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Louis Lim
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Research Profile (preview)
Chemicals & Drugs
Anatomy
Phenomena
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Genes & Molecular Sequences
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Physiology
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Network (preview)
23
Manser, Ed
20
Leung, Thomas
11
Tan, Ivan
7
Chen, Xiang-qun
6
Hall, Christine
6
Zhao, Zhuo-Shen
5
Ahmed, Sohail
5
Kozma, Robert
4
Loo, Tsui-Han
4
Dong, Jing-Ming
4
Koh, Cheng-Gee
4
Monfries, Clinton
3
Tan, L
3
Teo, Mabel
3
Ferrari, Giovanna
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Publications
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Geonetwork of Louis Lim (preview)
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All Publications
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2009: Chan Wing; Tian Rui; Lee Yeow-Fong; Sit Soon Tuck; Lim Louis; Manser Ed
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
The Journal of biological chemistry 2009;284(12):8185-94.
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2009: Dong Jing-Ming; Lau Lei-Shong; Ng Yuen-Wai; Lim Louis; Manser Ed
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation.
The Biochemical journal 2009;418(1):173-84.
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2009: Bahri Sami M; Choy Juliana M; Manser Edward; Lim Louis; Yang Xiaohang
The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis.
Developmental biology 2009;325(1):15-23.
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2008: Chan Perry M; Lim Louis; Manser Edward
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
The Journal of biological chemistry 2008;283(36):24949-61.
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2008: Xie Yi; Tan E-Jean; Wee Shimei; Manser Edward; Lim Louis; Koh Cheng-Gee
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.
Journal of cell science 2008;121(Pt 4):514-21.
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2006: Yong Jeffery; Tan Ivan; Lim Louis; Leung Thomas
Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
The Journal of biological chemistry 2006;281(42):31202-11.
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2005: Zhao Zhuo-Shen; Lim Jet Phey; Ng Yuen-Wai; Lim Louis; Manser Ed
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
Molecular cell 2005;20(2):237-49.
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2005: Marler Katharine J M; Kozma Robert; Ahmed Sohail; Dong Jing-Ming; Hall Christine; Lim Louis
Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK.
Molecular and cellular biology 2005;25(12):5226-41.
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2005: Hall Christine; Lim Louis; Leung Thomas
C1, see them all.
Trends in biochemical sciences 2005;30(4):169-71.
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2005: Li Zhigang; McNulty Dean E; Marler Katharine J M; Lim Louis; Hall Christine; Annan Roland S; Sacks David B
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.
The Journal of biological chemistry 2005;280(14):13871-8.
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2004: Brown Matthew; Jacobs Tom; Eickholt Britta; Ferrari Giovanna; Teo Mabel; Monfries Clinton; Qi Robert Z; Leung Thomas; Lim Louis; Hall Christine
Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(41):8994-9004.
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2004: Ng Yvonne; Tan Ivan; Lim Louis; Leung Thomas
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
The Journal of biological chemistry 2004;279(33):34156-64.
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2004: Loo Tsui-Han; Ng Yuen-Wai; Lim Louis; Manser Ed
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.
Molecular and cellular biology 2004;24(9):3849-59.
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2003: Tan Ivan; Cheong Albert; Lim Louis; Leung Thomas
Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity.
Gene 2003;304():107-15.
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2002: Chan Wing; Kozma Robert; Yasui Yoshihiro; Inagaki Masaki; Leung Thomas; Manser Ed; Lim Louis
Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase.
European journal of cell biology 2002;81(12):692-701.
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2002: Leung Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.
FEBS letters 2002;532(3):445-9.
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2002: Dong Jing-Ming; Leung Thomas; Manser Edward; Lim Louis
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
European journal of cell biology 2002;81(4):231-42.
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2002: Chen Xiang-qun; Tan Ivan; Ng Chong Han; Hall Christine; Lim Louis; Leung Thomas
Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies.
The Journal of biological chemistry 2002;277(15):12680-8.
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2002: Koh Cheng-Gee; Tan E-Jean; Manser Edward; Lim Louis
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
Current biology : CB 2002;12(4):317-21.
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2002: Zhao Zhoushen; Lim Louis
A Ras-based module to generate 32P-labeled fusion proteins for blot overlays.
Methods in molecular biology (Clifton, N.J.) 2002;189():87-95.
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2002: Tan Ivan; Lim Louis; Leung Thomas
Introduction of dominant inhibitory proteins directed against ROK and MRCK kinases.
Methods in molecular biology (Clifton, N.J.) 2002;189():111-9.
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2001: Koh C G; Manser E; Zhao Z S; Ng C P; Lim L
Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles.
Journal of cell science 2001;114(Pt 23):4239-51.
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2001: Hall C; Brown M; Jacobs T; Ferrari G; Cann N; Teo M; Monfries C; Lim L
Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase.
The Journal of biological chemistry 2001;276(46):43482-6.
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2001: Hall C; Michael G J; Cann N; Ferrari G; Teo M; Jacobs T; Monfries C; Lim L
alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5191-202.
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2001: Zhao Z; Lim L; Manser E
Blot overlays with 32P-labeled fusion proteins.
Methods (San Diego, Calif.) 2001;24(3):194-200.
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2001: Tan I; Ng C H; Lim L; Leung T
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
The Journal of biological chemistry 2001;276(24):21209-16.
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2001: Chong C; Tan L; Lim L; Manser E
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.
The Journal of biological chemistry 2001;276(20):17347-53.
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2001: Teo M; Tan L; Lim L; Manser E
The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors.
The Journal of biological chemistry 2001;276(21):18392-8.
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2001: Tan I; Seow K T; Lim L; Leung T
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Molecular and cellular biology 2001;21(8):2767-78.
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2001: Govind S; Kozma R; Monfries C; Lim L; Ahmed S
Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin.
The Journal of cell biology 2001;152(3):579-94.
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2000: Zhao Z S; Manser E; Loo T H; Lim L
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.
Molecular and cellular biology 2000;20(17):6354-63.
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2000: Zhao Z S; Manser E; Lim L
Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.
Molecular and cellular biology 2000;20(11):3906-17.
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2000: Sarner S; Kozma R; Ahmed S; Lim L
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells.
Molecular and cellular biology 2000;20(1):158-72.
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1999: Yap S F; Chen W; Lim L
Molecular characterization of the Caenorhabditis elegans Rho GDP-dissociation inhibitor.
European journal of biochemistry / FEBS 1999;266(3):1090-100.
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1999: Chen X Q; Tan I; Leung T; Lim L
The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.
The Journal of biological chemistry 1999;274(28):19901-5.
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1998: Sin W C; Chen X Q; Leung T; Lim L
RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network.
Molecular and cellular biology 1998;18(11):6325-39.
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1998: Dong J M; Leung T; Manser E; Lim L
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha.
The Journal of biological chemistry 1998;273(35):22554-62.
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1998: Obermeier A; Ahmed S; Manser E; Yen S C; Hall C; Lim L
PAK promotes morphological changes by acting upstream of Rac.
The EMBO journal 1998;17(15):4328-39.
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1998: Ahmed S; Prigmore E; Govind S; Veryard C; Kozma R; Wientjes F B; Segal A W; Lim L
Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox).
The Journal of biological chemistry 1998;273(25):15693-701.
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1998: Zhao Z S; Manser E; Chen X Q; Chong C; Leung T; Lim L
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.
Molecular and cellular biology 1998;18(4):2153-63.
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1998: Manser E; Loo T H; Koh C G; Zhao Z S; Chen X Q; Tan L; Tan I; Leung T; Lim L
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.
Molecular cell 1998;1(2):183-92.
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1998: Leung T; Chen X Q; Tan I; Manser E; Lim L
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Molecular and cellular biology 1998;18(1):130-40.
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1998: Manser E; Leung T; Lim L
Identification and characterization of small GTPase-associated kinases.
Methods in molecular biology (Clifton, N.J.) 1998;84():295-305.
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1997: Kozma R; Sarner S; Ahmed S; Lim L
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.
Molecular and cellular biology 1997;17(3):1201-11.
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1997: Manser E; Huang H Y; Loo T H; Chen X Q; Dong J M; Leung T; Lim L
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
Molecular and cellular biology 1997;17(3):1129-43.
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