Philip Barker

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Bertrand Mathieu J M; Doiron Karine; Labbé Katherine; Korneluk Robert G; Barker Philip A; Saleh Maya
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Barker Philip A
A p75(NTR) pivoting paradigm propels perspicacity.
Barker Philip A
Whither proBDNF?

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2009: Bertrand Mathieu J M; Doiron Karine; Labbé Katherine; Korneluk Robert G; Barker Philip A; Saleh Maya
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Immunity 2009;30(6):789-801.
2009: Barker Philip A
A p75(NTR) pivoting paradigm propels perspicacity.
Neuron 2009;62(1):3-5.
2009: Barker Philip A
Whither proBDNF?
Nature neuroscience 2009;12(2):105-6.
2008: Bertrand Mathieu J M; Milutinovic Snezana; Dickson Kathleen M; Ho Wai Chi; Boudreault Alain; Durkin Jon; Gillard John W; Jaquith James B; Morris Stephen J; Barker Philip A
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.
Molecular cell 2008;30(6):689-700.
2008: Boutilier Jacqueline; Ceni Claire; Pagdala Promila C; Forgie Alison; Neet Kenneth E; Barker Philip A
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation.
The Journal of biological chemistry 2008;283(19):12709-16.
2008: Moore Simon W; Lai Wing Sun Karen; Xie Fang; Barker Philip A; Conti Marco; Kennedy Timothy E
Soluble adenylyl cyclase is not required for axon guidance to netrin-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(15):3920-4.
2007: Ramos Alberto; Ho Wai Chi; Forte Stephanie; Dickson Kathleen; Boutilier Jacqueline; Favell Kristy; Barker Philip A
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(6):1498-506.
2007: Barker Philip A
High affinity not in the vicinity?
Neuron 2007;53(1):1-4.
2006: Sirerol-Piquer Maria Salomé; Ayerdi-Izquierdo Ana; Morante-Redolat José Manuel; Herranz-Pérez Vicente; Favell Kristy; Barker Philip A; Pérez-Tur Jordi
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.
Human molecular genetics 2006;15(23):3436-45.
2006: Salehi Amir H; Morris Stephen J; Ho Wai-Chi; Dickson Kathleen M; Doucet Genevieve; Milutinovic Snezana; Durkin Jon; Gillard John W; Barker Philip A
AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.
Chemistry & biology 2006;13(2):213-23.
2005: Makkerh Joe P S; Ceni Claire; Auld Daniel S; Vaillancourt François; Dorval Genevieve; Barker Philip A
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.
EMBO reports 2005;6(10):936-41.
2005: Ceni Claire; Barker Philip A
Getting RIP'd Stunts Your Growth.
Neuron 2005;46(6):839-40.
2005: Ho Wai Chi; Dickson Kathleen M; Barker Philip A
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.
Cancer research 2005;65(10):4273-81.
2004: Becker Esther B E; Howell Jenny; Kodama Yuki; Barker Philip A; Bonni Azad
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(40):8762-70.
2004: Dickson Kathleen M; Bhakar Asha L; Barker Philip A
TRAF6-dependent NF-kB transcriptional activity during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(1):122-7.
2004: Barker Philip A
p75NTR is positively promiscuous: novel partners and new insights.
Neuron 2004;42(4):529-33.
2004: Bouchard Jean-François; Moore Simon W; Tritsch Nicolas X; Roux Philippe P; Shekarabi Masoud; Barker Philip A; Kennedy Timothy E
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(12):3040-50.
2004: Paul Christine E; Vereker Emily; Dickson Kathleen M; Barker Philip A
A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(8):1917-23.
2003: Bhakar Asha L; Howell Jenny L; Paul Christine E; Salehi Amir H; Becker Esther B E; Said Farid; Bonni Azad; Barker Philip A
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(36):11373-81.
2002: Roux Philippe P; Dorval Geneviève; Boudreau Mathieu; Angers-Loustau Alexandre; Morris Stephen J; Makkerh Joe; Barker Philip A
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.
The Journal of biological chemistry 2002;277(51):49473-80.
2002: Salehi Amir H; Xanthoudakis Steven; Barker Philip A
NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.
The Journal of biological chemistry 2002;277(50):48043-50.
2002: Bhakar Asha L; Tannis Laura-Lee; Zeindler Christine; Russo Maria Pia; Jobin Christian; Park David S; MacPherson Sandra; Barker Philip A
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8466-75.
2002: Kendall Stephen E; Goldhawk Donna E; Kubu Chris; Barker Philip A; Verdi Joseph M
Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.
Mechanisms of development 2002;117(1-2):187-200.
2002: Barker Philip A; Hussain Natasha K; McPherson Peter S
Retrograde signaling by the neurotrophins follows a well-worn trk.
Trends in neurosciences 2002;25(8):379-81.
2002: Roux Philippe P; Barker Philip A
Neurotrophin signaling through the p75 neurotrophin receptor.
Progress in neurobiology 2002;67(3):203-33.
2002: Barker Philip A; Salehi Amir
The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.
Journal of neuroscience research 2002;67(6):705-12.
2001: Roux P P; Bhakar A L; Kennedy T E; Barker P A
The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway.
The Journal of biological chemistry 2001;276(25):23097-104.
2000: Kryl D; Barker P A
TTIP is a novel protein that interacts with the truncated T1 TrkB neurotrophin receptor.
Biochemical and biophysical research communications 2000;279(3):925-30.
2000: Kubu C J; Goldhawk D G; Barker P A; Verdi J M
Identification of the translational initiation codon in human MAGED1.
Genomics 2000;70(1):150-2.
2000: Salehi A H; Roux P P; Kubu C J; Zeindler C; Bhakar A; Tannis L L; Verdi J M; Barker P A
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
Neuron 2000;27(2):279-88.
1999: Roux P P; Colicos M A; Barker P A; Kennedy T E
p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):6887-96.
1999: Bhakar A L; Roux P P; Lachance C; Kryl D; Zeindler C; Barker P A
The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress.
The Journal of biological chemistry 1999;274(30):21443-9.
1999: Kryl D; Yacoubian T; Haapasalo A; Castren E; Lo D; Barker P A
Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5823-33.
1999: MacPhee I; Barker P A
Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation.
Journal of neurochemistry 1999;72(4):1423-30.
1998: Barker P A
p75NTR: A study in contrasts.
Cell death and differentiation 1998;5(5):346-56.
1998: Becher B; Barker P A; Owens T; Antel J P
CD95-CD95L: can the brain learn from the immune system?
Trends in neurosciences 1998;21(3):114-7.
1998: Ladiwala U; Lachance C; Simoneau S J; Bhakar A; Barker P A; Antel J P
p75 neurotrophin receptor expression on adult human oligodendrocytes: signaling without cell death in response to NGF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(4):1297-304.
1997: Lachance C; Belliveau D J; Barker P A
Blocking nerve growth factor binding to the p75 neurotrophin receptor on sympathetic neurons transiently reduces trkA activation but does not affect neuronal survival.
Neuroscience 1997;81(3):861-71.
1997: MacPhee I J; Barker P A
Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain.
The Journal of biological chemistry 1997;272(38):23547-51.
1997: Majdan M; Lachance C; Gloster A; Aloyz R; Zeindler C; Bamji S; Bhakar A; Belliveau D; Fawcett J; Miller F D; Barker P A
Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6988-98.
1996: D'Souza S D; Bonetti B; Balasingam V; Cashman N R; Barker P A; Troutt A B; Raine C S; Antel J P
Multiple sclerosis: Fas signaling in oligodendrocyte cell death.
The Journal of experimental medicine 1996;184(6):2361-70.
1993: Murphy R A; Acheson A; Hodges R; Haskins J; Richards C; Reklow E; Chlumecky V; Barker P A; Alderson R F; Lindsay R M
Immunological relationships of NGF, BDNF, and NT-3: recognition and functional inhibition by antibodies to NGF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):2853-62.
1992: Barker P A; Murphy R A
The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins.
Molecular and cellular biochemistry 1992;110(1):1-15.
1991: Barker P A; Miller F D; Large T H; Murphy R A
Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.
The Journal of biological chemistry 1991;266(28):19113-9.
1991: Acheson A; Barker P A; Alderson R F; Miller F D; Murphy R A
Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF.
Neuron 1991;7(2):265-75.
1989: Murphy R A; Chlumecky V; Smillie L B; Carpenter M; Nattriss M; Anderson J K; Rhodes J A; Barker P A; Siminoski K; Campenot R B
Isolation and characterization of a glycosylated form of beta nerve growth factor in mouse submandibular glands.
The Journal of biological chemistry 1989;264(21):12502-9.
1988: Barker P A; Gilchrist J S; Belcastro A N
An improved method for the isolation of rat cardiac sarcoplasmic reticulum.
Molecular and cellular biochemistry 1988;84(1):87-95.

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Philip Barker

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