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Jeffrey Lifson

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Haesun Park; Michael Piatak; Louis J Picker; Andrew W Sylwester; Lauren Adamson; Michael K Axthelm; Tae Ha; Shoko I Hagen; Alfred Legasse; Jeffrey D Lifson; Juliana M McElrath; Karl Mullen; Arys Nogueron; Robert A Seder
Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates.
Gregory Q Del Prete; Ronald C Desrosiers; Luis D Giavedoni; Dan H Barouch; Elena Chertova; Jeffrey D Lifson; Preston A Marx; Christopher J Miller; Laura Newman; David H O'Connor; Kelli Oswald; Ranajit Pal; Laura M Parodi; Michael Piatak; Carolyn Reid; James D Roser; Matthew Scarlotta; Brandon F Keele
Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Brian Tabb; Charles M Trubey; W Gregory Alvord; Jason M Brenchley; Xing Pei Hao; Levelle D Harris; Jeffrey D Lifson; Rhonda Macallister; David R Morcock; Mirko Paiardini; Michael Piatak; Octavio A Quiñones; Guido Silvestri; Jeremy Smedley; Jacob D Estes
Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection.

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All Publications

2013: Haesun Park; Michael Piatak; Louis J Picker; Andrew W Sylwester; Lauren Adamson; Michael K Axthelm; Tae Ha; Shoko I Hagen; Alfred Legasse; Jeffrey D Lifson; Juliana M McElrath; Karl Mullen; Arys Nogueron; Robert A Seder
Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4103-15.
2013: Gregory Q Del Prete; Ronald C Desrosiers; Luis D Giavedoni; Dan H Barouch; Elena Chertova; Jeffrey D Lifson; Preston A Marx; Christopher J Miller; Laura Newman; David H O'Connor; Kelli Oswald; Ranajit Pal; Laura M Parodi; Michael Piatak; Carolyn Reid; James D Roser; Matthew Scarlotta; Brandon F Keele
Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Journal of virology 2013;87(8):4584-95.
2013: Brian Tabb; Charles M Trubey; W Gregory Alvord; Jason M Brenchley; Xing Pei Hao; Levelle D Harris; Jeffrey D Lifson; Rhonda Macallister; David R Morcock; Mirko Paiardini; Michael Piatak; Octavio A Quiñones; Guido Silvestri; Jeremy Smedley; Jacob D Estes
Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection.
The Journal of infectious diseases 2013;207(6):880-92.
2013: Monica Vaccari; David Venzon; Steven E Bosinger; Melvin N Doster; Barbara K Felber; Claudio Fenizia; Guido Ferrari; Donald N Forthal; Yongjun Guan; Anna Hryniewicz; Brandon F Keele; Jeffrey D Lifson; Zhong-Min Ma; Chris J Miller; David Montefiori; Tia Morgan; George Pavlakis; Justin Pollara; Margherita Rosati; Guido Silvestri; James Tartaglia; Genoveffa Franchini
Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure.
Journal of virology 2013;87(6):3538-48.
2013: Vainav Patel; Candido Alicea; Rama R Amara; Julian W Bess; Kate E Broderick; Barbara K Felber; Yongjun Guan; Vanessa M Hirsch; Wensheng Huang; Rashmi Jalah; Welkin Johnson; Brandon F Keele; Viraj Kulkarni; Jeffrey D Lifson; Michael Piatak; Harriet L Robinson; Margherita Rosati; Niranjan Y Sardesai; Xiaoying Shen; Georgia D Tomaras; Antonio Valentin; David J Venzon; Agneta S von Gegerfelt; William T Williams; George Pavlakis
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2975-80.
2013: Daniel Mendoza; Stephen A Migueles; Bennett Peterson; Eva Rakasz; Julia E Rood; Douglas Schneider; Matthew Trivett; Charles M Trubey; David Watkins; Nicole Doria-Rose; Genoveffa Franchini; Claire W Hallahan; Sarah Johnson; Jeffrey D Lifson; Vicky Coalter; Mark Connors
Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.
PLoS pathogens 2013;9(2):e1003195.
2013: Nichole R Klatt; Michael M Lederman; Jeffrey D Lifson; Michael D Miller; David R Morcock; Molly Perkins; Mariam Quiñones; Julie A Segre; Xiaoyong Sun; Carol L Vinton; Lauren A Canary; Clayton B Deming; Jacob D Estes; Nicholas T Funderburg; Elias K Haddad; Daria J Hazuda; Jason M Brenchley
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.
The Journal of clinical investigation 2013;123(2):903-7.
2013: Poonam Pegu; Mangala Rao; Donald Stablein; Jim Tartaglia; Georgia D Tomaras; Monica Vaccari; David Venzon; Stephen Whitney; Shari Gordon; Yongjun Guan; Lauren Hudacik; Brandon F Keele; Jerome Kim; Jeffrey D Lifson; Nelson Michael; David Montefiori; Ranajit Pal; S Munir Alam; Erik Billings; Melvin Doster; Claudio Fenizia; Guido Ferrari; Maria Grazia Ferrari; Genoveffa Franchini
Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial.
Journal of virology 2013;87(3):1708-19.
2013: Joel R Meyerson; Erin E H Tran; Theo Verrips; Weizao Chen; Dimiter S Dimitrov; Andrea Gorlani; Oleg Kuybeda; Jeffrey D Lifson; Sriram Subramaniam
Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):513-8.
2012: Philip A Mudd; Shari M Piaskowski; Michael Piatak; Karen A Power; Eva G Rakasz; Aaron Seese; Damien C Tully; Marlon G Veloso de Santana; Todd M Allen; David B Allison; Alex T Bean; Myrna Bonaldo; Saverio Capuano; Lijie Duan; Adam J Ericsen; Jessica Furlott; Ricardo Galler; Adrianne D Gladden; Ashley T Haase; Young-il Kim; Jeffrey D Lifson; Mauricio A Martins; Kim L Weisgrau; Nancy A Wilson; David I Watkins
Vaccine-induced CD8+ T cells control AIDS virus replication.
Nature 2012;491(7422):129-33.
2012: Yoshinori Fukazawa; Shoko I Hagen; Scott G Hansen; Francois Lefebvre; Alfred W Legasse; Yuan Li; Jeffrey D Lifson; Richard Lum; Eisa Mahyari; Adrian McDermott; David C Montefiori; Kelli Oswald; Haesun Park; Michael Piatak; Michael K Axthelm; Jin Young Bae; Mark J Cameron; Noel Coombes; Paul T Edlefsen; Guido Ferrari; Rafick P Sékaly; Rebecca Shoemaker; Andrew T Smith; Petra Stafova; Tonya Swanson; Andrew Sylwester; Marcelo Delos Reyes; Louis J Picker
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.
Nature medicine 2012;18(11):1673-81.
2012: Meropi Aravantinou; James Blanchard; Giulia Calenda; Nina Derby; José A Fernández-Romero; Agegnehu Gettie; Daniel Goldman; Jessica Kenney; Jeffrey D Lifson; Paul Mawson; Radhika Menon; Michael Piatak; Samantha Seidor; Rachel Singer; Natalia Teleshova; Guillermo Villegas; Thomas M Zydowsky; Ciby J Abraham; Melissa Robbiani
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.
AIDS research and human retroviruses 2012;28(11):1467-75.
2012: Jessica Kenney; Jeffrey D Lifson; Radhika Menon; Michael Piatak; Ciby J Abraham; Meropi Aravantinou; James Blanchard; Nina Derby; José A Fernández-Romero; Agegnehu Gettie; Samantha Seidor; Rachel Singer; Shimin Zhang; Thomas M Zydowsky; Melissa Robbiani
A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.
AIDS research and human retroviruses 2012;28(11):1476-84.
2012: N R Klatt; Jeffrey D Lifson; J D Milner; A M Ortiz; Mirko Paiardini; L Pan; G Silvestri; X Sun; B Tabb; C L Vinton; L K Yokomizo; G Alter; J S Barber; Yasmine Belkaid; L A Canary; Barbara Cervasi; Q Dang; J D Estes; Elias K Haddad; L D Harris; V M Hirsch; Jason M Brenchley
Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.
Mucosal immunology 2012;5(6):646-57.
2012: Rachel Singer; Meropi Aravantinou; James Blanchard; Nina Derby; José A Fernández-Romero; Agegnehu Gettie; Daniel Goldman; Jessica Kenney; Larisa Kizima; Jeffrey D Lifson; Paul Mawson; Radhika Menon; Michael Piatak; Melissa Robbiani; Aixa Rodriguez; Samantha Seidor; Thomas M Zydowsky
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.
Science translational medicine 2012;4(150):150ra123.
2012: Melisa L Budde; Brian T Cain; Emily N Chin; Adam J Ericsen; Thomas C Friedrich; Emma Gostick; Justin M Greene; Max Harris; Jeffrey D Lifson; Shelby L O'Connor; Ngoc H Pham; Michael Piatak; David A Price; Matthew Scarlotta; Jason T Weinfurter; Ericka A Becker; David O'Connor
Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.
Journal of virology 2012;86(14):7596-604.
2012: Afam A Okoye; Byung S Park; Audrie Pattenn; Christopher Pexton; Michael Piatak; Chike Abana; Michael K Axthelm; Alfred Legasse; Jeffrey D Lifson; Richard Lum; Shannon Planer; Matthew Reyes; Mukta Rohankhedkar; Andrew W Sylwester; Louis J Picker
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.
The Journal of experimental medicine 2012;209(4):641-51.
2012: Gregory Q Del Prete; Jacob D Estes; Xing Pei Hao; Mary F Kearney; Brandon F Keele; Vineet N KewalRamani; Abigail Lara; Kyeongeun Lee; Rhonda Macallister; Kunio Nagashima; Vinay K Pathak; James D Roser; Jeremy Smedley; Jon Spindler; Charles M Trubey; Ann Wiegand; Julian W Bess; Chawaree Chaipan; Elena Chertova; John M Coffin; Jeffrey D Lifson
Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques.
Journal of virology 2012;86(6):3152-66.
2012: Michael D Alpert; Angela Carville; Ronald C Desrosiers; Jackson D Harvey; R Paul Johnson; W Anderson Lauer; Wenjun Li; Jeffrey D Lifson; Keith G Mansfield; Michael Piatak; R Keith Reeves; David T Evans
ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge.
PLoS pathogens 2012;8(8):e1002890.
2012: Louis J Picker; Scott G Hansen; Jeffrey D Lifson
New paradigms for HIV/AIDS vaccine development.
Annual review of medicine 2012;63():95-111.
2011: Tommi A White; Alberto Bartesaghi; Julian W Bess; Mario J Borgnia; M Jason V de la Cruz; James A Hoxie; Jeffrey D Lifson; Jacqueline L S Milne; Rachna Nandwani; Sriram Subramaniam
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
Journal of virology 2011;85(23):12114-23.
2011: John P Bilello; R Paul Johnson; William Lauer; Wenjun Li; Jeffrey D Lifson; Julieta M Manrique; Keith G Mansfield; Young C Shin; Ronald C Desrosiers
Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus.
Journal of virology 2011;85(23):12708-20.
2011: Zhong-Min Ma; Huma Qureshi; Mars Stone; Veronique Desilva; Linda Fritts; Brandon F Keele; Jeffrey D Lifson; Christopher J Miller
SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma.
AIDS research and human retroviruses 2011;27(12):1259-69.
2011: Elena Martinelli; Michael Piatak; Hugo Tharinger; James Arthos; James Blanchard; Ines Frank; Agegnehu Gettie; Jeffrey D Lifson; Melissa Robbiani
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target.
PLoS pathogens 2011;7(6):e1002109.
2011: R Singer; N Derby; A Rodriguez; L Kizima; J Kenney; M Aravantinou; A Chudolij; Agegnehu Gettie; J Blanchard; Jeffrey D Lifson; Michael Piatak; J A Fernández-Romero; T M Zydowsky; Melissa Robbiani
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.
Journal of virology 2011;85(11):5504-12.
2011: Scott G Hansen; Julia C Ford; Matthew S Lewis; Abigail B Ventura; Colette M Hughes; Lia Coyne-Johnson; Nathan Whizin; Kelli Oswald; Rebecca Shoemaker; Tonya Swanson; Alfred W Legasse; Maria J Chiuchiolo; Christopher L Parks; Michael K Axthelm; Jay A Nelson; Michael A Jarvis; Michael Piatak; Jeffrey D Lifson; Louis J Picker
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.
Nature 2011;473(7348):523-7.
2011: Ming Zeng; Anthony J Smith; Stephen W Wietgrefe; Peter J Southern; Timothy W Schacker; Cavan S Reilly; Jacob D Estes; GREGORY BURTON; Guido Silvestri; Jeffrey D Lifson; John V Carlis; Ashley T Haase
Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections.
The Journal of clinical investigation 2011;121(3):998-1008.
2011: M F Kearney; Vineet N KewalRamani; Rachel K Bagni; John M Coffin; G Q Del Prete; K A Delviks-Frankenberry; Ralph W deVere White; K Lee; Jeffrey D Lifson; W M Linehan; Frank Maldarelli; John W Mellors; Vinay Pathak; Peter A Pinto; J Spindler; Cathy D Vocke; A Wiegand; S F J Le Grice
Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.
Advances in virology 2011;2011():272193.
2011: Jessica Kenney; Meropi Aravantinou; Rachel Singer; Mayla Hsu; Aixa Rodriguez; Larisa Kizima; Ciby J Abraham; Radhika Menon; Samantha Seidor; Anne Chudolij; Agegnehu Gettie; James Blanchard; Jeffrey D Lifson; Michael Piatak; Jose A Fernández-Romero; Thomas M Zydowsky; Melissa Robbiani
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.
PloS one 2011;6(1):e15835.
2011: Mary Kearney; Jon Spindler; Wei Shao; Frank Maldarelli; Sarah Palmer; Shiu-Lok Hu; Jeffrey D Lifson; Vineet N KewalRamani; John W Mellors; John M Coffin; Zandrea Ambrose
Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy.
Journal of virology 2011;85(2):1067-76.
2010: Michael D Alpert; Andrew R Rahmberg; William Neidermyer; Sharon K Ng; Angela Carville; Jeremy V Camp; Robert L Wilson; Michael Piatak; Keith G Mansfield; Wenjun Li; Christopher J Miller; Jeffrey D Lifson; Pamela A Kozlowski; David T Evans
Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge.
Journal of virology 2010;84(20):10748-64.
2010: Amanda Leone; Mukta Rohankhedkar; Afam Okoye; Alfred Legasse; Michael K Axthelm; Francios VILLINGER; Michael Piatak; Jeffrey D Lifson; Brigitte Assouline; Michel Morre; Louis J Picker; Donald L Sodora
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1650-9.
2010: Richard L Felts; Kedar Narayan; Jacob D Estes; Dan Shi; Charles M Trubey; Jing Fu; Lisa M Hartnell; Gordon T Ruthel; Douglas K Schneider; Kunio Nagashima; Julian W Bess; Sina Bavari; Bradley C Lowekamp; DONALD BLISS; Jeffrey D Lifson; Sriram Subramaniam
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13336-41.
2010: N R Klatt; L D Harris; C L Vinton; H Sung; J A Briant; B Tabb; D Morcock; J W McGinty; Jeffrey D Lifson; Bernard A P Lafont; Malcolm Martin; A D Levine; J D Estes; Jason M Brenchley
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
Mucosal immunology 2010;3(4):387-98.
2010: Tommi A White; Alberto Bartesaghi; Mario J Borgnia; Joel R Meyerson; M Jason V de la Cruz; Julian W Bess; Rachna Nandwani; James A Hoxie; Jeffrey D Lifson; Jacqueline L S Milne; Sriram Subramaniam
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
PLoS pathogens 2010;6(12):e1001249.
2010: Panagiotis Vagenas; Meropi Aravantinou; Vennansha G Williams; Edith Jasny; Michael Piatak; Jeffrey D Lifson; Andres M Salazar; James L Blanchard; Agegnehu Gettie; Melissa Robbiani
A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation.
PloS one 2010;5(9):e12891.
2010: Pavel Pugach; Anders Krarup; Agegnehu Gettie; Marcelo Kuroda; James Blanchard; Michael Piatak; Jeffrey D Lifson; Alexandra Trkola; Melissa Robbiani
In vivo binding and retention of CD4-specific DARPin 57.2 in macaques.
PloS one 2010;5(8):e12455.
2010: Jacob T Minang; Matthew T Trivett; Diane L Bolton; Charles M Trubey; Jacob D Estes; Yuan Li; Jeremy Smedley; Rhonda Pung; margherita rosati; Rashmi Jalah; George Pavlakis; Barbara K Felber; Michael Piatak; Mario Roederer; Jeffrey D Lifson; David E Ott; Claes Ohlen
Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):315-26.
2010: Diane L Bolton; Jacob T Minang; Matthew T Trivett; Kaimei Song; Jennifer J Tuscher; Yuan Li; Michael Piatak; David O'Connor; Jeffrey D Lifson; Mario Roederer; Claes Ohlen
Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):303-14.
2010: Nadine C Salisch; Daniel E Kaufmann; Amany S Awad; R Keith Reeves; Daniel P Tighe; Yuan Li; Michael Piatak; Jeffrey D Lifson; David T Evans; Florencia Pereyra; Gordon J Freeman; R Paul Johnson
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):476-87.
2009: Panagiotis Vagenas; Vennansha G Williams; Michael Piatak; Julian W Bess; Jeffrey D Lifson; James L Blanchard; Agegnehu Gettie; Melissa Robbiani
Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239.
Journal of acquired immune deficiency syndromes (1999) 2009;52(4):433-42.
2009: Afam Okoye; Haesun J Park; Mukta Rohankhedkar; Lia Coyne-Johnson; Richard Lum; Joshua M Walker; Shannon Planer; Alfred W Legasse; Andrew W Sylwester; Michael Piatak; Jeffrey D Lifson; Donald L Sodora; Francios VILLINGER; Michael K Axthelm; Joern E Schmitz; Louis J Picker
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
The Journal of experimental medicine 2009;206(7):1575-88.
2009: Nancy A Wilson; Brandon F Keele; Jason S Reed; Shari M Piaskowski; Caitlin E MacNair; Andrew J Bett; Xiaoping Liang; Fubao Wang; Elizabeth Thoryk; Gwendolyn J Heidecker; Michael P Citron; Lingyi Huang; Jing Lin; Salvatore Vitelli; Chanook D Ahn; Masahiko Kaizu; Nicholas J Maness; Matthew R Reynolds; Thomas C Friedrich; John T Loffredo; Eva G Rakasz; Stephen Erickson; David Allison; Michael Piatak; Jeffrey D Lifson; John W Shiver; Danilo R Casimiro; George M Shaw; Beatrice H Hahn; David Ian Watkins
Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge.
Journal of virology 2009;83(13):6508-21.
2009: Bapi Pahar; Andrew Lackner; Michael Piatak; Jeffrey D Lifson; Xiaolei Wang; Arpita Das; Binhua Ling; David C Montefiori; Ronald S Veazey
Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge.
Virology 2009;387(2):273-84.
2009: Qingsheng Li; Jacob D Estes; Patrick M Schlievert; Lijie Duan; Amanda J Brosnahan; Peter J Southern; Cavan S Reilly; Marnie L Peterson; Nancy J Schultz-Darken; Kevin G Brunner; Karla R Nephew; Stefan E Pambuccian; Jeffrey D Lifson; John V Carlis; Ashley T Haase
Glycerol monolaurate prevents mucosal SIV transmission.
Nature 2009;458(7241):1034-8.
2009: Zhong-Min Ma; Mars Stone; Michael Piatak; Becky Schweighardt; Nancy Haigwood; David Montefiori; Jeffrey D Lifson; Michael P Busch; Christopher J Miller
High specific infectivity of plasma virus from the pre-ramp-up and ramp-up stages of acute simian immunodeficiency virus infection.
Journal of virology 2009;83(7):3288-97.
2009: Theodora Hatziioannou; Zandrea Ambrose; Nancy P-Y Chung; Michael Piatak; Fang Yuan; Charles M Trubey; Vicky Coalter; Rebecca Kiser; Doug Schneider; Jeremy Smedley; Rhonda Pung; Mercy Gathuka; Jacob D Estes; Ronald S Veazey; Vineet N KewalRamani; Jeffrey D Lifson; Paul D Bieniasz
A macaque model of HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4425-9.
2009: Scott G Hansen; Cassandra Vieville; Nathan Whizin; Lia Coyne-Johnson; Don C Siess; Derek D Drummond; Alfred W Legasse; Michael K Axthelm; Kelli Oswald; Charles M Trubey; Michael Piatak; Jeffrey D Lifson; Jay A Nelson; Michael A Jarvis; Louis J Picker
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.
Nature medicine 2009;15(3):293-9.
2009: Matthew D Eberly; Muhamuda Kader; waseem Hassan; Kenneth A Rogers; Jianzhong Zhou; Yvonne M Mueller; Mary J Mattapallil; Michael Piatak; Jeffrey D Lifson; Peter D Katsikis; Mario Roederer; Francios VILLINGER; Joseph J Mattapallil
Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1439-48.
2009: Rosemarie D Mason; Sheilajen Alcantara; Viv Peut; Liyen Loh; Jeffrey D Lifson; Robert De Rose; Stephen J Kent
Inactivated simian immunodeficiency virus-pulsed autologous fresh blood cells as an immunotherapy strategy.
Journal of virology 2009;83(3):1501-10.
2009: Federica Crostarosa; Meropi Aravantinou; Onome J Akpogheneta; Edith Jasny; Andrew Shaw; Jessica Kenney; Michael Piatak; Jeffrey D Lifson; Aaron Teitelbaum; Lieyu Hu; Anne Chudolij; Thomas M Zydowsky; James Blanchard; Agegnehu Gettie; Melissa Robbiani
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy.
PloS one 2009;4(11):e8060.
2009: Wei Shao; Mary Kearney; Frank Maldarelli; John W Mellors; Robert M Stephens; Jeffrey D Lifson; Vineet N KewalRamani; Zandrea Ambrose; John M Coffin; Sarah E Palmer
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.
Retrovirology 2009;6():101.
2009: Rachel Lubong Sabado; Daniel G Kavanagh; Daniel E Kaufmann; Karlhans Fru; Ethan Babcock; Eric Rosenberg; Bruce Walker; Jeffrey D Lifson; Nina Bhardwaj; Marie Larsson
In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.
PloS one 2009;4(1):e4256.
2009: Bin Jia; Sharon K Ng; M Quinn DeGottardi; Michael Piatak; Eloisa Yuste; Angela Carville; Keith G Mansfield; Wenjun Li; Barbra A Richardson; Jeffrey D Lifson; David T Evans
Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.
PLoS pathogens 2009;5(1):e1000272.
2009: Susanna Trapp; Nina R Derby; Rachel Singer; Andrew Shaw; Vennansha G Williams; Stuart G Turville; Julian W Bess; Jeffrey D Lifson; Melissa Robbiani
Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.
Journal of virology 2009;83(2):884-95.
2008: Eloisa Yuste; Jacqueline Bixby; Jeffrey D Lifson; Shuji Sato; Welkin Johnson; Ronald C Desrosiers
Glycosylation of gp41 of simian immunodeficiency virus shields epitopes that can be targets for neutralizing antibodies.
Journal of virology 2008;82(24):12472-86.
2008: Muhamuda Kader; Wail M Hassan; Matthew Eberly; Michael Piatak; Jeffrey D Lifson; Mario Roederer; Joseph J Mattapallil
Antiretroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in rectal mucosa during acute simian immunodeficiency virus infection.
Journal of virology 2008;82(22):11467-71.
2008: Olivier Manches; David H Munn; Anahita Fallahi; Jeffrey D Lifson; Laurence Chaperot; Joel Plumas; Nina Bhardwaj
HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.
The Journal of clinical investigation 2008;118(10):3431-9.
2008: Shuji Sato; Eloisa Yuste; William A Lauer; Eun Hyuk Chang; Jennifer S Morgan; Jacqueline G Bixby; Jeffrey D Lifson; Ronald C Desrosiers; Welkin E Johnson
Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo.
Journal of virology 2008;82(19):9739-52.
2008: Laurence Vachot; Vennansha G Williams; Julian W Bess; Jeffrey D Lifson; Melissa Robbiani
Candida albicans-induced DC activation partially restricts HIV amplification in DCs and increases DC to T-cell spread of HIV.
Journal of acquired immune deficiency syndromes (1999) 2008;48(4):398-407.
2008: Zandrea Ambrose; Lara Compton; Michael Piatak; Ding Lu; W Gregory Alvord; Mariusz S Lubomirski; James E K Hildreth; Jeffrey D Lifson; Christopher J Miller; Vineet N KewalRamani
Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.
Journal of virology 2008;82(13):6591-9.
2008: Sriram Venneti; Dafna Bonneh-Barkay; Brian J Lopresti; Stephanie bissel; Guoji Wang; Chester A Mathis; Michael Piatak; Jeffrey D Lifson; julia nyaundi; Michael Murphey-Corb; Clayton A Wiley
Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.
The American journal of pathology 2008;172(6):1603-16.
2008: Ronald S Veazey; Paula M Acierno; Kimberly J McEvers; Susanne H C Baumeister; Gabriel J Foster; Melisa D Rett; Michael H Newberg; Marcelo J Kuroda; Kenneth Williams; Eun-Young Kim; Steven M Wolinsky; E Peter Rieber; Michael Piatak; Jeffrey D Lifson; David C Montefiori; Charles R Brown; Vanessa M Hirsch; Joern schmitz
Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.
Journal of virology 2008;82(11):5618-30.
2008: Ines Frank; Hella Stössel; Agegnehu Gettie; Stuart G Turville; J W Bess; Jeffrey D Lifson; I Sivin; Nikolaus Romani; Melissa Robbiani
A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells.
Journal of virology 2008;82(11):5329-39.
2008: Eun-Young Kim; Ronald S Veazey; Roland Zahn; Kimberly J McEvers; Susanne H C Baumeister; Gabriel J Foster; Melisa D Rett; Michael H Newberg; Marcelo J Kuroda; E Peter Rieber; Michael Piatak; Jeffrey D Lifson; Norman L Letvin; Steven Wolinsky; Joern schmitz
Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
Journal of virology 2008;82(11):5631-5.
2008: Keith Mansfield; Sabine M Lang; Marie-Claire E Gauduin; Hannah B Sanford; Jeffrey D Lifson; R Paul Johnson; Ronald C Desrosiers
Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery.
Journal of virology 2008;82(8):4135-48.
2008: John C Tilton; Maura M Manion; Marlise R Luskin; Alison J Johnson; Andy A Patamawenu; Claire W Hallahan; Nancy A Cogliano-Shutta; JoAnn M Mican; Richard Davey; Shyam Kottilil; Jeffrey D Lifson; Julia A Metcalf; Richard A Lempicki; Mark Connors
Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro.
Journal of virology 2008;82(8):3997-4006.
2008: Jacob T Minang; Eugene V Barsov; Fang Yuan; Matthew Trivett; Michael Piatak; Jeffrey D Lifson; David E Ott; Claes Ohlen
Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones.
Virology 2008;372(2):430-41.
2008: Stuart G Turville; Meropi Aravantinou; Todd Miller; Jessica Kenney; Aaron Teitelbaum; Lieyu Hu; Anne Chudolij; Tom M Zydowsky; Michael Piatak; Julian W Bess; Jeffrey D Lifson; James Blanchard; Agegnehu Gettie; Melissa Robbiani
Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity.
PloS one 2008;3(9):e3162.
2008: Atze T Das; Bep Klaver; Mireille Centlivre; Alex Harwig; Marcel Ooms; Mark Page; Neil Almond; Fang Yuan; Mike Piatak; Jeffrey D Lifson; Ben Berkhout
Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution.
Retrovirology 2008;5():44.
2008: Juan P Giraldo-Vela; Richard Rudersdorf; Chungwon Chung; Ying Qi; Lyle T Wallace; Benjamin Bimber; Gretta J Borchardt; Debra L Fisk; Chrystal E Glidden; John T Loffredo; Shari M Piaskowski; Jessica Furlott; Juan P Morales-Martinez; Nancy A Wilson; William M Rehrauer; Jeffrey D Lifson; Mary Carrington; David Ian Watkins
The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.
Journal of virology 2008;82(2):859-70.
2008: M Quinn DeGottardi; Sharon K Lew; Michael Piatak; Bin Jia; Yang Feng; Sandra Lee; Jason M Brenchley; Daniel C Douek; Toshiaki Kodama; Jeffrey D Lifson; David T Evans
Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism.
Journal of virology 2008;82(1):321-34.
2007: Galit Alter; Maureen P Martin; Nickolas Teigen; William H Carr; Todd J Suscovich; Arne Schneidewind; Hendrik Streeck; Michael T Waring; Angela Meier; Christian Brander; Jeffrey D Lifson; Todd M Allen; Mary Carrington; Marcus Altfeld
Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.
The Journal of experimental medicine 2007;204(12):3027-36.
2007: Zandrea Ambrose; Sarah Palmer; Valerie F Boltz; Mary Kearney; Kay Larsen; Patricia Polacino; Leon Flanary; Kelli Oswald; Michael Piatak; Jeremy Smedley; Wei Shao; Norbert Bischofberger; Frank Maldarelli; Jason T Kimata; John W Mellors; Shiu-Lok Hu; John M Coffin; Jeffrey D Lifson; Vineet N KewalRamani
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
Journal of virology 2007;81(22):12145-55.
2007: Jonah B Sacha; Chungwon Chung; Jason Reed; Anna K Jonas; Alexander T Bean; Sean P Spencer; Wonhee Lee; Lara Vojnov; Richard Rudersdorf; Thomas C Friedrich; Nancy A Wilson; Jeffrey D Lifson; David Ian Watkins
Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.
Journal of virology 2007;81(21):11703-12.
2007: Patricia L Earl; Jeffrey L Americo; Linda S Wyatt; Leigh Anne Eller; David C Montefiori; Russ Byrum; Michael Piatak; Jeffrey D Lifson; Rama Rao Amara; Harriet L Robinson; John W Huggins; Bernard Moss
Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate.
Virology 2007;366(1):84-97.
2007: Afam Okoye; Martin Meier-Schellersheim; Jason M Brenchley; Shoko I Hagen; Joshua M Walker; Mukta Rohankhedkar; Richard Lum; John B Edgar; Shannon Planer; Alfred Legasse; Andrew W Sylwester; Michael Piatak; Jeffrey D Lifson; Vernon C Maino; Donald L Sodora; Daniel C Douek; Michael K Axthelm; Zvi Grossman; Louis J Picker
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
The Journal of experimental medicine 2007;204(9):2171-85.
2007: John T Loffredo; Jess Maxwell; Ying Qi; Chrystal E Glidden; Gretta J Borchardt; Taeko Soma; Alexander T Bean; Dominic Beal; Nancy A Wilson; William M Rehrauer; Jeffrey D Lifson; Mary Carrington; David Ian Watkins
Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
Journal of virology 2007;81(16):8827-32.
2007: Rachel L Sabado; Ethan Babcock; Daniel G Kavanagh; Veronica Tjomsland; Bruce D Walker; Jeffrey D Lifson; Nina Bhardwaj; Marie Larsson
Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.
European journal of immunology 2007;37(7):1752-63.
2007: Rachid Sougrat; Alberto Bartesaghi; Jeffrey D Lifson; Adam E Bennett; Julian W Bess; Daniel J Zabransky; Sriram Subramaniam
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.
PLoS pathogens 2007;3(5):e63.
2007: Hanne Andersen; Eugene V Barsov; Matthew Trivett; Charles M Trubey; Luis D Giavedoni; Jeffrey D Lifson; David E Ott; Claes Ohlén
Transduction with human telomerase reverse transcriptase immortalizes a rhesus macaque CD8+ T cell clone with maintenance of surface marker phenotype and function.
AIDS research and human retroviruses 2007;23(3):456-65.
2007: Jonah B Sacha; Chungwon Chung; Eva G Rakasz; Sean P Spencer; Anna K Jonas; Alexander T Bean; Wonhee Lee; Benjamin J Burwitz; Jason J Stephany; John T Loffredo; David Allison; Sama Adnan; Akihiko Hoji; Nancy A Wilson; Thomas C Friedrich; Jeffrey D Lifson; Otto O Yang; David Ian Watkins
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2746-54.
2007: Jacob D Estes; Stephen Wietgrefe; Timothy W Schacker; Peter J Southern; Gregory Beilman; Cavan Reilly; Jeffrey M Milush; Jeffrey D Lifson; Donald L Sodora; John V Carlis; Ashley T Haase
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.
The Journal of infectious diseases 2007;195(4):551-61.
2007: Amitinder Kaur; Hannah B Sanford; Deirdre Garry; Sabine Lang; Sherry A Klumpp; Daisuke Watanabe; Roderick T Bronson; Jeffrey D Lifson; margherita rosati; George Pavlakis; Barbara K Felber; David M Knipe; Ronald C Desrosiers
Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Virology 2007;357(2):199-214.
2007: Christiane Stahl-Hennig; Martin Eisenblatter; Monika Franz; Heribert Stoiber; Klara Tenner-Racz; You-Suk Suh; Edith Jasny; Barbara Falkensammer; Mariagrazia Ugucchioni; Gudmundur Georgsson; Carlo Baroni; Manfred P Dierich; Jeffrey D Lifson; Ralph M Steinman; Klaus Uberla; Paul Racz; Ralf Ignatius
A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum.
Frontiers in bioscience : a journal and virtual library 2007;12():2107-23.
2006: Natalia Teleshova; Jessica Kenney; Gary Van Nest; Jason Marshall; Jeffrey D Lifson; Irving Sivin; Jason Dufour; Rudolf Bohm; Agegnehu Gettie; Melissa Robbiani
Local and systemic effects of intranodally injected CpG-C immunostimulatory-oligodeoxyribonucleotides in macaques.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8531-41.
2006: Marie-Claire E Gauduin; Yi Yu; Amy Barabasz; Angela Carville; Michael Piatak; Jeffrey D Lifson; Ronald C Desrosiers; R Paul Johnson
Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection.
The Journal of experimental medicine 2006;203(12):2661-72.
2006: Geoffrey Stone; Suzanne Barzee; Victoria Snarsky; Celsa A Spina; Jeffrey D Lifson; Vinod Kumar Bhaskara Pillai; Rama Rao Amara; Francios VILLINGER; Richard Kornbluth
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro.
Clinical and vaccine immunology : CVI 2006;13(11):1223-30.
2006: Theodora Hatziioannou; Michael Princiotta; Michael Piatak; Fang Yuan; Fengwen Zhang; Jeffrey D Lifson; Paul D Bieniasz
Generation of simian-tropic HIV-1 by restriction factor evasion.
Science (New York, N.Y.) 2006;314(5796):95.
2006: Elena Chertova; Oleg Chertov; Lori V Coren; James D Roser; Charles M Trubey; Julian W Bess; Raymond C Sowder; Eugene V Barsov; Brian L Hood; Robert J Fisher; Kunio Nagashima; Thomas P Conrads; Timothy D Veenstra; Jeffrey D Lifson; David E Ott
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.
Journal of virology 2006;80(18):9039-52.
2006: Ping Zhu; Jun Liu; Julian W Bess; Elena Chertova; Jeffrey D Lifson; Henry Grisé; Gilad A Ofek; Kenneth A Taylor; Kenneth H Roux
Distribution and three-dimensional structure of AIDS virus envelope spikes.
Nature 2006;441(7095):847-52.
2006: Louis J Picker; Edward F Reed-Inderbitzin; Shoko I Hagen; John B Edgar; Scott G Hansen; Alfred Legasse; Shannon Planer; Michael Piatak; Jeffrey D Lifson; Vernon C Maino; Michael K Axthelm; Francios VILLINGER
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates.
The Journal of clinical investigation 2006;116(6):1514-24.
2006: Eugene V Barsov; Hanne Andersen; Vicky J Coalter; Mary Carrington; Jeffrey D Lifson; David E Ott
Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics.
Immunology letters 2006;105(1):26-37.
2006: Levi J Yant; Thomas C Friedrich; Randall C Johnson; Gemma E May; Nicholas J Maness; Alissa M Enz; Jeffrey D Lifson; David O'Connor; Mary Carrington; David Ian Watkins
The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.
Journal of virology 2006;80(10):5074-7.
2006: Jacob D Estes; Qingsheng Li; Matthew R Reynolds; Stephen Wietgrefe; Lijie Duan; Timothy W Schacker; Louis J Picker; David Ian Watkins; Jeffrey D Lifson; Cavan Reilly; John V Carlis; Ashley T Haase
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
The Journal of infectious diseases 2006;193(5):703-12.
2006: Rui Zhang; Jeffrey D Lifson; Claire Chougnet
Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions.
Blood 2006;107(5):1989-95.
2006: Natalia Teleshova; Jessica Kenney; V Williams; Gary Van Nest; Jason Marshall; Jeffrey D Lifson; Irving Sivin; Jason Dufour; Rudolf Bohm; Agegnehu Gettie; Melissa Pope
CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques.
Journal of leukocyte biology 2006;79(2):257-67.
2006: Jennifer G Sambrook; Arman Bashirova; Hanne Andersen; Michael Piatak; George S Vernikos; Penny Coggill; Jeffrey D Lifson; Mary Carrington; Stephan Beck
Identification of the ancestral killer immunoglobulin-like receptor gene in primates.
BMC genomics 2006;7():209.
2006: Wayne C Koff; Philip R Johnson; David Ian Watkins; Dennis R Burton; Jeffrey D Lifson; Kim J Hasenkrug; Adrian B McDermott; Alan Schultz; Timothy J Zamb; Rosanne Boyle; Ronald C Desrosiers
HIV vaccine design: insights from live attenuated SIV vaccines.
Nature immunology 2006;7(1):19-23.
2005: Jean-Philippe Herbeuval; Jean-Charles Grivel; Adriano Boasso; Andrew W Hardy; Claire Chougnet; Matthew J Dolan; Hideo Yagita; Jeffrey D Lifson; Gene M Shearer
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.
Blood 2005;106(10):3524-31.
2005: Anne-Sophie Beignon; Kelli McKenna; mojca skoberne; Olivier Manches; Ida Dasilva; Daniel G Kavanagh; Marie Larsson; Robert J Gorelick; Jeffrey D Lifson; Nina Bhardwaj
Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.
The Journal of clinical investigation 2005;115(11):3265-75.
2005: Qingsheng Li; Jeffrey D Lifson; Lijie Duan; Timothy W Schacker; Cavan Reilly; John V Carlis; Jacob D Estes; Ashley T Haase
Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.
The Journal of infectious diseases 2005;192(7):1269-76.
2005: A Nichole Cline; Julian W Bess; Michael Piatak; Jeffrey D Lifson
Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS.
Journal of medical primatology 2005;34(5-6):303-12.
2005: Kenneth Williams; Susan V Westmoreland; Jane B Greco; Eva M Ratai; Lentz Margaret; Woong-Ki Kim; Robert A Fuller; John P Kim; Patrick Autissier; Prabhat Sehgal; Ray F Schinazi; Norbert Bischofberger; Michael Piatak; Jeffrey D Lifson; Eliezer Masliah; R Gilberto González
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
The Journal of clinical investigation 2005;115(9):2534-45.
2005: Mark K Louder; Anna Sambor; Elena Chertova; Tai Hunte; Sarah Barrett; Fallon Ojong; eric sanders-buell; Susan Zolla-Pazner; Francine E McCutchan; James D Roser; Dana Gabuzda; Jeffrey D Lifson; John R Mascola
HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.
Virology 2005;339(2):226-38.
2005: Silvia Peretti; Andrew Shaw; James Blanchard; Rudolf Bohm; Gavin Morrow; Jeffrey D Lifson; Agegnehu Gettie; Melissa Pope
Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses.
Blood 2005;106(4):1305-13.
2005: Marc Busch; Kristina Abel; Jun Li; Michael Piatak; Jeffrey D Lifson; Christopher J Miller
Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge.
Vaccine 2005;23(31):4036-47.
2005: Joern schmitz; R Paul Johnson; Harold M McClure; Kelledy Manson; Michael S Wyand; Marcelo J Kuroda; Michelle A Lifton; Rajinder Khunkhun; Kimberly J McEvers; Jacqueline Gillis; Michael Piatak; Jeffrey D Lifson; Gudrun Grosschupff; Paul Racz; Klara Tenner-Racz; E Peter Rieber; Kristine Kuus-Reichel; Rebecca Gelman; Norman L Letvin; David C Montefiori; Ruth Ruprecht; Ronald C Desrosiers; Keith A Reimann
Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
Journal of virology 2005;79(13):8131-41.
2005: David T Evans; Jennifer E Bricker; Hannah B Sanford; Sabine Lang; Angela Carville; Barbra A Richardson; Michael Piatak; Jeffrey D Lifson; Keith G Mansfield; Ronald C Desrosiers
Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239.
Journal of virology 2005;79(12):7707-20.
2005: Eun-Young Kim; Marc Busch; Kristina Abel; Linda Fritts; Patty Bustamante; Jennifer Stanton; Ding Lu; Samuel Wu; Jennifer Glowczwskie; Tracy Rourke; Derek Bogdan; Michael Piatak; Jeffrey D Lifson; Ronald C Desrosiers; Steven Wolinsky; Christopher J Miller
Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef.
Journal of virology 2005;79(8):4886-95.
2005: Jean-Philippe Herbeuval; Adriano Boasso; Jean-Charles Grivel; Andrew W Hardy; Stephanie A Anderson; Matthew J Dolan; Claire Chougnet; Jeffrey D Lifson; Gene M Shearer
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.
Blood 2005;105(6):2458-64.
2005: David R Morcock; James A Thomas; Tracy D Gagliardi; Robert J Gorelick; James D Roser; Elena Chertova; Julian W Bess; David E Ott; Quentin J Sattentau; Ines Frank; Melissa Pope; Jeffrey D Lifson; Louis E. Henderson; Bruce J Crise
Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.
Journal of virology 2005;79(3):1533-42.
2004: Tomek Swigut; Louis Alexander; Jennifer Morgan; Jeffrey D Lifson; Keith G Mansfield; Sabine Lang; R Paul Johnson; Jacek Skowronski; Ronald Desrosiers
Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus.
Journal of virology 2004;78(23):13335-44.
2004: Louis J Picker; Shoko I Hagen; Richard Lum; Edward F Reed-Inderbitzin; Lyn M Daly; Andrew W Sylwester; Joshua M Walker; Don C Siess; Michael Piatak; Chenxi Wang; David Allison; Vernon C Maino; Jeffrey D Lifson; Toshiaki Kodama; Michael K Axthelm
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.
The Journal of experimental medicine 2004;200(10):1299-314.
2004: Michael M Lederman; Ronald S Veazey; Robin E Offord; Donald E Mosier; Jason Dufour; Megan Mefford; Michael Piatak; Jeffrey D Lifson; Janelle R Salkowitz; Benigno Rodriguez; Andrew Blauvelt; Oliver Hartley
Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5.
Science (New York, N.Y.) 2004;306(5695):485-7.
2004: Hanne Andersen; Jeffrey L Rossio; Vicky J Coalter; Barbara Poore; Maureen P Martin; Mary Carrington; Jeffrey D Lifson
Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level.
Cellular immunology 2004;231(1-2):85-95.
2004: Lorley Villamide-Herrera; Ralf Ignatius; Michael A Eller; K Wilkinson; C Griffin; Erin Mehlhop; Jennifer Jones; S Y Han; Mark G Lewis; S Parrish; Thomas C VanCott; Jeffrey D Lifson; Sarah J Schlesinger; John R Mascola; Melissa Pope
Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo.
AIDS research and human retroviruses 2004;20(8):871-84.
2004: Natalia Teleshova; Jessica Kenney; Jennifer Jones; Jason Marshall; Gary Van Nest; Jason Dufour; Rudolf Bohm; Jeffrey D Lifson; Agegnehu Gettie; Melissa Pope
CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1647-57.
2004: Jeffrey D Lifson; Jeffrey L Rossio; Michael Piatak; Julian W Bess; Elena Chertova; Douglas K Schneider; Vicky J Coalter; Barbara Poore; Rebecca F Kiser; Robert J Imming; Anthony J Scarzello; Louis E. Henderson; W Gregory Alvord; Vanessa M Hirsch; Raoul E Benveniste; Larry O Arthur
Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins.
AIDS research and human retroviruses 2004;20(7):772-87.
2004: Wendy Fitzgerald; Andrew W Sylwester; Jean-Charles Grivel; Jeffrey D Lifson; Leonid Margolis
Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo.
Journal of virology 2004;78(13):7061-8.
2004: Marie-Claire E Gauduin; Amitinder Kaur; Shabbir Ahmad; Tilahun D Yilma; Jeffrey D Lifson; R Paul Johnson
Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques.
Journal of immunological methods 2004;288(1-2):61-79.
2004: Jean-François Fonteneau; Marie Larsson; Anne-Sophie Beignon; Kelli McKenna; Ida Dasilva; Ali Amara; Yong-Jun Liu; Jeffrey D Lifson; Dan R Littman; Nina Bhardwaj
Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells.
Journal of virology 2004;78(10):5223-32.
2004: Daniela Verthelyi; Vivian W Wang; Jeffrey D Lifson; Dennis M Klinman
CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques.
AIDS (London, England) 2004;18(7):1003-8.
2004: Zhi-Qiang Zhang; Stephen Wietgrefe; Qingsheng Li; Marta Dykhuizen Shore; Lijie Duan; Cavan Reilly; Jeffrey D Lifson; Ashley T Haase
Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5640-5.
2004: Simone E Gloster; Philippa Newton; David Cornforth; Jeffrey D Lifson; Ian Williams; George M Shaw; Persephone Borrow
Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection.
AIDS (London, England) 2004;18(5):749-55.
2004: Stuart G Turville; John J Santos; Ines Frank; paul cameron; John Wilkinson; Monica Miranda-Saksena; Joanne Dable; Hella Stössel; Nikolaus Romani; Michael Piatak; Jeffrey D Lifson; Melissa Pope; Anthony L Cunningham
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
Blood 2004;103(6):2170-9.
2004: Thomas C Friedrich; Elizabeth J Dodds; Levi J Yant; Lara Vojnov; Richard Rudersdorf; Candice Cullen; David T Evans; Ronald C Desrosiers; Bianca R Mothé; John Sidney; Alessandro Sette; Kevin Kunstman; Steven Wolinsky; Michael Piatak; Jeffrey D Lifson; Austin Hughes; Nancy Wilson; David O'Connor; David Ian Watkins
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Nature medicine 2004;10(3):275-81.
2004: Rui Zhang; Carl J Fichtenbaum; David A Hildeman; Jeffrey D Lifson; Claire Chougnet
CD40 ligand dysregulation in HIV infection: HIV glycoprotein 120 inhibits signaling cascades upstream of CD40 ligand transcription.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2678-86.
2003: Ping Zhu; Elena Chertova; Julian W Bess; Jeffrey D Lifson; Larry O Arthur; Jun Liu; Kenneth A Taylor; Kenneth H Roux
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15812-7.
2003: Charles M Trubey; Elena Chertova; Lori V Coren; Joanne M Hilburn; Catherine V Hixson; Kunio Nagashima; Jeffrey D Lifson; David E Ott
Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles.
Journal of virology 2003;77(23):12699-709.
2003: Ronald S Veazey; Per Johan Klasse; Thomas J Ketas; Jacqueline D Reeves; Michael Piatak; Kevin Kunstman; Shawn E Kuhmann; Preston A Marx; Jeffrey D Lifson; Jason Dufour; Megan Mefford; Ivona Pandrea; Steven Wolinsky; Robert W Doms; Julie A DeMartino; Salvatore J Siciliano; Kathy Lyons; Martin S Springer; John P Moore
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
The Journal of experimental medicine 2003;198(10):1551-62.
2003: Ines Frank; John J Santos; Erin Mehlhop; Lorley Villamide-Herrera; Christine Santisteban; Agegnehu Gettie; Ralf Ignatius; Jeffrey D Lifson; Melissa Pope
Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses.
Journal of acquired immune deficiency syndromes (1999) 2003;34(1):7-19.
2003: Marc Busch; Ding Lu; Linda Fritts; Jeffrey D Lifson; Christopher J Miller
Comparison of virology and immunology in SHIV 89.6 proviral DNA and virus-inoculated rhesus macaques.
Journal of medical primatology 2003;32(4-5):240-6.
2003: Jeffrey D Lifson; Michael Piatak; A N Cline; Jeffrey L Rossio; Jeanette E Purcell; Ivona Pandrea; Norbert Bischofberger; James Blanchard; Ronald S Veazey
Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge.
Journal of medical primatology 2003;32(4-5):201-10.
2003: Ronald S Veazey; Jeffrey D Lifson; Joern schmitz; Marcelo J Kuroda; Michael Piatak; Ivona Pandrea; Jeanette E Purcell; Rudolf Bohm; James Blanchard; Kenneth C Williams; Andrew Lackner
Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues.
Journal of medical primatology 2003;32(4-5):194-200.
2003: Ronald S Veazey; Jeffrey D Lifson; Ivona Pandrea; Jeanette E Purcell; Michael Piatak; Andrew Lackner
Simian immunodeficiency virus infection in neonatal macaques.
Journal of virology 2003;77(16):8783-92.
2003: Louis Alexander; Petr O Illyinskii; Sabine M Lang; Robert E Means; Jeffrey D Lifson; Keith Mansfield; Ronald C Desrosiers
Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys.
Journal of virology 2003;77(12):6823-35.
2003: Amitinder Kaur; Nadine Kassis; Corrina L Hale; Meredith Simon; Michelle Elliott; Alicia Gomez-Yafal; Jeffrey D Lifson; Ronald C Desrosiers; Fred Wang; Peter A Barry; Michael Mach; R Paul Johnson
Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS.
Journal of virology 2003;77(10):5749-58.
2003: Daniela Verthelyi; Mayda Gursel; Richard Kenney; Jeffrey D Lifson; Shuying Liu; Joan Mican; Dennis M Klinman
CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4717-23.
2003: Elena Chertova; Bruce J Crise; David R Morcock; Julian W Bess; Louis E. Henderson; Jeffrey D Lifson
Sites, mechanism of action and lack of reversibility of primate lentivirus inactivation by preferential covalent modification of virion internal proteins.
Current molecular medicine 2003;3(3):265-72.
2003: David T Evans; Li-Mei Chen; Jacqueline Gillis; Kuei-Chin Lin; Brian Harty; Gail P Mazzara; Ruben O Donis; Keith G Mansfield; Jeffrey D Lifson; Ronald C Desrosiers; Jorge E Galán; R Paul Johnson
Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system.
Journal of virology 2003;77(4):2400-9.
2003: Joern schmitz; Marcelo J Kuroda; Sampa Santra; Meredith A Simon; Michelle A Lifton; Wenyu Lin; Rajinder Khunkhun; Michael Piatak; Jeffrey D Lifson; Gudrun Grosschupff; Rebecca Gelman; Paul Racz; Klara Tenner-Racz; Keith A Mansfield; Norman L Letvin; David C Montefiori; Keith A Reimann
Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.
Journal of virology 2003;77(3):2165-73.
2003: Ronald L Willey; Russ Byrum; Michael Piatak; Young B Kim; Michael W Cho; Jeffrey L Rossio; Julian Bess; Tatsuhiko Igarashi; Yasuyuki Endo; Larry O Arthur; Jeffrey D Lifson; Malcolm Martin
Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles.
Journal of virology 2003;77(2):1163-74.
2003: Welkin E Johnson; Jeffrey D Lifson; Sabine M Lang; R Paul Johnson; Ronald C Desrosiers
Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus.
Journal of virology 2003;77(1):375-81.
2003: Arman Bashirova; Li Wu; Jie Cheng; Thomas D Martin; Maureen P Martin; Raoul E Benveniste; Jeffrey D Lifson; Vineet N KewalRamani; Austin Hughes; Mary Carrington
Novel member of the CD209 (DC-SIGN) gene family in primates.
Journal of virology 2003;77(1):217-27.
2002: Todd M Allen; Peicheng Jing; Briana Calore; Helen Horton; David O'Connor; Tomas Hanke; Marian Piekarczyk; Richard Ruddersdorf; Bianca R Mothé; Carol Emerson; Nancy Wilson; Jeffrey D Lifson; Igor M Belyakov; Jay A Berzofsky; Chenxi Wang; David Allison; David C Montefiori; Ronald C Desrosiers; Steven Wolinsky; Kevin Kunstman; John D Altman; Alessandro Sette; Andrew J McMichael; David Ian Watkins
Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
Journal of virology 2002;76(20):10507-11.
2002: Janice E Clements; Tahar Babas; Joseph L Mankowski; K Suryanarayana; Michael Piatak; Patrick M Tarwater; Jeffrey D Lifson; MARY ZINK
The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.
The Journal of infectious diseases 2002;186(7):905-13.
2002: Anil Kumar; Sampa Mukherjee; Jing Shen; Shilpa Buch; Zhuang Li; Istvan Adany; Zhenqian Liu; Wu Zhuge; Michael Piatak; Jeffrey D Lifson; Harold M McClure; Opendra Narayan
Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virus.
Virology 2002;301(2):189-205.
2002: Jeffrey D Lifson; Michael Piatak; Jeffrey L Rossio; Julian W Bess; Elena Chertova; D Schneider; Rebecca F Kiser; Vicky J Coalter; Barbara Poore; Robert J Imming; R C Desrosiers; Louis E. Henderson; Larry O Arthur
Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge.
Journal of medical primatology 2002;31(4-5):205-16.
2002: B Ling; Ronald S Veazey; C Penedo; K Xu; Jeffrey D Lifson; Preston A Marx
Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma.
Journal of medical primatology 2002;31(4-5):154-63.
2002: Binhua Ling; Ronald S Veazey; Amara Luckay; Cecilia Penedo; Keyu Xu; Jeffrey D Lifson; Preston A Marx
SIV(mac) pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans.
AIDS (London, England) 2002;16(11):1489-96.
2002: Marie Larsson; Jean-François Fonteneau; Margareta Lirvall; Patrick A J Haslett; Jeffrey D Lifson; Nina Bhardwaj
Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus.
AIDS (London, England) 2002;16(10):1319-29.
2002: Elena Chertova; Julian W Bess; Bruce J Crise; Raymond C Sowder II; Terra M Schaden; Joanne M Hilburn; James A Hoxie; Raoul E Benveniste; Jeffrey D Lifson; Louis E. Henderson; Larry O Arthur
Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus.
Journal of virology 2002;76(11):5315-25.
2002: Stephanie bissel; Guoji Wang; Mimi Ghosh; Todd A Reinhart; Saverio Capuano; Kelly Stefano Cole; Michael Murphey-Corb; Michael Piatak Jr; Jeffrey D Lifson; Clayton A Wiley
Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis.
The American journal of pathology 2002;160(3):927-41.
2002: Ines Frank; Michael Piatak; H Stoessel; Nikolaus Romani; David Bonnyay; Jeffrey D Lifson; Melissa Pope
Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs.
Journal of virology 2002;76(6):2936-51.
2002: Erin Mehlhop; Loreley A Villamide; Ines Frank; Agegnehu Gettie; Christine Santisteban; Davorka Messmer; Ralf Ignatius; Jeffrey D Lifson; Melissa Pope
Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses.
Journal of immunological methods 2002;260(1-2):219-34.
2002: Jeffrey D Lifson; Malcolm Martin
One step forwards, one step back.
Nature 2002;415(6869):272-3.
2001: Ronald S Veazey; Marie-Claire E Gauduin; Keith G Mansfield; IC Tham; John D Altman; Jeffrey D Lifson; Andrew Lackner; R Paul Johnson
Emergence and kinetics of simian immunodeficiency virus-specific CD8(+) T cells in the intestines of macaques during primary infection.
Journal of virology 2001;75(21):10515-9.
2001: Jeffrey D Lifson; Jeffrey L Rossio; Michael Piatak; Tom` Parks; L Li; Rebecca F Kiser; Vicky J Coalter; B Fisher; Bernard M Flynn; S Czajak; Vanessa M Hirsch; Keith A Reimann; Joern schmitz; John Ghrayeb; Norbert Bischofberger; Martin A Nowak; R C Desrosiers; D Wodarz
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.
Journal of virology 2001;75(21):10187-99.
2001: Shane Crotty; Christopher J Miller; B L Lohman; M R Neagu; Lara Compton; Ding Lu; F X Lü; Linda Fritts; Jeffrey D Lifson; Raul Andino
Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors.
Journal of virology 2001;75(16):7435-52.
2001: MARK ESSER; David Raymond Graham; Lori V Coren; Charles M Trubey; Julian W Bess; Larry O Arthur; David E Ott; Jeffrey D Lifson
Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation.
Journal of virology 2001;75(13):6173-82.
2001: MARK ESSER; Julian W Bess; K Suryanarayana; Elena Chertova; D Marti; M Carrington; Larry O Arthur; Jeffrey D Lifson
Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1.
Journal of virology 2001;75(3):1152-64.
2001: Anil Kumar; Jeffrey D Lifson; Zhuang Li; Fenglan Jia; Sampa Mukherjee; Istvan Adany; Zhenqian Liu; Michael Piatak; Darlene Sheffer; Harold M McClure; Opendra Narayan
Sequential immunization of macaques with two differentially attenuated vaccines induced long-term virus-specific immune responses and conferred protection against AIDS caused by heterologous simian human immunodeficiency Virus (SHIV(89.6)P).
Virology 2001;279(1):241-56.
2001: Anil Kumar; Shilpa Buch; LL Foresman; N Bischofberger; Jeffrey D Lifson; Opendra Narayan
Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.
Virology 2001;279(1):97-108.
2000: Robert J Gorelick; Raoul E Benveniste; Jeffrey D Lifson; JL Yovandich; William R Morton; L Kuller; Bernard M Flynn; Bradley A Fisher; Jeffrey L Rossio; Michael Piatak; Julian W Bess; Louis E. Henderson; Larry O Arthur
Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost.
Journal of virology 2000;74(24):11935-49.
2000: Marilyn S Smith; LL Foresman; G J Lopez; J Tsay; D Wodarz; Jeffrey D Lifson; A Page; C Wang; Zhuang Li; Istvan Adany; Shilpa Buch; N Bischofberger; Opendra Narayan
Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.
Virology 2000;277(2):306-15.
2000: Shainn-Wei Wang; Pamela A Kozlowski; G Schmelz; Kelledy Manson; Michael S Wyand; RL Glickman; David Montefiori; Jeffrey D Lifson; R Paul Johnson; Marian R Neutra; Anna Aldovini
Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions.
Journal of virology 2000;74(22):10514-22.
2000: PS Silverstein; Glenn A Mackay; Sampa Mukherjee; Zhuang Li; Michael Piatak; Jeffrey D Lifson; Opendra Narayan; Anil Kumar
Pathogenic simian/human immunodeficiency virus SHIV(KU) inoculated into immunized macaques caused infection, but virus burdens progressively declined with time.
Journal of virology 2000;74(22):10489-97.
2000: Simoy Goldstein; Charles R Brown; Houman Dehghani; Jeffrey D Lifson; Vanessa M Hirsch
Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication.
Journal of virology 2000;74(20):9388-95.
2000: C G Murphy; William Lucas; Robert E Means; Susan Czajak; Corrina L Hale; Jeffrey D Lifson; Amitinder Kaur; R Paul Johnson; David M Knipe; Ronald C Desrosiers
Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus.
Journal of virology 2000;74(17):7745-54.
2000: D Wodarz; RA Arnaout; Martin A Nowak; Jeffrey D Lifson
Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1400):1021-9.
2000: Anil Kumar; Jeffrey D Lifson; PS Silverstein; Fenglan Jia; Darlene Sheffer; Zhuang Li; Opendra Narayan
Evaluation of immune responses induced by HIV-1 gp120 in rhesus macaques: effect of vaccination on challenge with pathogenic strains of homologous and heterologous simian human immunodeficiency viruses.
Virology 2000;274(1):149-64.
2000: Robert J Gorelick; Jeffrey D Lifson; JL Yovandich; Jeffrey L Rossio; Michael Piatak; A J Scarzello; W B Knott; Julian W Bess; Bradley A Fisher; Bernard M Flynn; Louis E. Henderson; Larry O Arthur; Raoul E Benveniste
Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination.
Journal of medical primatology 2000;29(3-4):209-19.
2000: D Wodarz; K M Page; RA Arnaout; A R Thomsen; Jeffrey D Lifson; Martin A Nowak
A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1395):329-43.
2000: Jeffrey D Lifson; Jeffrey L Rossio; RA Arnaout; L Li; Tom` Parks; Douglas K Schneider; Rebecca F Kiser; Vicky J Coalter; G Walsh; Robert J Imming; B Fisher; Bernard M Flynn; Norbert Bischofberger; Michael Piatak; Vanessa M Hirsch; Martin A Nowak; D Wodarz
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.
Journal of virology 2000;74(6):2584-93.
2000: Vanessa M Hirsch; Jeffrey D Lifson
Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention.
Advances in pharmacology (San Diego, Calif.) 2000;49():437-77.
1999: MARY ZINK; K Suryanarayana; Joseph L Mankowski; Anding Shen; Michael Piatak; JP Spelman; Darryl L Carter; Robert J Adams; Jeffrey D Lifson; Janice E Clements
High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis.
Journal of virology 1999;73(12):10480-8.
1999: Michael S Wyand; Kelledy Manson; David C Montefiori; Jeffrey D Lifson; R Paul Johnson; Ronald C Desrosiers
Protection by live, attenuated simian immunodeficiency virus against heterologous challenge.
Journal of virology 1999;73(10):8356-63.
1999: R Paul Johnson; Jeffrey D Lifson; Susan Czajak; Kelly Stefano Cole; Kelledy Manson; RL Glickman; J Yang; David C Montefiori; Ronald Montelaro; Michael S Wyand; Ronald C Desrosiers
Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.
Journal of virology 1999;73(6):4952-61.
1999: Harriet L Robinson; David C Montefiori; R Paul Johnson; Kelledy Manson; M L Kalish; Jeffrey D Lifson; T A Rizvi; S Lu; Shiu-Lok Hu; Gail P Mazzara; Dennis Panicali; James G. Herndon; R Glickman; Maria Angelito Candido; Shari L Lydy; Michael S Wyand; Harold M McClure
Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations.
Nature medicine 1999;5(5):526-34.
1999: MARK ESSER; T Mori; I Mondor; Quentin J Sattentau; Barna Dey; Edward A Berger; M R Boyd; Jeffrey D Lifson
Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.
Journal of virology 1999;73(5):4360-71.
1999: Svetlana Glushakova; Jean-Charles Grivel; K Suryanarayana; P Meylan; Jeffrey D Lifson; R Desrosiers; Leonid Margolis
Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.
Journal of virology 1999;73(5):3968-74.
1999: Robert J Gorelick; Tracy D Gagliardi; William J Bosche; TA Wiltrout; Lori V Coren; D J Chabot; Jeffrey D Lifson; Louis E. Henderson; Larry O Arthur
Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences.
Virology 1999;256(1):92-104.
1999: Robert J Gorelick; Raoul E Benveniste; Tracy D Gagliardi; TA Wiltrout; L K Busch; William J Bosche; Lori V Coren; Jeffrey D Lifson; P J Bradley; Louis E. Henderson; Larry O Arthur
Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo.
Virology 1999;253(2):259-70.
1998: Vanessa M Hirsch; Mark E Sharkey; Charles R Brown; B Brichacek; Simoy Goldstein; J Wakefield; Russ Byrum; WR Elkins; B H Hahn; Jeffrey D Lifson; Mario Stevenson
Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: evidence of macrophage-dependent viral amplification.
Nature medicine 1998;4(12):1401-8.
1998: Andrew W Sylwester; Jean-Charles Grivel; Wendy Fitzgerald; J L Rossio; Jeffrey D Lifson; Leonid Margolis
CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
Journal of virology 1998;72(11):9345-7.
1998: SV Joag; Zhen Qian Liu; Edward B Stephens; Marilyn S Smith; Anil Kumar; Zhuang Li; C Wang; Darlene Sheffer; Fenglan Jia; LL Foresman; Istvan Adany; Jeffrey D Lifson; Harold M McClure; Opendra Narayan
Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS.
Journal of virology 1998;72(11):9069-78.
1998: Larry O Arthur; Julian W Bess; Elena Chertova; Jeffrey L Rossio; MARK ESSER; Raoul E Benveniste; Louis E. Henderson; Jeffrey D Lifson
Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine.
AIDS research and human retroviruses 1998;14 Suppl 3():S311-9.
1998: Jeffrey L Rossio; MARK ESSER; K Suryanarayana; Douglas K Schneider; Julian W Bess; GM Vasquez; TA Wiltrout; Elena Chertova; M K Grimes; Quentin J Sattentau; Larry O Arthur; Louis E. Henderson; Jeffrey D Lifson
Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.
Journal of virology 1998;72(10):7992-8001.
1998: Vanessa M Hirsch; G Dapolito; A Hahn; Jeffrey D Lifson; David Montefiori; Charles R Brown; Robert M Goeken
Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia.
Journal of virology 1998;72(8):6482-9.
1998: Koen K A Van Rompay; Marta L Marthas; Jeffrey D Lifson; CJ Berardi; GM Vasquez; E Agatep; Z A Dehqanzada; Kenneth C Cundy; Norbert Bischofberger; Niels C Pedersen
Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.
AIDS research and human retroviruses 1998;14(9):761-73.
1998: Che-Chung Tsai; Peter Emau; KE Follis; TW Beck; Raoul E Benveniste; Norbert Bischofberger; Jeffrey D Lifson; William R Morton
Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment.
Journal of virology 1998;72(5):4265-73.
1998: Ronald C Desrosiers; Jeffrey D Lifson; J S Gibbs; Susan Czajak; AY Howe; L O Arthur; R Paul Johnson
Identification of highly attenuated mutants of simian immunodeficiency virus.
Journal of virology 1998;72(2):1431-7.
1998: K Suryanarayana; TA Wiltrout; GM Vasquez; Vanessa M Hirsch; Jeffrey D Lifson
Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction.
AIDS research and human retroviruses 1998;14(2):183-9.
1997: Jeffrey D Lifson; Martin A Nowak; Simoy Goldstein; Jeffrey L Rossio; A Kinter; GM Vasquez; TA Wiltrout; C Brown; D Schneider; L Wahl; Alun L Lloyd; J Williams; WR Elkins; Anthony Fauci; Vanessa M Hirsch
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.
Journal of virology 1997;71(12):9508-14.
1997: Martin A Nowak; Alun L Lloyd; GM Vasquez; TA Wiltrout; L M Wahl; Norbert Bischofberger; J Williams; A Kinter; Anthony Fauci; Vanessa M Hirsch; Jeffrey D Lifson
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection.
Journal of virology 1997;71(10):7518-25.
1996: Vanessa M Hirsch; Thomas R Fuerst; G Sutter; MW Carroll; L C Yang; S Goldstein; M Piatak; W R Elkins; W G Alvord; D C Montefiori; Bernard Moss; Jeffrey D Lifson
Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.
Journal of virology 1996;70(6):3741-52.
1996: Jeffrey Linnen; J Wages; Z Y Zhang-Keck; Kirk Fry; K Z Krawczynski; Harvey Alter; E Koonin; M Gallagher; M Alter; S Hadziyannis; Peter Karayiannis; Kevin Fung; Y Nakatsuji; James Shih; L Young; M Piatak; C Hoover; J Fernandez; S Chen; J C Zou; T Morris; KC Hyams; S Ismay; Jeffrey D Lifson; Georg Hess; Steven K H Foung; Howard Thomas; D Bradley; H Margolis; JP Kim
Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.
Science (New York, N.Y.) 1996;271(5248):505-8.
1996: Bernard Moss; MW Carroll; Linda S Wyatt; Jack R Bennink; Vanessa M Hirsch; S Goldstein; W R Elkins; Thomas R Fuerst; Jeffrey D Lifson; M Piatak; Nicholas P Restifo; Willem W Overwijk; R Chamberlain; STEVEN ROSENBERG; G Sutter
Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates.
Advances in experimental medicine and biology 1996;397():7-13.
1995: Y Cao; David D Ho; J Todd; R Kokka; M Urdea; Jeffrey D Lifson; M Piatak; S Chen; Beatrice H Hahn; Michael S Saag
Clinical evaluation of branched DNA signal amplification for quantifying HIV type 1 in human plasma.
AIDS research and human retroviruses 1995;11(3):353-61.
1994: Carl E Mackewicz; L C Yang; Jeffrey D Lifson; Jay A Levy
Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection.
Lancet 1994;344(8938):1671-3.
1993: M Piatak; Michael S Saag; L C Yang; S J Clark; John C Kappes; K C Luk; Beatrice H Hahn; George M Shaw; Jeffrey D Lifson
Determination of plasma viral load in HIV-1 infection by quantitative competitive polymerase chain reaction.
AIDS (London, England) 1993;7 Suppl 2():S65-71.
1993: M Piatak; L C Yang; K C Luk; Jeffrey D Lifson; Michael S Saag; S J Clark; John C Kappes; Beatrice H Hahn; George M Shaw
Viral dynamics in primary HIV-1 infection.
Lancet 1993;341(8852):1099.
1993: M Piatak; Michael S Saag; L C Yang; S J Clark; John C Kappes; K C Luk; Beatrice H Hahn; George M Shaw; Jeffrey D Lifson
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
Science (New York, N.Y.) 1993;259(5102):1749-54.
1993: M Piatak; K C Luk; B Williams; Jeffrey D Lifson
Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species.
BioTechniques 1993;14(1):70-81.
1991: Edward A Berger; Jeffrey D Lifson; L E Eiden
Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8082-6.