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Yingchun Li

Research Profile

Chemicals & Drugs

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Physiology

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Molecular Structure

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Publications

TOP 3
Ping-Chuan Tsai; Andrew Bigley; Yingchun Li; Eman Ghanem; C Linn Cadieux; Shane A Kasten; Tony E Reeves; Douglas M Cerasoli; Frank M Raushel
Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase.
Tinh T Nguyen; Alexander A Fedorov; Lakenya Williams; Elena V Fedorov; Yingchun Li; Chengfu Xu; Steven C Almo; Frank M Raushel
The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Eman Ghanem; Yingchun Li; Chengfu Xu; Frank M Raushel
Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.

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All Publications

2010: Ping-Chuan Tsai; Andrew Bigley; Yingchun Li; Eman Ghanem; C Linn Cadieux; Shane A Kasten; Tony E Reeves; Douglas M Cerasoli; Frank M Raushel
Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase.
Biochemistry 2010;49(37):7978-87.
2009: Tinh T Nguyen; Alexander A Fedorov; Lakenya Williams; Elena V Fedorov; Yingchun Li; Chengfu Xu; Steven C Almo; Frank M Raushel
The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry 2009;48(37):8879-90.
2007: Eman Ghanem; Yingchun Li; Chengfu Xu; Frank M Raushel
Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.
Biochemistry 2007;46(31):9032-40.
2006: Charity Nowlan; Yingchun Li; Johannes C Hermann; Timothy Evans; Joseph Carpenter; Eman Ghanem; Brian Shoichet; Frank M Raushel
Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library.
Journal of the American Chemical Society 2006;128(49):15892-902.
2006: Johannes C Hermann; Eman Ghanem; Yingchun Li; Frank M Raushel; John J Irwin; Brian Shoichet
Predicting substrates by docking high-energy intermediates to enzyme structures.
Journal of the American Chemical Society 2006;128(49):15882-91.
2006: LaKenya Williams; Tinh Nguyen; Yingchun Li; Tamiko N Porter; Frank M Raushel
Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion.
Biochemistry 2006;45(24):7453-62.
2005: Yingchun Li; Frank M Raushel
Inhibitors designed for the active site of dihydroorotase.
Bioorganic chemistry 2005;33(6):470-83.
2004: Tamiko N Porter; Yingchun Li; Frank M Raushel
Mechanism of the dihydroorotase reaction.
Biochemistry 2004;43(51):16285-92.
2004: Min-Sun Park; Craig M Hill; Yingchun Li; R Kristoffer Hardy; Hemant Khanna; Yong-Ho Khang; Frank M Raushel
Catalytic properties of the PepQ prolidase from Escherichia coli.
Archives of biochemistry and biophysics 2004;429(2):224-30.
2004: Yingchun Li; Sarah D Aubert; Eugene G Maes; Frank M Raushel
Enzymatic resolution of chiral phosphinate esters.
Journal of the American Chemical Society 2004;126(29):8888-9.
2004: Sarah D Aubert; Yingchun Li; Frank M Raushel
Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase.
Biochemistry 2004;43(19):5707-15.
2003: Karin T Lum; Henry J Huebner; Yingchun Li; Timothy D Phillips; Frank M Raushel
Organophosphate nerve agent toxicity in Hydra attenuata.
Chemical research in toxicology 2003;16(8):953-7.
2003: Yingchun Li; Sarah D Aubert; Frank M Raushel
Operational control of stereoselectivity during the enzymatic hydrolysis of racemic organophosphorus compounds.
Journal of the American Chemical Society 2003;125(25):7526-7.
2002: Wen-Shan Li; Yingchun Li; Craig M Hill; Karin T Lum; Frank M Raushel
Enzymatic synthesis of chiral organophosphothioates from prochiral precursors.
Journal of the American Chemical Society 2002;124(14):3498-9.