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Gosse Adema

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Nina Karthaus; Maaike W G Looman; Annemiek van Spriel; Marleen Ansems; Saartje Hontelez; Gosse J Adema
Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cells.
Saartje Hontelez; Nina Karthaus; Maaike W G Looman; Marleen Ansems; Gosse J Adema
DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.
E H J G Aarntzen; Gosse J Adema; Fernando Bonetto; Luis J Cruz; Carl G Figdor; Arend Heerschap; W Joost Lesterhuis; Wim J Oyen; Cornelius J A Punt; Gerty Schreibelt; Mangala Srinivas; Mandy W M M van de Rakt; Maichel van Riel; Pauline Verdijk; I Jolanda M De Vries
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.

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2013: Nina Karthaus; Maaike W G Looman; Annemiek van Spriel; Marleen Ansems; Saartje Hontelez; Gosse J Adema
Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cells.
Molecular immunology 2013;55(3-4):409-17.
2013: Saartje Hontelez; Nina Karthaus; Maaike W G Looman; Marleen Ansems; Gosse J Adema
DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3172-9.
2013: E H J G Aarntzen; Gosse J Adema; Fernando Bonetto; Luis J Cruz; Carl G Figdor; Arend Heerschap; W Joost Lesterhuis; Wim J Oyen; Cornelius J A Punt; Gerty Schreibelt; Mangala Srinivas; Mandy W M M van de Rakt; Maichel van Riel; Pauline Verdijk; I Jolanda M De Vries
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1525-33.
2013: Kim Timmermans; Michiel Vaneker; Theo S Plantinga; Gert Jan Scheffer; Gosse J Adema; Leo A B Joosten; Matthijs Kox; Mihai G Netea
Blueprints of signaling interactions between pattern recognition receptors: implications for the design of vaccine adjuvants.
Clinical and vaccine immunology : CVI 2013;20(3):427-32.
2013: Dennis Lindau; Pieter Wesseling; Paul Gielen; Michiel Kroesen; Gosse J Adema
The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells.
Immunology 2013;138(2):105-15.
2013: Barbara M Schulte; Frank J M van Kuppeveld; Jochem M D Galama; Esther D Kers-Rebel; Amy C Prosser; Gosse J Adema
Differential Susceptibility and Response of Primary Human Myeloid BDCA1(+) Dendritic Cells to Infection with Different Enteroviruses.
PloS one 2013;8(4):e62502.
2013: E H J G Aarntzen; Gosse J Adema; Willeke A M Blokx; Kalijn Bol; Alexandra J Croockewit; I Jolanda M De Vries; Johannes H W de Wilt; John B A G Haanen; J F M Jacobs; William W Kwok; W Joost Lesterhuis; Roel Mus; Cornelis J A Punt; Dirk Schadendorf; Gerty Schreibelt; Danita Schuurhuis; Michelle M van Rossum; Carl G Figdor
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.
Cancer research 2013;73(1):19-29.
2012: E H J G Aarntzen; Gosse J Adema; Kalijn Bol; Carl G Figdor; Joannes F M Jacobs; W Joost Lesterhuis; Cornelis J A Punt; Gerty Schreibelt; Michelle M van Rossum; I Jolanda M De Vries
Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma.
Cancer research 2012;72(23):6102-10.
2012: Marleen Ansems; Saartje Hontelez; Nina Karthaus; Maaike W G Looman; Jack A Schalken; Gerald W Verhaegh; Tilly W Aalders; Gosse J Adema
DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells.
The Prostate 2012;72(16):1708-17.
2012: E H J G Aarntzen; Gosse J Adema; Marjo Beldhuis-Valkis; Huberdina M L M Brouwers; I Jolanda M De Vries; Joop H C Göertz; Irma Joosten; Cornelis J A Punt; Paul J Tacken; Mandy W M M van de Rakt; Renate G van der Molen; J F M Jacobs
Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters.
Cancer immunology, immunotherapy : CII 2012;61(11):2003-11.
2012: E H J G Aarntzen; Willeke A M Blokx; Kalijn Bol; Alexandra J Croockewit; I Jolanda M De Vries; Johannes H W de Wilt; Tjitske Duiveman-de Boer; Carl G Figdor; J F M Jacobs; W Joost Lesterhuis; Roel Mus; Cornelis J A Punt; Gerty Schreibelt; Danita Schuurhuis; Kris Thielemans; Michelle M van Rossum; Gosse J Adema
Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(19):5460-70.
2012: Barbara M Schulte; Massimo Trucco; Gosse J Adema; Rita Bottino; Eelco J P de Koning; Marten A Engelse; Jochem M Galama; Richard J F Huijbens; Esther D Kers-Rebel; Kjerstin H W Lanke; Jon D Piganelli; Timothy R D J Radstake; Frank J M van Kuppeveld
Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.
Diabetes 2012;61(8):2030-6.
2012: Saartje Hontelez; Nina Karthaus; Maaike W G Looman; Vassilis Triantis; Malou Zuidscherwoude; Marleen Ansems; Gosse J Adema
Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(1):138-45.
2012: Justin H Fransen; Gosse J Adema; Jo H Berden; Claudia M Koeter; Johan Van der Vlag; Luuk B Hilbrands
Effect of administration of apoptotic blebs on disease development in lupus mice.
Autoimmunity 2012;45(4):290-7.
2012: Veronique Moulin; E Wielders; Dagmar Eleveld-Trancikova; Carl Figdor; J B A G Haanen; Bastiaan Jan Herman Jansen; R A J Janssen; Maaike W G Looman; M E Morgan; Gosse J Adema
Targeting dendritic cells with antigen via dendritic cell-associated promoters.
Cancer gene therapy 2012;19(5):303-11.
2012: S Hontelez; Mihai G Netea; Anna Sanecka; Annemiek van Spriel; Gosse J Adema
Molecular view on PRR cross-talk in antifungal immunity.
Cellular microbiology 2012;14(4):467-74.
2012: Gerty Schreibelt; Paul J Tacken; Jurjen Tel; Carl G Figdor; Lieke J J Klinkenberg; Martin Kreutz; Gosse J Adema; Gordon D Brown; Luis J Cruz; I Jolanda M De Vries
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.
Blood 2012;119(10):2284-92.
2012: Michiel Kroesen; Dennis Lindau; Peter Hoogerbrugge; Gosse J Adema
Immunocombination therapy for high-risk neuroblastoma.
Immunotherapy 2012;4(2):163-74.
2012: Anna Sanecka; Maaike A van Hout-Kuijer; Joris Veltman; Suzanne Welten; Marleen Ansems; Dagmar Eleveld-Trancikova; Christian Gilissen; Martijn A Huynen; Bastiaan Jan Herman Jansen; Maaike W G Looman; Amy C Prosser; Iziah E Sama; Gosse J Adema
Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells.
Molecular immunology 2012;50(1-2):66-73.
2011: Stefan Nierkens; T J M Ruers; Stephen P Schoenberger; Susan Togher; Jori Wagenaars; Melissa Wassink; Gosse J Adema; Louis Boon; Martijn H M G M den Brok; Carl G Figdor; Zacarias Garcia; edith janssen
Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells.
Cancer research 2011;71(20):6428-37.
2011: W Joost Lesterhuis; Sophie Lucas; Roel Mus; Wim J G Oyen; Cornelis J A Punt; Nicole M Scharenborg; Gerty Schreibelt; Mandy W M M van de Rakt; Michelle M van Rossum; Erik H J G Aarntzen; Gosse J Adema; Otto C Boerman; Sandra Croockewit; Annemiek J de Boer; I Jolanda M De Vries; J F M Jacobs; Annechien J A Lambeck; Carl G Figdor
Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(17):5725-35.
2011: Ingrid S Zeelenberg; Sebastian Amigorena; Alexandre Boissonnas; Martijn H M G M den Brok; Carl G Figdor; Eric J R Jansen; Clotilde Théry; Alie van der Schaaf; Maaike A Van Hout-Kuijer; Wendy W C van Maren; Jori A L Wagenaars; Gosse J Adema
Antigen localization controls T cell-mediated tumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1281-8.
2011: Ingrid M E Desar; Christina A Hulsbergen-vandeKaa; Wim J G Oyen; Peter F A Mulders; Winette T A van der Graaf; Gosse J Adema; Carla M L van Herpen; J F M Jacobs; I Jolanda M De Vries
Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients.
International journal of cancer. Journal international du cancer 2011;129(2):507-12.
2011: Jurjen Tel; Daniel Benitez-Ribas; Sander Hoosemans; Alessandra Cambi; Gosse J Adema; Carl G Figdor; Paul J Tacken; I Jolanda M De Vries
DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.
European journal of immunology 2011;41(4):1014-23.
2011: Theo S Plantinga; Wendy W C van Maren; Jeroen van Bergenhenegouwen; Marjolijn Hameetman; Stefan Nierkens; Cor Jacobs; Dirk J de Jong; Leo A B Joosten; Belinda van't Land; Johan Garssen; Gosse J Adema; Mihai G Netea
Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics.
Clinical and vaccine immunology : CVI 2011;18(4):621-8.
2011: I Jolanda M De Vries; Chiara Castelli; Caroline Huygens; Joannes F M Jacobs; Julie Stockis; Beatrice Schuler-Thurner; Gosse J Adema; Cornelis J A Punt; Licia Rivoltini; Gerold Schuler; Pierre G Coulie; Sophie Lucas
Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(4):841-8.
2011: W Joost Lesterhuis; Gerty Schreibelt; Nicole M Scharenborg; H Mary-lène H Brouwer; M J P Gerritsen; Sandra Croockewit; Pierre G Coulie; Ruurd Torensma; Gosse J Adema; Carl G Figdor; I Jolanda M De Vries; Cornelis J A Punt
Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.
Cancer immunology, immunotherapy : CII 2011;60(2):249-60.
2011: Marije Oosting; Patrick Sturm; Hadewych J M ter Hofstede; Jos W M van der Meer; Gosse J Adema; Bart Jan Kullberg; Mihai G Netea; Leo A B Joosten
TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.
PloS one 2011;6(10):e25998.
2011: Anna Sanecka; Kathrin Warner; Marleen Ansems; Katharina Danielski; Martijn H den Brok; Dagmar Eleveld-Trancikova; Bastiaan Jan Herman Jansen; Amy C Prosser; Gosse J Adema
DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells.
BMC immunology 2011;12():57.
2011: Wendy W C van Maren; Stefan Nierkens; Liza W Toonen; Judith M Bolscher; Roger P M Sutmuller; Gosse J Adema
Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation.
BMC immunology 2011;12():23.
2010: W Joost Lesterhuis; I Jolanda M De Vries; Gerty Schreibelt; Danita Schuurhuis; Erik H Aarntzen; Annemiek De Boer; Nicole M Scharenborg; Mandy W M M van de Rakt; Erik J Hesselink; Carl G Figdor; Gosse J Adema; Cornelis J A Punt
Immunogenicity of dendritic cells pulsed with CEA peptide or transfected with CEA mRNA for vaccination of colorectal cancer patients.
Anticancer research 2010;30(12):5091-7.
2010: W Joost Lesterhuis; I J M de Vries; E A Aarntzen; A de Boer; Nicole M Scharenborg; Mandy W M M van de Rakt; Dick Johan van Spronsen; F W Preijers; Carl G Figdor; Gosse J Adema; Cornelis J A Punt
A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatin/capecitabine chemotherapy in colon cancer patients.
British journal of cancer 2010;103(9):1415-21.
2010: Joannes F M Jacobs; Cornelis J A Punt; W Joost Lesterhuis; Roger P M Sutmuller; H Mary-Lène H Brouwer; Nicole M Scharenborg; Ina S Klasen; Luuk B Hilbrands; Carl G Figdor; I Jolanda M De Vries; Gosse J Adema
Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(20):5067-78.
2010: Gerty Schreibelt; Jurjen Tel; Kwinten H E W J Sliepen; Daniel Benitez-Ribas; Carl G Figdor; Gosse J Adema; I Jolanda M De Vries
Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2010;59(10):1573-82.
2010: J F M Jacobs; Albert J Idema; Kalijn F Bol; J André Grotenhuis; I Jolanda M De Vries; Pieter Wesseling; Gosse J Adema
Prognostic significance and mechanism of Treg infiltration in human brain tumors.
Journal of neuroimmunology 2010;225(1-2):195-9.
2010: Gerty Schreibelt; Daniel Benitez-Ribas; Danita Schuurhuis; Annechien J A Lambeck; Maaike van Hout-Kuijer; Niels Schaft; Cornelis J A Punt; Carl G Figdor; Gosse J Adema; I Jolanda M De Vries
Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells.
Blood 2010;116(4):564-74.
2010: Dagmar Eleveld-Trancikova; Anna Sanecka; Maaike A van Hout-Kuijer; Maaike W G Looman; Ilona A M Hendriks; Bastiaan Jan Herman Jansen; Gosse J Adema
DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.
Molecular immunology 2010;47(11-12):1963-73.
2010: Robbert van der Voort; Viviènne Verweij; Theo M de Witte; Edwin Lasonder; Gosse J Adema; Harry Dolstra
An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.
Journal of leukocyte biology 2010;87(6):1029-39.
2010: Aneta M Schaap-Oziemlak; Reinier A P Raymakers; Saskia M Bergevoet; Christian Gilissen; Bastiaan Jan Herman Jansen; Gosse J Adema; Gesine Kögler; Carlos le Sage; Reuven Agami; Bert A van der Reijden; Joop H Jansen
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells.
Stem cells and development 2010;19(6):877-85.
2010: Barbara M Schulte; Matthijs Kramer; Marleen Ansems; Kjerstin H W Lanke; Neeltje van Doremalen; Jon D Piganelli; Rita Bottino; Massimo Trucco; Jochem M D Galama; Gosse J Adema; Frank J M van Kuppeveld
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.
Diabetes 2010;59(5):1182-91.
2010: Bastiaan Jan Herman Jansen; Christian Gilissen; Helene Roelofs; Aneta Schaap-Oziemlak; Joris Veltman; Reinier A P Raymakers; Joop H Jansen; Gesine Kögler; Carl G Figdor; Ruurd Torensma; Gosse J Adema
Functional differences between mesenchymal stem cell populations are reflected by their transcriptome.
Stem cells and development 2010;19(4):481-90.
2010: Barbara M Schulte; Judith Bakkers; Kjerstin H W Lanke; Willem J G Melchers; Ciska Westerlaken; Wil Allebes; Henk-Jan Aanstoot; G Jan Bruining; Gosse J Adema; Frank J M van Kuppeveld; Jochem M D Galama
Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection.
Viral immunology 2010;23(1):99-104.
2010: Lieke C J van den Berk; Bastiaan Jan Herman Jansen; Kim G C Siebers-Vermeulen; Helene Roelofs; Carl G Figdor; Gosse J Adema; Ruurd Torensma
Mesenchymal stem cells respond to TNF but do not produce TNF.
Journal of leukocyte biology 2010;87(2):283-9.
2010: M Ansems; S Hontelez; M W G Looman; N Karthaus; Peter Bult; J J Han Bonenkamp; J H Jansen; F C G J Sweep; Paul Span; Gosse J Adema
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
Journal of the National Cancer Institute 2010;102(1):54-68.
2010: Anieta M Sieuwerts; Marleen Ansems; Maxime P Look; Paul Span; Vanja de Weerd; Anne van Galen; John A Foekens; Gosse J Adema; John Martens
Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study.
Breast cancer research : BCR 2010;12(6):R103.
2010: Justin H Fransen; Johan van der Vlag; Jurjen Ruben; Gosse J Adema; Jo H Berden; Luuk B Hilbrands
The role of dendritic cells in the pathogenesis of systemic lupus erythematosus.
Arthritis research & therapy 2010;12(2):207.
2010: Matthijs Kramer; Barbara M Schulte; Dagmar Eleveld-Trancikova; Maaike van Hout-Kuijer; Liza W J Toonen; Jurjen Tel; I Jolanda M De Vries; Frank J M van Kuppeveld; Bastiaan Jan Herman Jansen; Gosse J Adema
Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection.
Journal of innate immunity 2010;2(4):360-70.
2009: Bart Ferwerda; Gerben Ferwerda; Theo S Plantinga; Janet A Willment; Annemiek B van Spriel; Hanka Venselaar; Clara C Elbers; Melissa D Johnson; Alessandra Cambi; Cristal Huysamen; Liesbeth Jacobs; Trees Jansen; Karlijn Verheijen; Laury Masthoff; Servaas A Morré; Gert Vriend; David L Williams; John R Perfect; Leo A B Joosten; Cisca Wijmenga; Jos W M van der Meer; Gosse J Adema; Bart Jan Kullberg; Gordon D Brown; Mihai G Netea
Human dectin-1 deficiency and mucocutaneous fungal infections.
The New England journal of medicine 2009;361(18):1760-7.
2009: Oliver Grauer; Pieter Wesseling; Gosse J Adema
Immunotherapy of diffuse gliomas: biological background, current status and future developments.
Brain pathology (Zurich, Switzerland) 2009;19(4):674-93.
2009: Pieter Wesseling; Gosse J Adema
Immunotherapy of diffuse gliomas: helping the brain fight back!
Brain pathology (Zurich, Switzerland) 2009;19(4):672-3.
2009: Mark Wenink; Kim C M Santegoets; Mieke F Roelofs; Richard Huijbens; Hans J P M Koenen; Ronald van Beek; Irma Joosten; Friederike Meyer-Wentrup; Linda Mathsson; Johan Ronnelid; Gosse J Adema; Ezio Bonvini; Scott Koenig; Wim B van den Berg; Piet L C M van Riel; Timothy R D J Radstake
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4509-20.
2009: Lieke C J van den Berk; Bastiaan Jan Herman Jansen; Kim G C Siebers-Vermeulen; Mihai G Netea; Talia Latuhihin; Saskia Bergevoet; Reinier A Raymakers; Gesine Kögler; Carl C Figdor; Gosse J Adema; Ruurd Torensma
Toll-like receptor triggering in cord blood mesenchymal stem cells.
Journal of cellular and molecular medicine 2009;13(9B):3415-26.
2009: Justin H Fransen; Luuk B Hilbrands; Jurjen Ruben; Monique Stoffels; Gosse J Adema; Johan Van der Vlag; Jo H Berden
Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17.
Arthritis and rheumatism 2009;60(8):2304-13.
2009: J F M Jacobs; Albert J Idema; Kalijn F Bol; Stefan Nierkens; Oliver Grauer; Pieter Wesseling; J André Grotenhuis; Peter M Hoogerbrugge; I Jolanda M De Vries; Gosse J Adema
Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.
Neuro-oncology 2009;11(4):394-402.
2009: Danita Schuurhuis; W Joost Lesterhuis; Matthijs Kramer; Maaike G M Looman; Maaike van Hout-Kuijer; Gerty Schreibelt; A C Inge Boullart; E H J G Aarntzen; Daniel Benitez-Ribas; Carl G Figdor; Cornelis J A Punt; I Jolanda M De Vries; Gosse J Adema
Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells.
Cancer immunology, immunotherapy : CII 2009;58(7):1109-15.
2009: J F M Jacobs; Pierre G Coulie; Carl G Figdor; Gosse J Adema; I Jolanda M De Vries; Peter M Hoogerbrugge
Targets for active immunotherapy against pediatric solid tumors.
Cancer immunology, immunotherapy : CII 2009;58(6):831-41.
2009: Antoine W T van Lieshout; Robbert van der Voort; L W J Toonen; S F G van Helden; Carl G Figdor; P L C M van Riel; T R D J Radstake; Gosse J Adema
Regulation of CXCL16 expression and secretion by myeloid cells is not altered in rheumatoid arthritis.
Annals of the rheumatic diseases 2009;68(6):1036-43.
2009: Danita Schuurhuis; Pauline Verdijk; Gerty Schreibelt; Erik H J G Aarntzen; Nicole M Scharenborg; Annemiek de Boer; Mandy W M M van de Rakt; Marieke Kerkhoff; Marie-Jeanne P Gerritsen; Femke Eijckeler; Johannes J Bonenkamp; Willeke Blokx; J Han van Krieken; Otto Boerman; Wim J G Oyen; Cornelis J A Punt; Carl G Figdor; Gosse J Adema; I Jolanda M De Vries
In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.
Cancer research 2009;69(7):2927-34.
2009: Pauline Verdijk; Erik H J G Aarntzen; W Joost Lesterhuis; A C Inge Boullart; Ellemieke Kok; Michelle M van Rossum; Simon Strijk; Femke Eijckeler; Johannes J Bonenkamp; Joannes F M Jacobs; Willeke Blokx; J Han J M Vankrieken; Irma Joosten; Otto Boerman; Wim J G Oyen; Gosse J Adema; Cornelis J A Punt; Carl G Figdor; I Jolanda M De Vries
Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2531-40.
2009: Annemiek van Spriel; Mariam Sofi; Kate H Gartlan; Alie van der Schaaf; Ineke Verschueren; Ruurd Torensma; Reinier A P Raymakers; Bruce E Loveland; Mihai G Netea; Gosse J Adema; Mark D Wright; Carl G Figdor
The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
PLoS pathogens 2009;5(3):e1000338.
2009: Friederike Meyer-Wentrup; Alessandra Cambi; Ben Joosten; Maaike W Looman; I Jolanda M De Vries; Carl G Figdor; Gosse J Adema
DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.
Journal of leukocyte biology 2009;85(3):518-25.
2009: Gosse J Adema
Dendritic cells from bench to bedside and back.
Immunology letters 2009;122(2):128-30.
2009: Bastiaan Jan Herman Jansen; Dagmar Eleveld-Trancikova; Anna Sanecka; Maaike van Hout-Kuijer; Ilona A M Hendriks; Maaike G W Looman; Jeanette Leusen; Gosse J Adema
OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.
Molecular immunology 2009;46(4):505-15.
2009: Stefan Nierkens; Martijn H den Brok; Thijs Roelofsen; Jori A L Wagenaars; Carl G Figdor; Theo J Ruers; Gosse J Adema
Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice.
PloS one 2009;4(12):e8368.
2009: J F M Jacobs; Hans van Bokhoven; Frank N Van Leeuwen; Christina A Hulsbergen-van de Kaa; I Jolanda M De Vries; Gosse J Adema; Peter M Hoogerbrugge; Arjan de Brouwer
Regulation of MYCN expression in human neuroblastoma cells.
BMC cancer 2009;9():239.
2009: Joannes F M Jacobs; E H J G Aarntzen; Lenny A G Sibelt; Willeke A Blokx; Anna C I Boullart; M J P Gerritsen; Peter M Hoogerbrugge; Carl G Figdor; Gosse J Adema; Cornelis J A Punt; I Jolanda M De Vries
Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.
Cancer immunology, immunotherapy : CII 2009;58(1):145-51.
2008: Oliver Grauer; Johan Molling; Erik Bennink; Liza W J Toonen; Roger P M Sutmuller; Stefan Nierkens; Gosse J Adema
TLR ligands in the local treatment of established intracerebral murine gliomas.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6720-9.
2008: Carla M L van Herpen; Robbert van der Voort; Jeroen A W M van der Laak; Ina S Klasen; Aniek O de Graaf; Léon C L van Kempen; I Jolanda M De Vries; Tjitske Duiveman-de Boer; Harry Dolstra; Ruurd Torensma; J H J M van Krieken; Gosse J Adema; P H M De Mulder
Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation.
International journal of cancer. Journal international du cancer 2008;123(10):2354-61.
2008: A C Inge Boullart; E H J G Aarntzen; Pauline Verdijk; Joannes F M Jacobs; Danita Schuurhuis; Daniel Benitez-Ribas; Gerty Schreibelt; Mandy W M M van de Rakt; Nicole M Scharenborg; Annemiek de Boer; Matthijs Kramer; Carl G Figdor; Cornelis J A Punt; Gosse J Adema; I Jolanda M De Vries
Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.
Cancer immunology, immunotherapy : CII 2008;57(11):1589-97.
2008: E H J G Aarntzen; Carl G Figdor; Gosse J Adema; Cornelis J A Punt; I Jolanda M De Vries
Dendritic cell vaccination and immune monitoring.
Cancer immunology, immunotherapy : CII 2008;57(10):1559-68.
2008: Gerben Ferwerda; Friederike Meyer-Wentrup; Bart Jan Kullberg; Mihai G Netea; Gosse J Adema
Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages.
Cellular microbiology 2008;10(10):2058-66.
2008: Wendy W C van Maren; J F M Jacobs; I Jolanda M De Vries; Stefan Nierkens; Gosse J Adema
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
Immunology 2008;124(4):445-52.
2008: Stefan Nierkens; Martijn H M G M den Brok; Roger P M Sutmuller; Oliver M Grauer; Erik J Bennink; Mary E Morgan; Carl G Figdor; T J M Ruers; Gosse J Adema
In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.
Cancer research 2008;68(13):5390-6.
2008: Joannes F M Jacobs; Oliver Grauer; Francis Brasseur; Peter M Hoogerbrugge; Pieter Wesseling; Corrie E Gidding; Mandy W M M van de Rakt; Carl G Figdor; Pierre G Coulie; I Jolanda M De Vries; Gosse J Adema
Selective cancer-germline gene expression in pediatric brain tumors.
Journal of neuro-oncology 2008;88(3):273-80.
2008: Paul J Tacken; Ben Joosten; Anita Reddy; Dayang Wu; Annemarie Eek; Peter Laverman; Anke Kretz-Rommel; Gosse J Adema; Ruurd Torensma; Carl G Figdor
No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7687-96.
2008: W Joost Lesterhuis; E H J G Aarntzen; I J M De Vries; Danita Schuurhuis; Carl G Figdor; Gosse J Adema; Cornelis J A Punt
Dendritic cell vaccines in melanoma: from promise to proof?
Critical reviews in oncology/hematology 2008;66(2):118-34.
2008: Friederike Meyer-Wentrup; Daniel Benitez-Ribas; Paul J Tacken; Cornelis J A Punt; Carl G Figdor; I Jolanda M De Vries; Gosse J Adema
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.
Blood 2008;111(8):4245-53.
2008: Oliver Grauer; Roger P M Sutmuller; Wendy van Maren; J F M Jacobs; Erik J Bennink; Liza W J Toonen; Stefan Nierkens; Gosse J Adema
Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.
International journal of cancer. Journal international du cancer 2008;122(8):1794-802.
2008: Matthijs Kramer; Barbara M Schulte; Liza W J Toonen; Paola M Barral; Paul B Fisher; Kjerstin H W Lanke; Jochem M D Galama; Frank J M van Kuppeveld; Gosse J Adema
Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells.
Journal of virology 2008;82(6):2930-7.
2008: Kevin M Dennehy; Gerben Ferwerda; Inês Faro-Trindade; Elwira Pyz; Janet A Willment; Philip R Taylor; Ann Kerrigan; S Vicky Tsoni; Siamon Gordon; Friederike Meyer-Wentrup; Gosse J Adema; Bart Jan Kullberg; Edina Schweighoffer; Victor L J Tybulewicz; Hector Mora-Montes; Neil A R Gow; David L Williams; Mihai G Netea; Gordon D Brown
Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
European journal of immunology 2008;38(2):500-6.
2008: Gerben Ferwerda; Matthijs Kramer; Dirk de Jong; Alessandra Piccini; Leo A B Joosten; Isabel Devesaginer; Stephen E Girardin; Gosse J Adema; Jos W M van der Meer; Bart Jan Kullberg; Anna Rubartelli; Mihai G Netea
Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta.
European journal of immunology 2008;38(1):184-91.
2007: J F M Jacobs; Peter M Hoogerbrugge; Mandy W M M van de Rakt; Erik H J G Aarntzen; Carl G Figdor; Gosse J Adema; I Jolanda M De Vries
Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients.
Pediatric blood & cancer 2007;49(7):924-7.
2007: Roger P M Sutmuller; Anja Garritsen; Gosse J Adema
Regulatory T cells and toll-like receptors: regulating the regulators.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii91-5.
2007: Cândida F Pereira; Ruurd Torensma; Konnie Hebeda; Anke Kretz-Rommel; Susan J Faas; Carl G Figdor; Gosse J Adema
In vivo targeting of DC-SIGN-positive antigen-presenting cells in a nonhuman primate model.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(7):705-14.
2007: I Jolanda M De Vries; Monique R Bernsen; Winny L Van Geloof; Nicole M Scharenborg; W Joost Lesterhuis; P D M Rombout; Goos N P van Muijen; Carl G Figdor; Cornelis J A Punt; Dirk J Ruiter; Gosse J Adema
In situ detection of antigen-specific T cells in cryo-sections using MHC class I tetramers after dendritic cell vaccination of melanoma patients.
Cancer immunology, immunotherapy : CII 2007;56(10):1667-76.
2007: Selina Khan; Martijn Bijker; Jimmy J Weterings; Hans J Tanke; Gosse J Adema; Thorbald van Hall; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Sjoerd H van der burg; Ferry Ossendorp
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
The Journal of biological chemistry 2007;282(29):21145-59.
2007: Oliver Grauer; Stefan Nierkens; Erik J Bennink; Liza W J Toonen; Louis Boon; Pieter Wesseling; Roger P M Sutmuller; Gosse J Adema
CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.
International journal of cancer. Journal international du cancer 2007;121(1):95-105.
2007: Matthijs Kramer; Barbara M Schulte; Liza W J Toonen; Mike A M de Bruijni; Jochem M D Galama; Gosse J Adema; Frank J M van Kuppeveld
Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells.
Cellular microbiology 2007;9(6):1507-18.
2007: Antoine W T van Lieshout; Calin Popa; Friederike Meyer-Wentrup; H L M Lemmers; Anton F H Stalenhoef; Gosse J Adema; P L C M van Riel; Lambertus J H Van Tits; Timothy Radstake
Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis.
Biochemical and biophysical research communications 2007;355(2):392-7.
2007: Oliver Grauer; Peter Pöschl; Annette Lohmeier; Gosse J Adema; Ulrich Bogdahn
Toll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2.
Journal of neuro-oncology 2007;82(2):151-61.
2007: Friederike Meyer-Wentrup; Carl G Figdor; Marleen Ansems; Peter Brossart; Mark D Wright; Gosse J Adema; Annemiek van Spriel
Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):154-62.
2007: J F M Jacobs; Francis Brasseur; Christina A Hulsbergen-van de Kaa; Mandy W M M van de Rakt; Carl G Figdor; Gosse J Adema; Peter M Hoogerbrugge; Pierre G Coulie; I Jolanda M De Vries
Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.
International journal of cancer. Journal international du cancer 2007;120(1):67-74.
2006: Martijn H M G M den Brok; Roger P M Sutmuller; Stefan Nierkens; Erik J Bennink; Cathelijne Frielink; Liza W J Toonen; Otto Boerman; Carl G Figdor; T J M Ruers; Gosse J Adema
Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity.
British journal of cancer 2006;95(7):896-905.
2006: Roger P M Sutmuller; Mary Morgan; Mihai G Netea; Oliver Grauer; Gosse J Adema
Toll-like receptors on regulatory T cells: expanding immune regulation.
Trends in immunology 2006;27(8):387-93.
2006: Martijn H M G M den Brok; Roger P M Sutmuller; Stefan Nierkens; Erik J Bennink; Liza W J Toonen; Carl G Figdor; T J M Ruers; Gosse J Adema
Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine.
Cancer research 2006;66(14):7285-92.
2006: Daniel Benitez-Ribas; Gosse J Adema; Gregor Winkels; Ina S Klasen; Cornelis J A Punt; Carl G Figdor; I Jolanda M De Vries
Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake.
The Journal of experimental medicine 2006;203(7):1629-35.
2006: W Joost Lesterhuis; I Jolanda M De Vries; Danita Schuurhuis; A C I Boullart; J F M Jacobs; Annemiek J de Boer; Nicole M Scharenborg; H M H Brouwer; Mandy W M M van de Rakt; Carl G Figdor; T J M Ruers; Gosse J Adema; Cornelis J A Punt
Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(6):974-80.
2006: Peter M Emmer; Johan Van der Vlag; Gosse J Adema; Luuk B Hilbrands
Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness.
Transplantation 2006;81(10):1451-9.
2006: Peter Laverman; I Jolanda M De Vries; Nicole M Scharenborg; Annemiek de Boer; Matthias Broekema; Wim J G Oyen; Carl G Figdor; Gosse J Adema; Otto Boerman
Development of 111In-labeled tumor-associated antigen peptides for monitoring dendritic-cell-based vaccination.
Nuclear medicine and biology 2006;33(4):453-8.
2006: Vassilis Triantis; Veronique Moulin; Maaike W G Looman; Franca C Hartgers; Richard A J Janssen; Gosse J Adema
Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT.
Journal of leukocyte biology 2006;79(5):1083-91.
2006: Linda M P le Blanc; Antoine W T van Lieshout; Gosse J Adema; P L C M van Riel; Marcel M Verbeek; Timothy Radstake
CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement.
Neuroscience letters 2006;397(1-2):145-8.
2006: Matthijs Kramer; Mihai G Netea; Dirk J de Jong; Bart Jan Kullberg; Gosse J Adema
Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation.
Journal of leukocyte biology 2006;79(4):860-6.
2006: Roger P M Sutmuller; Martijn H M G M den Brok; Matthijs Kramer; Erik J Bennink; Liza W J Toonen; Bart Jan Kullberg; Leo A B Joosten; Shizuo Akira; Mihai G Netea; Gosse J Adema
Toll-like receptor 2 controls expansion and function of regulatory T cells.
The Journal of clinical investigation 2006;116(2):485-94.
2006: Vassilis Triantis; Dagmar Eleveld-Trancikova; Maaike W G Looman; Franca C Hartgers; Richard A J Janssen; Gosse J Adema
Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):1081-9.
2006: Antoine W T van Lieshout; Robbert van der Voort; Linda M P le Blanc; Mieke F Roelofs; B Willem Schreurs; P L C M van Riel; Gosse J Adema; Timothy Radstake
Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid.
BMC immunology 2006;7():23.
2005: Gerben Ferwerda; Stephen E Girardin; Bart Jan Kullberg; Lionel Le Bourhis; Dirk J de Jong; Dennis M L Langenberg; Reinout van Crevel; Gosse J Adema; Tom H M Ottenhoff; Jos W M van der Meer; Mihai G Netea
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.
PLoS pathogens 2005;1(3):279-85.
2005: I Jolanda M De Vries; W Joost Lesterhuis; Jelle O Barentsz; Pauline Verdijk; J H J M van Krieken; Otto Boerman; Wim J G Oyen; Johannes J Bonenkamp; Jan B M Boezeman; Gosse J Adema; Jeff W M Bulte; Tom W J Scheenen; Cornelis J A Punt; Arend Heerschap; Carl G Figdor
Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.
Nature biotechnology 2005;23(11):1407-13.
2005: Timothy Radstake; Antoine W T van Lieshout; P L C M van Riel; Wim B van den Berg; Gosse J Adema
Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(11):1532-8.
2005: Martijn H M G M den Brok; Stefan Nierkens; Carl G Figdor; T J M Ruers; Gosse J Adema
Dendritic cells: tools and targets for antitumor vaccination.
Expert review of vaccines 2005;4(5):699-710.
2005: Mihai G Netea; Jos W M van der Meer; Roger P M Sutmuller; Gosse J Adema; Bart Jan Kullberg
From the Th1/Th2 paradigm towards a Toll-like receptor/T-helper bias.
Antimicrobial agents and chemotherapy 2005;49(10):3991-6.
2005: I Jolanda M De Vries; Monique R Bernsen; W Joost Lesterhuis; Nicole M Scharenborg; Simon P Strijk; M J P Gerritsen; Dirk J Ruiter; Carl G Figdor; Cornelis J A Punt; Gosse J Adema
Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5779-87.
2005: Paul J Tacken; I Jolanda M De Vries; Karlijn Gijzen; Ben Joosten; Dayang Wu; Russell P Rother; Susan J Faas; Cornelis J A Punt; Ruurd Torensma; Gosse J Adema; Carl G Figdor
Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.
Blood 2005;106(4):1278-85.
2005: Ferry Ossendorp; Nathalie Fu; Marcel Camps; Francesca Granucci; Sam J P Gobin; Peter J van den Elsen; Danita Schuurhuis; Gosse J Adema; Grayson Lipford; Tomoki Chiba; Alice J A M Sijts; Peter-M Kloetzel; Paola Ricciardi-Castagnoli; Cornelis J M Melief
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7815-22.
2005: Mihai G Netea; Gerben Ferwerda; Dirk J de Jong; Trees Jansen; Liesbeth Jacobs; Matthijs Kramer; Ton H J Naber; Joost P H Drenth; Stephen E Girardin; Bart Jan Kullberg; Gosse J Adema; Jos W M van der Meer
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6518-23.
2005: Robbert van der Voort; Antoine W T van Lieshout; Liza W J Toonen; Annet W Slöetjes; Wim B van den Berg; Carl G Figdor; Timothy Radstake; Gosse J Adema
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints.
Arthritis and rheumatism 2005;52(5):1381-91.
2005: Robbert van der Voort; Matthijs Kramer; Ernst Lindhout; Ruurd Torensma; Dagmar Eleveld-Trancikova; Antoine W T van Lieshout; Maaike W G Looman; T J M Ruers; Timothy Radstake; Carl G Figdor; Gosse J Adema
Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions.
Journal of leukocyte biology 2005;77(5):739-47.
2005: Friederike Meyer-Wentrup; Alessandra Cambi; Gosse J Adema; Carl G Figdor
"Sweet talk": closing in on C type lectin signaling.
Immunity 2005;22(4):399-400.
2005: Gosse J Adema; I Jolanda M De Vries; Cornelis J A Punt; Carl G Figdor
Migration of dendritic cell based cancer vaccines: in vivo veritas?
Current opinion in immunology 2005;17(2):170-4.
2005: C M L van Herpen; Johan Bussink; Albert J van der Kogel; Wenny J M Peeters; Robbert van der Voort; Anita van Schijndel; Peter C M de Wilde; Gosse J Adema; P H M De Mulder
Interleukin-12 has no effect on vascular density, perfusion, hypoxia and proliferation of an implanted human squamous cell carcinoma xenograft tumour despite up-regulation of ICAM-1.
Anticancer research 2005;25(2A):1015-21.
2005: C M L van Herpen; Jeroen A W M van der Laak; I Jolanda M De Vries; J H J M van Krieken; Peter C M de Wilde; Michiel G J Balvers; Gosse J Adema; P H M De Mulder
Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1899-909.
2005: Dagmar Eleveld-Trancikova; Vassilis Triantis; Veronique Moulin; Maaike W G Looman; Mietske Wijers; Jack Fransen; Angelique A C Lemckert; Menzo J E Havenga; Carl G Figdor; Richard A J Janssen; Gosse J Adema
The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum.
Journal of leukocyte biology 2005;77(3):337-43.
2005: Timothy Radstake; Robbert van der Voort; M ten Brummelhuis; Maarten C de Waal Malefijt; Maaike W G Looman; Carl G Figdor; Wim B van den Berg; Pilar Barrera; Gosse J Adema
Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors.
Annals of the rheumatic diseases 2005;64(3):359-67.
2005: I Jolanda M De Vries; Gosse J Adema; Cornelis J A Punt; Carl G Figdor
Phenotypical and functional characterization of clinical-grade dendritic cells.
Methods in molecular medicine 2005;109():113-26.
2004: Timothy Radstake; Arjen B Blom; Annet W Slöetjes; E O F van Gorselen; Gerard J Pesman; Linda P H Engelen; Ruurd Torensma; Wim B van den Berg; Carl G Figdor; P L E M van Lent; Gosse J Adema; Pilar Barrera
Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(12):1556-63.
2004: Derick G Wansink; Wilma Peters; Iris Schaafsma; Roger P M Sutmuller; Frank Oerlemans; Gosse J Adema; Bé Wieringa; Catharina E E M van der Zee; Wiljan Hendriks
Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity.
Physiological genomics 2004;19(1):50-60.
2004: Martijn H M G M den Brok; Roger P M Sutmuller; Robbert van der Voort; Erik J Bennink; Carl G Figdor; T J M Ruers; Gosse J Adema
In situ tumor ablation creates an antigen source for the generation of antitumor immunity.
Cancer research 2004;64(11):4024-9.
2004: Timothy Radstake; P L E M van Lent; Gerard J Pesman; Arjen B Blom; Fred G J Sweep; J Rönnelid; Gosse J Adema; Pilar Barrera; Wim B van den Berg
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.
Annals of the rheumatic diseases 2004;63(6):696-702.
2004: Jaina Leitch; Katie Fraser; Cecilia Lane; Kelley Putzu; Gosse J Adema; Qian-Jin Zhang; Wilfred A Jefferies; Jonathan Bramson; Yonghong Wan
CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5200-5.
2004: C M L van Herpen; Maaike W G Looman; Marijke Zonneveld; Nicole M Scharenborg; Peter C M de Wilde; Louis van de Locht; M A W Merkx; Gosse J Adema; P H M De Mulder
Intratumoral administration of recombinant human interleukin 12 in head and neck squamous cell carcinoma patients elicits a T-helper 1 profile in the locoregional lymph nodes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2626-35.
2004: Mihai G Netea; Roger P M Sutmuller; Corinna Hermann; Chantal A A Van Der Graaf; Jos W M van der Meer; J H J M van Krieken; Thomas Hartung; Gosse J Adema; Bart Jan Kullberg
Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3712-8.
2004: Nathalie Chaput; Noël Emile Célestin Schartz; Fabrice André; Julien Taïeb; Sophie Novault; Pierre Bonnaventure; Nathalie Aubert; Jacky Bernard; François Lemonnier; Miriam Merad; Gosse J Adema; Malcolm Adams; Maria Ferrantini; Antoine F Carpentier; Bernard Escudier; Thomas Tursz; Eric Angevin; Laurence Zitvogel
Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2137-46.
2004: W Joost Lesterhuis; I Jolanda M De Vries; Gosse J Adema; Cornelis J A Punt
Dendritic cell-based vaccines in cancer immunotherapy: an update on clinical and immunological results.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15 Suppl 4():iv145-51.
2004: Monique R Bernsen; J H S Diepstra; Patrick van Mil; Cornelis J A Punt; Carl G Figdor; Goos N P van Muijen; Gosse J Adema; Dirk J Ruiter
Presence and localization of T-cell subsets in relation to melanocyte differentiation antigen expression and tumour regression as assessed by immunohistochemistry and molecular analysis of microdissected T cells.
The Journal of pathology 2004;202(1):70-9.
2003: Sergei M Danilov; Elena Sadovnikova; Nicole M Scharenborg; Irina V Balyasnikova; Daria Svinareva; Elena L Semikina; Elena N Parovichnikova; Valerii G Savchenko; Gosse J Adema
Angiotensin-converting enzyme (CD143) is abundantly expressed by dendritic cells and discriminates human monocyte-derived dendritic cells from acute myeloid leukemia-derived dendritic cells.
Experimental hematology 2003;31(12):1301-9.
2003: I Jolanda M De Vries; W Joost Lesterhuis; Nicole M Scharenborg; Linda P H Engelen; Dirk J Ruiter; M J P Gerritsen; Sandra Croockewit; Cedrik Michael Britten; Ruurd Torensma; Gosse J Adema; Carl G Figdor; Cornelis J A Punt
Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5091-100.
2003: Andreas A O Eggert; Robbert van der Voort; Ruurd Torensma; Veronique Moulin; Otto Boerman; Wim J G Oyen; Cornelis J A Punt; Heleen Diepstra; Annemiek J de Boer; Carl G Figdor; Gosse J Adema
Analysis of dendritic cell trafficking using EGFP-transgenic mice.
Immunology letters 2003;89(1):17-24.
2003: Frank A D T G Wagener; Hans-Dieter Volk; Dean Willis; Nader G Abraham; Miguel P Soares; Gosse J Adema; Carl G Figdor
Different faces of the heme-heme oxygenase system in inflammation.
Pharmacological reviews 2003;55(3):551-71.
2003: C M L van Herpen; Richard Huijbens; Maaike W G Looman; Jolanda De Vries; Henri Marres; Johanna Van De Ven; Rob Hermsen; Gosse J Adema; P H M De Mulder
Pharmacokinetics and immunological aspects of a phase Ib study with intratumoral administration of recombinant human interleukin-12 in patients with head and neck squamous cell carcinoma: a decrease of T-bet in peripheral blood mononuclear cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):2950-6.
2003: Frank A D T G Wagener; Hugo Beurden van; Johannes W Von Den Hoff; Gosse J Adema; Carl G Figdor
The heme-heme oxygenase system: a molecular switch in wound healing.
Blood 2003;102(2):521-8.
2003: Helmut Jonuleit; Gosse J Adema; Edgar Schmitt
Immune regulation by regulatory T cells: implications for transplantation.
Transplant immunology 2003;11(3-4):267-76.
2003: Cornelis Kramers; Gosse J Adema; M Korte; jaap deinum
[Familial hyperactivity of angiotensin-converting enzyme (ACE)].
Nederlands tijdschrift voor geneeskunde 2003;147(11):507-10.
2003: Niels Schaft; Ralph A Willemsen; Jolanda de Vries; Birgit Lankiewicz; Bram W L Essers; Jan W Gratama; Carl G Figdor; Reinder L H Bolhuis; Reno Debets; Gosse J Adema
Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2186-94.
2003: Alessandra Cambi; Karlijn Gijzen; l Jolanda M de Vries; Ruurd Torensma; Ben Joosten; Gosse J Adema; Mihai G Netea; Bart Jan Kullberg; Luigina Romani; Carl G Figdor
The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.
European journal of immunology 2003;33(2):532-8.
2003: I Jolanda M De Vries; Daniëlle J E B Krooshoop; Nicole M Scharenborg; W Joost Lesterhuis; J H S Diepstra; Goos N P van Muijen; Simon P Strijk; T J M Ruers; Otto Boerman; Wim J G Oyen; Gosse J Adema; Cornelis J A Punt; Carl G Figdor
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state.
Cancer research 2003;63(1):12-7.
2002: Jeannette C Oosterwijk-Wakka; Dorien M Tiemessen; Ivar Bleumer; I Jolanda M De Vries; Wim Jongmans; Gosse J Adema; Frans M J Debruyne; P H M De Mulder; Egbert Oosterwijk; Peter F A Mulders
Vaccination of patients with metastatic renal cell carcinoma with autologous dendritic cells pulsed with autologous tumor antigens in combination with interleukin-2: a phase 1 study.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25(6):500-8.
2002: I Jolanda M De Vries; Andreas A O Eggert; Nicole M Scharenborg; Joost L M Vissers; W Joost Lesterhuis; Otto Boerman; Cornelis J A Punt; Gosse J Adema; Carl G Figdor
Phenotypical and functional characterization of clinical grade dendritic cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25(5):429-38.
2002: Joost L M Vissers; I Jolanda M De Vries; Linda P H Engelen; Nicole M Scharenborg; Janneke Molkenboer; Carl G Figdor; Egbert Oosterwijk; Gosse J Adema
Renal cell carcinoma-associated antigen G250 encodes a naturally processed epitope presented by human leukocyte antigen-DR molecules to CD4(+) T lymphocytes.
International journal of cancer. Journal international du cancer 2002;100(4):441-4.
2002: Carl G Figdor; Yvette van Kooyk; Gosse J Adema
C-type lectin receptors on dendritic cells and Langerhans cells.
Nature reviews. Immunology 2002;2(2):77-84.
2002: Björn Cochlovius; Marike J J G Stassar; Marco W Schreurs; Axel Benner; Gosse J Adema
Oral DNA vaccination: antigen uptake and presentation by dendritic cells elicits protective immunity.
Immunology letters 2002;80(2):89-96.
2001: Frank A D T G Wagener; A Eggert; Otto Boerman; W J Oyen; A Verhofstad; Nader G Abraham; Gosse J Adema; Yvette van Kooyk; Theo de Witte; Carl G Figdor
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase.
Blood 2001;98(6):1802-11.
2001: Cornelis Kramers; Sergei M Danilov; jaap deinum; Irina V Balyasnikova; Nicole M Scharenborg; Maaike W G Looman; F Boomsma; Marinus H de Keijzer; C.M. Duijn; S Martin; Florent Soubrier; Gosse J Adema
Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease.
Circulation 2001;104(11):1236-40.
2001: Joost L M Vissers; Franca C Hartgers; Ernst Lindhout; Carl G Figdor; Gosse J Adema
BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo.
European journal of immunology 2001;31(5):1544-9.
2001: Joost L M Vissers; Franca C Hartgers; Ernst Lindhout; M B Teunissen; Carl G Figdor; Gosse J Adema
Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo.
Journal of leukocyte biology 2001;69(5):785-93.
2001: Franca C Hartgers; Maaike W G Looman; B van der Woning; Gerard F M Merkx; Carl G Figdor; Gosse J Adema
Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene.
Immunogenetics 2001;53(2):145-9.
2001: Ernst Lindhout; Joost L M Vissers; Franca C Hartgers; Richard Huijbens; Nicole M Scharenborg; Carl G Figdor; Gosse J Adema
The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3284-9.
2000: Marco W Schreurs; Andreas A O Eggert; Annemiek J de Boer; Joost L M Vissers; Thorbald van Hall; Rienk Offringa; Carl G Figdor; Gosse J Adema
Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.
Cancer research 2000;60(24):6995-7001.
2000: Franca C Hartgers; Joost L M Vissers; Maaike W G Looman; C van Zoelen; C Huffine; Carl G Figdor; Gosse J Adema
DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells.
European journal of immunology 2000;30(12):3585-90.
2000: Franca C Hartgers; Carl G Figdor; Gosse J Adema
Towards a molecular understanding of dendritic cell immunobiology.
Immunology today 2000;21(11):542-5.
2000: Judith M D T Nelissen; Ruurd Torensma; M Pluyter; Gosse J Adema; Reinier A P Raymakers; Yvette van Kooyk; Carl G Figdor
Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS.
Experimental hematology 2000;28(4):422-32.
2000: Nuno R. dos Santos; Ruurd Torensma; Teun J de Vries; Marco W Schreurs; Diederik R H de Bruijn; Ellen Kater-Baats; D J Ruiter; Gosse J Adema; G N van Muijen; Ad Geurts van Kessel
Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.
Cancer research 2000;60(6):1654-62.
2000: Karin Grabmaier; Joost L M Vissers; Mirjam de Weijert; Jeannette C Oosterwijk-Wakka; A Van Bokhoven; R H Brakenhoff; E Noessner; P A Mulders; G Merkx; Carl G Figdor; Gosse J Adema; Egbert Oosterwijk
Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250.
International journal of cancer. Journal international du cancer 2000;85(6):865-70.
2000: Marco W Schreurs; A A Eggert; C J Punt; Carl G Figdor; Gosse J Adema
Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy.
Critical reviews in oncogenesis 2000;11(1):1-17.
1999: Cornelis J A Punt; I Jolanda M De Vries; Peter F A Mulders; Gosse J Adema; Carl G Figdor
[Immunology in medical practice. XXV. Use of dendritic cells in the immunotherapy of cancer].
Nederlands tijdschrift voor geneeskunde 1999;143(48):2408-14.
1999: Joost L M Vissers; I Jolanda M De Vries; Marco W Schreurs; Linda P H Engelen; Egbert Oosterwijk; Carl G Figdor; Gosse J Adema
The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes.
Cancer research 1999;59(21):5554-9.
1999: Marco W Schreurs; A A Eggert; Annemiek J de Boer; Carl G Figdor; Gosse J Adema
Generation and functional characterization of mouse monocyte-derived dendritic cells.
European journal of immunology 1999;29(9):2835-41.
1999: Andreas A O Eggert; Marco W Schreurs; Otto Boerman; Wim J G Oyen; Annemiek J de Boer; Cornelis J A Punt; Carl G Figdor; Gosse J Adema
Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration.
Cancer research 1999;59(14):3340-5.
1999: Björn Cochlovius; A Perschl; Gosse J Adema; Margot Zöller
Human melanoma therapy in the SCID mouse: in vivo targeting and reactivation of melanoma-specific cytotoxic T cells by bi-specific antibody fragments.
International journal of cancer. Journal international du cancer 1999;81(3):486-93.
1998: Marco W Schreurs; Annemiek J de Boer; Carl G Figdor; Gosse J Adema
Genetic vaccination against the melanocyte lineage-specific antigen gp100 induces cytotoxic T lymphocyte-mediated tumor protection.
Cancer research 1998;58(12):2509-14.
1998: Ernst Lindhout; Carl G Figdor; Gosse J Adema
Dendritic cells: migratory cells that are attractive.
Cell adhesion and communication 1998;6(2-3):117-23.
1997: Marco W Schreurs; Annemiek J de Boer; A Schmidt; Carl G Figdor; Gosse J Adema
Cloning, expression and tissue distribution of the murine homologue of the melanocyte lineage-specific antigen gp100.
Melanoma research 1997;7(6):463-70.
1997: Gosse J Adema; Franca C Hartgers; R Verstraten; E de Vries; G Marland; S Menon; J Foster; Y Xu; P Nooyen; T McClanahan; K B Bacon; Carl G Figdor
A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells.
Nature 1997;387(6634):713-7.
1997: A B Bakker; Sjoerd H van der burg; Richard Huijbens; J W Drijfhout; C J Melief; Gosse J Adema; Carl G Figdor
Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope.
International journal of cancer. Journal international du cancer 1997;70(3):302-9.
1997: Nathalie Brouwenstijn; Elisabeth H Slager; A B Bakker; Marco W Schreurs; CW van der Spek; Gosse J Adema; Peter I Schrier; Carl G Figdor
Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.
British journal of cancer 1997;76(12):1562-6.
1997: G Marland; Franca C Hartgers; R Veltkamp; M F Königswieser; D Gorman; T McClanahan; Carl G Figdor; Gosse J Adema
Analysis of dendritic cells at the genetic level.
Advances in experimental medicine and biology 1997;417():443-8.
1996: G Marland; A B Bakker; Gosse J Adema; Carl G Figdor
Dendritic cells in immune response induction.
Stem cells (Dayton, Ohio) 1996;14(5):501-7.
1996: Gosse J Adema; A B Bakker; Annemiek J de Boer; P Hohenstein; Carl G Figdor
pMel17 is recognised by monoclonal antibodies NKI-beteb, HMB-45 and HMB-50 and by anti-melanoma CTL.
British journal of cancer 1996;73(9):1044-8.
1995: A B Bakker; G Marland; Annemiek J de Boer; R J Huijbens; E H Danen; Gosse J Adema; Carl G Figdor
Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro.
Cancer research 1995;55(22):5330-4.
1995: A B Bakker; Marco W Schreurs; G Tafazzul; Annemiek J de Boer; Y Kawakami; Gosse J Adema; Carl G Figdor
Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1-restricted anti-melanoma CTL line.
International journal of cancer. Journal international du cancer 1995;62(1):97-102.
1994: Gosse J Adema; Annemiek J de Boer; A M Vogel; W A Loenen; Carl G Figdor
Molecular characterization of the melanocyte lineage-specific antigen gp100.
The Journal of biological chemistry 1994;269(31):20126-33.
1994: A B Bakker; Marco W Schreurs; Annemiek J de Boer; Y Kawakami; STEVEN ROSENBERG; Gosse J Adema; Carl G Figdor
Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.
The Journal of experimental medicine 1994;179(3):1005-9.
1993: Gosse J Adema; Annemiek J de Boer; R van 't Hullenaar; M Denijn; Dirk J Ruiter; A M Vogel; Carl G Figdor
Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA.
The American journal of pathology 1993;143(6):1579-85.