Ofer Lider

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Sela Uri; Dayan Molly; Hershkoviz Rami; Lider Ofer; Mozes Edna
A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3.
Zanin-Zhorov Alexandra; Tal-Lapidot Guy; Cahalon Liora; Cohen-Sfady Michal; Pevsner-Fischer Meirav; Lider Ofer; Cohen Irun R
Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling.
Bakalash Sharon; Rolls Asya; Lider Ofer; Schwartz Michal
Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats.

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All Publications

2008: Sela Uri; Dayan Molly; Hershkoviz Rami; Lider Ofer; Mozes Edna
A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1584-91.
2007: Zanin-Zhorov Alexandra; Tal-Lapidot Guy; Cahalon Liora; Cohen-Sfady Michal; Pevsner-Fischer Meirav; Lider Ofer; Cohen Irun R
Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):41-4.
2007: Bakalash Sharon; Rolls Asya; Lider Ofer; Schwartz Michal
Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats.
Investigative ophthalmology & visual science 2007;48(3):1181-90.
2006: Sela Uri; Dayan Molly; Hershkoviz Rami; Cahalon Liora; Lider Ofer; Mozes Edna
The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses.
European journal of immunology 2006;36(11):2971-80.
2006: Nussbaum Gabriel; Zanin-Zhorov Alexandra; Quintana Francisco; Lider Ofer; Cohen Irun R
Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis.
International immunology 2006;18(10):1413-9.
2006: Leiba M; Cahalon L; Shimoni A; Lider O; Zanin-Zhorov A; Hecht I; Sela U; Vlodavsky I; Nagler A
Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.
Journal of leukocyte biology 2006;80(2):399-406.
2006: Zanin-Zhorov Alexandra; Cahalon Liora; Tal Guy; Margalit Raanan; Lider Ofer; Cohen Irun R
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.
The Journal of clinical investigation 2006;116(7):2022-32.
2006: Rolls Asya; Cahalon Liora; Bakalash Sharon; Avidan Hila; Lider Ofer; Schwartz Michal
A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):547-9.
2005: Sela Uri; Mauermann Nora; Hershkoviz Rami; Zinger Heidy; Dayan Molly; Cahalon Liora; Liu Jian Ping; Mozes Edna; Lider Ofer
The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7255-63.
2005: Cohen-Sfady Michal; Nussbaum Gabriel; Pevsner-Fischer Meirav; Mor Felix; Carmi Pnina; Zanin-Zhorov Alexandra; Lider Ofer; Cohen Irun R
Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3594-602.
2005: Cooper Arik; Tal Guy; Lider Ofer; Shaul Yosef
Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3165-76.
2005: Zanin-Zhorov Alexandra; Tal Guy; Shivtiel Shoham; Cohen Michal; Lapidot Tsvee; Nussbaum Gabriel; Margalit Raanan; Cohen Irun R; Lider Ofer
Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):276-85.
2005: Zanin-Zhorov Alexandra; Bruck Rafael; Tal Guy; Oren Shirly; Aeed Hussein; Hershkoviz Rami; Cohen Irun R; Lider Ofer
Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3227-36.
2005: Abdul-Hai A; Hershkoviz R; Weiss L; Lider O; Slavin S
Effect of Linomide on adhesion molecules, TNF-alpha, nitrogen oxide, and cell adhesion.
International immunopharmacology 2005;5(2):231-9.
2005: Sela Uri; Hershkoviz Rami; Cahalon Liora; Lider Ofer; Mozes Edna
Down-regulation of stromal cell-derived factor-1alpha-induced T cell chemotaxis by a peptide based on the complementarity-determining region 1 of an anti-DNA autoantibody via up-regulation of TGF-beta secretion.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):302-9.
2004: Rolls Asya; Avidan Hila; Cahalon Liora; Schori Hadas; Bakalash Sharon; Litvak Vladimir; Lev Sima; Lider Ofer; Schwartz Michal
A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice.
The European journal of neuroscience 2004;20(8):1973-83.
2004: Porozov Svetlana; Cahalon Liora; Weiser Michael; Branski David; Lider Ofer; Oberbaum Menachem
Inhibition of IL-1beta and TNF-alpha secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S.
Clinical & developmental immunology 2004;11(2):143-9.
2004: Tal Guy; Mandelberg Avigdor; Dalal Ilan; Cesar Karine; Somekh Eli; Tal Asher; Oron Anat; Itskovich Svetlana; Ballin Ami; Houri Sion; Beigelman Avraham; Lider Ofer; Rechavi Gideon; Amariglio Ninette
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.
The Journal of infectious diseases 2004;189(11):2057-63.
2004: Hecht Iris; Hershkoviz Rami; Shivtiel Shoham; Lapidot Tzvi; Cohen Irun R; Lider Ofer; Cahalon Liora
Heparin-disaccharide affects T cells: inhibition of NF-kappaB activation, cell migration, and modulation of intracellular signaling.
Journal of leukocyte biology 2004;75(6):1139-46.
2004: Sotnikov Ilya; Hershkoviz Rami; Grabovsky Valentin; Ilan Neta; Cahalon Liora; Vlodavsky Israel; Alon Ronen; Lider Ofer
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5185-93.
2004: Sela Uri; Ganor Sharon; Hecht Iris; Brill Alexander; Miron Talia; Rabinkov Aharon; Wilchek Meir; Mirelman David; Lider Ofer; Hershkoviz Rami
Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.
Immunology 2004;111(4):391-9.
2004: Shenkman B; Brill A; Brill G; Lider O; Savion N; Varon D
Differential response of platelets to chemokines: RANTES non-competitively inhibits stimulatory effect of SDF-1 alpha.
Journal of thrombosis and haemostasis : JTH 2004;2(1):154-60.
2003: Zanin-Zhorov Alexandra; Hershkoviz Rami; Hecht Iris; Cahalon Liora; Lider Ofer
Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5882-9.
2003: Zanin-Zhorov Alexandra; Nussbaum Gabriel; Franitza Susanne; Cohen Irun R; Lider Ofer
T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1567-9.
2003: Hecht Iris; Cahalon Liora; Hershkoviz Rami; Lahat Adi; Franitza Suzanne; Lider Ofer
Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis.
International immunology 2003;15(1):29-38.
2002: Ariel Amiram; Novick Daniela; Rubinstein Menachem; Dinarello Charles A; Lider Ofer; Hershkoviz Rami
IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.
Journal of leukocyte biology 2002;72(1):192-8.
2002: Franitza Susanne; Kollet Orit; Brill Alexander; Vaday Gayle G; Petit Isabelle; Lapidot Tsvee; Alon Ronen; Lider Ofer
TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.
European journal of immunology 2002;32(1):193-202.
2002: Barshishat Michal; Ariel Amiram; Cahalon Liora; Chowers Yehuda; Lider Ofer; Schwartz Betty
TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells.
Clinical & experimental metastasis 2002;19(4):327-37.
2002: Peled Amnon; Hardan Izhar; Trakhtenbrot Luba; Gur Eyal; Magid Michal; Darash-Yahana Merav; Cohen Ninette; Grabovsky Valentin; Franitza Suzana; Kollet Orit; Lider Ofer; Alon Ronen; Rechavi Gideon; Lapidot Tsvee
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.
Stem cells (Dayton, Ohio) 2002;20(3):259-66.
2001: Brill A; Franitza S; Lider O; Hershkoviz R
Regulation of T-cell interaction with fibronectin by transforming growth factor-beta is associated with altered Pyk2 phosphorylation.
Immunology 2001;104(2):149-56.
2001: Vaday G G; Franitza S; Schor H; Hecht I; Brill A; Cahalon L; Hershkoviz R; Lider O
Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix.
Journal of leukocyte biology 2001;69(6):885-92.
2001: Brill A; Hershkoviz R; Vaday G G; Chowers Y; Lider O
Augmentation of RANTES-induced extracellular signal-regulated kinase mediated signaling and T cell adhesion by elastase-treated fibronectin.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7121-7.
2001: Vaday G G; Schor H; Rahat M A; Lahat N; Lider O
Transforming growth factor-beta suppresses tumor necrosis factor alpha-induced matrix metalloproteinase-9 expression in monocytes.
Journal of leukocyte biology 2001;69(4):613-21.
2001: Ariel A; Hershkoviz R; Altbaum-Weiss I; Ganor S; Lider O
Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3052-60.
2001: Chowers Y; Lider O; Schor H; Barshack I; Tal R; Ariel A; Bar-Meir S; Cohen I R; Cahalon L
Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.
Gastroenterology 2001;120(2):449-59.
2000: Vaday G G; Hershkoviz R; Rahat M A; Lahat N; Cahalon L; Lider O
Fibronectin-bound TNF-alpha stimulates monocyte matrix metalloproteinase-9 expression and regulates chemotaxis.
Journal of leukocyte biology 2000;68(5):737-47.
2000: Flaishon L; Hershkoviz R; Lantner F; Lider O; Alon R; Levo Y; Flavell R A; Shachar I
Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.
The Journal of experimental medicine 2000;192(9):1381-8.
2000: Achiron A; Mor F; Margalit R; Cohen I R; Lider O; Miron S
Suppression of experimental autoimmune encephalomyelitis by intravenously administered polyclonal immunoglobulins.
Journal of autoimmunity 2000;15(3):323-30.
2000: Franitza S; Hershkoviz R; Kam N; Lichtenstein N; Vaday G G; Alon R; Lider O
TNF-alpha associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2738-47.
2000: Ariel A; Lider O; Brill A; Cahalon L; Savion N; Varon D; Hershkoviz R
Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators.
Immunology 2000;100(3):345-51.
2000: Bruck R; Hershkoviz R; Lider O; Shirin H; Aeed H; Halpern Z
Non-peptidic analogs of the cell adhesion motif RGD prevent experimental liver injury.
The Israel Medical Association journal : IMAJ 2000;2 Suppl():74-80.
2000: Peled A; Kollet O; Ponomaryov T; Petit I; Franitza S; Grabovsky V; Slav M M; Nagler A; Lider O; Alon R; Zipori D; Lapidot T
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
Blood 2000;95(11):3289-96.
2000: Yavin E J; Preciado-Patt L; Rosen O; Yaron M; Suessmuth R D; Levartowsky D; Jung G; Lider O; Fridkin M
Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-gamma by human CD(4)(+) T-lymphocytes.
FEBS letters 2000;472(2-3):259-62.
2000: Levite M; Cahalon L; Peretz A; Hershkoviz R; Sobko A; Ariel A; Desai R; Attali B; Lider O
Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins.
The Journal of experimental medicine 2000;191(7):1167-76.
2000: Vaday G G; Lider O
Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation.
Journal of leukocyte biology 2000;67(2):149-59.
2000: Hershkoviz R; Schor H; Ariel A; Hecht I; Cohen I R; Lider O; Cahalon L
Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix.
Immunology 2000;99(1):87-93.
2000: Schor H; Vaday G G; Lider O
Modulation of leukocyte behavior by an inflamed extracellular matrix.
Developmental immunology 2000;7(2-4):227-38.
1999: Rabinovich G A; Ariel A; Hershkoviz R; Hirabayashi J; Kasai K I; Lider O
Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1.
Immunology 1999;97(1):100-6.
1999: Franitza S; Alon R; Lider O
Real-time analysis of integrin-mediated chemotactic migration of T lymphocytes within 3-D extracellular matrix-like gels.
Journal of immunological methods 1999;225(1-2):9-25.
1999: Rechter M; Lider O; Cahalon L; Baharav E; Dekel M; Seigel D; Vlodavsky I; Aingorn H; Cohen I R; Shoseyov O
A cellulose-binding domain-fused recombinant human T cell connective tissue-activating peptide-III manifests heparanase activity.
Biochemical and biophysical research communications 1999;255(3):657-62.
1999: Peled A; Petit I; Kollet O; Magid M; Ponomaryov T; Byk T; Nagler A; Ben-Hur H; Many A; Shultz L; Lider O; Alon R; Zipori D; Lapidot T
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Science (New York, N.Y.) 1999;283(5403):845-8.
1998: Ariel A; Yavin E J; Hershkoviz R; Avron A; Franitza S; Hardan I; Cahalon L; Fridkin M; Lider O
IL-2 induces T cell adherence to extracellular matrix: inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2465-72.
1998: Hodak E; Yosipovitch G; David M; Ingber A; Chorev L; Lider O; Cahalon L; Cohen I R
Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report.
Journal of the American Academy of Dermatology 1998;38(4):564-8.
1998: Levite M; Cahalon L; Hershkoviz R; Steinman L; Lider O
Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):993-1000.
1997: Shirin H; Bruck R; Aeed H; Hershkoviz R; Lider O; Kenet G; Avni Y; Halpern Z
Effects of intravenous immunoglobulins on T-cell mediated, concanavalin A-induced hepatitis in mice.
Liver 1997;17(6):275-80.
1997: Ariel A; Hershkoviz R; Cahalon L; Williams D E; Akiyama S K; Yamada K M; Chen C; Alon R; Lapidot T; Lider O
Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7.
European journal of immunology 1997;27(10):2562-70.
1997: Cahalon L; Lider O; Schor H; Avron A; Gilat D; Hershkoviz R; Margalit R; Eshel A; Shoseyev O; Cohen I R
Heparin disaccharides inhibit tumor necrosis factor-alpha production by macrophages and arrest immune inflammation in rodents.
International immunology 1997;9(10):1517-22.
1997: Miron S; Kachalsky S G; Hershkoviz R; Lider O
Pervanadate-induced adhesion of CD4+ T cell to fibronectin is associated with tyrosine phosphorylation of paxillin.
Journal of leukocyte biology 1997;62(3):405-13.
1997: Bruck R; Hershkoviz R; Lider O; Shirin H; Aeed H; Halpern Z
The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury.
The Yale journal of biology and medicine 1997;70(4):391-402.
1997: Hershkoviz R; Preciado-Patt L; Lider O; Fridkin M; Dastych J; Metcalfe D D; Mekori Y A
Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion.
The American journal of physiology 1997;273(1 Pt 1):C179-87.
1997: Hershkoviz R; Preciado-Patt L; Lider O; Fridkin M; Mekori Y A
Mast cell adhesion to extracellular matrix: local effects of acute phase reactants.
International archives of allergy and immunology 1997;113(1-3):295-6.
1997: Bruck R; Shirin H; Hershkoviz R; Lider O; Kenet G; Aeed H; Matas Z; Zaidel L; Halpern Z
Analysis of Arg-Gly-Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A induced hepatitis in mice.
Gut 1997;40(1):133-8.
1996: Frankel G; Lider O; Hershkoviz R; Mould A P; Kachalsky S G; Candy D C; Cahalon L; Humphries M J; Dougan G
The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins.
The Journal of biological chemistry 1996;271(34):20359-64.
1996: Bruck R; Hershkoviz R; Lider O; Aeed H; Zaidel L; Matas Z; Barg J; Halpern Z
Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated Arg-Gly-Asp epitope.
Journal of hepatology 1996;24(6):731-8.
1996: Hershkoviz R; Marikovsky M; Gilat D; Lider O
Keratinocytes-associated chemokines and enzymatically quiescent heparanase induce the binding of resting CD4+ T cells.
The Journal of investigative dermatology 1996;106(2):243-8.
1996: Preciado-Patt L; Hershkoviz R; Fridkin M; Lider O
Serum amyloid A binds specific extracellular matrix glycoproteins and induces the adhesion of resting CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1189-95.
1996: Gilat D; Cahalon L; Hershkoviz R; Lider O
Interplay of T cells and cytokines in the context of enzymatically modified extracellular matrix.
Immunology today 1996;17(1):16-20.
1996: Lider O; Kachalsky S G
Migrating T lymphocyte's interactions with blood vessel walls and extracellular matrix during inflammatory episodes.
Israel journal of medical sciences 1996;32(1):37-9.
1995: Hershkoviz R; Mor F; Miao H Q; Vlodavsky I; Lider O
Differential effects of polysulfated polysaccharide on experimental encephalomyelitis, proliferation of autoimmune T cells, and inhibition of heparanase activity.
Journal of autoimmunity 1995;8(5):741-50.
1995: Lider O; Cahalon L; Gilat D; Hershkoviz R; Siegel D; Margalit R; Shoseyov O; Cohen I R
A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5037-41.
1995: Gilat D; Hershkoviz R; Goldkorn I; Cahalon L; Korner G; Vlodavsky I; Lider O
Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.
The Journal of experimental medicine 1995;181(5):1929-34.
1995: Hershkoviz R; Goldkorn I; Lider O
Tumour necrosis factor-alpha interacts with laminin and functions as a pro-adhesive cytokine.
Immunology 1995;85(1):125-30.
1995: Hershkoviz R; Lider O; Bruck R; Aeed H; Greenspoon N; Halpern Z
Treatment of immune cell-mediated liver damage by nonpeptidic mimetics of the extracellular matrix-associated Arg-Gly-Asp epitope.
Journal of hepatology 1995;22(2):158-64.
1995: Lider O; Hershkoviz R; Kachalsky S G
Interactions of migrating T lymphocytes, inflammatory mediators, and the extracellular matrix.
Critical reviews in immunology 1995;15(3-4):271-83.
1994: Gilat D; Hershkoviz R; Mekori Y A; Vlodavsky I; Lider O
Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):4899-906.
1994: Hershkoviz R; Lider O; Baram D; Reshef T; Miron S; Mekori Y A
Inhibition of T cell adhesion to extracellular matrix glycoproteins by histamine: a role for mast cell degranulation products.
Journal of leukocyte biology 1994;56(4):495-501.
1994: Preciado-Patt L; Levartowsky D; Prass M; Hershkoviz R; Lider O; Fridkin M
Inhibition of cell adhesion to glycoproteins of the extracellular matrix by peptides corresponding to serum amyloid A. Toward understanding the physiological role of an enigmatic protein.
European journal of biochemistry / FEBS 1994;223(1):35-42.
1994: Cahalon L; Hershkoviz R; Gilat D; Miller A; Akiyama S K; Yamada K M; Lider O
Functional interactions of fibronectin and TNF alpha: a paradigm of physiological linkage between cytokines and extracellular matrix moieties.
Cell adhesion and communication 1994;2(3):269-73.
1994: Hershkoviz R; Cahalon L; Miron S; Alon R; Sapir T; Akiyama S K; Yamada K M; Lider O
TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):554-65.
1994: Greenspoon N; Hershkoviz R; Alon R; Gershonov E; Lavie B; Lider O
Novel psi-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibronectin.
International journal of peptide and protein research 1994;43(5):417-24.
1994: Hershkoviz R; Melamed S; Greenspoon N; Lider O
Nonpeptidic analogues of the Arg-Gly-Asp (RGD) sequence specifically inhibit the adhesion of human tenon's capsule fibroblasts to fibronectin.
Investigative ophthalmology & visual science 1994;35(5):2585-91.
1994: Achiron A; Margalit R; Hershkoviz R; Markovits D; Reshef T; Melamed E; Cohen I R; Lider O
Intravenous immunoglobulin treatment of experimental T cell-mediated autoimmune disease. Upregulation of T cell proliferation and downregulation of tumor necrosis factor alpha secretion.
The Journal of clinical investigation 1994;93(2):600-5.
1994: Hershkoviz R; Greenspoon N; Mekori Y A; Hadari R; Alon R; Kapustina G; Lider O
Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.
Clinical and experimental immunology 1994;95(2):270-6.
1994: Alon R; Cahalon L; Hershkoviz R; Elbaz D; Reizis B; Wallach D; Akiyama S K; Yamada K M; Lider O
TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1304-13.
1993: Varon D; Lider O; Dardik R; Shenkman B; Alon R; Hershkoviz R; Kapustina G; Savion N; Martinowitz U; Greenspoon N
Inhibition of integrin-mediated platelet aggregation, fibrinogen-binding, and interactions with extracellular matrix by nonpeptidic mimetics of Arg-Gly-Asp.
Thrombosis and haemostasis 1993;70(6):1030-6.
1993: Hardan I; Weiss L; Hershkoviz R; Greenspoon N; Alon R; Cahalon L; Reich S; Slavin S; Lider O
Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics.
International journal of cancer. Journal international du cancer 1993;55(6):1023-8.
1993: Lider O; Hershkoviz R; Alon R; Greenspoon N
Structure-function analysis of integrin-mediated cell functions by novel nonpeptidic conformational mimetics of the Arg-Gly-Asp and Leu-Asp-Val amino acid sequences.
Annals of the New York Academy of Sciences 1993;696():402-3.
1993: Hershkoviz R; Alon R; Mekori Y A; Gilat D; Cahalon L; Miller A; Lider O
Heat-stressed CD4+ T lymphocytes: differential modulations of adhesiveness to extracellular matrix glycoproteins, proliferative responses and tumour necrosis factor-alpha secretion.
Immunology 1993;79(2):241-7.
1993: Hershkoviz R; Miron S; Cahalon L; Lider O
The beta 1-integrin (CD29) receptors: mediators of T lymphocyte--extracellular matrix recognition that affect adhesion, activation and lymphokine secretion.
Israel journal of medical sciences 1993;29(5):321-5.
1993: Alon R; Hershkoviz R; Bayer E A; Wilchek M; Lider O
Streptavidin blocks immune reactions mediated by fibronectin-VLA-5 recognition through an Arg-Gly-Asp mimicking site.
European journal of immunology 1993;23(4):893-8.
1993: Greenspoon N; Hershkoviz R; Alon R; Varon D; Shenkman B; Marx G; Federman S; Kapustina G; Lider O
Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence.
Biochemistry 1993;32(4):1001-8.
1993: Hershkoviz R; Gilat D; Miron S; Mekori Y A; Aderka D; Wallach D; Vlodavsky I; Cohen I R; Lider O
Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages.
Immunology 1993;78(1):50-7.
1993: Hershkoviz R; Cahalon L; Gilat D; Miron S; Miller A; Lider O
Physically damaged extracellular matrix induces TNF-alpha secretion by interacting resting CD4+ T cells and macrophages.
Scandinavian journal of immunology 1993;37(1):111-5.
1992: Miron S; Hershkoviz R; Tirosh I; Schechter Y; Yayun A; Lider O
Involvement of a protein kinase C and protein phosphatases in adhesion of CD4+ T cells to and detachment from extracellular matrix proteins.
Cellular immunology 1992;144(1):182-9.
1992: Hershkoviz R; Alon R; Gilat D; Lider O
Activated T lymphocytes and macrophages secrete fibronectin which strongly supports cell adhesion.
Cellular immunology 1992;141(2):352-61.
1992: Hershkoviz R; Mor F; Gilat D; Cohen I R; Lider O
T cells in the spinal cord in experimental autoimmune encephalomyelitis are matrix adherent and secrete tumor necrosis factor alpha.
Journal of neuroimmunology 1992;37(1-2):161-6.
1992: Hershkoviz R; Miron S; Cohen I R; Miller A; Lider O
T lymphocyte adhesion to the fibronectin and laminin components of the extracellular matrix is regulated by the CD4 molecule.
European journal of immunology 1992;22(1):7-13.
1991: Lider O; Miller A; Miron S; Hershkoviz R; Weiner H L; Zhang X M; Heber-Katz E
Nonencephalitogenic CD4-CD8- V alpha 2V beta 8.2+ anti-myelin basic protein rat T lymphocytes inhibit disease induction.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1208-13.
1990: Lider O; Mekori Y A; Miller T; Bar-Tana R; Vlodavsky I; Baharav E; Cohen I R; Naparstek Y
Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity.
European journal of immunology 1990;20(3):493-9.
1989: Friedman A; Lider O; Beraud E; Cohen I R
Absence of major histocompatibility complex restriction in the interaction between processed basic protein and Ia of two rat strains.
Scandinavian journal of immunology 1989;29(6):747-50.
1989: Lider O; Baharav E; Mekori Y A; Miller T; Naparstek Y; Vlodavsky I; Cohen I R
Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.
The Journal of clinical investigation 1989;83(3):752-6.
1989: Lider O; Beraud E; Reshef T; Friedman A; Cohen I R
Vaccination against experimental autoimmune encephalomyelitis using a subencephalitogenic dose of autoimmune effector T cells. (2). Induction of a protective anti-idiotypic response.
Journal of autoimmunity 1989;2(1):87-99.
1989: Beraud E; Lider O; Baharav E; Reshef T; Cohen I R
Vaccination against experimental autoimmune encephalomyelitis using a subencephalitogenic dose of autoimmune effector cells (1). Characteristics of vaccination.
Journal of autoimmunity 1989;2(1):75-86.
1988: Lider O; Reshef T; Beraud E; Ben-Nun A; Cohen I R
Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis.
Science (New York, N.Y.) 1988;239(4836):181-3.
1987: Altmann D M; Lider O; Douek D C; Cohen I R
Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells.
European journal of immunology 1987;17(11):1635-40.
1986: Baharav E; Lider O; Margalit M; Cohen I R
A modified technique for experimental skin grafting.
Journal of immunological methods 1986;90(1):143-4.

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