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Tommy Liljefors

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Jakob Nilsson; Tommy Liljefors; Mogens Nielsen; Elsebet Østergaard Nielsen; Olov Sterner
3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABA(A) receptors.
Jakob Nilsson; Ritha Gidlöf; Elsebet Ø Nielsen; Tommy Liljefors; Mogens Nielsen; Olov Sterner
Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.
Helle Hald; Philip K Ahring; Daniel B Timmermann; Tommy Liljefors; Michael Gajhede; Jette S Kastrup
Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

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All Publications

2012: Jakob Nilsson; Tommy Liljefors; Mogens Nielsen; Elsebet Østergaard Nielsen; Olov Sterner
3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABA(A) receptors.
Bioorganic chemistry 2012;40(1):125-30.
2011: Jakob Nilsson; Ritha Gidlöf; Elsebet Ø Nielsen; Tommy Liljefors; Mogens Nielsen; Olov Sterner
Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.
Bioorganic & medicinal chemistry 2011;19(1):111-21.
2009: Helle Hald; Philip K Ahring; Daniel B Timmermann; Tommy Liljefors; Michael Gajhede; Jette S Kastrup
Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
Journal of molecular biology 2009;391(5):906-17.
2009: Christopher Armishaw; Anders A Jensen; Thomas Balle; Richard J Clark; Kasper Harpsøe; Christian Skonberg; Tommy Liljefors; Kristian Strømgaard
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.
The Journal of biological chemistry 2009;284(14):9498-512.
2009: Rikke Bergmann; Tommy Liljefors; Morten D Sørensen; Ismael Zamora
SHOP: receptor-based scaffold HOPping by GRID-based similarity searches.
Journal of chemical information and modeling 2009;49(3):658-69.
2009: Christopher J Armishaw; Anders A Jensen; Christian Skonberg; Tommy Liljefors; Kristian Strømgaard
Synthesis and biological activity of novel alpha-conotoxin analogues incorporating substituted proline derivatives.
Advances in experimental medicine and biology 2009;611():179-80.
2009: Camilla P Hansen; Anders A Jensen; Thomas Balle; Klaus Bitsch-Jensen; Mohamud M Hassan; Tommy Liljefors; Bente Frølund
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).
Bioorganic & medicinal chemistry letters 2009;19(1):87-91.
2008: Camilla P Hansen; Anders A Jensen; Jeppe K Christensen; Thomas Balle; Tommy Liljefors; Bente Frølund
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.
Journal of medicinal chemistry 2008;51(23):7380-95.
2008: Jakob Nilsson; Elsebet Østergaard Nielsen; Tommy Liljefors; Mogens Nielsen; Olov Sterner
Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors.
Bioorganic & medicinal chemistry letters 2008;18(21):5713-6.
2008: Erik Lager; Jakob Nilsson; Elsebet Østergaard Nielsen; Mogens Nielsen; Tommy Liljefors; Olov Sterner
Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.
Bioorganic & medicinal chemistry 2008;16(14):6936-48.
2008: Tommy Sander; Tommy Liljefors; Thomas Balle
Prediction of the receptor conformation for iGluR2 agonist binding: QM/MM docking to an extensive conformational ensemble generated using normal mode analysis.
Journal of molecular graphics & modelling 2008;26(8):1259-68.
2008: Mads Beich-Frandsen; Darryl S Pickering; Osman Mirza; Tommy N Johansen; Jeremy Greenwood; Bente Vestergaard; Arne Schousboe; Michael Gajhede; Tommy Liljefors; Jette S Kastrup
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.
Journal of medicinal chemistry 2008;51(5):1459-63.
2008: Kasper Harpsøe; Tommy Liljefors; Thomas Balle
Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis.
Journal of molecular graphics & modelling 2008;26(5):874-83.
2007: Birgitte H Kaae; Kasper Harpsøe; Jette S Kastrup; Alberto Contreras Sanz; Darryl S Pickering; Bjørn Metzler; Rasmus P Clausen; Michael Gajhede; Per Sauerberg; Tommy Liljefors; Ulf Madsen
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.
Chemistry & biology 2007;14(11):1294-303.
2007: Anders A Jensen; Darius P Zlotos; Tommy Liljefors
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Journal of medicinal chemistry 2007;50(19):4616-29.
2007: Helle Hald; Peter Naur; Darryl S Pickering; Desiree Sprogøe; Ulf Madsen; Daniel B Timmermann; Philip K Ahring; Tommy Liljefors; Arne Schousboe; Jan Egebjerg; Michael Gajhede; Jette S Kastrup
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
The Journal of biological chemistry 2007;282(35):25726-36.
2007: Christian Madsen; Anders A Jensen; Tommy Liljefors; Uffe Kristiansen; Birgitte Nielsen; Camilla P Hansen; Mogens Larsen; Bjarke Ebert; Benny Bang-Andersen; Povl Krogsgaard-Larsen; Bente Frølund
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Journal of medicinal chemistry 2007;50(17):4147-61.
2007: Kasper Harpsøe; Thomas Varming; Alex Haahr Gouliaev; Dan Peters; Tommy Liljefors
Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface.
Journal of molecular graphics & modelling 2007;26(1):213-25.
2007: Bente Frølund; Lars S Jensen; Signe I Storustovu; Tine B Stensbøl; Bjarke Ebert; Jan Kehler; Povl Krogsgaard-Larsen; Tommy Liljefors
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.
Journal of medicinal chemistry 2007;50(8):1988-92.
2006: karine audouze; Elsebet Ø Nielsen; Gunnar M Olsen; Philip K Ahring; Tino Dyhring; Dan Peters; Tommy Liljefors; Thomas Balle
New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling.
Journal of medicinal chemistry 2006;49(11):3159-71.
2006: Erik Lager; Pierre Andersson; Jakob Nilsson; Ingrid Pettersson; Elsebet Ø Nielsen; Mogens Nielsen; Olov Sterner; Tommy Liljefors
4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Journal of medicinal chemistry 2006;49(8):2526-33.
2006: Thomas Balle; Mikael Begtrup; Jerzy W Jaroszewski; Tommy Liljefors; Per-Ola Norrby
Regioselectivity in lithiation of 1-methylpyrazole: experimental, density functional theory and multinuclear NMR study.
Organic & biomolecular chemistry 2006;4(7):1261-7.
2006: Christina Kasper; Darryl S Pickering; Osman Mirza; Lars Olsen; Anders Skov Kristensen; Jeremy R Greenwood; Tommy Liljefors; Arne Schousboe; Frank Wätjen; Michael Gajhede; Bent W Sigurskjold; Jette S Kastrup
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
Journal of molecular biology 2006;357(4):1184-201.
2006: Dorte Krehan; Signe I Storustovu; Tommy Liljefors; Bjarke Ebert; Birgitte Nielsen; Povl Krogsgaard-Larsen; Bente Frølund
Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Journal of medicinal chemistry 2006;49(4):1388-96.
2006: Ann Bygvraa Svenningsen; Katrine Damkjaer Madsen; Tommy Liljefors; Gary I Stafford; Johannes Van Staden; Anna K Jäger
Biflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptor.
Journal of ethnopharmacology 2006;103(2):276-80.
2006: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Advances in pharmacology (San Diego, Calif.) 2006;54():53-71.
2005: Helmer Søhoel; Tommy Liljefors; Steven V Ley; Steven F Oliver; Alessandra Antonello; Martin D Smith; Carl Erik Olsen; John T Isaacs; S Brøgger Christensen
Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin.
Journal of medicinal chemistry 2005;48(22):7005-11.
2005: Anders A Jensen; Bente Frølund; Tommy Liljefors; Povl Krogsgaard-Larsen
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Journal of medicinal chemistry 2005;48(15):4705-45.
2005: Bente Frølund; Lars S Jensen; Luca Guandalini; Carolina Canillo; Henrik T Vestergaard; Uffe Kristiansen; Birgitte Nielsen; Tine B Stensbøl; Christian Madsen; Povl Krogsgaard-Larsen; Tommy Liljefors
Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2005;48(2):427-39.
2005: Anders Bach Nielsen; Karla Frydenvang; Tommy Liljefors; Anders Buur; Claus Larsen
Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(1):85-93.
2004: Pia Kahnberg; Michael H Howard; Tommy Liljefors; Mogens Nielsen; Elsebet Ø Nielsen; Olov Sterner; Ingrid Pettersson
The use of a pharmacophore model for identification of novel ligands for the benzodiazepine binding site of the GABAA receptor.
Journal of molecular graphics & modelling 2004;23(3):253-61.
2004: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors; Bjarke Ebert
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Biochemical pharmacology 2004;68(8):1573-80.
2004: H Rasmussen; Tommy Liljefors; B Petersson; P E Nielsen; T Liljefors; Jette S Kastrup
The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals.
Journal of biomolecular structure & dynamics 2004;21(4):495-502.
2004: Stine B Vogensen; Jeremy R Greenwood; Annemarie R Varming; Lotte Brehm; Darryl S Pickering; Birgitte Nielsen; Tommy Liljefors; Rasmus P Clausen; Tommy N Johansen; Povl Krogsgaard-Larsen
A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Organic & biomolecular chemistry 2004;2(2):206-13.
2004: Henrik Parshad; Karla Frydenvang; Tommy Liljefors; Henning Osholm Sorensen; Claus Larsen
Aqueous solubility study of salts of benzylamine derivatives and p-substituted benzoic acid derivatives using X-ray crystallographic analysis.
International journal of pharmaceutics 2004;269(1):157-68.
2003: Anders Poulsen; Berith Bjørnholm; Klaus Gundertofte; Irina D Pogozheva; Tommy Liljefors
Pharmacophore and receptor models for neurokinin receptors.
Journal of computer-aided molecular design 2003;17(11):765-83.
2003: Henrik Parshad; Karla Frydenvang; Tommy Liljefors; Claus Cornett; Claus Larsen
Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(4):263-72.
2003: Thomas Balle; Kim Andersen; Karina Krøjer Søby; Tommy Liljefors
Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole.
Journal of molecular graphics & modelling 2003;21(6):523-34.
2003: Esben J Bjerrum; Anders Skov Kristensen; Darryl S Pickering; Jeremy R Greenwood; Birgitte Nielsen; Tommy Liljefors; Arne Schousboe; Hans Bräuner-Osborne; Ulf Madsen
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
Journal of medicinal chemistry 2003;46(11):2246-9.
2003: Anne T Jørgensen; Morten Dahl Sørensen; Fredrik Björkling; Tommy Liljefors
Binding of alpha-hydroxy-beta-amino acid inhibitors to methionine aminopeptidase. The performance of two types of scoring functions.
Journal of computer-aided molecular design 2003;17(5-6):383-97.
2003: Bente Frølund; Lena Tagmose; Anne T Jørgensen; Uffe Kristiansen; Tine B Stensbøl; Tommy Liljefors; Povl Krogsgaard-Larsen
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.
European journal of medicinal chemistry 2003;38(4):447-9.
2003: Thomas Balle; Jens Perregaard; Anna Kirstine Larsen; Martha Teresa Ramirez; Karina Krøjer Søby; Tommy Liljefors; Kim Andersen
Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective alpha1 adrenoceptor antagonists.
Bioorganic & medicinal chemistry 2003;11(6):1065-78.
2003: Lennart Bunch; Tommy Liljefors; Jeremy R Greenwood; Karla Frydenvang; Hans Bräuner-Osborne; Povl Krogsgaard-Larsen; Ulf Madsen
Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.
The Journal of organic chemistry 2003;68(4):1489-95.
2003: Thomas Balle; Jens Perregaard; Martha Teresa Ramirez; Anna Kirstine Larsen; Karina Krøjer Søby; Tommy Liljefors; Kim Andersen
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Journal of medicinal chemistry 2003;46(2):265-83.
2003: Anders Hogner; Jeremy R Greenwood; Tommy Liljefors; Marie-Louise Lunn; Jan Egebjerg; Ingrid K Larsen; James Eric Gouaux; Jette S Kastrup
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
Journal of medicinal chemistry 2003;46(2):214-21.
2003: Morten Muhlig Nielsen; Tommy Liljefors; Povl Krogsgaard-Larsen; Jan Egebjerg
The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.
Molecular pharmacology 2003;63(1):19-25.
2002: Christina Kasper; Marie-Louise Lunn; Tommy Liljefors; James Eric Gouaux; Jan Egebjerg; Jette S Kastrup
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.
FEBS letters 2002;531(2):173-8.
2002: Martin Mortensen; Bente Frølund; Anne T Jørgensen; Tommy Liljefors; Povl Krogsgaard-Larsen; Bjarke Ebert
Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity.
European journal of pharmacology 2002;451(2):125-32.
2002: Pia Kahnberg; Erik Lager; Celia Rosenberg; Jette Schougaard; Linda Camet; Olov Sterner; Elsebet Østergaard Nielsen; Mogens Nielsen; Tommy Liljefors
Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor.
Journal of medicinal chemistry 2002;45(19):4188-201.
2002: Anders Hogner; Jette S Kastrup; R Jin; Tommy Liljefors; Mark L Mayer; Jan Egebjerg; Ingrid K Larsen; James Eric Gouaux
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
Journal of molecular biology 2002;322(1):93-109.
2002: Bente Frølund; Bjarke Ebert; Uffe Kristiansen; Tommy Liljefors; Povl Krogsgaard-Larsen
GABA(A) receptor ligands and their therapeutic potentials.
Current topics in medicinal chemistry 2002;2(8):817-32.
2002: Bente Frølund; Anne T Jørgensen; Lena Tagmose; Tine B Stensbøl; Henrik T Vestergaard; Christine Engblom; Uffe Kristiansen; Connie Sanchez; Povl Krogsgaard-Larsen; Tommy Liljefors
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2002;45(12):2454-68.
2002: Henrik Parshad; Karla Frydenvang; Tommy Liljefors; Claus Selch Larsen
Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach.
International journal of pharmaceutics 2002;237(1-2):193-207.
2002: Anders Poulsen; Tommy Liljefors; Klaus Gundertofte; Berith Bjørnholm
A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes.
Journal of computer-aided molecular design 2002;16(4):273-86.
2002: Anne T Jørgensen; Per-Ola Norrby; Tommy Liljefors
Investigation of the metal binding site in methionine aminopeptidase by density functional theory.
Journal of computer-aided molecular design 2002;16(3):167-79.
2002: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors
Specific GABA(A) agonists and partial agonists.
Chemical record (New York, N.Y.) 2002;2(6):419-30.
2001: Giuseppe Campiani; Elena Morelli; Vito Nacci; Caterina Fattorusso; Anna Ramunno; Ettore Novellino; J Greenwood; Tommy Liljefors; Roger Griffiths; Colin Sinclair; Helen Reavy; Anders Skov Kristensen; Darryl S Pickering; Arne Schousboe; Alfredo Cagnotto; Elena Fumagalli; Tiziana Mennini
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Journal of medicinal chemistry 2001;44(26):4501-4.
2001: P A Nielsen; Tommy Liljefors
Conformational analysis of kainate in aqueous solution in relation to its binding to AMPA and kainic acid receptors.
Journal of computer-aided molecular design 2001;15(8):753-63.
2001: P A Nielsen; Jerzy W Jaroszewski; Per-Ola Norrby; Tommy Liljefors
An NMR and ab initio quantum chemical study of acid-base equilibria for conformationally constrained acidic alpha-amino acids in aqueous solution.
Journal of the American Chemical Society 2001;123(9):2003-6.
2000: Bente Frølund; Lena Tagmose; Tommy Liljefors; Tine B Stensbøl; C Engblom; Uffe Kristiansen; Povl Krogsgaard-Larsen
A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.
Journal of medicinal chemistry 2000;43(26):4930-3.
2000: L Hartvig; B Lükensmejer; Tommy Liljefors; K Dekermendjian
Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function.
Journal of neurochemistry 2000;75(4):1746-53.
2000: Simon Feldbaek Nielsen; E O Nielsen; Gunnar M Olsen; Tommy Liljefors; Dan Peters
Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis.
Journal of medicinal chemistry 2000;43(11):2217-26.
1999: K Dekermendjian; Pia Kahnberg; Michael-Robin Witt; Olov Sterner; Mogens Nielsen; Tommy Liljefors
Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.
Journal of medicinal chemistry 1999;42(21):4343-50.
1999: SE Westh-Hansen; Michael-Robin Witt; K Dekermendjian; Tommy Liljefors; PB Rasmussen; Mogens Nielsen
Arginine residue 120 of the human GABAA receptor alpha 1, subunit is essential for GABA binding and chloride ion current gating.
Neuroreport 1999;10(11):2417-21.
1998: Simon Feldbaek Nielsen; S Brøgger Christensen; G Cruciani; Arsalan Kharazmi; Tommy Liljefors
Antileishmanial chalcones: statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis.
Journal of medicinal chemistry 1998;41(24):4819-32.
1998: Jonas Boström; Per-Ola Norrby; Tommy Liljefors
Conformational energy penalties of protein-bound ligands.
Journal of computer-aided molecular design 1998;12(4):383-96.