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Stephen Liggett

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Ryan G Aleong; Stephen B Liggett; Alastair D Robertson; William H Sauer; Michael R Bristow
Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.
Adam A Clark; Stephen B Liggett; Steven Munger
Extraoral bitter taste receptors as mediators of off-target drug effects.
Alexander G Vandell; Taimour Y Langaee; Stephen B Liggett; Maximilian T Lobmeyer; Carl J Pepine; Stephen T Turner; Kent R Bailey; Amber L Beitelshees; Eric Boerwinkle; Arlene B Chapman; Rhonda M Cooper-DeHoff; Brian E Gawronski; Yan Gong; John G Gums; Julie A Johnson
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.

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All Publications

2013: Ryan G Aleong; Stephen B Liggett; Alastair D Robertson; William H Sauer; Michael R Bristow
Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.
Circulation. Arrhythmia and electrophysiology 2013;6(1):137-43.
2012: Adam A Clark; Stephen B Liggett; Steven Munger
Extraoral bitter taste receptors as mediators of off-target drug effects.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(12):4827-31.
2012: Alexander G Vandell; Taimour Y Langaee; Stephen B Liggett; Maximilian T Lobmeyer; Carl J Pepine; Stephen T Turner; Kent R Bailey; Amber L Beitelshees; Eric Boerwinkle; Arlene B Chapman; Rhonda M Cooper-DeHoff; Brian E Gawronski; Yan Gong; John G Gums; Julie A Johnson
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
Hypertension 2012;60(4):957-64.
2012: Steven S An; Cynthia J Koziol-White; Richard C Kurten; Danielle Y Lee; Reynold A Panettieri; Chienhwa Wang; Kwangmi Ahn; Stephen B Liggett
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
American journal of physiology. Lung cellular and molecular physiology 2012;303(4):L304-11.
2012: Christopher M O'Connor; Jonathan F Plehn; J David Port; Alastair D Robertson; Marc A Silver; Ryan Walsh; Michel White; William T Abraham; Inder S Anand; James Carr; Peter E Carson; Gordon Davis; Mona Fiuzat; Stephen S Gottlieb; Laura C Lazzeroni; Stephen B Liggett; JoAnn Lindenfeld; Allen Medway; Alan B Miller; Guinevere A Murphy; Penny Nelson; Michael R Bristow
Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms.
PloS one 2012;7(10):e44324.
2011: Karen Dockstader; Anis Karimpour-Fard; Stephen B Liggett; Allen Medway; Penny Nelson; Karin Nunley; J David Port; Michael R Bristow; Carmen C Sucharov
Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor.
Physiological genomics 2011;43(23):1294-306.
2011: Peter Nagele; Stephen B Liggett
Genetic variation, β-blockers, and perioperative myocardial infarction.
Anesthesiology 2011;115(6):1316-27.
2011: Kathryn Robinett; Molly M Malone; Deepak A Deshpande; Stephen B Liggett
Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.
American journal of respiratory cell and molecular biology 2011;45(5):1069-74.
2011: Stephen B Liggett
Phosphorylation barcoding as a mechanism of directing GPCR signaling.
Science signaling 2011;4(185):pe36.
2011: Yury A Bochkov; Ann C Palmenberg; Wai-Ming Lee; Jennifer A Rathe; Svetlana P Amineva; Xin Sun; Thomas R Pasic; Nizar N Jarjour; Stephen B Liggett; James E Gern
Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C.
Nature medicine 2011;17(5):627-32.
2011: Chienhwa Wang; Aster H Juan; Alfredo Panebra; Stephen B Liggett
MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6246-51.
2011: Julie A Johnson; Stephen B Liggett
Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions.
Clinical pharmacology and therapeutics 2011;89(3):366-78.
2011: Chienhwa Wang; Rachel M Schillinger; Molly M Malone; Stephen B Liggett
Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L472-8.
2011: Qing Ling Duan; Brigitte R Gaume; Gregory A Hawkins; Blanca E Himes; Eugene R Bleecker; Barbara J Klanderman; Charles G Irvin; Stephen P Peters; Deborah A Meyers; John P Hanrahan; John J Lima; Augusto A Litonjua; Kelan G Tantisira; Stephen B Liggett
Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.
American journal of respiratory and critical care medicine 2011;183(4):449-54.
2011: Afshin Parsa; Yen-Pei C Chang; Reagan J Kelly; Mary C Corretti; Kathleen A Ryan; Shawn Robinson; Stephen S Gottlieb; Sharon L R Kardia; Alan R Shuldiner; Stephen B Liggett
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
Clinical and translational science 2011;4(1):17-23.
2011: Thomas Trian; Janette K Burgess; Kyoko Niimi; Lyn M Moir; Qi Ge; Patrick Berger; Stephen B Liggett; Judith L Black; Brian G Oliver
β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.
PloS one 2011;6(5):e20000.
2010: Deepak A Deshpande; Chienhwa Wang; Elizabeth L McIlmoyle; Kathryn Robinett; Rachel M Schillinger; Steven S An; James Sham; Stephen B Liggett
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.
Nature medicine 2010;16(11):1299-304.
2010: Ganapathy Jagatheesan; Sudarsan Rajan; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Greg Boivin; Grace M Arteaga; Hyun-Jin Tae; Stephen B Liggett; R John Solaro; David F Wieczorek
Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.
Journal of muscle research and cell motility 2010;31(3):227-39.
2010: Ann C Palmenberg; Jennifer A Rathe; Stephen B Liggett
Analysis of the complete genome sequences of human rhinovirus.
The Journal of allergy and clinical immunology 2010;125(6):1190-9; quiz 1200-1.
2010: Sudarsan Rajan; Ganapathy Jagatheesan; Chehade N Karam; Marco L Alves; Ilona Bodi; Arnold Schwartz; Christian F Bulcao; Karen M D'Souza; Shahab A Akhter; Gregory P Boivin; Dipak K Dube; Natalia N Petrashevskaya; Andrew B Herr; Roger Hullin; Stephen B Liggett; Beata M Wolska; R John Solaro; David F Wieczorek
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
Circulation 2010;121(3):410-8.
2010: Alfredo Panebra; Wayne C Wang; Molly M Malone; Demar R G Pitter; Scott T Weiss; Gregory A Hawkins; Stephen B Liggett
Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes.
PloS one 2010;5(7):e11819.
2010: Stephen B Liggett
Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.
Heart failure clinics 2010;6(1):27-33.
2010: Jennifer A Rathe; Xinyue Liu; Luke J Tallon; James E Gern; Stephen B Liggett
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.
Archives of virology 2010;155(1):83-7.
2010: Michael R Bristow; Guinevere A Murphy; Heidi Krause-Steinrauf; Jeffrey L Anderson; John F Carlquist; Surai Thaneemit; Vaishali Krishnan; William T Abraham; Brian D Lowes; J. David Port; Gordon W Davis; Laura C Lazzeroni; Alastair D Robertson; Phillip W Lavori; Stephen B Liggett
An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.
Circulation. Heart failure 2010;3(1):21-8.
2009: Stephen B Liggett
alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes.
Science translational medicine 2009;1(12):12ps15.
2009: Chienhwa Wang; Kathryn A Mihlbachler; Alicyn C Brunnett; Stephen B Liggett
Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):15007-12.
2009: Gerald W Dorn; Stephen B Liggett
Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure.
Molecular pharmacology 2009;76(3):466-80.
2009: Ganapathy Jagatheesan; Sudarsan Rajan; Emily M Schulz; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Arnold Schwartz; Gregory P Boivin; Grace M Arteaga; Tao Wang; Yi-Gang Wang; Muhammad Ashraf; Stephen B Liggett; John Lorenz; R John Solaro; David F Wieczorek
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H181-90.
2009: Ann C Palmenberg; David Spiro; Ryan Kuzmickas; Shiliang Wang; Appolinaire Djikeng; Jennifer A Rathe; Claire M Fraser-Liggett; Stephen B Liggett
Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.
Science (New York, N.Y.) 2009;324(5923):55-9.
2008: Gerald W Dorn; Stephen B Liggett
Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure.
Clinical and translational science 2008;1(3):255-62.
2008: Natalia Petrashevskaya; Brigitte R Gaume; Kathryn A Mihlbachler; Gerald W Dorn; Stephen B Liggett
Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy.
Clinical and translational science 2008;1(3):221-7.
2008: Augusto A Litonjua; Jessica Lasky-Su; Kady Schneiter; Kelan G Tantisira; Ross Lazarus; Barbara Klanderman; John J Lima; Charles G Irvin; Stephen P Peters; John P Hanrahan; Stephen B Liggett; Gregory A Hawkins; Deborah A Meyers; Eugene R Bleecker; Christoph Lange; Scott Weiss
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
American journal of respiratory and critical care medicine 2008;178(7):688-94.
2008: Steven M Swift; Brigitte R Gaume; Kersten M Small; Bruce Aronow; Stephen B Liggett
Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs.
Physiological genomics 2008;35(1):123-31.
2008: Amy J Sehnert; Susan E Daniels; Michael Elashoff; James A Wingrove; Christopher R Burrow; Benjamin Horne; Joseph B Muhlestein; Mark Donahue; Stephen B Liggett; Jeffrey L Anderson; William E Kraus
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
Journal of the American College of Cardiology 2008;52(8):644-51.
2008: Chienhwa Wang; Kathryn A Mihlbachler; Eugene R Bleecker; Scott Weiss; Stephen B Liggett
A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors.
Pharmacogenetics and genomics 2008;18(8):729-32.
2008: Stephen B Liggett; Sharon Cresci; Reagan J Kelly; Faisal M Syed; Scot J Matkovich; Harvey S Hahn; Abhinav Diwan; Jeffrey S Martini; Li Sparks; Rohan R Parekh; John A Spertus; Walter J Koch; Sharon L R Kardia; Gerald W Dorn
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Nature medicine 2008;14(5):510-7.
2008: Richard Einstein; Heather Jordan; Weiyin Zhou; Michael Brenner; Esther G Moses; Stephen B Liggett
Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5230-5.
2008: Alfredo Panebra; Mary Rose Schwarb; Steven M Swift; Scott Weiss; Eugene R Bleecker; Gregory A Hawkins; Stephen B Liggett
Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation.
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L190-5.
2008: Sharon L R Kardia; Reagan J Kelly; Mehdi A Keddache; Bruce Aronow; Gregory A Grabowski; Harvey S Hahn; Karen L Case; Lynne E Wagoner; Gerald W Dorn; Stephen B Liggett
Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival.
BMC medical genetics 2008;9():93.
2008: Kersten M Small; Jeanne Mialet Perez; Stephen B Liggett
Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.
Journal of cardiovascular pharmacology 2008;51(1):106-10.
2007: Stephen B Liggett; Reagan J Kelly; Rohan R Parekh; Scot J Matkovich; Bonnie J Benner; Harvey S Hahn; Faisal M Syed; Anita S Galvez; Karen L Case; Nancy McGuire; Amy Odley; Li Sparks; Sharon L R Kardia; Gerald W Dorn
A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Human molecular genetics 2007;16(22):2740-50.
2007: Natalia N Petrashevskaya; Stephen B Liggett
Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure.
Cardiovascular research 2007;75(4):631-3.
2007: Alfredo Panebra; Mary Rose Schwarb; Clare B Glinka; Stephen B Liggett
Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L453-62.
2007: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Grace M Arteaga; R John Solaro; Stephen B Liggett; David F Wieczorek
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H949-58.
2007: Sudarsan Rajan; Rafeeq Ahmed; Ganapathy Jagatheesan; Natalia N Petrashevskaya; Gregory P Boivin; Dalia Urboniene; Grace M Arteaga; Beata M Wolska; R John Solaro; Stephen B Liggett; David F Wieczorek
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Circulation research 2007;101(2):205-14.
2007: Alfredo Panebra; Mary Rose Schwarb; Clare B Glinka; Stephen B Liggett
Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence.
American journal of respiratory cell and molecular biology 2007;36(6):654-60.
2007: Dennis W McGraw; Jean M Elwing; Kevin M Fogel; Chienhwa Wang; Clare B Glinka; Kathryn A Mihlbachler; Marc E Rothenberg; Stephen B Liggett
Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.
The Journal of clinical investigation 2007;117(5):1391-8.
2007: Stephen B Liggett
Long-distance affair with adrenal GRK2 hangs up heart failure.
Nature medicine 2007;13(3):246-8.
2007: Steven M Swift; Mary Rose Schwarb; Kathryn A Mihlbachler; Stephen B Liggett
Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity.
American journal of respiratory cell and molecular biology 2007;36(2):236-43.
2006: Gregory A Hawkins; Kelan G Tantisira; Deborah A Meyers; Elizabeth J Ampleford; Wendy C Moore; Barbara J Klanderman; Stephen B Liggett; Stephen P Peters; Scott Weiss; Eugene R Bleecker
Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.
American journal of respiratory and critical care medicine 2006;174(10):1101-9.
2006: Stephen B Liggett
Genetic variability of the beta2 adrenergic receptor and asthma exacerbations.
Thorax 2006;61(11):925-7.
2006: Dennis W McGraw; Kevin M Fogel; Sue Kong; Augusto A Litonjua; Evangelia G Kranias; Bruce Aronow; Stephen B Liggett
Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility.
Physiological genomics 2006;27(2):171-7.
2006: Scott Weiss; Augusto A Litonjua; C Lange; Ross Lazarus; Stephen B Liggett; Eugene R Bleecker; Kelan G Tantisira
Overview of the pharmacogenetics of asthma treatment.
The pharmacogenomics journal 2006;6(5):311-26.
2006: Stephen B Liggett; Jeanne Mialet Perez; Surai Thaneemit; Stewart A Weber; Scott M Greene; Danielle Hodne; Bradley Nelson; Jennifer Morrison; Michael J Domanski; Lynne E Wagoner; William T Abraham; Jeffrey L Anderson; John F Carlquist; Heidi Krause-Steinrauf; Laura C Lazzeroni; J. David Port; Philip W Lavori; Michael R Bristow
A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11288-93.
2006: Jeanne Mialet Perez; Stephen B Liggett
Pharmacogenetics of beta1-adrenergic receptors in heart failure and hypertension.
Archives des maladies du coeur et des vaisseaux 2006;99(6):616-20.
2006: Dennis W McGraw; Kathryn A Mihlbachler; Mary Rose Schwarb; Fahema F Rahman; Kersten M Small; Khalid F Almoosa; Stephen B Liggett
Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.
The Journal of clinical investigation 2006;116(5):1400-9.
2006: Stephen B Liggett
Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow.
Circulation 2006;113(15):1818-20.
2006: Kersten M Small; Mary Rose Schwarb; Clare Glinka; Cheryl T Theiss; Kari M Brown; Carrie A Seman; Stephen B Liggett
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment.
Biochemistry 2006;45(15):4760-7.
2006: Kersten M Small; Kari M Brown; Carrie A Seman; Cheryl T Theiss; Stephen B Liggett
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5472-7.
2006: Stephen B Liggett
Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify.
The Journal of clinical investigation 2006;116(4):875-7.
2006: Shahab A Akhter; Karen M D'Souza; Natalia N Petrashevskaya; Jeanne Mialet Perez; Stephen B Liggett
Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1427-32.
2006: Wen Zhao; Qunying Yuan; Jiang Qian; Jason R Waggoner; Anand Pathak; Guoxiang Chu; Bryan Mitton; Xiaoyin Sun; Jay Jin; Julian C Braz; Harvey S Hahn; Yehia Marreez; Faisal M Syed; Piero Pollesello; Arto Annila; Hong-Sheng Wang; Jo El J Schultz; Jeffery D Molkentin; Stephen B Liggett; Gerald W Dorn; Evangelia G Kranias
The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Circulation 2006;113(7):995-1004.
2005: Stephen B Liggett
Lymphocyte GRK levels as biomarkers in heart failure.
European heart journal 2005;26(17):1695-6.
2005: Kelan G Tantisira; Kersten M Small; Augusto A Litonjua; Scott Weiss; Stephen B Liggett
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.
Human molecular genetics 2005;14(12):1671-7.
2005: Dennis W McGraw; Stephen B Liggett
Molecular mechanisms of beta2-adrenergic receptor function and regulation.
Proceedings of the American Thoracic Society 2005;2(4):292-6; discussion 311-2.
2004: Elliot Israel; Vernon M Chinchilli; Jean G Ford; Homer A Boushey; Reuben M Cherniack; Timothy J Craig; Aaron Deykin; Joanne K Fagan; John V Fahy; James Fish; Monica Kraft; Susan J Kunselman; Stephen C Lazarus; Robert F Lemanske; Stephen B Liggett; Richard J Martin; Nandita Mitra; Stephen P Peters; Eric Silverman; Christine A Sorkness; Stanley J Szefler; Michael E Wechsler; Scott Weiss; Jeffrey M Drazen
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
Lancet 2004;364(9444):1505-12.
2004: Stephen B Liggett
Polymorphisms of beta-adrenergic receptors in heart failure.
The American journal of medicine 2004;117(7):525-7.
2004: Jeanne Mialet Perez; Stuart A Green; William E Miller; Stephen B Liggett
A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation.
The Journal of biological chemistry 2004;279(37):38603-7.
2004: Stephen B Liggett
Genetically modified mouse models for pharmacogenomic research.
Nature reviews. Genetics 2004;5(9):657-63.
2004: Kersten M Small; Jeanne Mialet Perez; Carrie A Seman; Cheryl T Theiss; Kari M Brown; Stephen B Liggett
Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13020-5.
2004: Kelan G Tantisira; Stephen L Lake; Eric S Silverman; Lyle Palmer; Ross Lazarus; Edwin K Silverman; Stephen B Liggett; Erwin W Gelfand; Lanny J Rosenwasser; Brent Richter; Elliot Israel; Michael E Wechsler; Stacey Gabriel; David Altshuler; Eric Lander; Jeffrey M Drazen; Scott Weiss
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids.
Human molecular genetics 2004;13(13):1353-9.
2004: Stephen B Liggett
The two-timing thyroid.
Nature medicine 2004;10(6):582-3.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Shilpa G Lalchandani; Xiaoyang Zhang; Seoung Soo Hong; Stephen B Liggett; Wei Li; Bob Moore; Duane D Miller; Dennis R Feller
Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors.
Biochemical pharmacology 2004;67(1):87-96.
2003: Vinciane Gaussin; James E Tomlinson; Christophe Depre; Stefan Engelhardt; Christopher L Antos; Gen Takagi; Lutz Hein; James N Topper; Stephen B Liggett; Eric N Olson; Martin J Lohse; Stephen F Vatner; Dorothy E Vatner
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.
Circulation 2003;108(23):2926-33.
2003: Harvey S Hahn; Yehia Marreez; Amy Odley; Amber Sterbling; Martin G Yussman; K Chad Hilty; Ilona Bodi; Stephen B Liggett; Arnold Schwartz; Gerald W Dorn
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Circulation research 2003;93(11):1111-9.
2003: Myron C Gerson; Lynne E Wagoner; Nancy McGuire; Stephen B Liggett
Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003;10(6):583-9.
2003: Jeanne Mialet Perez; Deborah A Rathz; Natalia N Petrashevskaya; Harvey S Hahn; Lynne E Wagoner; Arnold Schwartz; Gerald W Dorn; Stephen B Liggett
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
Nature medicine 2003;9(10):1300-5.
2003: Kersten M Small; Kari M Brown; Cheryl T Theiss; Carrie A Seman; Scott Weiss; Stephen B Liggett
An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation.
Pharmacogenetics 2003;13(9):535-41.
2003: Dennis W McGraw; Khalid F Almoosa; Richard J Paul; Brian K Kobilka; Stephen B Liggett
Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.
The Journal of clinical investigation 2003;112(4):619-26.
2003: Math P Cuajungco; Yukio Ando; Felicia B Axelrod; Italo Biaggioni; David S Goldstein; Alan E Guttmacher; Katrina Gwinn-Hardy; Maureen K Hahn; Max J Hilz; Giris Jacob; Jordan Jens; William R Kennedy; Stephen B Liggett; Daniel O'Connor; Sonia R Peltzer; David Robertson; Berish Y Rubin; Quandra Scudder; Linda J Smith; Gail E Sonenshein; Jesper Q Svejstrup; Yang Xu; Susan A Slaugenhaupt
Hereditary dysautonomias: current knowledge and collaborations for the future.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2003;13(3):180-95.
2003: Stephen B Liggett
Polymorphisms of adrenergic receptors: variations on a theme.
Assay and drug development technologies 2003;1(2):317-26.
2003: Deborah A Rathz; Kimberly N Gregory; Ying Fang; Kari M Brown; Stephen B Liggett
Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling.
The Journal of biological chemistry 2003;278(12):10784-9.
2003: Kobra Haghighi; Fotis Kolokathis; Luke Pater; Roy A Lynch; Michio Asahi; Anthony O Gramolini; Guo-Chang Fan; Dimitris Tsiapras; Harvey S Hahn; Stamatis Adamopoulos; Stephen B Liggett; Gerald W Dorn; David H MacLennan; Dimitrios Th Kremastinos; Evangelia G Kranias
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
The Journal of clinical investigation 2003;111(6):869-76.
2003: Kersten M Small; Debra A Tanguay; Krishnan Nandabalan; Ping Zhan; J Claiborne Stephens; Stephen B Liggett
Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2003;3(1):65-71.
2003: Kersten M Small; Dennis W McGraw; Stephen B Liggett
Pharmacology and physiology of human adrenergic receptor polymorphisms.
Annual review of pharmacology and toxicology 2003;43():381-411.
2002: Stephen B Liggett
Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling.
The Journal of allergy and clinical immunology 2002;110(6 Suppl):S223-7.
2002: Shilpa G Lalchandani; Longping Lei; Weiping Zheng; Mustafa M Suni; Bob Moore; Stephen B Liggett; Duane D Miller; Dennis R Feller
Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype.
The Journal of pharmacology and experimental therapeutics 2002;303(3):979-84.
2002: Lynne E Wagoner; Laura L Craft; Paul Zengel; Nancy McGuire; Deborah A Rathz; Gerald W Dorn; Stephen B Liggett
Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure.
American heart journal 2002;144(5):840-6.
2002: Kersten M Small; Lynne E Wagoner; Al Levin; Sharon L R Kardia; Stephen B Liggett
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
The New England journal of medicine 2002;347(15):1135-42.
2002: Kersten M Small; Carrie A Seman; Alex Castator; Kari M Brown; Stephen B Liggett
False positive non-synonymous polymorphisms of G-protein coupled receptor genes.
FEBS letters 2002;516(1-3):253-6.
2002: Mei Liang; Margaret G Eason; Cheryl T Theiss; Stephen B Liggett
Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization.
European journal of pharmacology 2002;437(1-2):41-6.
2002: Stephen B Liggett
Polymorphisms of the beta2-adrenergic receptor.
The New England journal of medicine 2002;346(7):536-8.
2002: Deborah A Rathz; Kari M Brown; Lisa A Kramer; Stephen B Liggett
Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking.
Journal of cardiovascular pharmacology 2002;39(2):155-60.
2002: Kersten M Small; Deborah A Rathz; Stephen B Liggett
Identification of adrenergic receptor polymorphisms.
Methods in enzymology 2002;343():459-75.
2001: Mei Liang; N J Freedman; Cheryl T Theiss; Stephen B Liggett
Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
Biochemistry 2001;40(49):15031-7.
2001: Dennis W McGraw; N Fukuda; Paul F James; SL Forbes; Alison L Woo; Jerry B Lingrel; David P Witte; Michael A Matthay; Stephen B Liggett
Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L895-903.
2001: Kersten M Small; Stephen B Liggett
Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms.
Trends in pharmacological sciences 2001;22(9):471-7.
2001: Kersten M Small; Kari M Brown; SL Forbes; Stephen B Liggett
Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy.
The Journal of biological chemistry 2001;276(34):31596-601.
2001: Stuart A Green; Deborah A Rathz; A J Schuster; Stephen B Liggett
The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s).
European journal of pharmacology 2001;421(3):141-7.
2001: Stephen B Liggett
Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown.
The Journal of clinical investigation 2001;107(8):947-8.
2001: Stephen B Liggett
Pharmacogenetic applications of the Human Genome project.
Nature medicine 2001;7(3):281-3.
2001: Kersten M Small; Kari M Brown; SL Forbes; Stephen B Liggett
Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.
The Journal of biological chemistry 2001;276(7):4917-22.
2001: Rajesh Dash; Vivek J Kadambi; Albrecht G Schmidt; NM Tepe; Danuta Biniakiewicz; Michael J Gerst; AM Canning; William T Abraham; Brian D Hoit; Stephen B Liggett; John N Lorenz; Gerald W Dorn; Evangelia G Kranias
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Circulation 2001;103(6):889-96.
2001: Eric S Silverman; Stephen B Liggett; E W Gelfand; L J Rosenwasser; Rebecca M Baron; S Bolk; Scott Weiss; Jeffrey M Drazen
The pharmacogenetics of asthma: a candidate gene approach.
The pharmacogenomics journal 2001;1(1):27-37.
2001: Elliot Israel; Jeffrey M Drazen; Stephen B Liggett; Homer A Boushey; Reuben M Cherniack; Vernon M Chinchilli; Dan M Cooper; John V Fahy; James E Fish; Jean G Ford; Monica Kraft; Susan J Kunselman; Stephen C Lazarus; Robert F Lemanske; Richard J Martin; Diane E McLean; Stephen P Peters; Edwin K Silverman; Christine A Sorkness; Stanley J Szefler; Scott Weiss; CN Yandava
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.
International archives of allergy and immunology 2001;124(1-3):183-6.
2000: Kersten M Small; SL Forbes; Kari M Brown; Stephen B Liggett
An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.
The Journal of biological chemistry 2000;275(49):38518-23.
2000: EA Jewell-Motz; Kersten M Small; Cheryl T Theiss; Stephen B Liggett
alpha 2A/alpha 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation.
The Journal of biological chemistry 2000;275(37):28989-93.
2000: C M Drysdale; D W McGraw; C B Stack; J Claiborne Stephens; Richard Judson; Krishnan Nandabalan; K Arnold; G Ruano; Stephen B Liggett
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10483-8.
2000: Stephen B Liggett
Pharmacogenetics of beta-1- and beta-2-adrenergic receptors.
Pharmacology 2000;61(3):167-73.
2000: Dennis W McGraw; SL Forbes; J C Mak; David P Witte; patricia carrigan; George Leikauf; Stephen B Liggett
Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2000;279(2):L379-89.
2000: Kersten M Small; SL Forbes; Fahema F Rahman; K M Bridges; Stephen B Liggett
A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors.
The Journal of biological chemistry 2000;275(30):23059-64.
2000: Elliot Israel; Jeffrey M Drazen; Stephen B Liggett; Homer A Boushey; Reuben M Cherniack; Vernon M Chinchilli; Dan M Cooper; John V Fahy; James E Fish; Jean G Ford; Monica Kraft; Susan J Kunselman; Stephen C Lazarus; Robert F Lemanske; Richard J Martin; Diane E McLean; Stephen P Peters; Edwin K Silverman; Christine A Sorkness; Stanley J Szefler; Scott Weiss; CN Yandava
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma.
American journal of respiratory and critical care medicine 2000;162(1):75-80.
2000: Lynne E Wagoner; Laura L Craft; B Singh; Damodhar P Suresh; P W Zengel; Nancy McGuire; William T Abraham; T C Chenier; Gerald W Dorn; Stephen B Liggett
Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.
Circulation research 2000;86(8):834-40.
2000: Stephen B Liggett; NM Tepe; John N Lorenz; AM Canning; T D Jantz; S Mitarai; Atsuko Yatani; Gerald W Dorn
Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level.
Circulation 2000;101(14):1707-14.
2000: L Yan; R E Galinsky; J A Bernstein; Stephen B Liggett; Richard M Weinshilboum
Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.
Pharmacogenetics 2000;10(3):261-6.
2000: Kersten M Small; SL Forbes; Fahema F Rahman; Stephen B Liggett
Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling.
Biochemistry 2000;39(10):2815-21.
2000: Stephen B Liggett
beta(2)-adrenergic receptor pharmacogenetics.
American journal of respiratory and critical care medicine 2000;161(3 Pt 2):S197-201.
2000: Brian D Hoit; Damodhar P Suresh; Laura L Craft; Richard A Walsh; Stephen B Liggett
beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals.
American heart journal 2000;139(3):537-42.
2000: Stephen B Liggett
The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma.
The Journal of allergy and clinical immunology 2000;105(2 Pt 2):S487-92.
2000: Gerald W Dorn; NM Tepe; Guangyu Wu; Atsuko Yatani; Stephen B Liggett
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Molecular pharmacology 2000;57(2):278-87.
2000: NM Tepe; Stephen B Liggett
Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor.
Journal of receptor and signal transduction research 2000;20(1):75-85.
1999: NM Tepe; John N Lorenz; Atsuko Yatani; Rajesh Dash; Evangelia G Kranias; Gerald W Dorn; Stephen B Liggett
Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling.
Biochemistry 1999;38(50):16706-13.
1999: Dennis W McGraw; Stephen B Liggett
Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29 Suppl 4():43-5.
1999: Dennis W McGraw; SL Forbes; Lisa A Kramer; David P Witte; CN Fortner; Richard J Paul; Stephen B Liggett
Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity.
The Journal of biological chemistry 1999;274(45):32241-7.
1999: Stephen B Liggett
Plastic adenylyl cyclase.
American journal of respiratory cell and molecular biology 1999;21(5):564-6.
1999: J D Moore; D A Mason; Stuart A Green; J Hsu; Stephen B Liggett
Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.
Human mutation 1999;14(3):271.
1999: NM Tepe; Stephen B Liggett
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse.
FEBS letters 1999;458(2):236-40.
1999: Stephen B Liggett
Molecular and genetic basis of beta2-adrenergic receptor function.
The Journal of allergy and clinical immunology 1999;104(2 Pt 2):S42-6.
1999: Kersten M Small; JF Feng; J Lorenz; E T Donnelly; A Yu; Mie-Jae Im; Gerald W Dorn; Stephen B Liggett
Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation.
The Journal of biological chemistry 1999;274(30):21291-6.
1999: Gerald W Dorn; NM Tepe; John N Lorenz; Walter J Koch; Stephen B Liggett
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6400-5.
1999: D A Mason; J D Moore; Stuart A Green; Stephen B Liggett
A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.
The Journal of biological chemistry 1999;274(18):12670-4.
1998: Dennis W McGraw; SL Forbes; Lisa A Kramer; Stephen B Liggett
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.
The Journal of clinical investigation 1998;102(11):1927-32.
1998: EA Jewell-Motz; ET Donnelly; Margaret G Eason; Stephen B Liggett
Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation.
Biochemistry 1998;37(45):15720-5.
1998: Stephen B Liggett; Lynne E Wagoner; Laura L Craft; Richard W Hornung; Brian D Hoit; T C McIntosh; Richard A Walsh
The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.
The Journal of clinical investigation 1998;102(8):1534-9.
1998: TD Weir; N Mallek; Andrew J Sandford; Tony R Bai; N Awadh; J Mark FitzGerald; D Cockcroft; A James; Stephen B Liggett; Peter D Paré
beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma.
American journal of respiratory and critical care medicine 1998;158(3):787-91.
1998: John W Adams; Y Sakata; MG Davis; Valerie P Sah; Yingxiao Wang; Stephen B Liggett; Kenneth R Chien; Joan Heller Brown; Gerald W Dorn
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10140-5.
1998: Mei Liang; Margaret G Eason; EA Jewell-Motz; M A Williams; Cheryl T Theiss; Gerald W Dorn; Stephen B Liggett
Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C.
Molecular pharmacology 1998;54(1):44-9.
1998: Y Sakata; Brian D Hoit; Stephen B Liggett; Richard A Walsh; Gerald W Dorn
Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice.
Circulation 1998;97(15):1488-95.
1998: Stephen B Liggett
Pharmacogenetics of relevant targets in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 1():77-9; discussion 80-1.
1998: Dennis W McGraw; ET Donnelly; Margaret G Eason; Stuart A Green; Stephen B Liggett
Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor.
Cellular signalling 1998;10(3):197-204.
1998: Stephen B Liggett
Structural determinants of alpha 2-adrenergic receptor regulation.
Advances in pharmacology (San Diego, Calif.) 1998;42():438-42.
1997: Stephen B Liggett
Polymorphisms of the beta2-adrenergic receptor and asthma.
American journal of respiratory and critical care medicine 1997;156(4 Pt 2):S156-62.
1997: JC Dewar; J Wilkinson; Amanda Henry; N S Thomas; IJ Doull; N Morton; P Lio; John F Harvey; Stephen B Liggett; Stephen T Holgate; Ian P Hall
The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.
The Journal of allergy and clinical immunology 1997;100(2):261-5.
1997: D D D'Angelo; Y Sakata; John N Lorenz; Gregory P Boivin; R A Walsh; Stephen B Liggett; Gerald W Dorn
Transgenic Galphaq overexpression induces cardiac contractile failure in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8121-6.
1997: EA Jewell-Motz; ET Donnelly; Margaret G Eason; Stephen B Liggett
Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor.
Biochemistry 1997;36(29):8858-63.
1997: Brian D Hoit; S F Khoury; Y Shao; M Gabel; Stephen B Liggett; Richard A Walsh
Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons.
Circulation 1997;96(2):592-8.
1997: Gerald W Dorn; K J Oswald; TS McCluskey; David G Kuhel; Stephen B Liggett
Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C.
Biochemistry 1997;36(21):6415-23.
1997: Dennis W McGraw; Stephen B Liggett
Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor.
The Journal of biological chemistry 1997;272(11):7338-44.
1997: E Kiss; István Ferenc Édes; Y Sato; W Luo; Stephen B Liggett; Evangelia G Kranias
beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts.
The American journal of physiology 1997;272(2 Pt 2):H785-90.
1996: Stuart A Green; A P Spasoff; R A Coleman; M Johnson; Stephen B Liggett
Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor.
The Journal of biological chemistry 1996;271(39):24029-35.
1996: J Turki; John N Lorenz; Stuart A Green; E T Donnelly; M Jacinto; Stephen B Liggett
Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10483-8.
1996: EA Jewell-Motz; Stephen B Liggett
G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes.
The Journal of biological chemistry 1996;271(30):18082-7.
1996: Margaret G Eason; Stephen B Liggett
Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains.
The Journal of biological chemistry 1996;271(22):12826-32.
1995: Stephen B Liggett
Genetics of beta 2-adrenergic receptor variants in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25 Suppl 2():89-94; discussion 95-6.
1995: J Turki; Stuart A Green; K B Newman; M A Meyers; Stephen B Liggett
Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist.
The American journal of physiology 1995;269(5 Pt 1):L709-14.
1995: Margaret G Eason; Stephen B Liggett
Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling.
The Journal of biological chemistry 1995;270(42):24753-60.
1995: EA Jewell-Motz; Stephen B Liggett
An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization.
Biochemistry 1995;34(37):11946-53.
1995: N J Freedman; Stephen B Liggett; D E Drachman; G Pei; Marc G Caron; R J Lefkowitz
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
The Journal of biological chemistry 1995;270(30):17953-61.
1995: Stephen B Liggett; R Levi; H Metzger
G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma.
American journal of respiratory and critical care medicine 1995;152(1):394-402.
1995: Stuart A Green; J Turki; Pablo A Bejarano; I P Hall; Stephen B Liggett
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.
American journal of respiratory cell and molecular biology 1995;13(1):25-33.
1995: Ian P Hall; Amanda Henry; P Wilding; Stephen B Liggett
Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.
Lancet 1995;345(8959):1213-4.
1995: J Turki; Stephen B Liggett
Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma.
American journal of respiratory cell and molecular biology 1995;12(5):531-9.
1995: J Turki; J Pak; Stuart A Green; R J Martin; Stephen B Liggett
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
The Journal of clinical investigation 1995;95(4):1635-41.
1995: Margaret G Eason; S P Moreira; Stephen B Liggett
Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor.
The Journal of biological chemistry 1995;270(9):4681-8.
1995: Stuart A Green; J Turki; I P Hall; Stephen B Liggett
Implications of genetic variability of human beta 2-adrenergic receptor structure.
Pulmonary pharmacology 1995;8(1):1-10.
1994: Margaret G Eason; M T Jacinto; C T Theiss; Stephen B Liggett
The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11178-82.
1994: Stuart A Green; Stephen B Liggett
A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration.
The Journal of biological chemistry 1994;269(42):26215-9.
1994: Stuart A Green; J Turki; M Innis; Stephen B Liggett
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.
Biochemistry 1994;33(32):9414-9.
1994: Margaret G Eason; M T Jacinto; Stephen B Liggett
Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs.
Molecular pharmacology 1994;45(4):696-702.
1993: Stuart A Green; G Cole; M Jacinto; M Innis; Stephen B Liggett
A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.
The Journal of biological chemistry 1993;268(31):23116-21.
1993: Margaret G Eason; Stephen B Liggett
Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues.
Molecular pharmacology 1993;44(1):70-5.
1993: Margaret G Eason; Stephen B Liggett
Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner.
Biochemical and biophysical research communications 1993;193(1):318-23.
1993: Stephen B Liggett; N J Freedman; Debra Anne Schwinn; R J Lefkowitz
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3665-9.
1993: Stephen B Liggett; John R Raymond
Pharmacology and molecular biology of adrenergic receptors.
Baillière's clinical endocrinology and metabolism 1993;7(2):279-306.
1993: R F Thomas; Stephen B Liggett
Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human.
Molecular pharmacology 1993;43(3):343-8.
1993: E Reihsaus; M Innis; N MacIntyre; Stephen B Liggett
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.
American journal of respiratory cell and molecular biology 1993;8(3):334-9.
1992: Margaret G Eason; Stephen B Liggett
Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2.
The Journal of biological chemistry 1992;267(35):25473-9.
1992: Stephen B Liggett
Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells.
Molecular pharmacology 1992;42(4):634-7.
1992: Margaret G Eason; H Kurose; B D Holt; John R Raymond; Stephen B Liggett
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
The Journal of biological chemistry 1992;267(22):15795-801.
1992: William E Kraus; J P Longabaugh; Stephen B Liggett
Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor.
The American journal of physiology 1992;263(2 Pt 1):E226-30.
1992: Jeffrey E Saffitz; Stephen B Liggett
Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites.
Circulation research 1992;70(6):1320-5.
1992: R F Thomas; B D Holt; Debra A Schwinn; Stephen B Liggett
Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4490-4.
1992: S A Green; B D Holt; Stephen B Liggett
Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs.
Molecular pharmacology 1992;41(5):889-93.
1992: Stephen B Liggett; J Ostrowski; L C Chesnut; H Kurose; John R Raymond; Marc G Caron; R J Lefkowitz
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.
The Journal of biological chemistry 1992;267(7):4740-6.
1991: A Dejgaard; Stephen B Liggett; N J Christensen; P E Cryer; J Hilsted
Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity.
Scandinavian journal of clinical and laboratory investigation 1991;51(8):659-66.
1991: Debra A Schwinn; Bruce J Leone; Donat R Spahn; L C Chesnut; SO Page; R L McRae; Stephen B Liggett
Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation.
Circulation 1991;84(6):2559-67.
1991: Debra A Schwinn; SO Page; J P Middleton; W Lorenz; Stephen B Liggett; K Yamamoto; E G Lapetina; Marc G Caron; R J Lefkowitz; S Cotecchia
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.
Molecular pharmacology 1991;40(5):619-26.
1991: Stephen B Liggett
Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases.
Pharmacological research : the official journal of the Italian Pharmacological Society 1991;24 Suppl 1():29-41.
1991: Stephen B Liggett; Marc G Caron; R J Lefkowitz; M Hnatowich
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.
The Journal of biological chemistry 1991;266(8):4816-21.
1991: M D Bates; S E Senogles; J R Bunzow; Stephen B Liggett; Olivier Civelli; Marc G Caron
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.
Molecular pharmacology 1991;39(1):55-63.
1991: Stephen B Liggett; J Ostrowski; L C Chesnut; Marc G Caron; R J Lefkowitz
Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor.
Transactions of the Association of American Physicians 1991;104():40-7.
1991: Stephen B Liggett; Debra A Schwinn
Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor.
DNA sequence : the journal of DNA sequencing and mapping 1991;2(1):61-3.
1990: Stephen B Liggett; A D Renfro
Energy expenditures of mechanically ventilated nonsurgical patients.
Chest 1990;98(3):682-6.
1990: W P Hausdorff; M J Lohse; Michel Bouvier; Stephen B Liggett; Marc G Caron; R J Lefkowitz
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.
Symposia of the Society for Experimental Biology 1990;44():225-40.
1989: Stephen B Liggett; Michel Bouvier; B F O'Dowd; Marc G Caron; R J Lefkowitz; A DeBlasi
Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization.
Biochemical and biophysical research communications 1989;165(1):257-63.
1989: Stephen B Liggett; Michel Bouvier; W P Hausdorff; B O'Dowd; Marc G Caron; R J Lefkowitz
Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.
Molecular pharmacology 1989;36(4):641-6.
1989: Stephen B Liggett; S D Shah; Philip E Cryer
Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo.
The American journal of physiology 1989;256(5 Pt 1):E600-9.
1989: Stephen B Liggett
Beta-adrenoceptor-effector system of the human macrophage U937 cell line.
European journal of pharmacology 1989;163(1):171-4.
1989: Stephen B Liggett; S D Shah; Philip E Cryer
Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis.
The Journal of clinical investigation 1989;83(3):803-9.
1989: Stephen B Liggett
Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages.
The American review of respiratory disease 1989;139(2):552-5.
1988: P J Boyle; Stephen B Liggett; S D Shah; Philip E Cryer
Direct muscarinic cholinergic inhibition of hepatic glucose production in humans.
The Journal of clinical investigation 1988;82(2):445-9.
1988: Stephen B Liggett; C C Daughaday; R M Senior
Ipratropium in patients with COPD receiving cholinesterase inhibitors.
Chest 1988;94(1):210-2.
1988: Stephen B Liggett; J C Marker; S D Shah; C L Roper; Philip E Cryer
Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans.
The Journal of clinical investigation 1988;82(1):48-56.
1988: Stephen B Liggett; S D Shah; Philip E Cryer
Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy.
The American journal of physiology 1988;254(6 Pt 1):E795-8.
1987: Stephen B Liggett; R E St John; S S Lefrak
Determination of resting energy expenditure utilizing the thermodilution pulmonary artery catheter.
Chest 1987;91(4):562-6.
1982: Stephen B Liggett; J R Berger; J Hush
Cerebrospinal fluid xanthochromia with rifampin.
Annals of neurology 1982;12(2):228-9.
1982: Stephen B Liggett
Propylhexedrine Intoxication: Clinical Presentation and Pharmacology.
Southern medical journal 1982;75(2):250-1.
1981: Ramon A Boza; Stephen B Liggett
Pseudohallucinations: radio reception through shrapnel fragments.
The American journal of psychiatry 1981;138(9):1263-4.