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Zuomei Li

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Chunlin Ke; Zuomei Li; Jianguang Luo; Deliang Qiao; Yi Sun; Hong Ye; Xiaoxiong Zeng
Immunostimulatory activity and structure of polysaccharide from Streptococcus equi subsp. zooepidemicus.
Abderrazzak Merzouki; Rebecca S Young; Michael D Buschmann; Susannah Gal; Myriam Jean; Zuomei Li; Si Liao; Steve N Slilaty
Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.
Anas Younes; L Jeffrey Medeiros; Sattva S Neelapu; Yasuhiro Oki; Tracy Patterson; Jessica K Paulus; M Renee Ward; Jeffrey M Besterman; R Gregory Bociek; Daniela Buglio; Amanda Copeland; Michel Drouin; Michelle Fanale; Ahmed Galal; Yuan Ji; John Kuruvilla; Zuomei Li; Robert E Martell
Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial.

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All Publications

2013: Chunlin Ke; Zuomei Li; Jianguang Luo; Deliang Qiao; Yi Sun; Hong Ye; Xiaoxiong Zeng
Immunostimulatory activity and structure of polysaccharide from Streptococcus equi subsp. zooepidemicus.
International journal of biological macromolecules 2013;57():218-25.
2012: Abderrazzak Merzouki; Rebecca S Young; Michael D Buschmann; Susannah Gal; Myriam Jean; Zuomei Li; Si Liao; Steve N Slilaty
Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.
Anticancer research 2012;32(10):4423-32.
2011: Anas Younes; L Jeffrey Medeiros; Sattva S Neelapu; Yasuhiro Oki; Tracy Patterson; Jessica K Paulus; M Renee Ward; Jeffrey M Besterman; R Gregory Bociek; Daniela Buglio; Amanda Copeland; Michel Drouin; Michelle Fanale; Ahmed Galal; Yuan Ji; John Kuruvilla; Zuomei Li; Robert E Martell
Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial.
The lancet oncology 2011;12(13):1222-8.
2010: Shaheen Sikandar; Diana Dizon; Xiling Shen; Zuomei Li; Jeffery Besterman; Steven M Lipkin
The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
Oncotarget 2010;1(7):596-605.
2009: Pierre Tessier; David V Smil; Amal Wahhab; Silvana Leit; Jubrail Rahil; Zuomei Li; Robert Déziel; Jeffrey M Besterman
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(19):5684-8.
2009: Sukhdev Manku; Martin Allan; Natalie Nguyen; Alain Ajamian; Jacques Rodrigue; Eric Therrien; James Wang; Tim Guo; Jubrail Rahil; Andrea J Petschner; Alina Nicolescu; Sylvain Lefebvre; Zuomei Li; Marielle Fournel; Jeffrey M Besterman; Robert Déziel; Amal Wahhab
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(7):1866-70.
2009: Stéphane Raeppel; Nancy Zhou; Frédéric Gaudette; Silvana Leit; Isabelle Paquin; Guillaume Larouche; Oscar Moradei; Sylvie Fréchette; Ljubomir Isakovic; Daniel Delorme; Marielle Fournel; Ann Kalita; Aihua Lu; Marie-Claude Trachy-Bourget; Pu T Yan; Jianhong Liu; Jubrail Rahil; James Wang; Jeffrey M Besterman; Koji Murakami; Zuomei Li; Arkadii Vaisburg
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
Bioorganic & medicinal chemistry letters 2009;19(3):644-9.
2009: David V Smil; Sukhdev Manku; Yves A Chantigny; Silvana Leit; Amal Wahhab; Theresa P Yan; Marielle Fournel; Christiane Maroun; Zuomei Li; Anne-Marie Lemieux; Alina Nicolescu; Jubrail Rahil; Sylvain Lefebvre; Anthony Panetta; Jeffrey M Besterman; Robert Déziel
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(3):688-92.
2009: Amal Wahhab; David Smil; Alain Ajamian; Martin Allan; Yves Chantigny; Eric Therrien; Natalie Nguyen; Sukhdev Manku; Silvana Leit; Jubrail Rahil; Andrea J Petschner; Ai-Hua Lu; Alina Nicolescu; Sylvain Lefebvre; Samuel Montcalm; Marielle Fournel; Theresa P Yan; Zuomei Li; Jeffrey M Besterman; Robert Déziel
Sulfamides as novel histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(2):336-40.
2008: Claire Bonfils; Donald R Walkinshaw; Xiang-Jiao Yang; Jeffrey M Besterman; Zuomei Li
Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases.
Expert opinion on drug discovery 2008;3(9):1041-65.
2008: Guillermo Garcia-Manero; Sarit Assouline; Jorge Cortes; Zeev Estrov; Andrew Lamb; Hui Yang; Willie M Newsome; Wilson H Miller; Caroline Rousseau; Ann Kalita; Claire Bonfils; Marja Dubay; Tracy-Ann Patterson; Zuomei Li; Jeffrey M Besterman; Gregory Reid; Eric Laille; Robert E Martell; Mark Minden
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia.
Blood 2008;112(4):981-9.
2008: Nancy Zhou; Oscar Moradei; Stephane Raeppel; Silvana Leit; Sylvie Frechette; Frederic Gaudette; Isabelle Paquin; Naomy Bernstein; Giliane Bouchain; Arkadii Vaisburg; Zhiyun Jin; Jeff Gillespie; James Wang; Marielle Fournel; Pu T Yan; Marie-Claude Trachy-Bourget; Ann Kalita; Aihua Lu; Jubrail Rahil; A Robert MacLeod; Zuomei Li; Jeffrey M Besterman; Daniel Delorme
Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
Journal of medicinal chemistry 2008;51(14):4072-5.
2008: Claire Bonfils; Ann Kalita; Marja Dubay; Lillian L Siu; Michael A Carducci; Gregory Reid; Robert E Martell; Jeffrey M Besterman; Zuomei Li
Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3441-9.
2008: Lillian L Siu; Roberto Pili; Ignacio Duran; Wells A Messersmith; Eric X Chen; Rana Sullivan; Martha Maclean; Serina King; Shirley Brown; Gregory K Reid; Zuomei Li; Ann M Kalita; Eric J Laille; Jeffrey M Besterman; Robert E Martell; Michael A Carducci
Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(12):1940-7.
2008: Marielle Fournel; Claire Bonfils; Yu Hou; Pu Theresa Yan; Marie-Claude Trachy-Bourget; Ann Kalita; Jianhong Liu; Ai-Hua Lu; Nancy Z Zhou; Marie-France Robert; Jeffrey Gillespie; James J Wang; Hélène Ste-Croix; Jubrail Rahil; Sylvain Lefebvre; Oscar Moradei; Daniel Delorme; A Robert MacLeod; Jeffrey M Besterman; Zuomei Li
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo.
Molecular cancer therapeutics 2008;7(4):759-68.
2008: Sylvie Fréchette; Silvana Leit; Soon Hyung Woo; Guillaume Lapointe; Guillaume Jeannotte; Oscar Moradei; Isabelle Paquin; Giliane Bouchain; Stéphane Raeppel; Frédéric Gaudette; Nancy Zhou; Arkadii Vaisburg; Marielle Fournel; Pu T Yan; Marie-Claude Trachy-Bourget; Ann Kalita; Marie-France Robert; Aihua Lu; Jubrail Rahil; A Robert Macleod; Jeffrey M Besterman; Zuomei Li; Daniel Delorme
4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(4):1502-6.
2008: Isabelle Paquin; Stéphane Raeppel; Silvana Leit; Frédéric Gaudette; Nancy Zhou; Oscar Moradei; Oscar Saavedra; Naomy Bernstein; Franck Raeppel; Giliane Bouchain; Sylvie Fréchette; Soon Hyung Woo; Arkadii Vaisburg; Marielle Fournel; Ann Kalita; Marie-France Robert; Aihua Lu; Marie-Claude Trachy-Bourget; Pu T Yan; Jianhong Liu; Jubrail Rahil; A Robert MacLeod; Jeffrey M Besterman; Zuomei Li; Daniel Delorme
Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(3):1067-71.
2007: Arkadii Vaisburg; Isabelle Paquin; Naomy Bernstein; Sylvie Frechette; Frederic Gaudette; Silvana Leit; Oscar Moradei; Stephane Raeppel; Nancy Zhou; Giliane Bouchain; Soon Hyung Woo; Zhiyun Jin; Jeff Gillespie; James Wang; Marielle Fournel; Pu T Yan; Marie-Claude Trachy-Bourget; Marie-France Robert; Aihua Lu; Jimmy Yuk; Jubrail Rahil; A Robert MacLeod; Jeffrey M Besterman; Zuomei Li; Daniel Delorme
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(24):6729-33.
2007: Oscar Moradei; Tammy C Mallais; Sylvie Frechette; Isabelle Paquin; Pierre E Tessier; Silvana Leit; Marielle Fournel; Claire Bonfils; Marie-Claude Trachy-Bourget; Jianhong Liu; Theresa P Yan; Ai-Hua Lu; Jubrail Rahil; James Wang; Sylvain Lefebvre; Zuomei Li; Arkadii Vaisburg; Jeffrey M Besterman
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.
Journal of medicinal chemistry 2007;50(23):5543-6.
2006: Oscar Moradei; Silvana Leit; Nancy Zhou; Sylvie Fréchette; Isabelle Paquin; Stéphane Raeppel; Frédéric Gaudette; Giliane Bouchain; Soon Hyung Woo; Arkadii Vaisburg; Marielle Fournel; Ann Kalita; Aihua Lu; Marie-Claude Trachy-Bourget; Pu T Yan; Jianhong Liu; Zuomei Li; Jubrail Rahil; A Robert MacLeod; Jeffrey M Besterman; Daniel Delorme
Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(15):4048-52.
2004: Arkadii Vaisburg; Naomy Bernstein; Sylvie Frechette; Martin Allan; Elie Abou Khalil; Silvana Leit; Oscar Moradei; Giliane Bouchain; James Wang; Soon Hyung Woo; Marielle Fournel; Pu T Yan; Marie-Claude Trachy-Bourget; Ann Kalita; Carole Beaulieu; Zuomei Li; A Robert MacLeod; Jeffrey M Besterman; Daniel Delorme
(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(1):283-7.
2003: Giliane Bouchain; Silvana Leit; Sylvie Frechette; Elie Abou Khalil; Rico Lavoie; Oscar Moradei; Soon Hyung Woo; Marielle Fournel; Pu T Yan; Ann Kalita; Marie-Claude Trachy-Bourget; Carole Beaulieu; Zuomei Li; Marie-France Robert; A Robert MacLeod; Jeffrey M Besterman; Daniel Delorme
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.
Journal of medicinal chemistry 2003;46(5):820-30.
2002: Marielle Fournel; Marie-Claude Trachy-Bourget; Pu T Yan; Ann Kalita; Claire Bonfils; Carole Beaulieu; Sylvie Frechette; Silvana Leit; Elie Abou Khalil; Soon Hyung Woo; Daniel Delorme; A Robert MacLeod; Jeffrey M Besterman; Zuomei Li
Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.
Cancer research 2002;62(15):4325-30.
2002: Soon Hyung Woo; Sylvie Frechette; Elie Abou Khalil; Giliane Bouchain; Arkadii Vaisburg; Naomy Bernstein; Oscar Moradei; Silvana Leit; Martin Allan; Marielle Fournel; Marie-Claude Trachy-Bourget; Zuomei Li; Jeffrey M Besterman; Daniel Delorme
Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.
Journal of medicinal chemistry 2002;45(13):2877-85.
2001: R Lavoie; Giliane Bouchain; Sylvie Frechette; Soon Hyung Woo; Elie Abou Khalil; Silvana Leit; Marielle Fournel; Pu T Yan; Marie-Claude Trachy-Bourget; Carole Beaulieu; Zuomei Li; Jeffrey M Besterman; Daniel Delorme
Design and synthesis of a novel class of histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(21):2847-50.