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Amy Liang

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Seock-Kyu Khim; John G Bauman; Jarred Evans; Beverly Freeman; Beverly King; Thomas Kirkland; Monica J Kochanny; Dao Lentz; Amy Liang; Lisa Mendoza; Gary Phillips; Jih-Lie Tseng; Robert G Wei; Hong Ye; Limei Yu; John Parkinson; William J Guilford
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.
Brad Buckman; Yuo-Ling Chou; Margaret A McCarrick; Amy Liang; Dao Lentz; Raju Mohan; Michael M Morrissey; Kenneth J Shaw; Lan Trinh; David R Light
Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors.
Bin Ye; Yuo-Ling Chou; Rushad Karanjawala; Wheeseong Lee; Shou-Fu Lu; Kenneth J Shaw; Steven Jones; Dao Lentz; Amy Liang; Jih-Lie Tseng; Qingyu Wu; Zuchun Zhao
Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).

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All Publications

2008: Seock-Kyu Khim; John G Bauman; Jarred Evans; Beverly Freeman; Beverly King; Thomas Kirkland; Monica J Kochanny; Dao Lentz; Amy Liang; Lisa Mendoza; Gary Phillips; Jih-Lie Tseng; Robert G Wei; Hong Ye; Limei Yu; John Parkinson; William J Guilford
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(14):3895-8.
2005: Brad Buckman; Yuo-Ling Chou; Margaret A McCarrick; Amy Liang; Dao Lentz; Raju Mohan; Michael M Morrissey; Kenneth J Shaw; Lan Trinh; David R Light
Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(9):2249-52.
2004: Bin Ye; Yuo-Ling Chou; Rushad Karanjawala; Wheeseong Lee; Shou-Fu Lu; Kenneth J Shaw; Steven Jones; Dao Lentz; Amy Liang; Jih-Lie Tseng; Qingyu Wu; Zuchun Zhao
Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).
Bioorganic & medicinal chemistry letters 2004;14(3):761-5.
2003: Bin Ye; Shawn Bauer; Brad Buckman; Ameen Ghannam; Brian D Griedel; Seock-Kyu Khim; Wheeseong Lee; Karna L Sacchi; Kenneth J Shaw; Amy Liang; Qingyu Wu; Zuchun Zhao
Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).
Bioorganic & medicinal chemistry letters 2003;13(19):3361-5.
2002: Gary Phillips; William J Guilford; Brad Buckman; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Margaret A McCarrick; Raju Mohan; Howard P Ng; Michael Pinkerton; Babu Subramanyam; Elena Ho; Lan Trinh; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Journal of medicinal chemistry 2002;45(12):2484-93.
2002: Shung Wu; William J Guilford; Yuo-Ling Chou; Brian D Griedel; Amy Liang; Steve Sakata; Kenneth J Shaw; Lan Trinh; Wei Xu; Zuchun Zhao; Michael M Morrissey
Design and synthesis of aminophenol-based factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(9):1307-10.
2002: Howard P Ng; Brad Buckman; Keith Eagen; William J Guilford; Monica J Kochanny; Raju Mohan; Kenneth J Shaw; Shung C Wu; Dao Lentz; Amy Liang; Lan Trinh; Elena Ho; David Smith; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Mark E Sullivan; Michael M Morrissey; Gary B Phillips
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Bioorganic & medicinal chemistry 2002;10(3):657-66.
2000: Zuchun Zhao; Damian O Arnaiz; Brian D Griedel; Steve Sakata; Jerry L Dallas; Marc Whitlow; Lan Trinh; Joseph Post; Amy Liang; Michael M Morrissey; Kenneth J Shaw
Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(9):963-6.
2000: Damian O Arnaiz; Zuchun Zhao; Amy Liang; Lan Trinh; M Witlow; Sunil Koovakkat; Kenneth J Shaw
Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(9):957-61.
1999: William J Guilford; Kenneth J Shaw; Jerry L Dallas; Sunil Koovakkat; Wheeseong Lee; Amy Liang; David R Light; Margaret A McCarrick; Marc Whitlow; Bin Ye; Michael M Morrissey
Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.
Journal of medicinal chemistry 1999;42(26):5415-25.
1999: Marc Whitlow; Damian O Arnaiz; Brad Buckman; David D Davey; Brian D Griedel; William J Guilford; Sunil Koovakkat; Amy Liang; Raju Mohan; Gary B Phillips; M Seto; Kenneth J Shaw; Wei Xu; Zuchun Zhao; David R Light; Michael M Morrissey
Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 8):1395-404.
1999: Gary Phillips; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Howard P Ng; M Pinkerton; Lan Trinh; Marc Whitlow; A M Beatty; Michael M Morrissey
Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
Journal of medicinal chemistry 1999;42(10):1749-56.
1998: Gary B Phillips; Brad Buckman; David D Davey; Keith Eagen; William J Guilford; Josephine W Hinchman; Elena Ho; Sunil Koovakkat; Amy Liang; David R Light; Raju Mohan; Howard P Ng; Joseph M Post; Kenneth J Shaw; D Smith; Babu Subramanyam; Mark E Sullivan; Lan Trinh; Ronald Vergona; Janette Walters; K White; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Journal of medicinal chemistry 1998;41(19):3557-62.
1998: Kenneth J Shaw; William J Guilford; Jerry L Dallas; S K Koovakkaat; Margaret A McCarrick; Amy Liang; David R Light; Michael M Morrissey
(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.
Journal of medicinal chemistry 1998;41(19):3551-6.
1998: Brad Buckman; Raju Mohan; Sunil Koovakkat; Amy Liang; Lan Trinh; Michael M Morrissey
Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(16):2235-40.
1998: Raju Mohan; W Yun; Brad Buckman; Amy Liang; Lan Trinh; Michael M Morrissey
Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(14):1877-82.