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Massimo Libra

Research Profile

Physiology

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Maura Sonego; Barbara Valeri; Marina Bagnoli; Mattia Barbareschi; Barbara Belletti; Silvana Canevari; Vincenzo Canzonieri; Alfonso Colombatti; Alessandra Dall'acqua; Sara D'Andrea; Giannino Del Sal; Giorgio Giorda; Massimo Libra; Francesca Lovat; Sara Lovisa; Delia Mezzanzanica; Loredana Militello; Marco Napoli; Barbara Pivetta; Monica Schiappacassi; Gustavo Baldassarre
Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.
Grazia Malaponte; Maria Clorinda Mazzarino; Loredana Militello; Jerry Polesel; Daniela Sambataro; Massimiliano Anzaldi; Valentina Bevelacqua; Saverio Candido; Valerio Fiore; Massimo Libra; Nadia Vella; Salvatore Santo Signorelli
IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.
Paolo Fagone; Massimo Libra; Santa Mammana; Katia Mangano; James A McCubrey; Marinella Coco; Marco Donia; cinzia quattrocchi; Ferdinando Nicoletti
Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.

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All Publications

2013: Maura Sonego; Barbara Valeri; Marina Bagnoli; Mattia Barbareschi; Barbara Belletti; Silvana Canevari; Vincenzo Canzonieri; Alfonso Colombatti; Alessandra Dall'acqua; Sara D'Andrea; Giannino Del Sal; Giorgio Giorda; Massimo Libra; Francesca Lovat; Sara Lovisa; Delia Mezzanzanica; Loredana Militello; Marco Napoli; Barbara Pivetta; Monica Schiappacassi; Gustavo Baldassarre
Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.
EMBO molecular medicine 2013;5(5):707-22.
2013: Grazia Malaponte; Maria Clorinda Mazzarino; Loredana Militello; Jerry Polesel; Daniela Sambataro; Massimiliano Anzaldi; Valentina Bevelacqua; Saverio Candido; Valerio Fiore; Massimo Libra; Nadia Vella; Salvatore Santo Signorelli
IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.
Cytokine 2013;62(1):64-9.
2013: Paolo Fagone; Massimo Libra; Santa Mammana; Katia Mangano; James A McCubrey; Marinella Coco; Marco Donia; cinzia quattrocchi; Ferdinando Nicoletti
Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.
Basic & clinical pharmacology & toxicology 2013;112(1):63-9.
2012: William H Chappell; Richard A Franklin; Michelle M LaHair; Massimo Libra; Alberto M Martelli; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Jerry Polesel; Linda Steelman; Agostino Tafuri; Renato Talamini; Steven L Abrams; Saverio Candido; Melchiorre Cervello; James A McCubrey
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Cell cycle (Georgetown, Tex.) 2012;11(23):4447-61.
2012: Giulia Costanza Leonardi; Saverio Candido; Maurizio Carbone; Diana Cinà; Valeria Colaianni; Sebastiano F Garozzo; Massimo Libra
microRNAs and thyroid cancer: biological and clinical significance (Review).
International journal of molecular medicine 2012;30(5):991-9.
2012: William H Chappell; Massimo Libra; Alberto M Martelli; Steven L Abrams; Ralph Arlinghaus; Saverio Candido; Melchiorre Cervello; Giuseppe Montalto; Jerry Polesel; Linda Steelman; Renato Talamini; James A McCubrey
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
Oncotarget 2012;3(10):1236-45.
2012: James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Richard A Franklin; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.
Oncotarget 2012;3(10):1068-111.
2012: Giulia Costanza Leonardi; James A McCubrey; Fabio Raiti; Saverio Candido; Maurizio Carbone; Diana Cinà; Valeria Colaianni; Sebastiano Garozzo; Massimo Libra
BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review).
Molecular medicine reports 2012;6(4):687-94.
2012: James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.
Oncotarget 2012;3(9):954-87.
2012: Valentina Bevelacqua; Ylenia Bevelacqua; Saverio Candido; Fabio D'Amico; Pietro Gangemi; Claudio Guarneri; Massimo Libra; Maria Clorinda Mazzarino; James A McCubrey; Evangelia Skarmoutsou; Angela Strazzanti; Alfredo Amoroso; Grazia Malaponte
Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma.
Oncotarget 2012;3(8):882-92.
2012: Giulia Costanza Leonardi; Massimo Libra; Andrea Marconi; Lidia Proietti; Venerando Rapisarda; Aurora Scalisi; Salvo Travali; Francesca Catalano; Concettina Fenga
Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review).
Oncology reports 2012;28(2):418-28.
2012: Salvatore Santo Signorelli; Massimo Simili; Giuseppe Puccia; Massimiliano Anzaldi; Valerio Fiore; Massimo Libra; Grazia Malaponte; Sergio Neri
Patients with unrecognized peripheral arterial disease (PAD) assessed by ankle-brachial index (ABI) present a defined profile of proinflammatory markers compared to healthy subjects.
Cytokine 2012;59(2):294-8.
2012: Giulia Costanza Leonardi; Saverio Candido; Melchiorre Cervello; Daria Nicolosi; Fabio Raiti; Demetrios A Spandidos; Salvatore Travali; Massimo Libra
The tumor microenvironment in hepatocellular carcinoma (review).
International journal of oncology 2012;40(6):1733-47.
2012: James A McCubrey; Sanja Mijatovic; Negin Misaghian; Giuseppeo Montalto; Ferdinando Nicoletti; Linda Steelman; Francac Stivala; Steven L Abrams; Jorg Basecke; Antonio Bonati; Melchiorre Cervello; William H Chappell; Lucio Cocco; Camilla Evangelisti; Piotr Laidler; Massimo Libra; Giovanni Ligresti; Danijela Maksimovic-Ivanic; Alberto M Martelli
Targeting the cancer initiating cell: the ultimate target for cancer therapy.
Current pharmaceutical design 2012;18(13):1784-95.
2012: Francesca Maira; Grazia Malaponte; James A McCubrey; Alessia Erika Russo; Saverio Candido; Alessia Catania; Massimo Libra; Concettina Fenga
Molecular targeted therapy in melanoma: a way to reverse resistance to conventional drugs.
Current drug delivery 2012;9(1):17-29.
2011: Silvia Caggia; Massimo Libra; Grazia Malaponte; Venera Cardile
Modulation of YY1 and p53 expression by transforming growth factor-β3 in prostate cell lines.
Cytokine 2011;56(2):403-10.
2011: James A McCubrey; Sanja Mijatovic; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Franca Stivala; Steven L Abrams; Jörg Bäsecke; Melchiorre Cervello; William H Chappell; Lucio Cocco; C Ruth Kempf; Massimo Libra; Danijela Maksimovic-Ivanic; Graziella Malaponte; Alberto M Martelli
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.
Journal of cellular physiology 2011;226(11):2762-81.
2011: Linda Steelman; Franca Stivala; Ellis W T Wong; Patrick Navolanic; Ferdinando Nicoletti; Steven L Abrams; William H Chappell; Lucio Cocco; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; James A McCubrey
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.
Cell cycle (Georgetown, Tex.) 2011;10(17):3003-15.
2011: Nadia Vella; Giuseppe Toffoli; Marco Aiello; Massimo Libra; Alessia Erika Russo; Aurora Scalisi; Roberto Sorio; Demetrios A Spandidos; Franca Stivala
'Genetic profiling' and ovarian cancer therapy (review).
Molecular medicine reports 2011;4(5):771-7.
2011: Marco Donia; Paolo Fagone; Salvatore Galvagna; Massimo Libra; Katia Mangano; Massimiliano Anzaldi; Pietro Di Gregorio; Roberto Di Marco; Ferdinando Nicoletti
Phase II study of the antiretroviral activity and safety of the glucocorticoid receptor antagonist mifepristone in HIV-1-infected patients.
International journal of molecular medicine 2011;28(3):437-42.
2011: Melissa L Sokolosky; Kristin M Stadelman; Linda Steelman; Franca Stivala; Steven L Abrams; William H Chappell; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; Ferdinando Nicoletti; James A McCubrey
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy.
Oncotarget 2011;2(7):538-50.
2011: Linda Steelman; Franca Stivala; F Nicoletti; P Ruvolo; V Ruvolo; Steven L Abrams; Jörg Bäsecke; W Chappell; Marco Donia; Camilla Evangelisti; P Fagone; Richard A Franklin; C R Kempf; Massimo Libra; Alberto M Martelli; James A McCubrey
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Leukemia 2011;25(7):1080-94.
2011: Alberto M Martelli; F Nicoletti; P Ruvolo; V Ruvolo; Linda Steelman; Franca Stivala; Steven L Abrams; Jörg Bäsecke; W Chappell; Marco Donia; Camilla Evangelisti; P Fagone; C R Kempf; Massimo Libra; James A McCubrey
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.
Leukemia 2011;25(7):1064-79.
2011: Jerry Polesel; Silvia Franceschi; Renato Talamini; Eva Negri; Luigi Barzan; Maurizio Montella; Massimo Libra; Emanuela Vaccher; Giovanni Franchin; Carlo La Vecchia; Diego Serraino
Tobacco smoking, alcohol drinking, and the risk of different histological types of nasopharyngeal cancer in a low-risk population.
Oral oncology 2011;47(6):541-5.
2011: Marco Aiello; Nadia Vella; Calogero Cannavò; Aurora Scalisi; Demetrios A Spandidos; Giuseppe Toffoli; Angela Buonadonna; Massimo Libra; Franca Stivala
Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).
Molecular medicine reports 2011;4(2):203-8.
2011: Linda Steelman; William H Chappell; Steven L Abrams; Ruth C Kempf; Jacquelyn Long; Piotr Laidler; Sanja Mijatovic; Danijela Maksimovic-Ivanic; Franca Stivala; Maria Clorinda Mazzarino; Marco Donia; Paolo Fagone; Graziella Malaponte; Ferdinando Nicoletti; Massimo Libra; Michele Milella; Agostino Tafuri; Antonio Bonati; Jörg Bäsecke; Lucio Cocco; Camilla Evangelisti; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello; James A McCubrey
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.
Aging 2011;3(3):192-222.
2011: William H Chappell; Linda Steelman; Jacquelyn M Long; Ruth C Kempf; Steven L Abrams; Richard A Franklin; Jörg Bäsecke; Franca Stivala; Marco Donia; Paolo Fagone; Graziella Malaponte; Maria C Mazzarino; Ferdinando Nicoletti; Massimo Libra; Danijela Maksimovic-Ivanic; Sanja Mijatovic; Giuseppe Montalto; Melchiorre Cervello; Piotr Laidler; Michele Milella; Agostino Tafuri; Antonio Bonati; Camilla Evangelisti; Lucio Cocco; Alberto M Martelli; James A McCubrey
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.
Oncotarget 2011;2(3):135-64.
2011: Alfredo Amoroso; Sameh Hafsi; Loredana Militello; Alessia E Russo; Zohra Soua; Maria C Mazzarino; Franca Stivala; Massimo Libra
Understanding rituximab function and resistance: implications for tailored therapy.
Frontiers in bioscience : a journal and virtual library 2011;16():770-82.
2010: Marco Donia; Bruno Cacopardo; Massimo Libra; Guido Scalia; James A McCubrey; Ferdinando Nicoletti
New perspectives in HCV therapy: entry inhibitors.
Recent patents on anti-infective drug discovery 2010;5(3):181-94.
2010: Andrea Marconi; Saverio Candido; Renato Talamini; Massimo Libra; Ferdinando Nicoletti; Demetrios A Spandidos; Franca Stivala; Lidia Proietti
Prevalence of hepatitis C virus infection among health-care workers: A 10-year survey.
Molecular medicine reports 2010;3(4):561-4.
2010: Venera Cardile; Massimo Libra; Silvia Caggia; giuseppina frasca; Kazuo Umezawa; Franca Stivala; Maria Clorinda Mazzarino; Ylenia Bevelacqua; Marinella Coco; Grazia Malaponte
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, prevents inflammatory injury induced by interferon-gamma and histamine in NCTC 2544 keratinocytes.
Clinical and experimental pharmacology & physiology 2010;37(7):679-83.
2010: Massimo Libra; Jerry Polesel; Alessia Erika Russo; Valli De Re; Diana Cinà; Diego Serraino; Ferdinando Nicoletti; Demetrios A Spandidos; Franca Stivala; Renato Talamini
Extrahepatic disorders of HCV infection: a distinct entity of B-cell neoplasia?
International journal of oncology 2010;36(6):1331-40.
2010: James A McCubrey; Linda Steelman; Steven L Abrams; William H Chappell; Suzanne Russo; Roger Ove; Michele Milella; Agostino Tafuri; Paolo Lunghi; Antonio Bonati; Franca Stivala; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello
Emerging MEK inhibitors.
Expert opinion on emerging drugs 2010;15(2):203-23.
2010: Steven L Abrams; Linda Steelman; John G Shelton; Ellis W T Wong; William H Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.
Cell cycle (Georgetown, Tex.) 2010;9(9):1781-91.
2010: Steven L Abrams; Linda Steelman; John G Shelton; William Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.
Cell cycle (Georgetown, Tex.) 2010;9(9):1839-46.
2010: Linda Steelman; Steven L Abrams; John G Shelton; William H Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs.
Cell cycle (Georgetown, Tex.) 2010;9(8):1629-38.
2010: Sanja Mijatovic; Danijela Maksimovic-Ivanic; Gordana Timotijevic; Djordje Miljkovic; Marco Donia; Massimo Libra; Marinella Coco; James McCubrey; Yousef Al-Abed; Aleksandra Korac; Stanislava Stosic-Grujicic; Ferdinando Nicoletti
Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO.
Free radical biology & medicine 2010;48(8):1090-9.
2010: Giancarlo Castellano; Elena Torrisi; Giovanni Ligresti; Ferdinando Nicoletti; Grazia Malaponte; Salvatore Traval; James A McCubrey; Silvana Canevari; Massimo Libra
Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression.
Cell cycle (Georgetown, Tex.) 2010;9(3):557-63.
2010: Venera Cardile; giuseppina frasca; Massimo Libra; Silvia Caggia; Kazuo Umezawa; Annamaria Panico; Grazia Malaponte
Dehydroxymethylepoxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1beta-induced human chondrocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(4-5):543-50.
2009: James A McCubrey; Linda Steelman; Steven L Abrams; William H Chappell; Suzanne Russo; Roger Ove; Michele Milella; Agostino Tafuri; Paolo Lunghi; Antonio Bonati; Franca Stivala; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello
Emerging Raf inhibitors.
Expert opinion on emerging drugs 2009;14(4):633-48.
2009: Alessia E Russo; Elena Torrisi; Ylenia Bevelacqua; Rosario Perrotta; Massimo Libra; James A McCubrey; Demetrios A Spandidos; Franca Stivala; Grazia Malaponte
Melanoma: molecular pathogenesis and emerging target therapies (Review).
International journal of oncology 2009;34(6):1481-9.
2009: Danijela Maksimovic-Ivanic; Sanja Mijatovic; Djordje Miljkovic; Ljubica Harhaji-Trajkovic; Gordana Timotijevic; Marija Mojic; Darrin Dabideen; Kai Fan Cheng; James A McCubrey; Katia Mangano; Yousef Al-Abed; Massimo Libra; Gianni Garotta; Stanislava Stosic-Grujicic; Ferdinando Nicoletti
The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.
Molecular cancer therapeutics 2009;8(5):1169-78.
2009: Giovanni Ligresti; Loredana Militello; Linda Steelman; Andrea Cavallaro; Francesco Basile; Ferdinando Nicoletti; Franca Stivala; James A McCubrey; Massimo Libra
PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.
Cell cycle (Georgetown, Tex.) 2009;8(9):1352-8.
2009: Massimo Libra; Aurora Scalisi; Nadia Vella; Silvia Clementi; Roberto Sorio; Franca Stivala; Demetrios A Spandidos; Clorinda Mazzarino
Uterine cervical carcinoma: role of matrix metalloproteinases (review).
International journal of oncology 2009;34(4):897-903.
2009: Carla Loreto; Maria Luisa Carnazza; Venera Cardile; Massimo Libra; Laura Lombardo; Grazia Malaponte; Giuseppina Martinez; Giuseppe Musumeci; Veronica Papa; Lucio Cocco
Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells.
International journal of oncology 2009;34(2):371-6.
2009: N Misaghian; G Ligresti; Linda Steelman; Fred E Bertrand; Jörg Bäsecke; Massimo Libra; F Nicoletti; Franca Stivala; Michele Milella; A Tafuri; Melchiorre Cervello; A M Martelli; James A McCubrey
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.
Leukemia 2009;23(1):25-42.
2008: James A McCubrey; Steven L Abrams; G Ligresti; N Misaghian; E W T Wong; Linda Steelman; Jörg Bäsecke; J Troppmair; Massimo Libra; F Nicoletti; S Molton; Martin McMahon; C Evangelisti; A M Martelli
Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance.
Leukemia 2008;22(11):2080-90.
2008: Linda Steelman; Kristin M Stadelman; William H Chappell; Stefan Horn; Jörg Bäsecke; Melchiorre Cervello; Ferdinando Nicoletti; Massimo Libra; Franca Stivala; Alberto M Martelli; James A McCubrey
Akt as a therapeutic target in cancer.
Expert opinion on therapeutic targets 2008;12(9):1139-65.
2008: Sanja Mijatovic; Danijela Maksimovic-Ivanic; Marija Mojic; Graziella Malaponte; Massimo Libra; Vera Cardile; Djordje Miljkovic; Ljubica Harhaji; Darrin Dabideen; Kai Fan Cheng; Ylenia Bevelacqua; Marco Donia; Gianni Garotta; Yousef Al-Abed; Stanislava Stosic-Grujicic; Ferdinando Nicoletti
Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(2):177-83.
2008: Massimo Libra; Annunziata Gloghini; Grazia Malaponte; Pietro Gangemi; Valli De Re; Bruno Cacopardo; Demetrios A Spandidos; Ferdinando Nicoletti; Franca Stivala; Anna Linda Zignego; Antonino Carbone
Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.
Journal of hepatology 2008;49(2):170-4.
2008: Linda Steelman; Patrick M Navolanic; M L Sokolosky; J R Taylor; B D Lehmann; William H Chappell; Steven L Abrams; E W T Wong; K M Stadelman; David M Terrian; N R Leslie; A M Martelli; Franca Stivala; Massimo Libra; Richard A Franklin; James A McCubrey
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Oncogene 2008;27(29):4086-95.
2008: Mara Fornasarig; Alessandro Marco Minisini; Silvia Clementi; Ettore Bidoli; Alessandra Viel; Renato Cannizzaro; Elio Campagnutta; Gianni Boz; Massimo Libra
Risk analysis of colorectal cancer in women with endometrial carcinoma.
Molecular medicine reports 2008;1(4):549-53.
2008: Giovanni Ligresti; Massimo Libra; Loredana Militello; Silvia Clementi; Marco Donia; Rosa Imbesi; Grazia Malaponte; Alessandro Cappellani; James A McCubrey; Franca Stivala
Breast cancer: Molecular basis and therapeutic strategies (Review).
Molecular medicine reports 2008;1(4):451-8.
2008: John Lee; Brian D Lehmann; David M Terrian; William H Chappell; Franca Stivala; Massimo Libra; Alberto M Martelli; Linda Steelman; James A McCubrey
Targeting prostate cancer based on signal transduction and cell cycle pathways.
Cell cycle (Georgetown, Tex.) 2008;7(12):1745-62.
2008: Katia Mangano; Niranjan Sardesai; Maria Antonia D'Alcamo; Massimo Libra; Lucia Malaguarnera; Marco Donia; Klaus Bendtzen; Pierluigi Meroni; Ferdinando Nicoletti
In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.
European journal of pharmacology 2008;586(1-3):313-21.
2008: Linda Steelman; Steven L Abrams; J Whelan; Fred E Bertrand; D E Ludwig; J Bäsecke; Massimo Libra; Franca Stivala; Michele Milella; A Tafuri; P Lunghi; A Bonati; A M Martelli; James A McCubrey
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Leukemia 2008;22(4):686-707.
2008: James A McCubrey; Linda Steelman; Steven L Abrams; Fred E Bertrand; D E Ludwig; J Bäsecke; Massimo Libra; Franca Stivala; Michele Milella; A Tafuri; P Lunghi; A Bonati; A M Martelli
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.
Leukemia 2008;22(4):708-22.
2008: Linda Steelman; Patrick M Navolanic; Richard A Franklin; Antonio Bonati; Massimo Libra; Franca Stivala; Alberto M Martelli; James A McCubrey
Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).
Molecular medicine reports 2008;1(2):139-60.
2008: Danijela Maksimovic-Ivanic; Sanja Mijatovic; Ljubica Harhaji; Djordje Miljkovic; Darrin Dabideen; Kai Fan Cheng; Katia Mangano; Graziella Malaponte; Yousef Al-Abed; Massimo Libra; Gianni Garotta; Ferdinando Nicoletti; Stanislava Stosic-Grujicic
Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo.
Molecular cancer therapeutics 2008;7(3):510-20.
2008: James A McCubrey; Melissa L Sokolosky; Brian D Lehmann; Jackson R Taylor; Patrick M Navolanic; William H Chappell; Steven L Abrams; Kristin M Stadelman; Ellis W T Wong; Negin Misaghian; Stefan Horn; Jörg Bäsecke; Massimo Libra; Franca Stivala; Giovanni Ligresti; Agostino Tafuri; Michele Milella; Marek Zarzycki; Andrzej Dzugaj; Francesca Chiarini; Camilla Evangelisti; Alberto M Martelli; David M Terrian; Richard A Franklin; Linda Steelman
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
Advances in enzyme regulation 2008;48():113-35.
2007: Grazia Malaponte; Massimo Libra; Ylenia Bevelacqua; Paola Merito; Pasquale Fatuzzo; Francesco Rapisarda; Maria Cristina; Gabriele Naselli; Franca Stivala; Maria Clorinda Mazzarino; Pietro Castellino
Inflammatory status in patients with chronic renal failure: the role of PTX3 and pro-inflammatory cytokines.
International journal of molecular medicine 2007;20(4):471-81.
2007: Valli De Re; Laura Caggiari; Salvatore De Vita; Cesare Mazzaro; M Lenzi; M Galli; Giuseppe Monti; Clodoveo Ferri; Anna Linda Zignego; A Gabrielli; Domenico Sansonno; Franco Dammacco; Massimo Libra; N Sacchi; R Talamini; Michele Spina; Renato Cannizzaro; Massimo Guidoboni; R Dolcetti
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007;39 Suppl 1():S65-71.
2007: James A McCubrey; Linda Steelman; William H Chappell; Steven L Abrams; Ellis W T Wong; Fumin Chang; Brian D Lehmann; David M Terrian; Michele Milella; Agostino Tafuri; Franca Stivala; Massimo Libra; Jorg Basecke; Camilla Evangelisti; Alberto M Martelli; Richard A Franklin
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.
Biochimica et biophysica acta 2007;1773(8):1263-84.
2007: Valli De Re; Laura Caggiari; Maria Paola Simula; Salvatore De Vita; Cesare Mazzaro; Marco Lenzi; Galli M Massimo; Giuseppe Monti; Clodoveo Ferri; Anna Linda Zignego; Armando Gabrielli; Domenico Sansonno; Franco Dammacco; Massimo Libra; Nicoletta Sacchi; Renato Talamini; Michele Spina; Umberto Tirelli; Renato Cannizzaro; Riccardo Dolcetti
Role of the HLA class II: HCV-related disorders.
Annals of the New York Academy of Sciences 2007;1107():308-18.
2007: Matilde Y Follo; Sara Mongiorgi; Costanza Bosi; Alessandra Cappellini; Carlo Finelli; Francesca Chiarini; Veronica Papa; Massimo Libra; giovanni martinelli; Lucio Cocco; Alberto M Martelli
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation.
Cancer research 2007;67(9):4287-94.
2007: James A McCubrey; Linda Steelman; Richard A Franklin; Steven L Abrams; William H Chappell; Ellis W T Wong; Brian D Lehmann; David M Terrian; Jorg Basecke; Franca Stivala; Massimo Libra; Camilla Evangelisti; Alberto M Martelli
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Advances in enzyme regulation 2007;47():64-103.
2006: Valentina Bevelacqua; Massimo Libra; Maria Clorinda Mazzarino; Pietro Gangemi; Giuseppina Nicotra; Salvatore Curatolo; Daniela Massimino; Antonio Plumari; Paola Merito; Guido Valente; Franca Stivala; Stefano La Greca; Grazia Malaponte
Long pentraxin 3: a marker of inflammation in untreated psoriatic patients.
International journal of molecular medicine 2006;18(3):415-23.
2006: Massimo Libra; Grazia Malaponte; Valentina Bevelacqua; Roberta Siciliano; Paola Castrogiovanni; Alberto Fulvi; Giuseppe Micali; Giovanni Ligresti; Maria Clorinda Mazzarino; Franca Stivala; Salvatore Travali; James A McCubrey
Absence of BRAF gene mutation in non-melanoma skin tumors.
Cell cycle (Georgetown, Tex.) 2006;5(9):968-70.
2006: G Letizia D'Amico; Daniela Di Benedetto; Franca Maria Pezzino; Vincenza Giuffrida; Massimo Libra; Marco Fichera; Grazia Mauceri; Giancarlo Rappazzo; Rosario D'Agata; Enzo Vicari; Salvatore Travali; Aldo E Calogero
Quantitative evaluation of partial deletions of the DAZ gene cluster.
International journal of molecular medicine 2006;17(5):785-9.
2006: Massimo Libra; Katia Mangano; Massimiliano Anzaldi; cinzia quattrocchi; Marco Donia; Roberto Di Marco; Salvatore Santo Signorelli; Guido Scalia; Anna Linda Zignego; Valli De Re; Maria Clorinda Mazzarino; Ferdinando Nicoletti
Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders.
Oncology reports 2006;15(5):1305-8.
2006: Roberto Sorio; Giuseppe Toffoli; Diana Crivellari; alessandra bearz; giuseppe corona; Anna Maria Colussi; Massimo Libra; R Talamini; Andrea Veronesi
Oral etoposide in elderly patients with advanced non small cell lung cancer: a clinical and pharmacological study.
Journal of chemotherapy (Florence, Italy) 2006;18(2):188-91.
2006: Angelo B Cefalù; Giacoma Barraco; Davide Noto; Vincenza Valenti; Carlo M Barbagallo; Gerardo Damian Elikir; Luis A Cuniberti; José P Werba; Massimo Libra; Salvatore Costa; Fabrizio Gianguzza; Alberto Notarbartolo; Salvatore Travali; Maurizio R Averna
Six novel mutations of the LDL receptor gene in FH kindred of Sicilian and Paraguayan descent.
International journal of molecular medicine 2006;17(3):539-46.
2006: Vincenza Giuffrida; Franca Maria Pezzino; Fabrizio Romano; Laura Litrico; Maria Rita Garofalo; Giuseppina Nicotra; Massimo Libra; Fabio D'Amico; Paola Castrogiovanni; Rosa Imbesi; Maurizio R Averna; Santo Sanfilippo; Rosario D'Agata; Enzo Vicari; Aldo E Calogero; Salvatore Travali
Gene expression in mouse spermatogenesis during ontogenesis.
International journal of molecular medicine 2006;17(3):523-8.
2006: Massimo Libra; Salvatore Santo Signorelli; Ylenia Bevelacqua; Patrick M Navolanic; Valentina Bevelacqua; J Polesel; R Talamini; Franca Stivala; Maria Clorinda Mazzarino; Grazia Malaponte
Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease.
Journal of clinical pathology 2006;59(2):211-5.
2006: Grazia Malaponte; Massimo Libra; Pietro Gangemi; Valentina Bevelacqua; Katia Mangano; Fabio D'Amico; Maria Clorinda Mazzarino; Franca Stivala; James A McCubrey; Salvatore Travali
Detection of BRAF gene mutation in primary choroidal melanoma tissue.
Cancer biology & therapy 2006;5(2):225-7.
2006: Antonino Carbone; Annunziata Gloghini; Massimo Libra; Daniela Gasparotto; Patrick M Navolanic; Michele Spina; Umberto Tirelli
A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(2):299-306.
2006: Manuela Indelicato; Valentina Chiarenza; Massimo Libra; Grazia Malaponte; Valentina Bevelacqua; Maurizio Marchini; James A McCubrey; Franca Stivala; Raffaella Scorza; Maria Clorinda Mazzarino
Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.
Journal of clinical laboratory analysis 2006;20(5):173-6.
2006: James A McCubrey; Linda Steelman; Steven L Abrams; John Lee; Fumin Chang; Fred E Bertrand; Patrick M Navolanic; David M Terrian; Richard A Franklin; Antonio B D'Assoro; Jeffrey Salisbury; Maria Clorinda Mazzarino; Franca Stivala; Massimo Libra
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
Advances in enzyme regulation 2006;46():249-79.
2005: Richard A Franklin; Massimo Libra; Franca Stivala; James A McCubrey
Two targets are better than one. Promising combination therapy to treat breast cancer.
Cancer biology & therapy 2005;4(11):1190-1.
2005: Domenico Sansonno; Felicia Anna Tucci; Valli De Re; Gianfranco Lauletta; Michele Montrone; Massimo Libra; Franco Dammacco
HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation.
Hepatology (Baltimore, Md.) 2005;42(5):1019-27.
2005: Massimo Libra; Manuela Indelicato; Valli De Re; Anna Linda Zignego; Annalisa Chiocchetti; Grazia Malaponte; Umberto Dianzani; Ferdinando Nicoletti; Franca Stivala; James A McCubrey; Maria Clorinda Mazzarino
Elevated Serum Levels of Osteopontin in HCV-Associated Lymphoproliferative Disorders.
Cancer biology & therapy 2005;4(11):1192-4.
2005: Maria Viola; Massimo Libra; Daniela Callari; Fulvia Sinatra; Daniele Spada; Davide Noto; Giovanni Emmanuele; Fabrizio Romano; Maurizio R Averna; Franca Maria Pezzino; Franca Stivala; Salvatore Travali
Bovine seminal ribonuclease is cytotoxic for both malignant and normal telomerase-positive cells.
International journal of oncology 2005;27(4):1071-7.
2005: Massimo Libra; Grazia Malaponte; Patrick M Navolanic; Pietro Gangemi; Valentina Bevelacqua; Lidia Proietti; Bibiana Bruni; Franca Stivala; Maria Clorinda Mazzarino; Salvatore Travali; James A McCubrey
Analysis of BRAF mutation in primary and metastatic melanoma.
Cell cycle (Georgetown, Tex.) 2005;4(10):1382-4.
2005: Lidia Proietti; Grazia Malaponte; Massimo Libra; Patrick M Navolanic; Ylenia Bevelacqua; Salvatore Travali; Maria Clorinda Mazzarino
Analysis of hepatitis C virus infection among health-care workers: an observational study.
Minerva gastroenterologica e dietologica 2005;51(3):255-9.
2005: Massimo Libra; Valli De Re; Annunziata Gloghini; Daniela Callari; Grazia Malaponte; Salvatore Travali; Maria Clorinda Mazzarino; Franca Stivala; Mauro Boiocchi; Antonino Carbone
Frequency of bcl-2/IgH translocation in patients with non-Hodgkin's lymphoma and chronic hepatitis C virus infection.
Minerva gastroenterologica e dietologica 2005;51(2):165-70.
2005: Massimo Libra; Daniela Capello; Annunziata Gloghini; Pasqualucci Laura; Eva Berra; Michaela Cerri; Daniela Gasparotto; Stivala Franca; Valli De Re; Gianluca Gaidano; Antonino Carbone
Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection.
The Journal of pathology 2005;206(1):87-91.
2005: Massimo Libra; Annunziata Gloghini; Patrick M Navolanic; Anna Linda Zignego; Valli De Re; Antonino Carbone
JH6 gene usage among HCV-associated MALT lymphomas harboring t(14;18) translocation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):3839; author reply 3839.
2005: Massimo Libra; Annunziata Gloghini; Valli De Re; Maurizio Rupolo; Patrick M Navolanic; Daniela Gasparotto; Franca Stivala; Michele Spina; Mauro Boiocchi; Antonino Carbone
Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses.
International journal of oncology 2005;26(4):945-50.
2005: Salvatore Santo Signorelli; Grazia Malaponte; Massimo Libra; Luigi Di Pino; Gabriella Celotta; Valentina Bevelacqua; Marcello Petrina; Giuseppina Nicotra; Manuela Indelicato; Patrick M Navolanic; Giovanni Pennisi; Maria Clorinda Mazzarino
Plasma levels and zymographic activities of matrix metalloproteinases 2 and 9 in type II diabetics with peripheral arterial disease.
Vascular medicine (London, England) 2005;10(1):1-6.
2005: Massimo Libra; Daniela Gasparotto; Annunziata Gloghini; Patrick M Navolanic; Valli De Re; Antonino Carbone
Hepatitis C virus (HCV) I hepatitis C virus (HCV) infection and lymphoproliferative disorders.
Frontiers in bioscience : a journal and virtual library 2005;10():2460-71.
2005: Lidia Proietti; R Visalli; M Cultrera; G Romeo; Massimo Libra; Salvatore Travali; Domenica Duscio
[In vitro exposure of U937 cells to potassium dichromate: study of apoptosis].
Giornale italiano di medicina del lavoro ed ergonomia 2005;27(1):35-8.
2004: Massimo Libra; Valli De Re; Annunziata Gloghini; Patrick M Navolanic; Antonino Carbone; Mauro Boiocchi
Second primary lymphoma or recurrence: a dilemma solved by VDJ rearrangement analysis.
Leukemia & lymphoma 2004;45(8):1539-43.
2004: Massimo Libra; Valli De Re; Annunziata Gloghini; Daniela Gasparotto; Laura Gragnani; Patrick M Navolanic; Salvatore De Vita; Maria Clorinda Mazzarino; Anna Linda Zignego; Antonino Carbone; Mauro Boiocchi
Detection of bcl-2 rearrangement in mucosa-associated lymphoid tissue lymphomas from patients with hepatitis C virus infection.
Haematologica 2004;89(7):873-4.
2004: Massimo Libra; Patrick M Navolanic; Renato Talamini; Erika Cecchin; Franca Sartor; Salvatore Tumolo; Sara Masier; Salvatore Travali; Mauro Boiocchi; Giuseppe Toffoli
Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy.
BMC cancer 2004;4():11.
2004: Giuseppe Sciacca; Agata Grillo; Gianluca Paravizzini; Martina Barchitta; Massimo Libra; Giovanni Emmanuele; Daniela Callari; Antonella Agodi; Salvatore Travali
D1S80 VNTR locus genotypes in a population of Southeastern Sicily: distribution and genetic disequilibrium.
American journal of human biology : the official journal of the Human Biology Council 2004;16(1):91-4.
2003: Massimo Libra; Renato Talamini; Diana Crivellari; Angela Buonadonna; Andrea Freschi; Peter Stefanovski; Massimiliano Berretta; Marcello De Cicco; Luca Balestreri; Alberto Merlo; Rachele Volpe; Enzo Galligioni; Roberto Sorio
Long-term survival in patients with metastatic renal cell carcinoma treated with continuous intravenous infusion of recombinant interleukin-2: the experience of a single institution.
Tumori 2003;89(4):400-4.
2003: Massimo Libra; Valli De Re; Salvatore De Vita; Daniela Gasparotto; Annunziata Gloghini; Maurizio Rupolo; Massimo Degan; Alessandra Marzotto; Franca Stivala; Antonino Carbone; Mauro Boiocchi
Low frequency of bcl-2 rearrangement in HCV-associated non-Hodgkin's lymphoma tissue.
Leukemia 2003;17(7):1433-6.
2003: Daniela Callari; Fulvia Sinatra; Gianluca Paravizzini; Massimo Libra; Giovanni Emmanuele; Barbara Fiore; Maria Francesca Pezzino; Daria Rasà; Maria Clorinda Mazzarino; Natale D'Alessandro; Salvatore Travali
All trans retinoic acid sensitizes colon cancer cells to hyperthermia cytotoxic effects.
International journal of oncology 2003;23(1):181-8.
2003: Massimo Libra; Roberto Sorio; Angela Buonadonna; Massimiliano Berretta; Peter Stefanovski; Giuseppe Toffoli; Giovanna Mazzaglia; Nicoletta Cordani; Franca Stivala; Mauro Boiocchi
Cisplatin may be a valid alternative approach in ovarian carcinoma with carboplatin hypersensitivity. Report of three cases.
Tumori 2003;89(3):311-3.
2003: Vincenzo Canzonieri; Massimiliano Berretta; Angela Buonadonna; Massimo Libra; Enrico Vasquez; Emilia Barbagallo; alessandra bearz; Salvatore Berretta
Solid pseudopapillary tumour of the pancreas.
The lancet oncology 2003;4(4):255-6.
2003: Giuseppe Toffoli; Roberta Gafà; Antonio Russo; Giovanni Lanza; Riccardo Dolcetti; Franca Sartor; Massimo Libra; Alessandra Viel; Mauro Boiocchi
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):743-8.
2002: Salvatore De Vita; Valli De Re; Domenico Sansonno; Annunziata Gloghini; Daniela Gasparotto; Massimo Libra; Stefania Sacco; Antonino Carbone; Gianfranco Ferraccioli; Mauro Boiocchi
Lack of HCV infection in malignant cells refutes the hypothesis of a direct transforming action of the virus in the pathogenesis of HCV-associated B-cell NHLs.
Tumori 2002;88(5):400-6.
2002: Massimo Libra; Valli De Re; Daniela Gasparotto; Annunziata Gloghini; Alessandra Marzotto; Isabella Milan; Umberto Tirelli; Franca Stivala; Antonino Carbone; Mauro Boiocchi
Differentiation between non-Hodgkin's lymphoma recurrence and second primary lymphoma by VDJ rearrangement analysis.
British journal of haematology 2002;118(3):809-12.
2002: Valli De Re; Salvatore De Vita; V Battistella; Alessandra Marzotto; Massimo Libra; Gianfranco Ferraccioli; Mauro Boiocchi
Absence of human parvovirus B19 DNA in myoepithelial sialadenitis of primary Sjögren's syndrome.
Annals of the rheumatic diseases 2002;61(9):855-6.
2002: Annunziata Gloghini; Gianluca Gaidano; Luigi Maria Larocca; Francesco Pierconti; Antonella Cingolani; Luigino Dal Maso; Daniela Capello; Silvia Franceschi; Umberto Tirelli; Massimo Libra; Huifeng Niu; Riccardo Dalla-Favera; Antonino Carbone
Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.
The American journal of pathology 2002;161(1):163-71.
2002: Peter Stefanovski; Ettore Bidoli; Antonino De Paoli; Angela Buonadonna; Giovanni Boz; Massimo Libra; Sandro Morassut; Carlo Rossi; A Carbone; Sergio Frustaci
Prognostic factors in soft tissue sarcomas: a study of 395 patients.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2002;28(2):153-64.
2002: Roberto Sorio; Renata Talamini; Giuseppe Toffoli; Davide Lombardi; Massimo Libra; Andrea Veronesi
Carboplatin in elderly patients.
Tumori 2002;88(1 Suppl 1):S35-6.
2001: Roberto Sorio; A Gallo; Massimo Libra; Giovanni Boz; Carlo Scarabelli
Neo-adjuvant medical treatment for advanced cervical cancer.
Tumori 2001;87(5):S22.