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Egil Lien

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Gregory I Vladimer; Dan Weng; Shubhendu Ghosh; Robyn Marty-Roix; Egil Lien
Inflammasomes and host defenses against bacterial infections.
Gregory I Vladimer; Dan Weng; Qin Liu; Joan C Mecsas; Sara W Montminy Paquette; Megan K Proulx; Vijay A K Rathinam; George Reed; Sivapriya Kailasan Vanaja; Marie Hjelmseth Aune; John Bertin; Joseph J Burbage; Joseph E Conlon; Katherine A Fitzgerald; Jon Goguen; Yoichiro Iwakura; Egil Lien
The NLRP12 inflammasome recognizes Yersinia pestis.
Ingvild Bjellmo Johnsen; Egil Lien; Thuy Thanh Nguyen; Bjarte Bergstrøm; Marit W. Anthonsen
Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA.

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All Publications

2013: Gregory I Vladimer; Dan Weng; Shubhendu Ghosh; Robyn Marty-Roix; Egil Lien
Inflammasomes and host defenses against bacterial infections.
Current opinion in microbiology 2013;16(1):23-31.
2012: Gregory I Vladimer; Dan Weng; Qin Liu; Joan C Mecsas; Sara W Montminy Paquette; Megan K Proulx; Vijay A K Rathinam; George Reed; Sivapriya Kailasan Vanaja; Marie Hjelmseth Aune; John Bertin; Joseph J Burbage; Joseph E Conlon; Katherine A Fitzgerald; Jon Goguen; Yoichiro Iwakura; Egil Lien
The NLRP12 inflammasome recognizes Yersinia pestis.
Immunity 2012;37(1):96-107.
2012: Ingvild Bjellmo Johnsen; Egil Lien; Thuy Thanh Nguyen; Bjarte Bergstrøm; Marit W. Anthonsen
Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA.
Cytokine 2012;57(3):337-46.
2010: Harald Husebye; Marie Hjelmseth Aune; Jørgen Stenvik; Eivind Samstad; Frode Skjeldal; Oyvind Halaas; Nadra Nilsen; Harald Stenmark; Eicke Latz; Egil Lien; Tom Eirik Mollnes; Oddmund Bakke; Terje Espevik
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Immunity 2010;33(4):583-96.
2010: Thuy Thanh Nguyen; Ingvild B Johnsen; Cathrine F Knetter; Finn Drabløs; Katherine A Fitzgerald; Egil Lien; Marit W. Anthonsen
Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).
The Journal of biological chemistry 2010;285(22):17011-9.
2010: Xianbao He; Samrawit Mekasha; Nikolaos Mavrogiorgos; Katherine A Fitzgerald; Egil Lien; Robin R Ingalls
Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5743-54.
2010: Peter Duewell; Hajime Kono; Katey J Rayner; Cherilyn M Sirois; Gregory Vladimer; Franz G Bauernfeind; George S Abela; luigi franchi; Gabriel Nuñez; Max Schnurr; Terje Espevik; Egil Lien; Katherine A Fitzgerald; Kenneth L Rock; Kathryn J Moore; Samuel D Wright; Veit Hornung; Eicke Latz
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Nature 2010;464(7293):1357-61.
2010: Jianmin Meng; Egil Lien; Douglas T Golenbock
MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
The Journal of biological chemistry 2010;285(12):8695-702.
2010: Mariane B Melo; Pia Kasperkovitz; Anna Cerny; Stephanie Könen-Waisman; Evelyn A Kurt-Jones; Egil Lien; Bruce Beutler; Jonathan C Howard; Douglas T Golenbock; Ricardo T Gazzinelli
UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
PLoS pathogens 2010;6(8):e1001071.
2009: Egil Lien; Danny Zipris
The role of Toll-like receptor pathways in the mechanism of type 1 diabetes.
Current molecular medicine 2009;9(1):52-68.
2009: Jan Kristian Damås; Giovanni Davì; Mogens Jensenius; Francesca Santilli; Kari Otterdal; Thor Ueland; Trude H Flo; Egil Lien; Terje Espevik; Stig S Frøland; Giustina Vitale; Didier Raoult; Pål Aukrust
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever.
The Journal of infection 2009;58(1):68-75.
2008: Nadra Nilsen; Susanne Deininger; Unni Nonstad; Frode Skjeldal; Harald Husebye; Dmitrii Rodionov; Sonja Von Aulock; Thomas Hartung; Egil Lien; Oddmund Bakke; Terje Espevik
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36.
Journal of leukocyte biology 2008;84(1):280-91.
2008: Vishal Jain; Annett Halle; Kristen A Halmen; Egil Lien; Marie Charrel-Dennis; Sanjay Ram; Douglas T Golenbock; Alberto Visintin
Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
Blood 2008;111(9):4637-45.
2007: Kimberly Pouliot; Ning Pan; Shixia Wang; Shan Lu; Egil Lien; Jon Goguen
Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis.
Infection and immunity 2007;75(7):3571-80.
2007: Danny Zipris; Egil Lien; Anjali Nair; Jenny X Xie; Dale L Greiner; John P Mordes; Aldo A Rossini
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):693-701.
2006: Alberto Visintin; Kristen A Halmen; Naseema Khan; Brian G Monks; Douglas T Golenbock; Egil Lien
MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
Journal of leukocyte biology 2006;80(6):1584-92.
2006: Sara W Montminy; Naseema Khan; Sara McGrath; Mitchell J Walkowicz; Fiona Sharp; Joseph E Conlon; Koichi Fukase; Shoichi Kusumoto; Charles Sweet; Kensuke Miyake; Shizuo Akira; Robert J Cotter; Jon Goguen; Egil Lien
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.
Nature immunology 2006;7(10):1066-73.
2006: Ingvild Bjellmo Johnsen; Thuy Thanh Nguyen; Monika Ringdal; Anne Merete Tryggestad; Oddmund Bakke; Egil Lien; Terje Espevik; Marit W. Anthonsen
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
The EMBO journal 2006;25(14):3335-46.
2006: Seija Lehnardt; Philipp Henneke; Egil Lien; Dennis L Kasper; Joseph J Volpe; Ingo Bechmann; Robert Nitsch; Joerg R Weber; Douglas T Golenbock; Timothy Vartanian
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):583-92.
2005: Jutamas Ngampasutadol; Sanjay Ram; Anna Blom; Hanna Jarva; Ann E Jerse; Egil Lien; Jon Goguen; Sunita Gulati; Peter A Rice
Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17142-7.
2005: Danny Zipris; Egil Lien; Jenny X Xie; Dale L Greiner; John P Mordes; Aldo A Rossini
TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):131-42.
2004: Nadra Nilsen; Unni Nonstad; Naseema Khan; Cathrine F Knetter; Shizuo Akira; Anders Sundan; Terje Espevik; Egil Lien
Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88.
The Journal of biological chemistry 2004;279(38):39727-35.
2004: Frank C Gibson; Charlie Hong; Hsin-Hua Chou; Hiromichi Yumoto; Jiqiu Chen; Egil Lien; Jodie Wong; Caroline Attardo Genco
Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice.
Circulation 2004;109(22):2801-6.
2004: Eicke Latz; Annett Schoenemeyer; Alberto Visintin; Katherine A Fitzgerald; Brian G Monks; Cathrine F Knetter; Egil Lien; Nadra Nilsen; Terje Espevik; Douglas T Golenbock
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature immunology 2004;5(2):190-8.
2003: Ekambar R Kandimalla; Lakshmi Bhagat; Fu-Gang Zhu; Dong Yu; Yan-Ping Cong; Daqing Wang; Jimmy X Tang; Jin-Yan Tang; Cathrine F Knetter; Egil Lien; Sudhir Agrawal
A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14303-8.
2003: Eicke Latz; Alberto Visintin; Egil Lien; Katherine A Fitzgerald; Terje Espevik; Douglas T Golenbock
The LPS receptor generates inflammatory signals from the cell surface.
Journal of endotoxin research 2003;9(6):375-80.
2003: Terje Espevik; Eicke Latz; Egil Lien; Brian G Monks; Douglas T Golenbock
Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Scandinavian journal of infectious diseases 2003;35(9):660-4.
2002: Eicke Latz; Alberto Visintin; Egil Lien; Katherine A Fitzgerald; Brian G Monks; Evelyn A Kurt-Jones; Douglas T Golenbock; Terje Espevik
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
The Journal of biological chemistry 2002;277(49):47834-43.
2002: Philipp Henneke; Osamu Takeuchi; Richard Malley; Egil Lien; Robin R Ingalls; Mason W Freeman; Tanya N Mayadas; Victor Nizet; Shizuo Akira; Dennis L Kasper; Douglas T Golenbock
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3970-7.
2002: Trude H Flo; Liv Ryan; Eicke Latz; Osamu Takeuchi; Brian G Monks; Egil Lien; Øyvind Halaas; Shizuo Akira; Gudmund Skjåk-Braek; Douglas T Golenbock; Terje Espevik
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry 2002;277(38):35489-95.
2002: Raina N Fichorova; Amanda O Cronin; Egil Lien; Deborah J Anderson; Robin R Ingalls
Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2424-32.
2002: Brit Dybdahl; Alexander Wahba; Egil Lien; Trude H Flo; Anders Waage; Nilofer Qureshi; Olav F M Sellevold; Terje Espevik; Anders Sundan
Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.
Circulation 2002;105(6):685-90.
2002: Egil Lien; Robin R Ingalls
Toll-like receptors.
Critical care medicine 2002;30(1 Suppl):S1-11.
2001: Andrei E Medvedev; Philipp Henneke; Andra B Schromm; Egil Lien; Robin R Ingalls; Matthew J Fenton; Douglas T Golenbock; Stefanie N Vogel
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2257-67.
2001: Andra B Schromm; Egil Lien; Philipp Henneke; J C Chow; A Yoshimura; Holger Heine; Eicke Latz; Brian G Monks; D A Schwartz; K Miyake; Douglas T Golenbock
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
The Journal of experimental medicine 2001;194(1):79-88.
2001: Robin R Ingalls; Egil Lien; Douglas T Golenbock
Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
Infection and immunity 2001;69(4):2230-6.
2001: Trude H Flo; Oyvind Halaas; Sverre H Torp; Liv Ryan; Egil Lien; Brit Dybdahl; Anders Sundan; Terje Espevik
Differential expression of Toll-like receptor 2 in human cells.
Journal of leukocyte biology 2001;69(3):474-81.
2000: Trude H Flo; Oyvind Halaas; Egil Lien; Liv Ryan; Giuseppe Teti; Douglas T Golenbock; Anders Sundan; Terje Espevik
Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2064-9.
2000: Egil Lien; TK Means; Holger Heine; A Yoshimura; Shoichi Kusumoto; Koichi Fukase; Matthew J Fenton; Masato Oikawa; N Qureshi; Brian G Monks; R W Finberg; Robin R Ingalls; Douglas T Golenbock
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
2000: Robin R Ingalls; Egil Lien; Douglas T Golenbock
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.
Journal of endotoxin research 2000;6(5):411-5.
1999: TK Means; Egil Lien; A Yoshimura; S Wang; Douglas T Golenbock; Matthew J Fenton
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6748-55.
1999: Egil Lien; Timothy J Sellati; A Yoshimura; Trude H Flo; G Rawadi; R W Finberg; J David Carroll; Terje Espevik; Robin R Ingalls; Justin D Radolf; Douglas T Golenbock
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
The Journal of biological chemistry 1999;274(47):33419-25.
1999: TK Means; S Wang; Egil Lien; A Yoshimura; Douglas T Golenbock; Matthew J Fenton
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3920-7.
1999: Timothy J Sellati; DA Bouis; Melissa J Caimano; J A Feulner; C Ayers; Egil Lien; Justin D Radolf
Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2049-56.
1999: A Yoshimura; Egil Lien; Robin R Ingalls; E Tuomanen; R Dziarski; Douglas T Golenbock
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):1-5.
1999: Holger Heine; C J Kirschning; Egil Lien; Brian G Monks; M Rothe; Douglas T Golenbock
Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6971-5.
1999: Robin R Ingalls; Holger Heine; Egil Lien; A Yoshimura; Douglas T Golenbock
Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
Infectious disease clinics of North America 1999;13(2):341-53, vii.
1998: Egil Lien; Pål Aukrust; Anders Sundan; F Müller; Stig S Frøland; Terje Espevik
Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events.
Blood 1998;92(6):2084-92.
1997: andrew jackson; Egil Lien; AB Alexandroff; Stephen Prescott; Terje Espevik; Keith James; Peter J Selby; Anders Sundan
Soluble urinary CD14 after intravesical bacille Calmette-Guérin immunotherapy for carcinoma in situ.
British journal of urology 1997;80(5):766-71.