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Keith Ligon

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Priscilla K Brastianos; Matthew D Ducar; Ian F Dunn; Gad Getz; William C Hahn; Peleg M Horowitz; Robert T Jones; Keith L Ligon; David N Louis; Laura E MacConaill; Aaron McKenna; Emanuele Palescandolo; Alina Raza; Sandro Santagata; Anat O Stemmer-Rachamimov; Ashwini Sunkavalli; Paul van Hummelen; Rameen Beroukhim
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
Livia S Eberlin; Alexandra J Golby; Jennifer L Ide; Alan K Jarmusch; Ferenc A Jolesz; Keith L Ligon; Xiaohui Liu; Isaiah Norton; Daniel Orringer; Sandro Santagata; Nathalie Y R Agar; Ian F Dunn; R Graham Cooks
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.
Mark W Kieran; Keith L Ligon; Laura E MacConaill; Benjamin E Rich; Charles W M Roberts; Susan N Chi; Levi A Garraway; Jaclyn A Biegel
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

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All Publications

2013: Priscilla K Brastianos; Matthew D Ducar; Ian F Dunn; Gad Getz; William C Hahn; Peleg M Horowitz; Robert T Jones; Keith L Ligon; David N Louis; Laura E MacConaill; Aaron McKenna; Emanuele Palescandolo; Alina Raza; Sandro Santagata; Anat O Stemmer-Rachamimov; Ashwini Sunkavalli; Paul van Hummelen; Rameen Beroukhim
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
Nature genetics 2013;45(3):285-9.
2013: Livia S Eberlin; Alexandra J Golby; Jennifer L Ide; Alan K Jarmusch; Ferenc A Jolesz; Keith L Ligon; Xiaohui Liu; Isaiah Norton; Daniel Orringer; Sandro Santagata; Nathalie Y R Agar; Ian F Dunn; R Graham Cooks
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1611-6.
2012: Mark W Kieran; Keith L Ligon; Laura E MacConaill; Benjamin E Rich; Charles W M Roberts; Susan N Chi; Levi A Garraway; Jaclyn A Biegel
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.
Pediatric blood & cancer 2012;59(7):1155-7.
2012: Steven N Quayle; Sachet A Shukla; Pablo Tamayo; Ruprecht Wiedemeyer; Yonghong Xiao; Li Zhuang; Robert W Dewan; William C Hahn; Sam Haidar; Emmet Huang-Hobbs; Keith L Ligon; Milan G Chheda; Lynda Chin
Integrative functional genomics identifies RINT1 as a novel GBM oncogene.
Neuro-oncology 2012;14(11):1325-31.
2012: Jimann Shin; Lilianna Solnica-Krezel; Scot A Wolfe; Marc A Wolman; Arun Padmanabhan; Suzanne Dahlberg; Eric D de Groh; Jonathan A Epstein; Michael Granato; Feng Guo; Sam Haidar; Shuning He; John P Kanki; Seok-Hyung Kim; Nathan D Lawson; Jeong-Soo Lee; Keith L Ligon; A Thomas Look
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
Disease models & mechanisms 2012;5(6):881-94.
2012: Andrew S Chi; William T Curry; Dora Dias-Santagata; Leif Ellisen; Keith L Ligon; David N Louis; Charles D Stiles; Daphne L Wang; Patrick Y Wen; Tracy T Batchelor; Darrell Borger; A John Iafrate
Prospective, high-throughput molecular profiling of human gliomas.
Journal of neuro-oncology 2012;110(1):89-98.
2012: Gavin P Dunn; Ian F Dunn; Frank B Furnari; Giannicola Genovese; Pankaj K Agarwalla; Cameron Brennan; Benito Campos; Webster K Cavenee; Milan G Chheda; Lynda Chin; Ronald A DePinho; Keith L Ligon; Steven N Quayle; Mikael L Rinne; Alan Wang; Jill Wykosky; William C Hahn
Emerging insights into the molecular and cellular basis of glioblastoma.
Genes & development 2012;26(8):756-84.
2012: Livia S Eberlin; Alexandra J Golby; Keith L Ligon; Isaiah Norton; Sandro Santagata; R Graham Cooks; Allison L Dill; Nathalie Y R Agar
Classifying human brain tumors by lipid imaging with mass spectrometry.
Cancer research 2012;72(3):645-54.
2012: Steven N Quayle; Ruprecht Wiedemeyer; Richard K Wilson; Li Zhuang; Robert W Dewan; Li Ding; Emmet Huang-Hobbs; Jennifer Y Lee; Keith L Ligon; Gordon B Mills; Lewis C Cantley; Lydia W T Cheung; Lynda Chin
Somatic mutations of PIK3R1 promote gliomagenesis.
PloS one 2012;7(11):e49466.
2012: Justin M Craig; Charles G Eberhart; Shaun D Fouse; D Ashley Hill; Ahmed Idbaih; Mark W Kieran; Keith L Ligon; Massimo Loda; Linda R Margraf; Andrew D Norden; Memet Ozek; Shakti Ramkissoon; Sandro Santagata; AYDIN SAV; Natalie Vena; Patrick Y Wen; Azra H Ligon
DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.
PloS one 2012;7(6):e38881.
2012: Fausto J Rodriguez; Keith L Ligon; Brent A Orr; Charles G Eberhart
Neoplastic cells are a rare component in human glioblastoma microvasculature.
Oncotarget 2012;3(1):98-106.
2011: Yongji Tian; Natalie Vena; Jennifer A Chan; Justin M Craig; Levi A Garraway; Stewart Goldman; Mark W Kieran; Azra H Ligon; Neal I Lindeman; Janina A Longtine; Laura E MacConaill; Madeha Mahmoud; Memet Ozek; Veena Rajaram; Benjamin E Rich; Sandro Santagata; AYDIN SAV; Charles D Stiles; Hala Taha; Keith L Ligon
Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.
The Journal of molecular diagnostics : JMD 2011;13(6):669-77.
2011: Galina Gabriely; Jaime Imitola; Santosh kesari; Keith L Ligon; Ravi S Narayan; Johanna M Niers; Robert M Stephens; Bakhos A Tannous; Thomas Wurdinger; Ming Yi; Christine Esau; Anna M Krichevsky
Human glioma growth is controlled by microRNA-10b.
Cancer research 2011;71(10):3563-72.
2011: Cécile L Maire; Keith L Ligon
Glioma models: new GEMMs add "class" with genomic and expression correlations.
Cancer cell 2011;19(3):295-7.
2010: Akitake Mukasa; Jill Wykosky; Keith L Ligon; Lynda Chin; Webster K Cavenee; Frank B Furnari
Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2616-21.
2010: Maria G McIntire; Sandro Santagata; Keith L Ligon; Lucian R Chirieac
Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.
American journal of translational research 2010;2(3):309-15.
2009: Sandro Santagata; Cecile L Maire; Ahmed Idbaih; Lars Geffers; Mick Correll; Kristina Holton; John Quackenbush; Keith L Ligon
CRX is a diagnostic marker of retinal and pineal lineage tumors.
PloS one 2009;4(11):e7932.
2009: Santosh kesari; David Schiff; Jan Drappatz; Debra LaFrankie; Lisa M Doherty; Eric A Macklin; Alona Muzikansky; Sandro Santagata; Keith L Ligon; Andrew D Norden; Abigail Ciampa; Joanna Bradshaw; Brenda Levy; Gospova Radakovic; Naren Ramakrishna; Peter Black; Patrick Y Wen
Phase II study of protracted daily temozolomide for low-grade gliomas in adults.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):330-7.
2008: Ulrich Schüller; Vivi M Heine; junhao mao; Alvin T Kho; Allison K Dillon; Young-Goo Han; Emmanuelle Huillard; Tao Sun; Azra H Ligon; Ying Qian; Qiufu Ma; Arturo Alvarez-Buylla; Andrew P McMahon; David H Rowitch; Keith L Ligon
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer cell 2008;14(2):123-34.
2008: Santosh kesari; David Schiff; John W Henson; Alona Muzikansky; Debra C Gigas; Lisa M Doherty; Tracy T Batchelor; Janina A Longtine; Keith L Ligon; Susan Weaver; Andrea Laforme; Naren Ramakrishna; Peter Black; Jan Drappatz; Abigail Ciampa; Judah Folkman; Mark W Kieran; Patrick Y Wen
Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults.
Neuro-oncology 2008;10(3):300-8.
2008: Ruprecht Wiedemeyer; Cameron Brennan; Timothy P Heffernan; Yonghong Xiao; John Mahoney; Alexei Protopopov; Hongwu Zheng; Graham Bignell; Frank B Furnari; Webster K Cavenee; William C Hahn; Koichi Ichimura; V Peter Collins; Gerald Chu; Michael R Stratton; Keith L Ligon; P Andrew Futreal; Lynda Chin
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Cancer cell 2008;13(4):355-64.
2008: Saraid S Billiards; Robin L Haynes; Rebecca D Folkerth; Natalia S Borenstein; Felicia L Trachtenberg; David H Rowitch; Keith L Ligon; Joseph J Volpe; Hannah C Kinney
Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.
Brain pathology (Zurich, Switzerland) 2008;18(2):153-63.
2007: Frank B Furnari; Tim Fenton; Robert M Bachoo; Akitake Mukasa; Jayne M Stommel; Alexander H Stegh; William C Hahn; Keith L Ligon; David N Louis; Cameron Brennan; Lynda Chin; Ronald A DePinho; Webster K Cavenee
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Genes & development 2007;21(21):2683-710.
2007: Michelle L Monje; Hannes Vogel; Marilyn Masek; Keith L Ligon; Paul G Fisher; Theo D Palmer
Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies.
Annals of neurology 2007;62(5):515-20.
2007: Jayne M Stommel; Alec C Kimmelman; Haoqiang Ying; Roustem Nabioullin; Aditya H Ponugoti; Ruprecht Wiedemeyer; Alexander H Stegh; James E Bradner; Keith L Ligon; Cameron Brennan; Lynda Chin; Ronald A DePinho
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Science (New York, N.Y.) 2007;318(5848):287-90.
2007: Sandro Santagata; Keith L Ligon; Jason L Hornick
Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors.
The American journal of surgical pathology 2007;31(6):836-45.
2007: Matthew Robert Ramsey; Janakiraman Krishnamurthy; Zhijun Li; Chad Torrice; Weili Lin; Daniel R Carrasco; Keith L Ligon; Yue Xiong; Norman E Sharpless
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Cancer research 2007;67(10):4732-41.
2007: Natalia T Leach; Yi Sun; Sebastien Michaud; Yi Zheng; Keith L Ligon; Azra H Ligon; Thomas Sander; Bruce Korf; Weining Lu; David J Harris; James Gusella; Richard L Maas; Bradley J Quade; Andrew J Cole; max kelz; Cynthia C Morton
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
American journal of human genetics 2007;80(4):792-9.
2007: Keith L Ligon; Emmanuelle Huillard; Shwetal Mehta; Santosh kesari; Hongye Liu; John A Alberta; Robert M Bachoo; Michael Kane; David N Louis; Ronald A DePinho; David J Anderson; Charles D Stiles; David H Rowitch
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
Neuron 2007;53(4):503-17.
2006: Audrey Rousseau; Catherine L Nutt; Rebecca A Betensky; A John Iafrate; Moonjoo Han; Keith L Ligon; David H Rowitch; David N Louis
Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
Journal of neuropathology and experimental neurology 2006;65(12):1149-56.
2006: Sandro Santagata; Jason L Hornick; Keith L Ligon
Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.
The American journal of surgical pathology 2006;30(12):1613-8.
2006: Elizabeth A Maher; Cameron Brennan; Patrick Y Wen; Laura Durso; Keith L Ligon; Aaron Richardson; Deepak Khatry; Bin Feng; Raktim Sinha; David N Louis; John Quackenbush; Peter Black; Lynda Chin; Ronald A DePinho
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.
Cancer research 2006;66(23):11502-13.
2006: junhao mao; Keith L Ligon; Elena Y Rakhlin; Sarah P Thayer; Roderick T Bronson; David H Rowitch; Andrew P McMahon
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
Cancer research 2006;66(20):10171-8.
2006: Janakiraman Krishnamurthy; Matthew Robert Ramsey; Keith L Ligon; Chad Torrice; Angela Koh; Susan Bonner-Weir; Norman E Sharpless
p16INK4a induces an age-dependent decline in islet regenerative potential.
Nature 2006;443(7110):453-7.
2006: Keith L Ligon; Stephen P J Fancy; Robin J M Franklin; David H Rowitch
Olig gene function in CNS development and disease.
Glia 2006;54(1):1-10.
2006: Keith L Ligon; Santosh kesari; Masaaki Kitada; Tao Sun; Heather A Arnett; John A Alberta; David J Anderson; Charles D Stiles; David H Rowitch
Development of NG2 neural progenitor cells requires Olig gene function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7853-8.
2006: Tao Sun; Brian P Hafler; Sovann Kaing; Masaaki Kitada; Keith L Ligon; Hans R Widlund; Dong-In Yuk; Charles D Stiles; David H Rowitch
Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.
Developmental biology 2006;292(1):152-64.
2005: Shumin Dong; Catherine L Nutt; Rebecca A Betensky; Anat Stemmer-Rachamimov; Nicholas C Denko; Keith L Ligon; David H Rowitch; David N Louis
Histology-based expression profiling yields novel prognostic markers in human glioblastoma.
Journal of neuropathology and experimental neurology 2005;64(11):948-55.
2004: Robert M Bachoo; Ryung S. Kim; Keith L Ligon; Elizabeth A Maher; Cameron Brennan; Nathan Billings; Suzanne Chan; Cheng Li; David H Rowitch; Wing H Wong; Ronald A DePinho
Molecular diversity of astrocytes with implications for neurological disorders.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8384-9.
2004: Keith L Ligon; John A Alberta; Alvin T Kho; Jennifer Weiss; Mary R Kwaan; Catherine L Nutt; David N Louis; Charles D Stiles; David H Rowitch
The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.
Journal of neuropathology and experimental neurology 2004;63(5):499-509.
2003: Keith L Ligon; Yann Echelard; Stavroula Assimacopoulos; Paul S Danielian; Sovann Kaing; Elizabeth A Grove; Andrew P McMahon; David H Rowitch
Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.
Development (Cambridge, England) 2003;130(10):2275-87.
2003: Jonathan D Picker; Ana C Puga; Harvey L Levy; Deborah Marsden; Vivian E Shih; Umberto Degirolami; Keith L Ligon; Stephen D Cederbaum; Rita M Kern; Gerald F Cox
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
The Journal of pediatrics 2003;142(3):349-52.
2002: Robert M Bachoo; Elizabeth A Maher; Keith L Ligon; Norman E Sharpless; Suzanne S Chan; Mingjian James You; Yi Tang; Jessica DeFrances; Elizabeth Stover; Ralph Weissleder; David H Rowitch; David N Louis; Ronald A DePinho
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Cancer cell 2002;1(3):269-77.
1996: Brian L Black; Keith L Ligon; Y Zhang; E N Olson
Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.
The Journal of biological chemistry 1996;271(43):26659-63.
1995: Peter Cserjesi; D Brown; Keith L Ligon; G E Lyons; N G Copeland; D J Gilbert; N A Jenkins; E N Olson
Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.
Development (Cambridge, England) 1995;121(4):1099-110.
1995: R Burgess; Peter Cserjesi; Keith L Ligon; E N Olson
Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.
Developmental biology 1995;168(2):296-306.
1994: J M Miano; Peter Cserjesi; Keith L Ligon; M Periasamy; E N Olson
Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.
Circulation research 1994;75(5):803-12.
1993: K Aka; Janet M Bruner; Melissa L Bondy; Keith L Ligon; T Nishi; Auro Del Giglio; R P Moser; Victor Levin; H Saya
Detection of p53 alterations in human astrocytomas using frozen tissue sections for the polymerase chain reaction.
Journal of neuro-oncology 1993;16(2):125-33.