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Zihai Li

Research Profile

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Chemicals & Drugs

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Physiology

Signal Transduction

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Unfolded Protein Response

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Publications

TOP 3
Bei Liu; Crystal Morales; Matthew Staron; Shaoli Sun; Stephen Tomlinson; Bill X Wu; Dianqing Wu; Craig E Crosson; Feng Hong; Ingyu Kim; Zihai Li
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Saleh M Rachidi; Shaoli Sun; W Jim Zheng; Tingting Qin; Zihai Li
Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker.
Janardan P Pandey; Zihai Li
The forgotten tale of immunoglobulin allotypes in cancer risk and treatment.

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All Publications

2013: Bei Liu; Crystal Morales; Matthew Staron; Shaoli Sun; Stephen Tomlinson; Bill X Wu; Dianqing Wu; Craig E Crosson; Feng Hong; Ingyu Kim; Zihai Li
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):6877-82.
2013: Saleh M Rachidi; Shaoli Sun; W Jim Zheng; Tingting Qin; Zihai Li
Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker.
PloS one 2013;8(3):e57911.
2013: Janardan P Pandey; Zihai Li
The forgotten tale of immunoglobulin allotypes in cancer risk and treatment.
Experimental hematology & oncology 2013;2(1):6.
2012: Elisabeth R Barton; Becky Brisson; davide laptop; Jose K James; Hanqin Lei; Zihai Li; Catherine A Makarewich; Olga Ostrovsky; SooHyun Park; Anastassios Philippou; Yair Argon
Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(9):3691-702.
2012: Urmila Maitra; Zihai Li; Bianca Baker; Daniel G S Capelluto; Hui Deng; Trevor Glaros; Liwu Li
Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(2):1014-23.
2012: Shuang Wu; Bei Liu; Abu Shadat M Noman; Krystal Dole; Feng Hong; Jennifer Issacs; Zihai Li
Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors.
The Journal of biological chemistry 2012;287(24):19896-903.
2012: Shuang Wu; Bei Liu; Daniel Gewirth; Beichu Guo; Feng Hong; Zihai Li
The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain.
The Journal of biological chemistry 2012;287(9):6735-42.
2012: Zihai Li; Chung-Tsen Hsueh; Delong Liu
Publish, not perish: Introducing Experimental Hematology & Oncology.
Experimental hematology & oncology 2012;1(1):1.
2012: Bei Liu; Matthew Staron; Zihai Li
Murine but not human basophil undergoes cell-specific proteolysis of a major endoplasmic reticulum chaperone.
PloS one 2012;7(6):e39442.
2011: Matthew Staron; Aleksandra Stojanovic; Shuang Wu; Bei Liu; Robert Bona; Xiaoping Du; Feng Hong; Zihai Li
Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.
Blood 2011;117(26):7136-44.
2011: Christophe Audouard; Florent Le Masson; Colette Charry; Zihai Li; Elisabeth S Christians
Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.
PloS one 2011;6(2):e17109.
2011: Xuemei Li; Kezhong Zhang; Zihai Li
Unfolded protein response in cancer: the physician's perspective.
Journal of hematology & oncology 2011;4():8.
2010: Jeremy P McAleer; Bei Liu; Zihai Li; Soo-Mun Ngoi; Jie Dai; Martin Oft; Anthony T Vella
Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization.
Journal of leukocyte biology 2010;88(1):21-31.
2010: Matthew Staron; Yi Yang; Bei Liu; Janet Li; Yuankai Shen; Juan Carlos Zúñiga-Pflücker; Hector L Aguila; Irving Goldschneider; Zihai Li
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.
Blood 2010;115(12):2380-90.
2010: Saad Z Usmani; Robert D Bona; Gabriela Chiosis; Zihai Li
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.
Journal of hematology & oncology 2010;3():40.
2010: Bei Liu; Yi Yang; Zhijuan Qiu; Matthew Staron; Feng Hong; Yi Li; Shuang Wu; Yunfeng Li; Bing Hao; Robert Bona; David Han; Zihai Li
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.
Nature communications 2010;1():79.
2010: Jung Min Han; Nam Hoon Kwon; Jin Young Lee; Seung Jae Jeong; Hee Jung Jung; Hyeong Rae Kim; Zihai Li; Sunghoon Kim
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
PloS one 2010;5(3):e9792.
2010: Bei Liu; John Nash; Carolyn Runowicz; Helen Swede; Richard Stevens; Zihai Li
Ovarian cancer immunotherapy: opportunities, progresses and challenges.
Journal of hematology & oncology 2010;3():7.
2009: Yi Li; Hui Zeng; Ren-He Xu; Bei Liu; Zihai Li
Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer.
Stem cells (Dayton, Ohio) 2009;27(12):3103-11.
2009: Crystal Morales; Shuang Wu; Yi Yang; Bing Hao; Zihai Li
Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5121-8.
2009: Saad Z Usmani; Robert Bona; Zihai Li
17 AAG for HSP90 inhibition in cancer--from bench to bedside.
Current molecular medicine 2009;9(5):654-64.
2009: Jie Dai; Bei Liu; Zihai Li
Regulatory T cells and Toll-like receptors: what is the missing link?
International immunopharmacology 2009;9(5):528-33.
2009: Mark G Goldstein; Zihai Li
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis.
Journal of hematology & oncology 2009;2():5.
2008: Madhav V Dhodapkar; Kavita M Dhodapkar; Zihai Li
Role of chaperones and FcgammaR in immunogenic death.
Current opinion in immunology 2008;20(5):512-7.
2008: Bei Liu; Zihai Li
Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.
Blood 2008;112(4):1223-30.
2008: Yi Qiao; Bei Liu; Zihai Li
Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.
Cancer immunity 2008;8():12.
2008: Z Wang; Bei Liu; Ping Wang; Xuemei Dong; Carlos Fernandez-Hernando; Zihai Li; Timothy Hla; Zihai Li; Kevin Claffey; Jonathan D. Smith; Dianqing Wu
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
The Journal of clinical investigation 2008;118(1):195-204.
2007: Jung Min Han; Sang Gyu Park; Bei Liu; Bum-Joon Park; Jin Young Kim; Cheng He Jin; Yeong Wook Song; Zihai Li; Sunghoon Kim
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases.
The American journal of pathology 2007;170(6):2042-54.
2007: Madhavi Gorusu; Peter Benn; Zihai Li; Min Fang
On the genesis and prognosis of variant translocations in chronic myeloid leukemia.
Cancer genetics and cytogenetics 2007;173(2):97-106.
2007: Jie Dai; Bei Liu; Soo-Mun Ngoi; Shaoli Sun; Anthony T Vella; Zihai Li
TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3219-25.
2007: Jie Dai; Bei Liu; Daniel J Cua; Zihai Li
Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96.
European journal of immunology 2007;37(3):706-15.
2007: Yi Yang; Bei Liu; Jie Dai; Pramod K Srivastava; David J Zammit; Leo Lefrançois; Zihai Li
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages.
Immunity 2007;26(2):215-26.
2006: Bei Liu; Yi Yang; Jie Dai; Ruslan Medzhitov; Marina A Freudenberg; Ping L Zhang; Zihai Li
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6880-8.
2005: Yi Yang; Zihai Li
Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?
Molecules and cells 2005;20(2):173-82.
2005: Michele T Pritchard; Zihai Li; Elizabeth A Repasky
Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages.
Journal of leukocyte biology 2005;78(3):630-8.
2005: Zihai Li; Yi Qiao; Bei Liu; Elizabeth J Laska; Priyamvadha Chakravarthi; Judith M Kulko; Robert D Bona; Min Fang; Upendra Hegde; Victor M Moyo; Susan H Tannenbaum; Antoine Ménoret; Judy Gaffney; Laura Glynn; Carolyn D Runowicz; Pramod K Srivastava
Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4460-8.
2005: Robert Peter Gale; Mary M Horowitz; Moshe Talpaz; David A Scheinberg; Jeffrey J Molldrem; Zihai Li; Michele Baccarani; John M Goldman; Sante Tura
Immune therapy of chronic myelogenous leukemia.
Leukemia research 2005;29(5):583-6.
2004: Hong Zheng; Zihai Li
Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):5929-33.
2004: Seung-Joo Lee; Lara Myers; Guruprasaadh Muralimohan; Jie Dai; Yi Qiao; Zihai Li; Robert S Mittler; Anthony T Vella
4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3002-12.
2004: Anna M DeFillipo; Jie Dai; Zihai Li
Heat shock-induced dendritic cell maturation is coupled by transient aggregation of ubiquitinated proteins independently of heat shock factor 1 or inducible heat shock protein 70.
Molecular immunology 2004;41(8):785-92.
2004: Zihai Li; Pramod Srivastava
Heat-shock proteins.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Appendix 1():Appendix 1T.
2004: Zihai Li
In vitro reconstitution of heat shock protein-peptide complexes for generating peptide-specific vaccines against cancers and infectious diseases.
Methods (San Diego, Calif.) 2004;32(1):25-8.
2003: Bei Liu; Jie Dai; Hong Zheng; Diliana Stoilova; Shaoli Sun; Zihai Li
Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15824-9.
2003: Douglas G Millar; Kristine M Garza; Bernhard Odermatt; Alisha R Elford; Nobuyuki Ono; Zihai Li; Pamela S Ohashi
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
Nature medicine 2003;9(12):1469-76.
2003: Hong Zheng; Ivor J Benjamin; Sreyashi Basu; Zihai Li
Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response.
European journal of immunology 2003;33(6):1754-62.
2003: Jie Dai; Bei Liu; Marissa M Caudill; Hong Zheng; Yi Qiao; Eckhard R Podack; Zihai Li
Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory.
Cancer immunity 2003;3():1.
2002: Bei Liu; Anna M DeFilippo; Zihai Li
Overcoming immune tolerance to cancer by heat shock protein vaccines.
Molecular cancer therapeutics 2002;1(12):1147-51.
2002: Zihai Li; Jie Dai; Hong Zheng; Bei Liu; Marissa Caudill
An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response.
Frontiers in bioscience : a journal and virtual library 2002;7():d731-51.
2002: Zihai Li; Antoine Menoret; Pramod Srivastava
Roles of heat-shock proteins in antigen presentation and cross-presentation.
Current opinion in immunology 2002;14(1):45-51.
2001: Hong Zheng; J Dai; D Stoilova; Zihai Li
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):6731-5.
2001: Antoine Ménoret; Zihai Li; M L Niswonger; A Altmeyer; Pramod K Srivastava
An endoplasmic reticulum protein implicated in chaperoning peptides to major histocompatibility of class I is an aminopeptidase.
The Journal of biological chemistry 2001;276(36):33313-8.