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Peter Light

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Deepak Narang; Isabelle M Paulsen; Gavin Searle; Raymond Tam; Wei Yang; Jason Baserman; Andrew Holt; Paul M Kerr; Janna L Kozuska; Peter E Light; Patrick E MacDonald; Jocelyn E Manning Fox; Frances Plane
Triton X-100 inhibits L-type voltage-operated calcium channels.
Dukgyu Lee; Peter E Light; Gary D Lopaschuk; Kimitoshi Nakamura; Barbara E Nickel; Tatsujiro Oka; Michal Opas; Sylvia Papp; Alison Robinson; Wattamon Srisakuldee; Jason R B Dyck; Beth Hunter; Elissavet Kardami; Marek Michalak
Calreticulin induces dilated cardiomyopathy.
Daniel Soliman; Lianguo Wang; Wei Yang; Christian C Carter; Alexander S Clanachan; Mohammad Fatehi; Kevin S C Hamming; Peter E Light
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.

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2013: Deepak Narang; Isabelle M Paulsen; Gavin Searle; Raymond Tam; Wei Yang; Jason Baserman; Andrew Holt; Paul M Kerr; Janna L Kozuska; Peter E Light; Patrick E MacDonald; Jocelyn E Manning Fox; Frances Plane
Triton X-100 inhibits L-type voltage-operated calcium channels.
Canadian journal of physiology and pharmacology 2013;91(4):316-24.
2013: Dukgyu Lee; Peter E Light; Gary D Lopaschuk; Kimitoshi Nakamura; Barbara E Nickel; Tatsujiro Oka; Michal Opas; Sylvia Papp; Alison Robinson; Wattamon Srisakuldee; Jason R B Dyck; Beth Hunter; Elissavet Kardami; Marek Michalak
Calreticulin induces dilated cardiomyopathy.
PloS one 2013;8(2):e56387.
2012: Daniel Soliman; Lianguo Wang; Wei Yang; Christian C Carter; Alexander S Clanachan; Mohammad Fatehi; Kevin S C Hamming; Peter E Light
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
The Journal of pharmacology and experimental therapeutics 2012;343(2):325-32.
2012: Sri N Batchu; Ketul R Chaudhary; Haitham El-Sikhry; Peter E Light; Gavin Y Oudit; Wei Yang; John M Seubert
Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection.
Journal of molecular and cellular cardiology 2012;53(1):43-52.
2012: Veronica Y Lang; Mohammad Fatehi; Peter E Light
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Pharmacogenetics and genomics 2012;22(3):206-14.
2011: Veronica Lang; Nermeen Youssef; Peter E Light
The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes.
Current diabetes reports 2011;11(6):543-51.
2011: István Baczkó; Z Husti; V Lang; I Leprán; Peter E Light
Sarcolemmal KATP channel modulators and cardiac arrhythmias.
Current medicinal chemistry 2011;18(24):3640-61.
2010: Debby P Y Koonen; Miranda M Y Sung; Cindy K C Kao; Vernon W Dolinsky; Timothy R Koves; Olga Ilkayeva; René L Jacobs; Dennis E Vance; Peter E Light; Deborah M Muoio; Maria Febbraio; Jason R B Dyck
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Diabetes 2010;59(6):1366-75.
2010: Veronica Lang; Peter E Light
The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes.
Pharmacogenomics and personalized medicine 2010;3():145-61.
2009: Daniel Soliman; Kevin S C Hamming; Laura C Matemisz; Peter E Light
Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.
Journal of molecular and cellular cardiology 2009;47(5):595-602.
2009: Karalyn D Folmes; Anita Y M Chan; Debby P Y Koonen; THOMAS CHACKO PULINILKUNNIL; István Baczkó; Beth E Hunter; Stephanie Thorn; Michael F Allard; Robert Roberts; Michael H Gollob; Peter E Light; Jason R B Dyck
Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen.
Circulation. Cardiovascular genetics 2009;2(5):457-66.
2009: Kevin S C Hamming; Daniel Soliman; Laura C Matemisz; Omid Niazi; Yiqiao Lang; Anna L Gloyn; Peter E Light
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
Diabetes 2009;58(10):2419-24.
2009: Vernon W Dolinsky; Anita Y M Chan; Isabelle Robillard Frayne; Peter E Light; Christine Des Rosiers; Jason R B Dyck
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.
Circulation 2009;119(12):1643-52.
2008: Melissa J S Chee; Karin Mörl; Diana Lindner; Nicole Merten; Gerald W Zamponi; Peter E Light; Annette G Beck-Sickinger; William F Colmers
The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.
The Journal of biological chemistry 2008;283(48):33337-46.
2008: Kevin S C Hamming; Michael J Riedel; Daniel Soliman; Laura C Matemisz; Nicola J Webster; Gavin J Searle; Patrick E MacDonald; Peter E Light
Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.
Molecular endocrinology (Baltimore, Md.) 2008;22(10):2293-306.
2008: Anita Y M Chan; Vernon W Dolinsky; Carrie-Lynn M Soltys; Benoit Viollet; Shairaz Baksh; Peter E Light; Jason R B Dyck
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
The Journal of biological chemistry 2008;283(35):24194-201.
2008: Nicola J Webster; Gavin J Searle; Patrick P L Lam; Ya-Chi Huang; Michael J Riedel; George Harb; Herbert Y Gaisano; Andrew Holt; Peter E Light
Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.
Endocrinology 2008;149(7):3679-87.
2008: H León; István Baczkó; Grzegorz Sawicki; Peter E Light; Richard Schulz
Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte.
British journal of pharmacology 2008;153(4):676-83.
2007: Jayan Nagendran; Stephen L Archer; Daniel Soliman; Vikram Gurtu; Rohit Moudgil; Alois Haromy; Chantal St Aubin; Linda Webster; Ivan M Rebeyka; David B Ross; Peter E Light; Jason R B Dyck; Evangelos D Michelakis
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Circulation 2007;116(3):238-48.
2007: Bernardo V Alvarez; Danielle E Johnson; Daniel Sowah; Daniel Soliman; Peter E Light; Ying Xia; Morris Karmazyn; Joseph R Casey
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.
The Journal of physiology 2007;579(Pt 1):127-45.
2006: Heather Fraser; Luiz Belardinelli; Lianguo Wang; Peter E Light; Jeffrey J McVeigh; Alexander S Clanachan
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.
Journal of molecular and cellular cardiology 2006;41(6):1031-8.
2006: C H R Wallace; István Baczkó; Lynn Jones; M Fercho; Peter E Light
Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.
British journal of pharmacology 2006;149(6):657-65.
2006: Michael J Riedel; István Baczkó; Gavin J Searle; Nicola Webster; Matthew Fercho; Lynn Jones; Jessica Lang; Jonathan Lytton; Jason R B Dyck; Peter E Light
Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.
The EMBO journal 2006;25(19):4605-14.
2006: Peter E Light
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S158-S161.
2005: Michael J Riedel; Peter E Light
Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channels.
Diabetes 2005;54(7):2070-9.
2005: István Baczkó; Lynn Jones; Claire F McGuigan; Jocelyn E Manning Fox; Manoj Gandhi; Wayne R Giles; Alexander S Clanachan; Peter E Light
Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):980-2.
2005: Michael J Riedel; Diana C Steckley; Peter E Light
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes.
Human genetics 2005;116(3):133-45.
2005: Jocelyn E Manning Fox; Lynn Jones; Peter E Light
Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line.
Journal of cardiovascular pharmacology 2005;45(1):30-5.
2004: Youhou Kang; Yuk M Leung; Jocelyn E Manning Fox; Fuzhen Xia; Huanli Xie; Laura Sheu; Robert G Tsushima; Peter E Light; Herbert Y Gaisano
Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.
The Journal of biological chemistry 2004;279(45):47125-31.
2004: Ni T Lam; Anthony T Cheung; Michael J Riedel; Peter E Light; Chris I Cheeseman; Timothy J Kieffer
Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells.
Journal of molecular endocrinology 2004;32(2):415-24.
2004: István Baczkó; Wayne R Giles; Peter E Light
Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.
British journal of pharmacology 2004;141(6):1059-67.
2004: Jocelyn E Manning Fox; Colin G Nichols; Peter E Light
Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues.
Molecular endocrinology (Baltimore, Md.) 2004;18(3):679-86.
2003: Jocelyn E Manning Fox; Jarkko Magga; Wayne R Giles; Peter E Light
Acyl coenzyme A esters differentially activate cardiac and beta-cell adenosine triphosphate-sensitive potassium channels in a side-chain length-specific manner.
Metabolism: clinical and experimental 2003;52(10):1313-9.
2003: Michael J Riedel; Parveen Boora; Diana Steckley; Gerda de Vries; Peter E Light
Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?
Diabetes 2003;52(10):2630-5.
2003: István Baczkó; Wayne R Giles; Peter E Light
Resting membrane potential regulates Na(+)-Ca2+ exchange-mediated Ca2+ overload during hypoxia-reoxygenation in rat ventricular myocytes.
The Journal of physiology 2003;550(Pt 3):889-98.
2003: Christopher P Ford; Patrick L Stemkowski; Peter E Light; Peter A Smith
Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4931-41.
2003: Peter E Light; Catriona H R Wallace; Jason R B Dyck
Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes.
Circulation 2003;107(15):1962-5.
2003: Wasim El-Kholy; Patrick E MacDonald; Jia-Hui Lin; Jing Wang; Jocelyn Manning Fox; Peter E Light; Qinghua Wang; Robert G Tsushima; Michael B Wheeler
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):720-2.
2002: Patrick E MacDonald; Wasim El-Kholy; Michael J Riedel; Anne Marie F Salapatek; Peter E Light; Michael B Wheeler
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.
Diabetes 2002;51 Suppl 3():S434-42.
2002: Peter E Light; Jocelyn E Manning Fox; Michael J Riedel; Michael B Wheeler
Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2135-44.
2002: Kevin S Thorneloe; Yoshiaki Maruyama; A Todd Malcolm; Peter E Light; Michael P Walsh; William C Cole
Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.
The Journal of physiology 2002;541(Pt 1):65-80.
2002: Jocelyn E Manning Fox; Hussein D Kanji; Robert J French; Peter E Light
Cardioselectivity of the sulphonylurea HMR 1098: studies on native and recombinant cardiac and pancreatic K(ATP) channels.
British journal of pharmacology 2002;135(2):480-8.
2001: Peter E Light; H D Kanji; Jocelyn E Manning Fox; Robert J French
Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2586-94.
2001: Hui Dong; Peter E Light; Robert J French; Jonathan Lytton
Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2.
The Journal of biological chemistry 2001;276(28):25919-28.
2000: Peter E Light; Christopher Bladen; Robert J Winkfein; Michael P Walsh; Robert J French
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9058-63.
2000: William C Cole; T Malcolm; Michael P Walsh; Peter E Light
Inhibition by protein kinase C of the K(NDP) subtype of vascular smooth muscle ATP-sensitive potassium channel.
Circulation research 2000;87(2):112-7.
1999: Peter E Light; Jonathan M Cordeiro; Robert J French
Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres.
Cardiovascular research 1999;44(2):356-69.
1999: Peter E Light
Cardiac KATP channels and ischemic preconditioning: current perspectives.
The Canadian journal of cardiology 1999;15(10):1123-30.
1999: Peter E Light
Pamicogrel (Kanebo).
IDrugs : the investigational drugs journal 1999;2(9):938-42.
1999: Peter E Light
Nesiritide citrate (Scios).
IDrugs : the investigational drugs journal 1999;2(3):259-64.
1998: Yakhin Shimoni; Peter E Light; Robert J French
Altered ATP sensitivity of ATP-dependent K+ channels in diabetic rat hearts.
The American journal of physiology 1998;275(4 Pt 1):E568-76.
1998: Peter E Light; Yakhin Shimoni; S Harbison; W Giles; Robert J French
Hypothyroidism decreases the ATP sensitivity of KATP channels from rat heart.
The Journal of membrane biology 1998;162(3):217-23.
1996: Peter E Light; A A Sabir; Bruce G Allen; Michael P Walsh; Robert J French
Protein kinase C-induced changes in the stoichiometry of ATP binding activate cardiac ATP-sensitive K+ channels. A possible mechanistic link to ischemic preconditioning.
Circulation research 1996;79(3):399-406.
1996: Peter E Light
Regulation of ATP-sensitive potassium channels by phosphorylation.
Biochimica et biophysica acta 1996;1286(1):65-73.
1996: X Han; Peter E Light; Wayne R Giles; Robert J French
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
The Journal of physiology 1996;490 ( Pt 2)():337-50.
1995: Peter E Light; Bruce G Allen; Michael P Walsh; Robert J French
Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase.
Biochemistry 1995;34(21):7252-7.
1994: Peter E Light; Robert J French
Glibenclamide selectively blocks ATP-sensitive K+ channels reconstituted from skeletal muscle.
European journal of pharmacology 1994;259(3):219-22.