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Herman Lim

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TOP 3
Mounir Andaloussi; Iwan J P De Esch; Rob Leurs; Herman D Lim; Chris B M Poulie; Maarten Sijm; Tiffany van der Meer; Rogier A Smits
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787.
Enade P Istyastono; Albert J Kooistra; Rob Leurs; Herman D Lim; Saskia Nijmeijer; Luc Roumen; Andrea C van de Stolpe; Henry Vischer; Iwan J P De Esch; Chris de Graaf
Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Sebastiaan Kuhne; Rob Leurs; Herman D Lim; Maikel Wijtmans; Iwan J P De Esch
Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

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All Publications

2013: Mounir Andaloussi; Iwan J P De Esch; Rob Leurs; Herman D Lim; Chris B M Poulie; Maarten Sijm; Tiffany van der Meer; Rogier A Smits
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787.
Bioorganic & medicinal chemistry letters 2013;23(9):2663-70.
2011: Enade P Istyastono; Albert J Kooistra; Rob Leurs; Herman D Lim; Saskia Nijmeijer; Luc Roumen; Andrea C van de Stolpe; Henry Vischer; Iwan J P De Esch; Chris de Graaf
Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Journal of medicinal chemistry 2011;54(23):8136-47.
2011: Sebastiaan Kuhne; Rob Leurs; Herman D Lim; Maikel Wijtmans; Iwan J P De Esch
Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?
Expert opinion on investigational drugs 2011;20(12):1629-48.
2011: Petra de Kruijf; Douglas S Auld; Chris de Graaf; Herman D Lim; Véronique A Renjaän; Luc Roumen; Martine J Smit; Maria L Webb; Jac C H M Wijkmans; Guido J R Zaman; Jiuqiao Zhao; Rob Leurs
Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.
Molecular pharmacology 2011;80(6):1108-18.
2011: Saskia A Overbeek; Martine J Smit; Anja I Srienc; Guido J R Zaman; Johan Garssen; P A J Henricks; Pim J Koelink; Aletta D Kraneveld; Herman D Lim; Frans P Nijkamp; Petra de Kruijf; Gert Folkerts
N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release.
European journal of pharmacology 2011;668(3):428-34.
2010: Petra de Kruijf; Herman D Lim; Saskia A Overbeek; Guido J R Zaman; Aletta D Kraneveld; Gert Folkerts; Rob Leurs; Martine J Smit
The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2.
European journal of pharmacology 2010;643(1):29-33.
2010: Herman D Lim; Chris de Graaf; Wen Jiang; Payman Sadek; Patricia M McGovern; Enade P Istyastono; Remko A Bakker; Iwan J P De Esch; Robin Thurmond; Rob Leurs
Molecular determinants of ligand binding to H4R species variants.
Molecular pharmacology 2010;77(5):734-43.
2009: Herman D Lim; Enade P Istyastono; Andrea van de Stolpe; Giuseppe Romeo; Silvia Gobbi; Marjo Schepers; Roger Lahaye; Wiro M P B Menge; Obbe P Zuiderveld; Aldo Jongejan; Rogier A Smits; Remko A Bakker; Eric E J Haaksma; Rob Leurs; Iwan J P De Esch
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Bioorganic & medicinal chemistry 2009;17(11):3987-94.
2009: Herman D Lim; Maristella Adami; Elena Guaita; Thomas Werfel; Rogier A Smits; Iwan J P De Esch; Remko A Bakker; Ralf Gutzmer; Gabriella Coruzzi; Rob Leurs
Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
British journal of pharmacology 2009;157(1):34-43.
2009: Rob Leurs; Paul L Chazot; Fiona C Shenton; Herman D Lim; Iwan J P De Esch
Molecular and biochemical pharmacology of the histamine H4 receptor.
British journal of pharmacology 2009;157(1):14-23.
2009: Petra de Kruijf; Jane van Heteren; Herman D Lim; Paolo G M Conti; Miranda M C van der Lee; Leontien Bosch; Koc-Kan Ho; Douglas Auld; Michael Ohlmeyer; Martine J Smit; Jac C H M Wijkmans; Guido J R Zaman; Martine J Smit; Rob Leurs
Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor.
The Journal of pharmacology and experimental therapeutics 2009;329(2):783-90.
2008: Herman D Lim; Aldo Jongejan; Remko A Bakker; Eric Haaksma; Iwan J P De Esch; Rob Leurs
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
The Journal of pharmacology and experimental therapeutics 2008;327(1):88-96.
2008: Richard M van Rijn; André van Marle; Paul L Chazot; Ellen Langemeijer; Yongjun Qin; Fiona C Shenton; Herman D Lim; Obbe P Zuiderveld; Kamonchanok Sansuk; Michel Dy; Martine J Smit; Cornelis P Tensen; Remko A Bakker; Rob Leurs
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
The Biochemical journal 2008;414(1):121-31.
2008: Rogier A Smits; Herman D Lim; Agnes Hanzer; Obbe P Zuiderveld; Elena Guaita; Maristella Adami; Gabriella Coruzzi; Rob Leurs; Iwan J P De Esch
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Journal of medicinal chemistry 2008;51(8):2457-67.
2006: Herman D Lim; Rogier A Smits; Remko A Bakker; Cindy M E van Dam; Iwan J P De Esch; Rob Leurs
Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.
Journal of medicinal chemistry 2006;49(23):6650-1.
2006: Rogier A Smits; Herman D Lim; Bart Stegink; Remko A Bakker; Iwan J P De Esch; Rob Leurs
Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.
Journal of medicinal chemistry 2006;49(15):4512-6.
2006: Marinella Govoni; Herman D Lim; Dris El-Atmioui; Wiro M P B Menge; Henk Timmerman; Remko A Bakker; Rob Leurs; Iwan J P De Esch
A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function.
Journal of medicinal chemistry 2006;49(8):2549-57.
2006: Herman D Lim; Rogier A Smits; Rob Leurs; Iwan J P De Esch
The emerging role of the histamine H4 receptor in anti-inflammatory therapy.
Current topics in medicinal chemistry 2006;6(13):1365-73.
2005: Herman D Lim; Richard M van Rijn; Ping Ling; Remko A Bakker; Robin Thurmond; Rob Leurs
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1310-21.