang Li; J R Parker; Y Chu; Elliott J Mufson; Jeffrey Kordower; T B Freeman
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12483-8.
2009: Anna G Orr; Adam L Orr; Xiao-Jiang Li; Robert E Gross; Stephen F Traynelis
Adenosine A(2A) receptor mediates microglial process retraction.
Nature neuroscience 2009;12(7):872-8.
2009: Lauren S Havel; Shihua Li; Xiao-Jiang Li
Nuclear accumulation of polyglutamine disease proteins and neuropathology.
Molecular brain 2009;2():21.
2008: Suzanne Tydlacka; Chuan-En Wang; Xuejun Wang; Shihua Li; Xiao-Jiang Li
Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(49):13285-95.
2008: Xiang Li; He Li; Xiao-Jiang Li
Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases.
Brain research reviews 2008;59(1):245-52.
2008: Liang L Zhou; Yun Zhao; Ashley Ringrose; Donna DeGeer; Erin Kennah; Ann E-J Lin; Guoqing Sheng; Xiao-Jiang Li; Ali Turhan; Xiaoyan Jiang
AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells.
The Journal of experimental medicine 2008;205(11):2657-71.
2008: Chuan-En Wang; Suzanne Tydlacka; Adam L Orr; Shang-Hsun Yang; Graham Kyrenia Rona; Michael R Hayden; Shihua Li; Anthony W S Chan; Xiao-Jiang Li
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
Human molecular genetics 2008;17(17):2738-51.
2008: emilie colin; Diana Zala; Géraldine Liot; Hélène Rangone; Maria Borrell-Pagès; Xiao-Jiang Li; Frédéric Saudou; Sandrine Humbert
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
The EMBO journal 2008;27(15):2124-34.
2008: Guoqing Sheng; Xingshun Xu; Yung-Feng Lin; Chuan-En Wang; Juan Rong; Dongmei Cheng; Junmin Peng; Xiaoyan Jiang; Shi-Hua Li; Xiao-Jiang Li
Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice.
The Journal of clinical investigation 2008;118(8):2785-95.
2008: Shang-Hsun Yang; Pei-Hsun Cheng; Heather Banta; Karolina Piotrowska-Nitsche; Jin-Jing Yang; Eric C H Cheng; Brooke Snyder; Katherine Larkin; Jun Liu; Jack Orkin; Zhi-Hui Fang; Yoland Smith; Jocelyne Bachevalier; Stuart ZOLA; Shi-Hua Li; Xiao-Jiang Li; Anthony W S Chan
Towards a transgenic model of Huntington's disease in a non-human primate.
Nature 2008;453(7197):921-4.
2008: Michelle Gray; Dyna I Shirasaki; Carlos Cepeda; Veronique Andre; Brian Wilburn; XIAO-HONG LU; Jifang Tao; Irene Yamazaki; Shi-Hua Li; Yi E Sun; Xiao-Jiang Li; Michael S Levine; X William Yang
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(24):6182-95.
2008: Adam L Orr; Shanshan Huang; Meredith A Roberts; John C Reed; Shihua Li; Xiao-Jiang Li
Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.
The Journal of biological chemistry 2008;283(23):16027-36.
2008: Chuan-En Wang; Hui Zhou; John R McGuire; Vincenzo Cerullo; Brendan Lee; Shi-Hua Li; Xiao-Jiang Li
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin.
The Journal of cell biology 2008;181(5):803-16.
2008: Silke Metzger; Juan Rong; Huu-Phuc Nguyen; Austin Cape; Jürgen Tomiuk; Anne S Soehn; Peter Propping; Yun Freudenberg-Hua; Jan Freudenberg; Liang Tong; Shi-Hua Li; Xiao-Jiang Li; Olaf Riess
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.
Human molecular genetics 2008;17(8):1137-46.
2008: Zhixue Liu; Sung-Wuk Jang; Xia Liu; Dongmei Cheng; Junmin Peng; Manuel Yepes; Xiao-Jiang Li; Steve Matthews; Colin Watts; Masahide Asano; Ikuko Hara-Nishimura; Hongbo R Luo; Keqiang Ye
Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.
Molecular cell 2008;29(6):665-78.
2008: Meyer J Friedman; Chuan-En Wang; Xiao-Jiang Li; Shihua Li
Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity.
The Journal of biological chemistry 2008;283(13):8283-90.
2008: Jianjun Wang; Chuan-En Wang; Adam Orr; Suzanne Tydlacka; Shi-Hua Li; Xiao-Jiang Li
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.
The Journal of cell biology 2008;180(6):1177-89.
2008: Adam L Orr; Shihua Li; Chuan-En Wang; He Li; Jianjun Wang; Juan Rong; Xingshun Xu; Pier Giorgio Mastroberardino; J Timothy Greenamyre; Xiao-Jiang Li
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(11):2783-92.
2008: Lin Mei; Kei Cho; C Justin Lee; Xiao-Jiang Li; Min Zhuo; Bong-Kiun Kaang
Welcome to molecular brain.
Molecular brain 2008;1():1.
2007: Meyer J Friedman; Anjali G Shah; Zhi-Hui Fang; Elizabeth G Ward; Stephen Warren; Shihua Li; Xiao-Jiang Li
Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration.
Nature neuroscience 2007;10(12):1519-28.
2007: Xiao-Jiang Li; Meyer Friedman; Shihua Li
Interacting proteins as genetic modifiers of Huntington disease.
Trends in genetics : TIG 2007;23(11):531-3.
2007: Juan Rong; Shi-Hua Li; Xiao-Jiang Li
Regulation of intracellular HAP1 trafficking.
Journal of neuroscience research 2007;85(14):3025-9.
2007: Stéphane Palfi; Emmanuel Brouillet; Béchir Jarraya; Jocelyne Bloch; Caroline Jan; Masahiro Shin; Françoise Condé; Xiao-Jiang Li; Patrick Aebischer; Philippe Hantraye; Nicole Deglon
Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1444-51.
2007: Xiaohui Zhang; Jeffrey A Winkles; Maria Carolina Gongora; Rohini Polavarapu; Jennifer S Michaelson; Kyungmin Hahm; Linda C Burkly; Meyer Friedman; Xiao-Jiang Li; Manuel Yepes
TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(3):534-44.
2007: Juan Rong; Shihua Li; Guoqing Sheng; Meng Wu; Brian Coblitz; Min Li; Haian Fu; Xiao-Jiang Li
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
The Journal of biological chemistry 2007;282(7):4748-56.
2007: Xiaofeng Gu; Veronique Andre; Carlos Cepeda; Shi-Hua Li; Xiao-Jiang Li; Michael S Levine; X William Yang
Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease.
Molecular neurodegeneration 2007;2():8.
2006: Jonathan Cornett; Lauren Smith; Meyer Friedman; Ji-Yeon Shin; Xiao-Jiang Li; Shi-Hua Li
Context-dependent dysregulation of transcription by mutant huntingtin.
The Journal of biological chemistry 2006;281(47):36198-204.
2006: Juan Rong; John R McGuire; Zhi-Hui Fang; Guoqing Sheng; Ji-Yeon Shin; Shi-Hua Li; Xiao-Jiang Li
Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):6019-30.
2006: Guoqing Sheng; Guo-qing Chang; John Y Lin; Zhao-Xue Yu; Zhi-Hui Fang; Juan Rong; Stuart A Lipton; Shi-Hua Li; Gang Tong; Sarah F Leibowitz; Xiao-Jiang Li
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior.
Nature medicine 2006;12(5):526-33.
2006: Byoung-Il Bae; Makoto R Hara; Matthew Cascio; Cheryl L Wellington; Michael R Hayden; Christopher A Ross; Hyo Chol Ha; Xiao-Jiang Li; Solomon H Snyder; Akira Sawa
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3405-9.
2006: John Russel McGuire; Juan Rong; Shi-Hua Li; Xiao-Jiang Li
Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons.
The Journal of biological chemistry 2006;281(6):3552-9.
2006: Guo-Qiang Bi; Vadim Bolshakov; Guojun Bu; Catherine M Cahill; Zhou-Feng Chen; Graham Collingridge; Robin L Cooper; Jens R Coorssen; Alaa El-Husseini; Vasco Galhardo; Wen-Biao Gan; Jianguo Gu; Kazuhide Inoue; John Isaac; Koichi Iwata; Zhengping Jia; Bong-Kiun Kaang; Mikito Kawamata; Satoshi Kida; Eric Klann; Tatsuro Kohno; Min Li; Xiao-Jiang Li; John F MacDonald; Karim Nader; Peter V Nguyen; Uhtaek Oh; Ke Ren; John C Roder; Michael W Salter; Weihong Song; Shuzo Sugita; Shao-Jun Tang; YUANXIANG TAO; Yu Tian Wang; Newton Woo; Melanie A Woodin; Zhen Yan; Megumu Yoshimura; Ming Xu; Zao C Xu; Xia Zhang; Mei Zhen; Min Zhuo
Recent advances in basic neurosciences and brain disease: from synapses to behavior.
Molecular pain 2006;2():38.
2006: Shihua Li; Xiao-Jiang Li
Multiple pathways contribute to the pathogenesis of Huntington disease.
Molecular neurodegeneration 2006;1():19.
2005: Ji-Yeon Shin; Zhi-Hui Fang; Zhao-Xue Yu; Chuan-En Wang; Shi-Hua Li; Xiao-Jiang Li
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity.
The Journal of cell biology 2005;171(6):1001-12.
2005: Min Liao; Jianying Shen; Yinong Zhang; Shi-Hua Li; Xiao-Jiang Li; He Li
Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(12):1517-24.
2005: Caroline L Benn; Christian Landles; He Li; Andrew D Strand; Ben Woodman; Kirupa Sathasivam; Shi-Hua Li; Shabnam Ghazi-Noori; Emma Hockly; Nadeem Faruque; Jang-Ho Cha; Paul T Sharpe; James M Olson; Xiao-Jiang Li; Gillian P Bates
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
Human molecular genetics 2005;14(20):3065-78.
2005: Xiaofeng Gu; Chenjian Li; Weizheng Wei; Victor Lo; Shiaoching Gong; Shi-Hua Li; Takuji Iwasato; Shigeyoshi Itohara; Xiao-Jiang Li; Istvan Mody; Nathaniel Heintz; X William Yang
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.
Neuron 2005;46(3):433-44.
2005: Jonathan Cornett; Fengli Cao; Chuan-En Wang; Christopher A Ross; Gillian P Bates; Shi-Hua Li; Xiao-Jiang Li
Polyglutamine expansion of huntingtin impairs its nuclear export.
Nature genetics 2005;37(2):198-204.
2005: Xiao-Jiang Li; Shi-Hua Li
HAP1 and intracellular trafficking.
Trends in pharmacological sciences 2005;26(1):1-3.
2004: Shi-Hua Li; Xiao-Jiang Li
Huntingtin and its role in neuronal degeneration.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2004;10(5):467-75.
2004: Shi-Hua Li; Xiao-Jiang Li
Huntingtin-protein interactions and the pathogenesis of Huntington's disease.
Trends in genetics : TIG 2004;20(3):146-54.
2003: Hui Zhou; Fengli Cao; Zhishan Wang; Zhao-Xue Yu; Huu-Phuc Nguyen; Joy Evans; Shi-Hua Li; Xiao-Jiang Li
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.
The Journal of cell biology 2003;163(1):109-18.
2003: He Li; Travis Wyman; Zhao-Xue Yu; Shi-Hua Li; Xiao-Jiang Li
Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release.
Human molecular genetics 2003;12(16):2021-30.
2003: Shi-Hua Li; Zhao-Xue Yu; Cui-Lin Li; Huu-Phuc Nguyen; Yong-Xing Zhou; Chuxia Deng; Xiao-Jiang Li
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(17):6956-64.
2003: Elizabeth J Slow; Jeremy M van Raamsdonk; Daniel Rogers; Sarah H Coleman; Graham Kyrenia Rona; Yu Deng; Rosemary Oh; Nagat Bissada; Sazzad M Hossain; Yu-Zhou Yang; Xiao-Jiang Li; Elizabeth M Simpson; Claire-Anne Gutekunst; Blair R Leavitt; Michael R Hayden
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Human molecular genetics 2003;12(13):1555-67.
2003: Zhao-Xue Yu; Shi-Hua Li; Joy Evans; Ajay Pillarisetti; He Li; Xiao-Jiang Li
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2193-202.
2003: Stephan von Hörsten; Ina Schmitt; Huu-Phuc Nguyen; Carsten Holzmann; Thorsten Schmidt; Thomas Walther; Michael Bader; Reinhard Pabst; Philipp Kobbe; Jana Krotova; Detlef Stiller; Ants Kask; Annika Vaarmann; Silvia Rathke-Hartlieb; Jörg B Schulz; Ute Grasshoff; Ingrid Bauer; Ana Maria Menezes Vieira-Saecker; Martin Paul; Lesley Jones; Katrin S Lindenberg; Bernhard G Landwehrmeyer; Andreas Bauer; Xiao-Jiang Li; Olaf Riess
Transgenic rat model of Huntington's disease.
Human molecular genetics 2003;12(6):617-24.
2003: WENZHEN DUAN; Zhihong Guo; Haiyang Jiang; Melvin Ware; Xiao-Jiang Li; Mark P Mattson
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2911-6.
2003: Shi-Hua Li; Xiao-Jiang Li
In vitro expression systems for the Huntington protein.
Methods in molecular biology (Clifton, N.J.) 2003;217():277-84.
2002: Liliana B Menalled; Jessica D Sison; Ying Wu; Melisa Olivieri; Xiao-Jiang Li; He Li; Scott Zeitlin; Marie-Francoise Chesselet
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):8266-76.
2002: Jen-Zen Chuang; Hui Zhou; Meicai Zhu; Shi-Hua Li; Xiao-Jiang Li; Ching-Hwa Sung
Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently.
The Journal of biological chemistry 2002;277(22):19831-8.
2002: Zhao-Xue Yu; Shi-Hua Li; Huu-Phuc Nguyen; Xiao-Jiang Li
Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice.
Human molecular genetics 2002;11(8):905-14.
2002: Shi-Hua Li; Anna L Cheng; Hui Zhou; Suzanne Lam; Manjula Rao; He Li; Xiao-Jiang Li
Interaction of Huntington disease protein with transcriptional activator Sp1.
Molecular and cellular biology 2002;22(5):1277-87.
2002: Xiao-Jiang Li; Zheng-Yun J Zhan; Rachel Knipe; David G Lynn
DNA-catalyzed polymerization.
Journal of the American Chemical Society 2002;124(5):746-7.
2001: Hong Zhou; Shi-Hua Li; Xiao-Jiang Li
Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation.
The Journal of biological chemistry 2001;276(51):48417-24.
2001: Donna L Smith; R Portier; Ben Woodman; Emma Hockly; Amarbirpal Mahal; William E Klunk; Xiao-Jiang Li; Erich E Wanker; Karl D Murray; Gillian P Bates
Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles.
Neurobiology of disease 2001;8(6):1017-26.
2001: Oskar Hansson; Ezia Guatteo; Nicola B Mercuri; Giorgio Bernardi; Xiao-Jiang Li; Roger F Castilho; Patrik Brundin
Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene.
The European journal of neuroscience 2001;14(9):1492-504.
2001: He Li; Shi-Hua Li; Zhao-Xue Yu; P Shelbourne; Xiao-Jiang Li
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(21):8473-81.
2001: F Cao; J J Levine; S H Li; Xiao-Jiang Li
Nuclear aggregation of huntingtin is not prevented by deletion of chaperone Hsp104.
Biochimica et biophysica acta 2001;1537(2):158-66.
2001: Gabriele Schilling; Hyder A Jinnah; Victoria Gonzales; Michael Coonfield; Y Kim; Jonathan D Wood; Donald L Price; Xiao-Jiang Li; Nancy Jenkins; Neal G Copeland; Timothy H Moran; Christopher A Ross; David R Borchelt
Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.
Neurobiology of disease 2001;8(3):405-18.
2001: C H Lin; Sara J Tallaksen-Greene; Wei-Ming Chien; Jamie A Cearley; Walker S Jackson; Andrew B Crouse; Shengjun Ren; Xiao-Jiang Li; Roger L Albin; Peter J Detloff
Neurological abnormalities in a knock-in mouse model of Huntington's disease.
Human molecular genetics 2001;10(2):137-44.
2000: Thomas B Freeman; F Cicchetti; Robert A Hauser; TW Deacon; Xiao-Jiang Li; Steven M Hersch; G Michael Nauert; Paul Sanberg; Jeffrey Kordower; Samuel Saporta; Ole Isacson
Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13877-82.
2000: Shi-Hua Li; S Lam; Anna L Cheng; Xiao-Jiang Li
Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis.
Human molecular genetics 2000;9(19):2859-67.
2000: He Li; Shi-Hua Li; H Johnston; P F Shelbourne; Xiao-Jiang Li
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity.
Nature genetics 2000;25(4):385-9.
2000: S H Li; H Li; E R Torre; Xiao-Jiang Li
Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth.
Molecular and cellular neurosciences 2000;16(2):168-83.
2000: Vanessa C Wheeler; JK White; Claire-Anne Gutekunst; Vladimir Vrbanac; M Weaver; Xiao-Jiang Li; S H Li; H Yi; Jean-Paul Vonsattel; James Gusella; Steven M Hersch; Wojtek Auerbach; Alexandra L Joyner; Marcy E MacDonald
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
Human molecular genetics 2000;9(4):503-13.
1999: S Kuemmerle; Claire-Anne Gutekunst; Adam M Klein; Xiao-Jiang Li; Shi-Hua Li; M Flint Beal; Steven M Hersch; Robert J Ferrante
Huntington aggregates may not predict neuronal death in Huntington's disease.
Annals of neurology 1999;46(6):842-9.
1999: Xiao-Jiang Li
The early cellular pathology of Huntington's disease.
Molecular neurobiology 1999;20(2-3):111-24.
1999: Shi-Hua Li; A L Cheng; He Li; Xiao-Jiang Li
Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5159-72.
1999: He Li; Shi-Hua Li; Anna L Cheng; L Mangiarini; Gillian P Bates; Xiao-Jiang Li
Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice.
Human molecular genetics 1999;8(7):1227-36.
1999: Victor O Ona; Mingwei Li; Jean-Paul Vonsattel; LJ Andrews; S Q Khan; W M Chung; AS Frey; A S Menon; Xiao-Jiang Li; Philip E Stieg; Junying Yuan; John B Penney; Anne B Young; Jang-Ho Cha; Robert M Friedlander
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.
Nature 1999;399(6733):263-7.
1999: JG Hodgson; N Agopyan; Claire-Anne Gutekunst; Blair R Leavitt; F LePiane; Roshni R Singaraja; Desmond J Smith; Nagat Bissada; Krista McCutcheon; Jamal Nasir; Laure Jamot; Xiao-Jiang Li; M E Stevens; E Rosemond; John C Roder; A G Phillips; E M Rubin; Steven M Hersch; Michael R Hayden
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Neuron 1999;23(1):181-92.
1999: Claire-Anne Gutekunst; Shi-Hua Li; Hong Yi; J S Mulroy; S Kuemmerle; R Jones; D Rye; Robert J Ferrante; Steven M Hersch; Xiao-Jiang Li
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2522-34.
1998: S H Li; Claire-Anne Gutekunst; Steven M Hersch; Xiao-Jiang Li
Association of HAP1 isoforms with a unique cytoplasmic structure.
Journal of neurochemistry 1998;71(5):2178-85.
1998: Claire-Anne Gutekunst; Shi-Hua Li; Hong Yi; Robert J Ferrante; Xiao-Jiang Li; Steven M Hersch
The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(19):7674-86.
1998: Shi-Hua Li; Seyed H Hosseini; Claire-Anne Gutekunst; Steven M Hersch; Robert J Ferrante; Xiao-Jiang Li
A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.
The Journal of biological chemistry 1998;273(30):19220-7.
1998: Shi-Hua Li; Xiao-Jiang Li
Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats.
Human molecular genetics 1998;7(5):777-82.
1998: Shi-Hua Li; Claire-Anne Gutekunst; Steven M Hersch; Xiao-Jiang Li
Interaction of huntingtin-associated protein with dynactin P150Glued.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(4):1261-9.
1996: Xiao-Jiang Li; Alan H Sharp; S H Li; Ted M Dawson; Solomon H Snyder; Christopher A Ross
Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4839-44.
1995: Xiao-Jiang Li; S H Li; Alan H Sharp; Frederick C Nucifora; Gabriele Schilling; Anthony A Lanahan; Paul F Worley; Solomon H Snyder; Christopher A Ross
A huntingtin-associated protein enriched in brain with implications for pathology.
Nature 1995;378(6555):398-402.
1995: Xiao-Jiang Li; Solomon H Snyder
Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds.
The Journal of biological chemistry 1995;270(30):17674-9.
1995: Xiao-Jiang Li; R H Xu; William B Guggino; Solomon H Snyder
Alternatively spliced forms of the alpha subunit of the epithelial sodium channel: distinct sites for amiloride binding and channel pore.
Molecular pharmacology 1995;47(6):1133-40.
1995: Alan H Sharp; S J Loev; Gabriele Schilling; S H Li; Xiao-Jiang Li; J Bao; M V Wagster; J A Kotzuk; Joseph P Steiner; A Lo
Widespread expression of Huntington's disease gene (IT15) protein product.
Neuron 1995;14(5):1065-74.
1994: Xiao-Jiang Li; Seth Blackshaw; Solomon H Snyder
Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1814-8.
1994: Ray E Hershberger; B L Newman; Tullio Florio; James R Bunzow; Olivier Civelli; Xiao-Jiang Li; Michael Forte; Philip J S Stork
The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways.
Endocrinology 1994;134(3):1277-85.
1993: S H Li; Gabriele Schilling; W Scott Young; Xiao-Jiang Li; Russell L Margolis; O Colin Stine; M V Wagster; Margaret H Abbott; ML Franz; NG Ranen
Huntington's disease gene (IT15) is widely expressed in human and rat tissues.
Neuron 1993;11(5):985-93.
1992: Xiao-Jiang Li; Michael Forte; R A North; Christopher A Ross; Solomon H Snyder
Cloning and expression of a rat somatostatin receptor enriched in brain.
The Journal of biological chemistry 1992;267(30):21307-12.
1992: Xiao-Jiang Li
Supersensitivity of isolated atria from diabetic rats to adenosine and methacholine: modulation by pertussis toxin.
The Journal of pharmacy and pharmacology 1992;44(2):142-4.
1992: Xiao-Jiang Li; Y N Wu; R A North; Michael Forte
Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster.
The Journal of biological chemistry 1992;267(1):9-12.
1991: Xiao-Jiang Li; William J Wolfgang; Y N Wu; R A North; Michael Forte
Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides.
The EMBO journal 1991;10(11):3221-9.