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James Liao

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Qing Mei Wang; Yulan Gong; Yoshiyuki Rikitake; Rosario Scalia; Timothy J Stalker; James K Liao
Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
Qian Zhou; Christoph Bode; Xinbing Han; Karol Kaminski; Yu Mei; Martin Moser; Goo Taeg Oh; Pat P Ongusaha; Hannah Schmitt; Takuhito Shoji; Kunzhong Zhang; James K Liao
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
James K Liao
Mitohormesis: another pleiotropic effect of statins?

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All Publications

2012: Qing Mei Wang; Yulan Gong; Yoshiyuki Rikitake; Rosario Scalia; Timothy J Stalker; James K Liao
Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
Vascular medicine (London, England) 2012;17(6):379-85.
2012: Qian Zhou; Christoph Bode; Xinbing Han; Karol Kaminski; Yu Mei; Martin Moser; Goo Taeg Oh; Pat P Ongusaha; Hannah Schmitt; Takuhito Shoji; Kunzhong Zhang; James K Liao
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Circulation 2012;126(18):2236-47.
2012: James K Liao
Mitohormesis: another pleiotropic effect of statins?
European heart journal 2012;33(11):1299-301.
2012: Doug A Medvetz; Pat P Ongusaha; Tanja Schlechter; Thomas N Darling; Elena A Goncharova; Venkatesh Hariharan; Ilse Hofmann; Hayden Huang; Damir Khabibullin; Vera P Krymskaya; James K Liao; Elizabeth P Henske
Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
PloS one 2012;7(11):e47842.
2011: Surya A Reis; Morgan N Thompson; Jong-Min Lee; Elisa Fossale; Hyung-Hwan Kim; James K Liao; Michael A Moskowitz; Stanley Y Shaw; Linda Dong; Stephen J Haggarty; Marcy E MacDonald; Ihn Sik Seong
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
Human molecular genetics 2011;20(12):2344-55.
2011: Qian Zhou; Christoph Gensch; James K Liao
Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.
Trends in pharmacological sciences 2011;32(3):167-73.
2011: Ying Wei; Muge Yemisci; Hyung-Hwan Kim; Lai Ming Yung; Hwa Kyoung Shin; Seo-Kyoung Hwang; Shuzhen Guo; Tao Qin; Nafiseh Alsharif; Volker Brinkmann; James K Liao; Eng H Lo; Christian Waeber
Fingolimod provides long-term protection in rodent models of cerebral ischemia.
Annals of neurology 2011;69(1):119-29.
2010: Olivier A Harari; James K Liao
NF-κB and innate immunity in ischemic stroke.
Annals of the New York Academy of Sciences 2010;1207():32-40.
2010: Qian Zhou; James K Liao
Pleiotropic effects of statins. - Basic research and clinical perspectives -.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(5):818-26.
2010: James K Liao
Rac1 and connective tissue growth factor. The missing link between atrial remodeling and the pathogenesis of atrial fibrillation?
Journal of the American College of Cardiology 2010;55(5):481-2.
2009: Anju Nohria; Adnan Prsic; Ping-Yen Liu; Ryuji Okamoto; Mark A Creager; Andrew Selwyn; James K Liao; Peter Ganz
Statins inhibit Rho kinase activity in patients with atherosclerosis.
Atherosclerosis 2009;205(2):517-21.
2009: Steven K Feske; Farzaneh A Sorond; Galen V Henderson; Minoru Seto; Asako Hitomi; Koh Kawasaki; Yasuo Sasaki; Toshio Asano; James K Liao
Increased leukocyte ROCK activity in patients after acute ischemic stroke.
Brain research 2009;1257():89-93.
2009: Ron Rawlings; Anju Nohria; Ping-Yen Liu; Jason Donnelly; Mark A Creager; Peter Ganz; Andrew Selwyn; James K Liao
Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
The American journal of cardiology 2009;103(4):437-41.
2009: Ping-Yen Liu; Yen-Wen Liu; Li-Jen Lin; Jyh-Hong Chen; James K Liao
Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.
Circulation 2009;119(1):131-8.
2009: Qian Zhou; James K Liao
Rho kinase: an important mediator of atherosclerosis and vascular disease.
Current pharmaceutical design 2009;15(27):3108-15.
2009: Naoki Sawada; Hyung-Hwan Kim; Michael A Moskowitz; James K Liao
Rac1 is a critical mediator of endothelium-derived neurotrophic activity.
Science signaling 2009;2(61):ra10.
2009: Qian Zhou; James K Liao
Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy.
Current pharmaceutical design 2009;15(5):467-78.
2008: Hong-Wei Wang; Ping-Yen Liu; Naotsugu Oyama; Yoshiyuki Rikitake; Shiro Kitamoto; Jonathan Gitlin; James K Liao; William A Boisvert
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3561-70.
2008: Joseph F Arboleda-Velasquez; Zhipeng Zhou; Hwa Kyoung Shin; Angeliki Louvi; Hyung-Hwan Kim; Sean I Savitz; James K Liao; Salvatore Salomone; Cenk Ayata; Michael A Moskowitz; Spyros Artavanis-Tsakonas
Linking Notch signaling to ischemic stroke.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4856-61.
2008: Hyung-Hwan Kim; James K Liao
Translational therapeutics of dipyridamole.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):s39-42.
2008: Pat P Ongusaha; Hank H Qi; Lakshmi Raj; Young-Bum Kim; Stuart A Aaronson; Roger J Davis; Yang Shi; James K Liao; Sam W Lee
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Science signaling 2008;1(47):ra14.
2008: Ping-Yen Liu; James K Liao
A method for measuring Rho kinase activity in tissues and cells.
Methods in enzymology 2008;439():181-9.
2008: Chao-Yung Wang; Ping-Yen Liu; James K Liao
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.
Trends in molecular medicine 2008;14(1):37-44.
2008: James K Liao
Is statin discontinuation an option in patients who have had a stroke?
Nature clinical practice. Neurology 2008;4(1):18-9.
2007: Nicolas Blondeau; Yushuan Lai; Sarah Tyndall; Margherita Popolo; Kamil Topalkara; James K Pru; Ling Zhang; Hyunghwan Kim; James K Liao; Kan Ding; Christian Waeber
Distribution of sphingosine kinase activity and mRNA in rodent brain.
Journal of neurochemistry 2007;103(2):509-17.
2007: Minoru Satoh; Christian M Matter; Hisakazu Ogita; Kyosuke Takeshita; Chao-Yung Wang; Gerald W Dorn; James K Liao
Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
Circulation 2007;115(25):3197-204.
2007: Hwa Kyoung Shin; Salvatore Salomone; E Michelle Potts; Sae-Won Lee; Eric Millican; Kensuke Noma; Paul L Huang; David A Boas; James K Liao; Michael A Moskowitz; Cenk Ayata
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):998-1009.
2007: Yasushi Mukai; Chao-Yung Wang; Yoshiyuki Rikitake; James K Liao
Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1937-42.
2007: James K Liao
Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
Circulation 2007;115(12):1615-21.
2007: Kyosuke Takeshita; Minoru Satoh; Masaaki Ii; Marcy Silver; Florian P Limbourg; Yasushi Mukai; Yoshiyuki Rikitake; Freddy Radtke; Thomas Gridley; Douglas Losordo; James K Liao
Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
Circulation research 2007;100(1):70-8.
2006: Anju Nohria; Matthew E Grunert; Yoshiyuki Rikitake; Kensuke Noma; Adnan Prsic; Peter Ganz; James K Liao; Mark A Creager
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
Circulation research 2006;99(12):1426-32.
2006: Yukio Hiroi; Hyung-Hwan Kim; Hao Ying; Fumihiko Furuya; Zhihong Huang; Tommaso Simoncini; Kensuke Noma; Kojiro Ueki; Ngoc-Ha Nguyen; Thomas S Scanlan; Michael A Moskowitz; Sheue-Yann Cheng; James K Liao
Rapid nongenomic actions of thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14104-9.
2006: Olivier A Harari; Pilar Alcaide; Daniela Ahl; Francis W Luscinskas; James K Liao
Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
Circulation research 2006;98(9):1134-40.
2006: Fan Xiang; Yasuhiko Sakata; Lei Cui; Joey M Youngblood; Hironori Nakagami; James K Liao; Ronglih Liao; Michael T Chin
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
American journal of physiology. Heart and circulatory physiology 2006;290(5):H1997-2006.
2006: Yasushi Mukai; Yoshiyuki Rikitake; Ichiro Shiojima; Sebastian Wolfrum; Minoru Satoh; Kyosuke Takeshita; Yukio Hiroi; Salvatore Salomone; Hyung-Hwan Kim; Laura E Benjamin; Kenneth Walsh; James K Liao
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
The Journal of clinical investigation 2006;116(2):334-43.
2005: Yoshiyuki Rikitake; James K Liao
Rho GTPases, statins, and nitric oxide.
Circulation research 2005;97(12):1232-5.
2005: Yoshiyuki Rikitake; Naotsugu Oyama; Chao-Yung C Wang; Kensuke Noma; Minoru Satoh; Hyung-Hwan Kim; James K Liao
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Circulation 2005;112(19):2959-65.
2005: Yoshiyuki Rikitake; Hyung-Hwan Kim; Zhihong Huang; Minoru Seto; Kazuo Yano; Toshio Asano; Michael A Moskowitz; James K Liao
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Stroke; a journal of cerebral circulation 2005;36(10):2251-7.
2005: James K Liao
Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol.
The American journal of cardiology 2005;96(5A):24F-33F.
2005: Yoshiyuki Rikitake; James K Liao
Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
Circulation 2005;111(24):3261-8.
2005: Minoru Asahi; Zhihong Huang; Sunu Thomas; Shin-ichi Yoshimura; Toshihisa Sumii; Tatsuro Mori; Jianhua Qiu; Sepideh Amin-Hanjani; Paul L Huang; James K Liao; Eng H Lo; Michael A Moskowitz
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(6):722-9.
2005: Yoshiyuki Rikitake; James K Liao
ROCKs as therapeutic targets in cardiovascular diseases.
Expert review of cardiovascular therapy 2005;3(3):441-51.
2005: Florian P Limbourg; Kyosuke Takeshita; Freddy Radtke; Roderick T Bronson; Michael T Chin; James K Liao
Essential role of endothelial Notch1 in angiogenesis.
Circulation 2005;111(14):1826-32.
2004: Jianxin Sun; James K Liao
Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2238-44.
2004: Sebastian Wolfrum; Andreas Dendorfer; Yoshiyuki Rikitake; Timothy J Stalker; Yulan Gong; Rosario Scalia; Peter Dominiak; James K Liao
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1842-7.
2004: Hironori Nakagami; James K Liao
Statins and myocardial hypertrophy.
Coronary artery disease 2004;15(5):247-50.
2004: Joshua A Beckman; James K Liao; Shauna Hurley; Leslie A Garrett; Daoshan Chui; Debi Mitra; Mark A Creager
Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.
Circulation research 2004;95(2):217-23.
2004: Thomas A Abbruzzese; Joaquim Havens; Michael Belkin; Magruder C Donaldson; Anthony D Whittemore; James K Liao; Michael S Conte
Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.
Journal of vascular surgery 2004;39(6):1178-85.
2003: Koichi Node; Masashi Fujita; Masafumi Kitakaze; Masatsugu Hori; James K Liao
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
Circulation 2003;108(7):839-43.
2003: Koh Kawasaki; Robert S Smith; Chung-Ming Hsieh; Jianxin Sun; Julie Chao; James K Liao
Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis.
Molecular and cellular biology 2003;23(16):5726-37.
2003: Hironori Nakagami; Masao Takemoto; James K Liao
NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.
Journal of molecular and cellular cardiology 2003;35(7):851-9.
2003: Sebastian Wolfrum; Michael Grimm; Marc Heidbreder; Andreas Dendorfer; Hugo A Katus; James K Liao; Gert Richardt
Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase.
Journal of cardiovascular pharmacology 2003;41(3):474-80.
2003: Tommaso Simoncini; Elena Rabkin; James K Liao
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):198-203.
2003: Hironori Nakagami; Kristin S Jensen; James K Liao
A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
Annals of medicine 2003;35(6):398-403.
2003: Alyson J Prorock; Ali Hafezi-Moghadam; Victor E Laubach; James K Liao; Klaus Ley
Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H133-40.
2002: Yasuhiko Sakata; Caramai N Kamei; Hironori Nakagami; Roderick Bronson; James K Liao; Michael T Chin
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16197-202.
2002: Karen J Ho; James K Liao
Nonnuclear actions of estrogen.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):1952-61.
2002: Florian P Limbourg; Zhihong Huang; Jean-Christophe Plumier; Tommaso Simoncini; Masayuki Fujioka; Jan P Tuckermann; Günther Schütz; Michael A Moskowitz; James K Liao
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
The Journal of clinical investigation 2002;110(11):1729-38.
2002: James K Liao
Beyond lipid lowering: the role of statins in vascular protection.
International journal of cardiology 2002;86(1):5-18.
2002: Jianxin Sun; James K Liao
Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13108-13.
2002: James K Liao
Isoprenoids as mediators of the biological effects of statins.
The Journal of clinical investigation 2002;110(3):285-8.
2002: Michael Grimm; Martin Spiecker; Raffaele De Caterina; Wee Soo Shin; James K Liao
Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants.
The Journal of biological chemistry 2002;277(29):26460-7.
2002: Michela C Rebsamen; Jianxin Sun; Anthony W Norman; James K Liao
1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase.
Circulation research 2002;91(1):17-24.
2002: Masao Takemoto; Jianxin Sun; Junko Hiroki; Hiroaki Shimokawa; James K Liao
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.
Circulation 2002;106(1):57-62.
2002: Jianxin Sun; XinXin Sui; J Alyce Bradbury; Darryl C Zeldin; Michael S Conte; James K Liao
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Circulation research 2002;90(9):1020-7.
2002: Ali Hafezi-Moghadam; Tommaso Simoncini; Zequan Yang; Florian P Limbourg; Jean-Christophe Plumier; Michael C Rebsamen; Chung-Ming Hsieh; Dao-Shan Chui; Kennard L Thomas; Alyson J Prorock; Victor E Laubach; Michael A Moskowitz; Brent A French; Klaus Ley; James K Liao
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
Nature medicine 2002;8(5):473-9.
2002: Lorraine M King; Jixiang Ma; Supawon Srettabunjong; Joan Graves; J Alyce Bradbury; Leping Li; Martin Spiecker; James K Liao; Harvey W Mohrenweiser; Darryl C Zeldin
Cloning of CYP2J2 gene and identification of functional polymorphisms.
Molecular pharmacology 2002;61(4):840-52.
2001: DE Marra; James K Liao
Salicylates and vascular smooth muscle cell proliferation: molecular mechanisms for cell cycle arrest.
Trends in cardiovascular medicine 2001;11(8):339-44.
2001: M Takemoto; K Node; H Nakagami; Y Liao; M Grimm; Y Takemoto; M Kitakaze; James K Liao
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
The Journal of clinical investigation 2001;108(10):1429-37.
2001: M Takemoto; James K Liao
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1712-9.
2001: Baichun Yang; L Graham; S Dikalov; Ronald P Mason; JR Falck; James K Liao; Darryl C Zeldin
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells.
Molecular pharmacology 2001;60(2):310-20.
2001: J Sun; C N Kamei; Matthew D Layne; Mukesh K Jain; James K Liao; Mu-En Lee; Michael T Chin
Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.
The Journal of biological chemistry 2001;276(21):18591-6.
2001: K Node; X L Ruan; J Dai; S X Yang; L Graham; D C Zeldin; James K Liao
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
The Journal of biological chemistry 2001;276(19):15983-9.
2001: Sepideh Amin-Hanjani; Nancy Stagliano; M Yamada; Paul L Huang; James K Liao; Michael A Moskowitz
Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
Stroke; a journal of cerebral circulation 2001;32(4):980-6.
2001: Raffaele De Caterina; todd bourcier; U Laufs; V La Fata; Guido Lazzerini; A S Neish; P Libby; James K Liao
Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(2):227-32.
2000: DE Marra; Tommaso Simoncini; James K Liao
Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1).
Circulation 2000;102(17):2124-30.
2000: Tommaso Simoncini; Ali Hafezi-Moghadam; Derek Brazil; Klaus Ley; W W Chin; James K Liao
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
Nature 2000;407(6803):538-41.
2000: U Laufs; Matthias Endres; Nancy Stagliano; Sepideh Amin-Hanjani; D S Chui; S X Yang; Tommaso Simoncini; M Yamada; Elena Rabkin; P G Allen; Paul L Huang; M Böhm; Frederick J Schoen; Michael A Moskowitz; James K Liao
Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
The Journal of clinical investigation 2000;106(1):15-24.
2000: M Yamada; Zhihong Huang; Turgay Dalkara; Matthias Endres; U Laufs; Christian Waeber; Paul L Huang; James K Liao; Michael A Moskowitz
Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(4):709-17.
2000: Martin Spiecker; Harald Darius; James K Liao
A functional role of I kappa B-epsilon in endothelial cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3316-22.
1999: K Node; Y Huo; X Ruan; B Yang; Martin Spiecker; K Ley; D C Zeldin; James K Liao
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
Science (New York, N.Y.) 1999;285(5431):1276-9.
1999: U Laufs; DE Marra; K Node; James K Liao
3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
The Journal of biological chemistry 1999;274(31):21926-31.
1999: Atsushi Miyamoto; S X Yang; U Laufs; X L Ruan; James K Liao
Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol.
The Journal of biological chemistry 1999;274(17):12055-60.
1999: Martin Spiecker; James K Liao
Assessing induction of I kappa B by nitric oxide.
Methods in enzymology 1999;300():374-88.
1998: U Laufs; James K Liao
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
The Journal of biological chemistry 1998;273(37):24266-71.
1998: HB Peng; Martin Spiecker; James K Liao
Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1970-6.
1998: Matthias Endres; U Laufs; Zhihong Huang; T Nakamura; P Huang; Michael A Moskowitz; James K Liao
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8880-5.
1998: Martin Spiecker; Harald Darius; K Kaboth; F Hübner; James K Liao
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
Journal of leukocyte biology 1998;63(6):732-9.
1998: U Laufs; V La Fata; Jorge Plutzky; James K Liao
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
Circulation 1998;97(12):1129-35.
1997: P Libby; G Sukhova; R T Lee; James K Liao
Molecular biology of atherosclerosis.
International journal of cardiology 1997;62 Suppl 2():S23-9.
1997: U Laufs; V L Fata; James K Liao
Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.
The Journal of biological chemistry 1997;272(50):31725-9.
1997: Martin Spiecker; HB Peng; James K Liao
Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.
The Journal of biological chemistry 1997;272(49):30969-74.
1997: U Laufs; M Böhm; James K Liao
[New findings on the action of HMG-CoA-reductase inhibitors].
Deutsche medizinische Wochenschrift (1946) 1997;122(41):1255-9.
1997: Y H Hong; HB Peng; V La Fata; James K Liao
Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2418-23.
1997: Atsushi Miyamoto; U Laufs; C Pardo; James K Liao
Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide.
The Journal of biological chemistry 1997;272(31):19601-8.
1996: Wee Soo Shin; H Kawaguchi; James K Liao; Y Wang; M Inukai; Teruhiko Toyo-Oka
Toxic action of nitric oxide on myocardial cells: direct evidence from gene transfer in vivo.
Journal of cardiac failure 1996;2(4 Suppl):S149-53.
1996: Wee Soo Shin; Y H Hong; H B Peng; R De Caterina; Peter Libby; James K Liao
Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity.
The Journal of biological chemistry 1996;271(19):11317-24.
1995: James K Liao; Javier J Zulueta; F S Yu; H B Peng; C G Cote; Paul M Hassoun
Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.
The Journal of clinical investigation 1995;96(6):2661-6.
1995: H B Peng; Tripathi B Rajavashisth; Peter Libby; James K Liao
Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells.
The Journal of biological chemistry 1995;270(28):17050-5.
1995: R De Caterina; Peter Libby; H B Peng; Victor J Thannickal; Tripathi B Rajavashisth; Michael A Gimbrone; Wee Soo Shin; James K Liao
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
The Journal of clinical investigation 1995;96(1):60-8.
1995: H B Peng; Peter Libby; James K Liao
Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B.
The Journal of biological chemistry 1995;270(23):14214-9.
1995: James K Liao; S L Clark
Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein.
The Journal of clinical investigation 1995;95(4):1457-63.
1995: James K Liao; Wee Soo Shin; W Y Lee; S L Clark
Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase.
The Journal of biological chemistry 1995;270(1):319-24.
1994: James K Liao
Inhibition of Gi proteins by low density lipoprotein attenuates bradykinin-stimulated release of endothelial-derived nitric oxide.
The Journal of biological chemistry 1994;269(17):12987-92.
1993: James K Liao; C J Homcy
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
The Journal of clinical investigation 1993;92(5):2168-72.
1993: James K Liao; C J Homey
The release of endothelium-derived relaxing factor via alpha 2-adrenergic receptor activation is specifically mediated by Gi alpha 2.
The Journal of biological chemistry 1993;268(26):19528-33.
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Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor.
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Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.
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