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Karen Liby

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Chemicals & Drugs

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TOP 3
Michael B Sporn; Karen T Liby
Is lycopene an effective agent for preventing prostate cancer?
Navneet Ammal Kaidery; Thomas W Kensler; Karen T Liby; Rajiv R Ratan; Natalya A Smirnova; Michael B Sporn; Rebecca Banerjee; M Flint Beal; Irina G Gazaryan; Dmitry M Hushpulian; Charlotte R Williams; Masayuki Yamamoto; Lichuan Yang; Bobby Thomas
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Kim Tran; Charlotte R Williams; Darlene B Royce; Lalji Gediya; Vincent Njar; Patricia A Pioli; Renee Risingsong; Michael B Sporn; Karen T Liby
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.

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All Publications

2013: Michael B Sporn; Karen T Liby
Is lycopene an effective agent for preventing prostate cancer?
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):384-6.
2013: Navneet Ammal Kaidery; Thomas W Kensler; Karen T Liby; Rajiv R Ratan; Natalya A Smirnova; Michael B Sporn; Rebecca Banerjee; M Flint Beal; Irina G Gazaryan; Dmitry M Hushpulian; Charlotte R Williams; Masayuki Yamamoto; Lichuan Yang; Bobby Thomas
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Antioxidants & redox signaling 2013;18(2):139-57.
2013: Kim Tran; Charlotte R Williams; Darlene B Royce; Lalji Gediya; Vincent Njar; Patricia A Pioli; Renee Risingsong; Michael B Sporn; Karen T Liby
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Carcinogenesis 2013;34(1):199-210.
2012: Karen T Liby; Michael B Sporn
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
Pharmacological reviews 2012;64(4):972-1003.
2012: Michael B Sporn; Karen T Liby
NRF2 and cancer: the good, the bad and the importance of context.
Nature reviews. Cancer 2012;12(8):564-71.
2012: Kim Tran; Charlotte R Williams; Renee Risingsong; Darlene B Royce; Michael B Sporn; Karen T Liby
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Cancer prevention research (Philadelphia, Pa.) 2012;5(5):726-34.
2011: Arie Neymotin; Noel Y Calingasan; Elizabeth Wille; Nima Naseri; Susanne Petri; Maria Damiano; Karen T Liby; Renee Risingsong; Michael Sporn; M Flint Beal; Mahmoud Kiaei
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.
Free radical biology & medicine 2011;51(1):88-96.
2011: Michael B Sporn; Karen T Liby; Mark M Yore; Liangfeng Fu; Justin M Lopchuk; Gordon W Gribble
New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.
Journal of natural products 2011;74(3):537-45.
2011: Eun-Hee Kim; Chu-Xia Deng; Michael B Sporn; Karen T Liby
CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(3):425-34.
2011: Jason L Townson; Ian C Macdonald; Karen T Liby; Lisa Mackenzie; David W Dales; Benjamin D Hedley; Paula J Foster; Michael B Sporn; Ann F Chambers
The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.
Clinical & experimental metastasis 2011;28(3):309-17.
2011: Tej K Pareek; Michael B Sporn; Anita Zaremba; Lianhua Bai; Abdelmadjid Belkadi; Mark L Cohen; Sashi Kesavapany; Karen T Liby; Sook L Loh; Colin Meyer; Robert H Miller; John J Letterio
Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.
Scientific reports 2011;1():201.
2011: Mark M Yore; Michael B Sporn; Scott A Gerber; Arminja N Kettenbach; Karen T Liby
Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.
PloS one 2011;6(7):e22862.
2010: Karen T Liby; Darlene B Royce; Renee Risingsong; Charlotte R Williams; Anirban Maitra; Ralph Hruban; Michael B Sporn
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1427-34.
2010: Cliona Stack; Daniel Ho; Elizabeth Wille; Noel Y Calingasan; Charlotte Williams; Karen T Liby; Michael Sporn; Magali Dumont; M Flint Beal
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease.
Free radical biology & medicine 2010;49(2):147-58.
2010: Tadashi Honda; Eric M Padegimas; Emilie David; Chitra Sundararajan; Karen T Liby; Charlotte Williams; Michael B Sporn; Melean Visnick
2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent.
Bioorganic & medicinal chemistry letters 2010;20(7):2275-8.
2010: Srinivas Nagaraj; Je-In Youn; Hannah Weber; Cristina Iclozan; Lily Lu; Matthew J Cotter; Colin Meyer; Carlos R Becerra; Mayer Fishman; Scott Antonia; Michael B Sporn; Karen T Liby; Bhupendra Rawal; Ji-Hyun Lee; Dmitry I Gabrilovich
Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(6):1812-23.
2009: Narsa Reddy Machireddy; Vegiraju Suryanaraya; Melinda S Yates; Steven R Kleeberger; Paul M Hassoun; Masayuki Yamamoto; Karen T Liby; Michael B Sporn; Thomas W Kensler; SEKHAR POTHIREDDY
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
American journal of respiratory and critical care medicine 2009;180(9):867-74.
2009: Ian Pitha-Rowe; Karen T Liby; Darlene B Royce; Michael Sporn
Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.
Investigative ophthalmology & visual science 2009;50(11):5339-47.
2009: Soona Shin; Junko Wakabayashi; Melinda S Yates; Nobunao Wakabayashi; Patrick Dolan; Susan Aja; Karen T Liby; Michael B Sporn; Masayuki Yamamoto; Thomas W Kensler
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
European journal of pharmacology 2009;620(1-3):138-44.
2009: Melinda S Yates; Quynh T Tran; Patrick Dolan; William O Osburn; Soona Shin; Colin C McCulloch; Jay B Silkworth; Keiko Taguchi; Masayuki Yamamoto; Charlotte R Williams; Karen T Liby; Michael B. Sporn; Thomas R Sutter; Thomas W Kensler
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Carcinogenesis 2009;30(6):1024-31.
2009: Thomas E Sussan; Tirumalai Rangasamy; David J Blake; Deepti Malhotra; Hazim El-Haddad; Djahida Bedja; Melinda S Yates; Ponvijay Kombairaju; Masayuki Yamamoto; Karen T Liby; Michael B. Sporn; Kathleen L Gabrielson; Hunter C Champion; Rubin M Tuder; Thomas W Kensler; Shyam Biswal
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):250-5.
2009: Lichuan Yang; Noel Y Calingasan; Bobby Thomas; Rajnish K Chaturvedi; Mahmoud Kiaei; Elizabeth J Wille; Karen T Liby; Charlotte Williams; Darlene Royce; Renee Risingsong; Eric S Musiek; Jason D Morrow; Michael B. Sporn; M Flint Beal
Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.
PloS one 2009;4(6):e5757.
2008: William O Osburn; Melinda S Yates; Patrick Dolan; Sining Chen; Karen T Liby; Michael B. Sporn; Keiko Taguchi; Masayuki Yamamoto; Thomas W Kensler
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(1):218-27.
2008: Karen T Liby; Candice C Black; Darlene B Royce; Charlotte R Williams; Renee Risingsong; Mark M Yore; Xi Liu; Tadashi Honda; Gordon W Gribble; William W Lamph; Thomas A Sporn; Ethan Dmitrovsky; Michael B. Sporn
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
Molecular cancer therapeutics 2008;7(5):1251-7.
2008: Albena T Dinkova-Kostova; Stephanie N Jenkins; Scott L Wehage; David L Huso; Andrea L Benedict; Katherine K Stephenson; Jed W Fahey; Hua Liu; Karen T Liby; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Paul Talalay
A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.
Biochemical and biophysical research communications 2008;367(4):859-65.
2007: Rajesh K Thimmulappa; RALPH FUCHS; Deepti Malhotra; Catherine Scollick; Kassim Traore; Jay H Bream; Michael A Trush; Karen T Liby; Michael B. Sporn; Thomas W Kensler; Shyam Biswal
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Antioxidants & redox signaling 2007;9(11):1963-70.
2007: Karen T Liby; Darlene B Royce; Renee Risingsong; Charlotte R Williams; Matthew D Wood; Roshantha A S Chandraratna; Michael B. Sporn
A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6237-43.
2007: Karen T Liby; Tadashi Honda; Charlotte R Williams; Renee Risingsong; Darlene B Royce; Nanjoo Suh; Albena T Dinkova-Kostova; Katherine K Stephenson; Paul Talalay; Chitra Sundararajan; Gordon W Gribble; Michael B. Sporn
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.
Molecular cancer therapeutics 2007;6(7):2113-9.
2007: Karen T Liby; Mark M Yore; Michael B. Sporn
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Nature reviews. Cancer 2007;7(5):357-69.
2007: Tadashi Honda; Chitra Sundararajan; Hidenori Yoshizawa; Xiaobo Su; Yukiko Honda; Karen T Liby; Michael B. Sporn; Gordon W Gribble
Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.
Journal of medicinal chemistry 2007;50(8):1731-4.
2007: Karen T Liby; Darlene B Royce; Charlotte R Williams; Renee Risingsong; Mark M Yore; Tadashi Honda; Gordon W Gribble; Ethan Dmitrovsky; Thomas A Sporn; Michael B. Sporn
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Cancer research 2007;67(6):2414-9.
2007: Thomas Hock; Karen T Liby; Marcienne Wright; Sean McConnell; Marina Schorpp-Kistner; Thomas M Ryan; Anupam Agarwal
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells.
The Journal of biological chemistry 2007;282(9):6875-86.
2007: Melinda S Yates; Masafumi Tauchi; Fumiki Katsuoka; Kathleen C Flanders; Karen T Liby; Tadashi Honda; Gordon W Gribble; Delinda A Johnson; Jeffrey A Johnson; Neal C Burton; Tomás R Guilarte; Masayuki Yamamoto; Michael B. Sporn; Thomas W Kensler
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Molecular cancer therapeutics 2007;6(1):154-62.
2006: Rajesh K Thimmulappa; Catherine Scollick; Kassim Traore; Melinda Yates; Michael A Trush; Karen T Liby; Michael B. Sporn; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
Biochemical and biophysical research communications 2006;351(4):883-9.
2006: Tadashi Honda; Karen T Liby; Xiaobo Su; Chitra Sundararajan; Yukiko Honda; Nanjoo Suh; Renee Risingsong; Charlotte R Williams; Darlene B Royce; Michael B. Sporn; Gordon W Gribble
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.
Bioorganic & medicinal chemistry letters 2006;16(24):6306-9.
2006: Mark M Yore; Karen T Liby; Tadashi Honda; Gordon W Gribble; Michael B. Sporn
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.
Molecular cancer therapeutics 2006;5(12):3232-9.
2006: Karen T Liby; Mara H Rendi; Nanjoo Suh; Darlene B Royce; Renee Risingsong; Charlotte R Williams; William W Lamph; Fernand Labrie; Stan Krajewski; Xiaochun Xu; Heetae Kim; Powel Brown; Michael B. Sporn
The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5902-9.
2006: Albena T Dinkova-Kostova; Stephanie N Jenkins; Jed W Fahey; Lingxiang Ye; Scott L Wehage; Karen T Liby; Katherine K Stephenson; Kristina L Wade; Paul Talalay
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.
Cancer letters 2006;240(2):243-52.
2006: Karen T Liby; Nga Voong; Charlotte R Williams; Renee Risingsong; Darlene B Royce; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; John J Letterio
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4288-93.
2006: Yan Ji; Hong Jin Lee; Catherine Goodman; Milan R Uskokovic; Karen T Liby; Michael B. Sporn; Nanjoo Suh
The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells.
Molecular cancer therapeutics 2006;5(6):1452-8.
2006: Melinda S Yates; Mi-Kyoung Kwak; Patricia A Egner; John Groopman; Sridevi Bodreddigari; Thomas R Sutter; Karen J Baumgartner; Bill D Roebuck; Karen T Liby; Mark M Yore; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Thomas W Kensler
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
Cancer research 2006;66(4):2488-94.
2005: Michael B. Sporn; Karen T Liby
Cancer chemoprevention: scientific promise, clinical uncertainty.
Nature clinical practice. Oncology 2005;2(10):518-25.
2005: Karen T Liby; Thomas Hock; Mark M Yore; Nanjoo Suh; Andrew E Place; Renee Risingsong; Charlotte R Williams; Darlene B Royce; Tadashi Honda; Yukiko Honda; Gordon W Gribble; Nathalie Hill-Kapturczak; Anupam Agarwal; Michael B. Sporn
The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.
Cancer research 2005;65(11):4789-98.
2005: Albena T Dinkova-Kostova; Karen T Liby; Katherine K Stephenson; W David Holtzclaw; Xiangqun Gao; Nanjoo Suh; Charlotte Williams; Renee Risingsong; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Paul Talalay
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4584-9.
2004: Tadashi Honda; Tomasz Janosik; Yukiko Honda; Jie Han; Karen T Liby; Charlotte R Williams; Robin D Couch; Amy C Anderson; Michael B. Sporn; Gordon W Gribble
Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.
Journal of medicinal chemistry 2004;47(20):4923-32.
2004: Mara H Rendi; Nanjoo Suh; William W Lamph; Stan Krajewski; John C Reed; Richard A Heyman; Andrew Berchuck; Karen T Liby; Renee Risingsong; Darlene B Royce; Charlotte R Williams; Michael B. Sporn
The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer.
Cancer research 2004;64(10):3566-71.
2003: Karen T Liby; Bonnie Neltner; Lisa Mohamet; Lindsey Menchen; Nira Ben-Jonathan
Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth.
Breast cancer research and treatment 2003;79(2):241-52.
2003: Karen T Liby; Bonnie Neltner; Lisa Mohamet; Craig J Burd; Nira Ben-Jonathan
Endostatin expression by MDA-MB-435 breast cancer cells effectively inhibits tumor growth.
Cancer biology & therapy 2003;2(1):48-52.
2002: Nira Ben-Jonathan; Karen T Liby; Molly McFarland; Michael Zinger
Prolactin as an autocrine/paracrine growth factor in human cancer.
Trends in endocrinology and metabolism: TEM 2002;13(6):245-50.
2001: Karen T Liby; H Wu; Bin Ouyang; S Wu; J Chen; W Dai
Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):527-33.
1999: S Khurana; Karen T Liby; Arthur R Buckley; Nira Ben-Jonathan
Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin.
Endocrinology 1999;140(9):4127-32.