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Catherine Abbadie

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Pengcheng P Shao; McHardy M Smith; Shu-Yu Sun; Andrew M Swensen; Deepu J Varughese; Vivien A Warren; Feng Ye; Catherine Abbadie; Randal M Bugianesi; Prasun K Chakravarty; Ge Dai; Maria L Garcia; Mitchell Green; Rodolfo J Haedo; James B Herrington; Nina Jochnowitz; Gregory J Kaczorowski; Xiaohua Li; Kathryn A Lyons; Erin McGowan; Owen B McManus; Shruti Mistry; Joseph L Duffy
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
S Tyagarajan; Prasun K Chakravarty; Min Park; Bishan Zhou; James B Herrington; Kevin Ratliff; Randal M Bugianesi; Brande Williams; Rodolfo J Haedo; Andrew M Swensen; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; Owen B McManus; Kathryn A Lyons; Xiaohua Li; Maria Madeira; Bindhu V Karanam; Mitchell Green; Michael J Forrest; Catherine Abbadie; Erin McGowan; Shruti Mistry; Nina Jochnowitz; Joseph L Duffy
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.

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All Publications

2012: Pengcheng P Shao; McHardy M Smith; Shu-Yu Sun; Andrew M Swensen; Deepu J Varughese; Vivien A Warren; Feng Ye; Catherine Abbadie; Randal M Bugianesi; Prasun K Chakravarty; Ge Dai; Maria L Garcia; Mitchell Green; Rodolfo J Haedo; James B Herrington; Nina Jochnowitz; Gregory J Kaczorowski; Xiaohua Li; Kathryn A Lyons; Erin McGowan; Owen B McManus; Shruti Mistry; Joseph L Duffy
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
Journal of medicinal chemistry 2012;55(22):9847-55.
2011: S Tyagarajan; Prasun K Chakravarty; Min Park; Bishan Zhou; James B Herrington; Kevin Ratliff; Randal M Bugianesi; Brande Williams; Rodolfo J Haedo; Andrew M Swensen; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; Owen B McManus; Kathryn A Lyons; Xiaohua Li; Maria Madeira; Bindhu V Karanam; Mitchell Green; Michael J Forrest; Catherine Abbadie; Erin McGowan; Shruti Mistry; Nina Jochnowitz; Joseph L Duffy
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorganic & medicinal chemistry letters 2011;21(2):869-73.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 2010;20(24):7479-82.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5536-40.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5480-3.
2010: Hiroshi Nagabukuro; Amanda Degenhardt; Katherine L Villa; Shruti L Mistry; Loise Gichuru; Nina Jochnowitz; Catherine Abbadie
Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats.
Autonomic neuroscience : basic & clinical 2010;156(1-2):19-26.
2010: Catherine Abbadie; Owen B McManus; Shu-Yu Sun; Randal M Bugianesi; Ge Dai; Rodolfo J Haedo; James B Herrington; Gregory J Kaczorowski; McHardy Smith; Andrew M Swensen; Vivien A Warren; Brande Williams; Stephen P Arneric; Cyrus Eduljee; Terrance P Snutch; Elizabeth W Tringham; Nina Jochnowitz; Annie Liang; D Euan MacIntyre; Erin McGowan; Shruti Mistry; Valerie V White; Scott B Hoyt; Clare London; Kathryn A Lyons; Patricia B Bunting; Sylvia Volksdorf; Joseph L Duffy
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
The Journal of pharmacology and experimental therapeutics 2010;334(2):545-55.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2009;19(18):5334-8.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorganic & medicinal chemistry letters 2009;19(18):5329-33.
2009: Erin McGowan; Scott B Hoyt; Xiaohua Li; Kathryn A Lyons; Catherine Abbadie
A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain.
Anesthesia and analgesia 2009;109(3):951-8.
2009: Fuqiang Zhao; Mangay Williams; Denise C Welsh; Xiangjun Meng; Amy Ritter; Catherine Abbadie; Jacquelynn J Cook; Alise S Reicin; Richard Hargreaves; Donald S Williams
fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord.
Pain 2009;145(1-2):110-9.
2009: Maria M Hadjimarkou; Catherine Abbadie; Lora J Kasselman; Yingxian Pan; Gavril W Pasternak; Richard J Bodnar
Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats.
Synapse (New York, N.Y.) 2009;63(7):585-97.
2009: Catherine Abbadie; Sonia Bhangoo; Yves De Koninck; Marzia Malcangio; Stéphane Melik-Parsadaniantz; Fletcher White
Chemokines and pain mechanisms.
Brain research reviews 2009;60(1):125-34.
2008: Clare London; Scott B Hoyt; William H Parsons; Brande S Williams; Vivien A Warren; Richard A Tschirret-Guth; McHardy Smith; Birgit T Priest; Erin McGowan; William J Martin; Kathryn A Lyons; Xiaohua Li; Bindhu V Karanam; Nina Jochnowitz; Maria L Garcia; John P Felix; Brian Dean; Catherine Abbadie; Gregory J Kaczorowski; Joseph L Duffy
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorganic & medicinal chemistry letters 2008;18(5):1696-701.
2007: Scott B Hoyt; Clare London; Hyun O Ok; Edward Gonzalez; Joseph L Duffy; Catherine Abbadie; Brian Dean; John P Felix; Maria L Garcia; Nina Jochnowitz; Bindhu V Karanam; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Richard A Tschirret-Guth; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(22):6172-7.
2007: J Menetski; S Mistry; M Lu; John S Mudgett; R M Ransohoff; Julie A DeMartino; D E Macintyre; Catherine Abbadie
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Neuroscience 2007;149(3):706-14.
2007: Scott B Hoyt; Clare London; David J. Gorin; Matthew J Wyvratt; Michael H Fisher; Catherine Abbadie; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; Amy Ritter; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(16):4630-4.
2006: Dong Ok; Chunshi Li; Catherine Abbadie; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; William J Martin; Birgit T Priest; McHardy Smith; Brande S Williams; Matthew J Wyvratt; William H Parsons
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.
Bioorganic & medicinal chemistry letters 2006;16(5):1358-61.
2005: Emer M Garry; Ada Delaney; Heather A Anderson; Eva C Sirinathsinghji; Rachel H Clapp; William J Martin; Paul R Kinchington; David L Krah; Catherine Abbadie; Susan M Fleetwood-Walker
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Pain 2005;118(1-2):97-111.
2005: Catherine Abbadie
Chemokines, chemokine receptors and pain.
Trends in immunology 2005;26(10):529-34.
2005: Jill A Lindia; Martin G Köhler; William J Martin; Catherine Abbadie
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Pain 2005;117(1-2):145-53.
2005: Jill A Lindia; Erin McGowan; Nina Jochnowitz; Catherine Abbadie
Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain.
The journal of pain : official journal of the American Pain Society 2005;6(7):434-8.
2005: Birgit T Priest; Beth A Murphy; Jill A Lindia; Carmen Diaz; Catherine Abbadie; Amy M Ritter; Paul A Liberator; Leslie M Iyer; Shera F Kash; Martin G Kohler; Gregory J Kaczorowski; D Euan MacIntyre; William J Martin
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9382-7.
2003: Catherine Abbadie; Jill A Lindia; Anne Marie Cumiskey; Laurence B Peterson; John S Mudgett; Ellen K Bayne; Julie A DeMartino; D Euan MacIntyre; Michael J Forrest
Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7947-52.
2003: Jill A Lindia; Catherine Abbadie
Distribution of the voltage gated sodium channel Na(v)1.3-like immunoreactivity in the adult rat central nervous system.
Brain research 2003;960(1-2):132-41.
2002: Catherine Abbadie; Marie Christine Lombard; Jean Marie Besson; Jodie A Trafton; Allan I Basbaum
Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions.
Brain research 2002;930(1-2):150-62.
2001: Jodie A Trafton; Catherine Abbadie; Allan I Basbaum
Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3656-64.
2000: Jodie A Trafton; Catherine Abbadie; K Marek; Allan I Basbaum
Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(23):8578-84.
1999: Jodie A Trafton; Catherine Abbadie; S Marchand; PW Mantyh; Allan I Basbaum
Spinal opioid analgesia: how critical is the regulation of substance P signaling?
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9642-53.
1999: Catherine Abbadie; Kate Skinner; Igor Mitrovic; Allan I Basbaum
Neurons in the dorsal column white matter of the spinal cord: complex neuropil in an unexpected location.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):260-5.
1998: Catherine Abbadie; Allan I Basbaum
The contribution of capsaicin-sensitive afferents to the dorsal root ganglion sprouting of sympathetic axons after peripheral nerve injury in the rat.
Neuroscience letters 1998;253(3):143-6.
1997: DS Rohde; WR McKay; D S Chang; Catherine Abbadie; Allan I Basbaum
The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of Fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine.
Neuroscience 1997;80(2):599-612.
1997: MA Peterson; Allan I Basbaum; Catherine Abbadie; DS Rohde; WR McKay; Bradley K Taylor
The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test.
Brain research 1997;755(1):9-16.
1997: DS Rohde; WR McKay; Catherine Abbadie; Allan I Basbaum
Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat.
Brain research 1997;745(1-2):83-95.
1997: Catherine Abbadie; Bradley K Taylor; MA Peterson; Allan I Basbaum
Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine.
Pain 1997;69(1-2):101-10.
1996: Catherine Abbadie; J L Brown; P W Mantyh; Allan I Basbaum
Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain.
Neuroscience 1996;70(1):201-9.